Published in Angew Chem Int Ed Engl on September 17, 2001
Synthesis of Anti-beta-substituted gamma,delta-unsaturated amino acids via Eschenmoser-Claisen rearrangement. Org Lett (2006) 1.05
Development of small molecules designed to modulate protein-protein interactions. J Comput Aided Mol Des (2006) 0.97
Stereoselective Synthesis of Quaternary Proline Analogues. European J Org Chem (2008) 0.92
Machine learning estimates of natural product conformational energies. PLoS Comput Biol (2014) 0.77
Desymmetrization of 7-azabicycloalkenes by tandem olefin metathesis for the preparation of natural product scaffolds. Beilstein J Org Chem (2007) 0.75
A mild and efficient approach to enantioenriched α-hydroxyethyl α,β-unsaturated δ-lactams. Tetrahedron Lett (2016) 0.75
(3R,7aS)-3-(TRICHLOROMETHYL)TETRAHYDROPYRROLO[1,2-C]OXAZOL-1(3H)-ONE: AN AIR AND MOISTURE STABLE REAGENT FOR THE SYNTHESIS OF OPTICALLY ACTIVE α-BRANCHED PROLINES. Organic Synth (2009) 0.75
Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature (2011) 5.35
Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature (2013) 2.49
AMBER force-field parameters for phosphorylated amino acids in different protonation states: phosphoserine, phosphothreonine, phosphotyrosine, and phosphohistidine. J Mol Model (2005) 1.69
Quinpramine is a novel compound effective in ameliorating brain autoimmune disease. Exp Neurol (2008) 1.44
Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists. J Med Chem (2002) 1.44
The structural evolution of dopamine D3 receptor ligands: structure-activity relationships and selected neuropharmacological aspects. Pharmacol Ther (2006) 1.33
Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. J Med Chem (2009) 1.18
Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane compartments. J Neurochem (2006) 1.13
Isolation of dammarane saponins from Panax notoginseng by high-speed counter-current chromatography. J Chromatogr A (2003) 1.12
Recent advances in the search for D3- and D4-selective drugs: probes, models and candidates. Trends Pharmacol Sci (2011) 1.10
Dopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus. Synapse (2006) 1.05
Labeling and glycosylation of peptides using click chemistry: a general approach to (18)F-glycopeptides as effective imaging probes for positron emission tomography. Angew Chem Int Ed Engl (2010) 1.03
Chirospecific synthesis of spirocyclic beta-lactams and their characterization as potent type II beta-turn inducing peptide mimetics. J Org Chem (2006) 1.01
Evaluation of lactam-bridged neurotensin analogues adjusting psi(Pro10) close to the experimentally derived bioactive conformation of NT(8-13). J Med Chem (2004) 1.01
Effective elimination of acute myeloid leukemic cells by recombinant bispecific antibody derivatives directed against CD33 and CD16. J Immunother (2010) 0.99
Histidine 6.55 is a major determinant of ligand-biased signaling in dopamine D2L receptor. Mol Pharmacol (2010) 0.98
Structure-based design of Tet repressor to optimize a new inducer specificity. Biochemistry (2004) 0.97
Argyreia nervosa (Burm. f.): receptor profiling of lysergic acid amide and other potential psychedelic LSD-like compounds by computational and binding assay approaches. J Ethnopharmacol (2013) 0.96
Fancy bioisosteres: novel paracyclophane derivatives as super-affinity dopamine D3 receptor antagonists. J Med Chem (2006) 0.96
A chimeric ligand approach leading to potent antiprion active acridine derivatives: design, synthesis, and biological investigations. J Med Chem (2006) 0.96
Functionally selective dopamine D₂, D₃ receptor partial agonists. J Med Chem (2014) 0.93
A gene regulation system with four distinct expression levels. J Gene Med (2006) 0.93
Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain. Mol Pharmacol (2004) 0.92
Class A G-protein-coupled receptor (GPCR) dimers and bivalent ligands. J Med Chem (2013) 0.92
Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes. J Med Chem (2005) 0.90
Electrostatic complexation and photoinduced electron transfer between Zn-cytochrome c and [olyanionic fullerene dendrimers. Chemistry (2003) 0.89
Two glucosylated abscisic acid derivates from avocado seeds (Persea americana Mill. Lauraceae cv. Hass). Phytochemistry (2004) 0.89
Novel insights into GPCR-peptide interactions: mutations in extracellular loop 1, ligand backbone methylations and molecular modeling of neurotensin receptor 1. Bioorg Med Chem (2008) 0.89
Bivalent dopamine D2 receptor ligands: synthesis and binding properties. J Med Chem (2011) 0.89
CoMFA and CoMSIA investigations revealing novel insights into the binding modes of dopamine D3 receptor agonists. J Med Chem (2005) 0.88
In vitro affinities of various halogenated benzamide derivatives as potential radioligands for non-invasive quantification of D(2)-like dopamine receptors. Bioorg Med Chem (2007) 0.88
SCRF-DFT and NMR comparison of tetracycline and 5a,6-anhydrotetracycline in solution. J Phys Chem B (2006) 0.88
Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands. J Med Chem (2007) 0.88
Muscarinic receptors as model targets and antitargets for structure-based ligand discovery. Mol Pharmacol (2013) 0.87
Functionally selective dopamine D2/D3 receptor agonists comprising an enyne moiety. J Med Chem (2013) 0.87
18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor. ChemMedChem (2008) 0.87
Dopamine D3 receptor ligands: recent advances in the control of subtype selectivity and intrinsic activity. Biochim Biophys Acta (2006) 0.87
Active-state models of ternary GPCR complexes: determinants of selective receptor-G-protein coupling. PLoS One (2013) 0.87
3,4,6-Tri-O-acetyl-2-deoxy-2-[18F]fluoroglucopyranosyl phenylthiosulfonate: a thiol-reactive agent for the chemoselective 18F-glycosylation of peptides. Bioconjug Chem (2007) 0.86
Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions. J Med Chem (2011) 0.86
Functional characterization of a partial loss-of-function mutation of the epithelial sodium channel (ENaC) associated with atypical cystic fibrosis. Cell Physiol Biochem (2009) 0.86
PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain. Eur J Neurosci (2006) 0.85
Molecular dynamics simulations of the effect of the G-protein and diffusible ligands on the β2-adrenergic receptor. J Mol Biol (2011) 0.85
Pharmacophore-guided drug discovery investigations leading to bioactive 5-aminotetrahydropyrazolopyridines. Implications for the binding mode of heterocyclic dopamine D3 receptor agonists. J Med Chem (2005) 0.84
Molecular dynamics simulation links conformation of a pore-flanking region to hyperekplexia-related dysfunction of the inhibitory glycine receptor. Chem Biol (2004) 0.84
Discovery of highly potent and neurotensin receptor 2 selective neurotensin mimetics. J Med Chem (2011) 0.84
Development of a metabolically stable neurotensin receptor 2 (NTS2) ligand. ChemMedChem (2012) 0.84
Peptide backbone modifications on the C-terminal hexapeptide of neurotensin. Bioorg Med Chem Lett (2008) 0.84
Syntheses, receptor bindings, in vitro and in vivo stabilities and biodistributions of DOTA-neurotensin(8-13) derivatives containing β-amino acid residues - a lesson about the importance of animal experiments. Chem Biodivers (2013) 0.82
Synthesis and evaluation of a (18)F-labeled diarylpyrazole glycoconjugate for the imaging of NTS1-positive tumors. J Med Chem (2013) 0.82
Simulating FRET from tryptophan: is the rotamer model correct? J Am Chem Soc (2006) 0.82
Distinct acidic clusters and hydrophobic residues in the alternative splice domains X1 and X2 of alpha7 integrins define specificity for laminin isoforms. J Mol Biol (2007) 0.82
Click chemistry on solid phase: parallel synthesis of N-benzyltriazole carboxamides as super-potent G-protein coupled receptor ligands. J Comb Chem (2006) 0.82
Click linker: efficient and high-yielding synthesis of a new family of SPOS resins by 1,3-dipolar cycloaddition. Org Lett (2003) 0.82
Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype. Bioorg Med Chem Lett (2004) 0.82
Fancy bioisosteres: synthesis, SAR, and pharmacological investigations of novel nonaromatic dopamine D3 receptor ligands. Bioorg Med Chem (2005) 0.82
Fancy bioisosteres: metallocene-derived G-protein-coupled receptor ligands with subnanomolar binding affinity and novel selectivity profiles. J Med Chem (2005) 0.82
Systematic surface scan of the most favorable interaction sites of magnesium ions with tetracycline. J Med Chem (2003) 0.82
Subtype selective tetracycline agonists and their application for a two-stage regulatory system. Chembiochem (2006) 0.81
Bivalent molecular probes for dopamine D2-like receptors. Bioorg Med Chem (2011) 0.81
Development of a bivalent dopamine D₂ receptor agonist. J Med Chem (2011) 0.81
Dopamine D2-like receptor agonists induce penile erection in male rats: differential role of D2, D3 and D4 receptors in the paraventricular nucleus of the hypothalamus. Behav Brain Res (2011) 0.81
Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies. J Med Chem (2008) 0.80
Biotransformation of 21-O-acetyl-deoxycorticosterone by cell suspension cultures of Digitalis lanata (strain W.1.4). Steroids (2012) 0.80
Fancy bioisosteres: synthesis and dopaminergic properties of the endiyne FAUC 88 as a novel non-aromatic D3 agonist. Bioorg Med Chem (2005) 0.80
Cross-receptor interactions between dopamine D2L and neurotensin NTS1 receptors modulate binding affinities of dopaminergics. ACS Chem Neurosci (2011) 0.80
Analogues of FAUC 73 revealing new insights into the structural requirements of nonaromatic dopamine D3 receptor agonists. Bioorg Med Chem (2004) 0.79
Engineering a GPCR-ligand pair that simulates the activation of D(2L) by Dopamine. ACS Chem Neurosci (2009) 0.79
The pH probe CypHer™5E is effectively quenched by FM dyes. J Fluoresc (2013) 0.79
FAUC 213, a highly selective dopamine D4 receptor full antagonist, exhibits atypical antipsychotic properties in behavioural and neurochemical models of schizophrenia. Psychopharmacology (Berl) (2004) 0.79
Induction of the tetracycline repressor: characterization by molecular-dynamics simulations. Proteins (2009) 0.79
Indoloparacyclophanes: Synthesis and Dopamine Receptor Binding of a Novel Arylbioisostere This work was supported by the Fonds der Chemischen Industrie. Angew Chem Int Ed Engl (2001) 0.79
Cyclohexanoid protoflavanones from the stem-bark and roots of Ongokea gore. Phytochemistry (2005) 0.78
The bulky N6 substituent of cabergoline is responsible for agonism of this drug at 5-hydroxytryptamine 5-HT2A and 5-HT2B receptors and thus is a determinant of valvular heart disease. J Pharmacol Exp Ther (2011) 0.78
2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356. Bioorg Med Chem Lett (2002) 0.78
Reaction of folic acid with reducing sugars and sugar degradation products. J Agric Food Chem (2002) 0.78
A new D₂ dopamine receptor agonist allosterically modulates A(2A) adenosine receptor signalling by interacting with the A(2A)/D₂ receptor heteromer. Cell Signal (2011) 0.78
Structural variations of piritrexim, a lipophilic inhibitor of human dihydrofolate reductase: synthesis, antitumor activity and molecular modeling investigations. Eur J Med Chem (2004) 0.78
1,1'-Disubstituted ferrocenes as molecular hinges in mono- and bivalent dopamine receptor ligands. J Med Chem (2009) 0.78
Bioisosteric replacement leading to biologically active [2.2]paracyclophanes with altered binding profiles for aminergic G-protein-coupled receptors. J Med Chem (2010) 0.78
Selective agonists for dopamine/neurotensin receptor heterodimers. ChemMedChem (2011) 0.78
A highly practical RCM approach towards a molecular building kit of spirocyclic reverse turn mimics. Chemistry (2006) 0.78
On the terminal homologation of physiologically active peptides as a means of increasing stability in human serum--neurotensin, opiorphin, B27-KK10 epitope, NPY. Chem Biodivers (2011) 0.78
Diarylpropane-1,3-dione derivatives as TetR-inducing tetracycline mimetics: Synthesis and biological investigations. Chembiochem (2009) 0.78
Characterization of the molecular fragment that is responsible for agonism of pergolide at serotonin 5-Hydroxytryptamine2B and 5-Hydroxytryptamine2A receptors. J Pharmacol Exp Ther (2007) 0.78
Bicyclic melatonin receptor agonists containing a ring-junction nitrogen: Synthesis, biological evaluation, and molecular modeling of the putative bioactive conformation. Bioorg Med Chem (2005) 0.77
Molecular building kit of fused-proline-derived peptide mimetics allowing specific adjustment of the dihedral Psi angle. J Org Chem (2007) 0.77
The therapeutically anti-prion active antibody-fragment scFv-W226: paramagnetic relaxation-enhanced NMR spectroscopy aided structure elucidation of the paratope-epitope interface. J Biomol Struct Dyn (2010) 0.77
Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. J Med Chem (2008) 0.77
Novel azulene derivatives for the treatment of erectile dysfunction. Bioorg Med Chem Lett (2012) 0.77