Published in Cell on October 05, 2001
Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations. Proc Natl Acad Sci U S A (2003) 3.67
Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance. Microbiol Mol Biol Rev (2009) 3.62
Y-family DNA polymerases and their role in tolerance of cellular DNA damage. Nat Rev Mol Cell Biol (2012) 3.43
Magnesium-induced assembly of a complete DNA polymerase catalytic complex. Structure (2006) 3.37
What a difference a decade makes: insights into translesion DNA synthesis. Proc Natl Acad Sci U S A (2007) 3.32
The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. Cell Res (2008) 3.15
Structure and mechanism of human DNA polymerase eta. Nature (2010) 2.69
Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase. EMBO J (2004) 2.43
Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis. EMBO J (2005) 2.37
Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): an archaeal DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic poleta. Nucleic Acids Res (2001) 2.29
Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the beta-clamp. EMBO J (2003) 2.25
Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitin. EMBO J (2006) 2.25
Crystallographic snapshots of a replicative DNA polymerase encountering an abasic site. EMBO J (2004) 2.14
Watching DNA polymerase η make a phosphodiester bond. Nature (2012) 1.92
Probing the active site tightness of DNA polymerase in subangstrom increments. Proc Natl Acad Sci U S A (2005) 1.89
Stepwise translocation of Dpo4 polymerase during error-free bypass of an oxoG lesion. PLoS Biol (2006) 1.89
Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity. Mol Cell Biol (2004) 1.85
Structural basis for the suppression of skin cancers by DNA polymerase eta. Nature (2010) 1.73
Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA. Nat Struct Mol Biol (2010) 1.72
Crystal structure of a benzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase. Proc Natl Acad Sci U S A (2004) 1.66
Low-fidelity DNA synthesis by human DNA polymerase theta. Nucleic Acids Res (2008) 1.65
Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients. Proc Natl Acad Sci U S A (2002) 1.63
Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases. Structure (2009) 1.59
Human DINB1-encoded DNA polymerase kappa is a promiscuous extender of mispaired primer termini. Proc Natl Acad Sci U S A (2002) 1.59
Unlocking the sugar "steric gate" of DNA polymerases. Biochemistry (2011) 1.56
UmuD and RecA directly modulate the mutagenic potential of the Y family DNA polymerase DinB. Mol Cell (2007) 1.51
Xeroderma pigmentosum-variant patients from America, Europe, and Asia. J Invest Dermatol (2008) 1.46
The dinB operon and spontaneous mutation in Escherichia coli. J Bacteriol (2003) 1.46
An error-prone family Y DNA polymerase (DinB homolog from Sulfolobus solfataricus) uses a 'steric gate' residue for discrimination against ribonucleotides. Nucleic Acids Res (2003) 1.44
The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism. J Biol Chem (2011) 1.43
A water-mediated and substrate-assisted catalytic mechanism for Sulfolobus solfataricus DNA polymerase IV. J Am Chem Soc (2007) 1.42
Crystal structures of flax rust avirulence proteins AvrL567-A and -D reveal details of the structural basis for flax disease resistance specificity. Plant Cell (2007) 1.41
Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selection. Biochemistry (2006) 1.40
Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal. Chem Res Toxicol (2009) 1.38
A new paradigm of DNA synthesis: three-metal-ion catalysis. Cell Biosci (2016) 1.38
Insights into the replisome from the structure of a ternary complex of the DNA polymerase III alpha-subunit. J Mol Biol (2008) 1.37
Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells. EMBO J (2002) 1.36
UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota. Mol Cell Biol (2006) 1.34
Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase iota. EMBO J (2009) 1.33
A structural gap in Dpo4 supports mutagenic bypass of a major benzo[a]pyrene dG adduct in DNA through template misalignment. Proc Natl Acad Sci U S A (2007) 1.33
Complex formation of yeast Rev1 and Rev7 proteins: a novel role for the polymerase-associated domain. Mol Cell Biol (2005) 1.33
Translesion DNA polymerases. Cold Spring Harb Perspect Biol (2013) 1.33
Structural and functional elucidation of the mechanism promoting error-prone synthesis by human DNA polymerase kappa opposite the 7,8-dihydro-8-oxo-2'-deoxyguanosine adduct. J Biol Chem (2009) 1.31
Enzymatic switching for efficient and accurate translesion DNA replication. Nucleic Acids Res (2004) 1.30
Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells. EMBO J (2003) 1.29
Insights into base selectivity from the 1.8 Å resolution structure of an RB69 DNA polymerase ternary complex. Biochemistry (2010) 1.29
Requirement of Watson-Crick hydrogen bonding for DNA synthesis by yeast DNA polymerase eta. Mol Cell Biol (2003) 1.27
DNA polymerase beta substrate specificity: side chain modulation of the "A-rule". J Biol Chem (2009) 1.25
Lesion processing: high-fidelity versus lesion-bypass DNA polymerases. Trends Biochem Sci (2008) 1.24
Small multicopy, non-integrative shuttle vectors based on the plasmid pRN1 for Sulfolobus acidocaldarius and Sulfolobus solfataricus, model organisms of the (cren-)archaea. Nucleic Acids Res (2007) 1.23
An overview of Y-Family DNA polymerases and a case study of human DNA polymerase η. Biochemistry (2014) 1.23
Error-prone DNA polymerases: novel structures and the benefits of infidelity. Cell (2001) 1.23
DNA polymerase catalysis in the absence of Watson-Crick hydrogen bonds: analysis by single-turnover kinetics. Biochemistry (2006) 1.23
Eukaryotic Y-family polymerases bypass a 3-methyl-2'-deoxyadenosine analog in vitro and methyl methanesulfonate-induced DNA damage in vivo. Nucleic Acids Res (2008) 1.21
Dissecting the fidelity of bacteriophage RB69 DNA polymerase: site-specific modulation of fidelity by polymerase accessory proteins. Genetics (2002) 1.18
RB69 DNA polymerase mutants with expanded nascent base-pair-binding pockets are highly efficient but have reduced base selectivity. Biochemistry (2009) 1.16
Kinetics, structure, and mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine bypass by human DNA polymerase η. J Biol Chem (2014) 1.14
Mechanism of template-independent nucleotide incorporation catalyzed by a template-dependent DNA polymerase. J Mol Biol (2006) 1.14
The L561A substitution in the nascent base-pair binding pocket of RB69 DNA polymerase reduces base discrimination. Biochemistry (2006) 1.13
Role of Pseudomonas aeruginosa dinB-encoded DNA polymerase IV in mutagenesis. J Bacteriol (2006) 1.13
Evaluating evolutionary models of stress-induced mutagenesis in bacteria. Nat Rev Genet (2013) 1.12
Yeast DNA polymerase eta makes functional contacts with the DNA minor groove only at the incoming nucleoside triphosphate. Proc Natl Acad Sci U S A (2003) 1.12
Structure of the human Rev1-DNA-dNTP ternary complex. J Mol Biol (2009) 1.12
Antibiotic resistance acquired through a DNA damage-inducible response in Acinetobacter baumannii. J Bacteriol (2013) 1.10
Accuracy, lesion bypass, strand displacement and translocation by DNA polymerases. Philos Trans R Soc Lond B Biol Sci (2004) 1.10
Escherichia coli DNA polymerase III can replicate efficiently past a T-T cis-syn cyclobutane dimer if DNA polymerase V and the 3' to 5' exonuclease proofreading function encoded by dnaQ are inactivated. J Bacteriol (2002) 1.10
Structural diversity of the Y-family DNA polymerases. Biochim Biophys Acta (2010) 1.10
Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion. PLoS One (2009) 1.09
Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions. EMBO J (2001) 1.09
A DinB variant reveals diverse physiological consequences of incomplete TLS extension by a Y-family DNA polymerase. Proc Natl Acad Sci U S A (2009) 1.08
A new model for SOS-induced mutagenesis: how RecA protein activates DNA polymerase V. Crit Rev Biochem Mol Biol (2010) 1.08
Novel role for the C terminus of Saccharomyces cerevisiae Rev1 in mediating protein-protein interactions. Mol Cell Biol (2006) 1.07
Highly organized but pliant active site of DNA polymerase beta: compensatory mechanisms in mutant enzymes revealed by dynamics simulations and energy analyses. Biophys J (2004) 1.07
Essential roles for imuA'- and imuB-encoded accessory factors in DnaE2-dependent mutagenesis in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2010) 1.07
Erroneous incorporation of oxidized DNA precursors by Y-family DNA polymerases. EMBO Rep (2003) 1.06
Kinetic analysis of correct nucleotide insertion by a Y-family DNA polymerase reveals conformational changes both prior to and following phosphodiester bond formation as detected by tryptophan fluorescence. J Biol Chem (2008) 1.06
Global conformational dynamics of a Y-family DNA polymerase during catalysis. PLoS Biol (2009) 1.05
Variation in mutation rates caused by RB69pol fidelity mutants can be rationalized on the basis of their kinetic behavior and crystal structures. J Mol Biol (2011) 1.03
Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase lambda. EMBO Rep (2008) 1.03
Versatility of Y-family Sulfolobus solfataricus DNA polymerase Dpo4 in translesion synthesis past bulky N2-alkylguanine adducts. J Biol Chem (2008) 1.03
Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota. Proc Natl Acad Sci U S A (2011) 1.03
Base-displaced intercalated structure of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme, a hotspot for -2 bp deletions. J Am Chem Soc (2006) 1.02
Processing of DNA lesions by archaeal DNA polymerases from Sulfolobus solfataricus. Nucleic Acids Res (2003) 1.02
Y586F mutation in murine leukemia virus reverse transcriptase decreases fidelity of DNA synthesis in regions associated with adenine-thymine tracts. Proc Natl Acad Sci U S A (2002) 1.01
A new anti conformation for N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (AAF-dG) allows Watson-Crick pairing in the Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4). Nucleic Acids Res (2006) 1.00
Mechanism of error-free and semitargeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4. Nat Struct Mol Biol (2010) 1.00
Comparison of the in vitro replication of the 7-(2-oxoheptyl)-1,N2-etheno-2'-deoxyguanosine and 1,N2-etheno-2'-deoxyguanosine lesions by Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4). Chem Res Toxicol (2010) 0.99
Human DNA polymerase kappa uses template-primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions. Genes Dev (2003) 0.98
An intramolecular FRET system monitors fingers subdomain opening in Klentaq1. Protein Sci (2008) 0.98
Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4. EMBO J (2010) 0.98
Structural insights into complete metal ion coordination from ternary complexes of B family RB69 DNA polymerase. Biochemistry (2011) 0.97
A mechanism of nucleotide misincorporation during transcription due to template-strand misalignment. Mol Cell (2006) 0.96
Quantum mechanics/molecular mechanics investigation of the chemical reaction in Dpo4 reveals water-dependent pathways and requirements for active site reorganization. J Am Chem Soc (2008) 0.95
Novel thermostable Y-family polymerases: applications for the PCR amplification of damaged or ancient DNAs. Nucleic Acids Res (2006) 0.95
Whole-exome sequencing enables rapid determination of xeroderma pigmentosum molecular etiology. PLoS One (2013) 0.94
Characterization of the elongation complex of dengue virus RNA polymerase: assembly, kinetics of nucleotide incorporation, and fidelity. J Biol Chem (2010) 0.94
DNA adduct structure-function relationships: comparing solution with polymerase structures. Chem Res Toxicol (2007) 0.94
Effects of accessory proteins on the bypass of a cis-syn thymine-thymine dimer by Saccharomyces cerevisiae DNA polymerase eta. Biochemistry (2007) 0.93
Mechanistic studies of the bypass of a bulky single-base lesion catalyzed by a Y-family DNA polymerase. J Biol Chem (2009) 0.93
Stable complexes formed by HIV-1 reverse transcriptase at distinct positions on the primer-template controlled by binding deoxynucleoside triphosphates or foscarnet. J Mol Biol (2007) 0.93
CHARMM: the biomolecular simulation program. J Comput Chem (2009) 27.71
Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis (2001) 12.85
Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond) (2008) 9.45
The Y-family of DNA polymerases. Mol Cell (2001) 6.49
A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci U S A (1998) 6.47
Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci U S A (2000) 5.49
Identification of additional genes belonging to the LexA regulon in Escherichia coli. Mol Microbiol (2000) 5.08
Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA. Nature (2000) 4.63
UmuD'(2)C is an error-prone DNA polymerase, Escherichia coli pol V. Proc Natl Acad Sci U S A (1999) 4.24
The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism. Genetics (1997) 4.04
Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis. Nature (2000) 3.95
Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc Natl Acad Sci U S A (1998) 3.88
UmuD mutagenesis protein of Escherichia coli: overproduction, purification, and cleavage by RecA. Proc Natl Acad Sci U S A (1988) 3.85
Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein. EMBO J (2001) 3.23
Hardness, softness, and the fukui function in the electronic theory of metals and catalysis. Proc Natl Acad Sci U S A (1985) 3.12
Molecular analysis of antibiotic resistance gene clusters in vibrio cholerae O139 and O1 SXT constins. Antimicrob Agents Chemother (2001) 3.10
poliota, a remarkably error-prone human DNA polymerase. Genes Dev (2000) 3.08
Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair. Cell (1999) 2.91
Short-window spectral analysis of cortical event-related potentials by adaptive multivariate autoregressive modeling: data preprocessing, model validation, and variability assessment. Biol Cybern (2000) 2.81
Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity. J Mol Biol (2001) 2.80
The use of global and local molecular parameters for the analysis of the gas-phase basicity of amines. J Am Chem Soc (1986) 2.64
Expression of the TMPRSS2:ERG fusion gene predicts cancer recurrence after surgery for localised prostate cancer. Br J Cancer (2007) 2.62
Mutagenic repair in Escherichia coli: products of the recA gene and of the umuD and umuC genes act at different steps in UV-induced mutagenesis. Proc Natl Acad Sci U S A (1985) 2.54
Composite active site of an ABC ATPase: MutS uses ATP to verify mismatch recognition and authorize DNA repair. Mol Cell (2001) 2.46
Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis. Cell (1998) 2.46
Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexes. Mol Cell Biol (1995) 2.37
Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Res (2000) 2.32
Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): an archaeal DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic poleta. Nucleic Acids Res (2001) 2.29
Reovirus as an oncolytic agent against experimental human malignant gliomas. J Natl Cancer Inst (2001) 2.27
Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase. Genes Dev (1999) 2.24
Biochemical basis of SOS-induced mutagenesis in Escherichia coli: reconstitution of in vitro lesion bypass dependent on the UmuD'2C mutagenic complex and RecA protein. Proc Natl Acad Sci U S A (1998) 2.22
Survival among women with triple receptor-negative breast cancer and brain metastases. Ann Oncol (2009) 2.21
Eukaryotic DNA polymerases: proposal for a revised nomenclature. J Biol Chem (2001) 2.15
A clinician-driven automated system for integration of pharmacogenetic interpretations into an electronic medical record. Clin Pharmacol Ther (2012) 2.12
Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta. Genomics (1999) 2.06
A versatile synthetic dimerizer for the regulation of protein-protein interactions. Proc Natl Acad Sci U S A (1997) 2.04
Activity of the purified mutagenesis proteins UmuC, UmuD', and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III. Proc Natl Acad Sci U S A (1992) 2.03
Crystal structure of the Xrcc4 DNA repair protein and implications for end joining. EMBO J (2000) 1.94
Medium-chain acyl-CoA dehydrogenase deficiency in children with non-ketotic hypoglycemia and low carnitine levels. Pediatr Res (1983) 1.91
Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2. Mol Cell Biol (1997) 1.89
Structural basis for MutH activation in E.coli mismatch repair and relationship of MutH to restriction endonucleases. EMBO J (1998) 1.84
Regulation of SOS mutagenesis by proteolysis. Proc Natl Acad Sci U S A (1996) 1.84
Linearly polarized emission from colloidal semiconductor quantum rods. Science (2001) 1.82
Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia. Clin Pharmacol Ther (2008) 1.82
mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality. Brain Res Mol Brain Res (1998) 1.78
A rapid method for cloning mutagenic DNA repair genes: isolation of umu-complementing genes from multidrug resistance plasmids R391, R446b, and R471a. J Bacteriol (1993) 1.75
Targeting of the UmuD, UmuD', and MucA' mutagenesis proteins to DNA by RecA protein. Proc Natl Acad Sci U S A (1993) 1.75
Activation of human lung mast cells by monomeric immunoglobulin E. Eur Respir J (2005) 1.74
Lon-mediated proteolysis of the Escherichia coli UmuD mutagenesis protein: in vitro degradation and identification of residues required for proteolysis. Genes Dev (1998) 1.73
A phenotype for enigmatic DNA polymerase II: a pivotal role for pol II in replication restart in UV-irradiated Escherichia coli. Proc Natl Acad Sci U S A (1999) 1.69
Long-term effects of a randomised trial of a 6-year lifestyle intervention in impaired glucose tolerance on diabetes-related microvascular complications: the China Da Qing Diabetes Prevention Outcome Study. Diabetologia (2010) 1.68
Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol Cell Biol (1996) 1.68
Specific RecA amino acid changes affect RecA-UmuD'C interaction. Mol Microbiol (1998) 1.66
Structure of the UmuD' protein and its regulation in response to DNA damage. Nature (1996) 1.66
Density-functional theory of the electronic structure of molecules. Annu Rev Phys Chem (1995) 1.64
Purification of a soluble UmuD'C complex from Escherichia coli. Cooperative binding of UmuD'C to single-stranded DNA. J Biol Chem (1996) 1.64
Subunit-specific degradation of the UmuD/D' heterodimer by the ClpXP protease: the role of trans recognition in UmuD' stability. EMBO J (2000) 1.64
Mutagenic repair in Escherichia coli. X. The umuC gene product may be required for replication past pyrimidine dimers but not for the coding error in UV-mutagenesis. Mol Gen Genet (1984) 1.62
Concordance of DMET plus genotyping results with those of orthogonal genotyping methods. Clin Pharmacol Ther (2012) 1.62
Fragile X gene instability: anchoring AGGs and linked microsatellites. Am J Hum Genet (1995) 1.61
Identification of a DinB/UmuC homolog in the archeon Sulfolobus solfataricus. Mutat Res (1996) 1.61
The Bacillus subtilis DinR binding site: redefinition of the consensus sequence. J Bacteriol (1998) 1.61
Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota. EMBO J (2000) 1.56
5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro. Science (2001) 1.55
Formation of chromosomal tandem arrays of the SXT element and R391, two conjugative chromosomally integrating elements that share an attachment site. J Bacteriol (2001) 1.55
The pharmacology of bimatoprost (Lumigan). Surv Ophthalmol (2001) 1.54
Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product. J Biol Chem (1995) 1.52
Insulin like growth factor binding protein-7 reduces growth of human breast cancer cells and xenografted tumors. Breast Cancer Res Treat (2010) 1.50
A novel phosphotyrosine motif with a critical amino acid at position -2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1. J Biol Chem (1997) 1.50
Elevated serum antibodies against insulin-like growth factor-binding protein-2 allow detecting early-stage cancers: evidences from glioma and colorectal carcinoma studies. Ann Oncol (2012) 1.49
Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines. J Natl Cancer Inst (1999) 1.46
Homeostatic regulation of copper uptake in yeast via direct binding of MAC1 protein to upstream regulatory sequences of FRE1 and CTR1. J Biol Chem (1997) 1.45
Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage. J Pathol (2013) 1.45
Aspartame is no more likely than placebo to cause urticaria/angioedema: results of a multicenter, randomized, double-blind, placebo-controlled, crossover study. J Allergy Clin Immunol (1993) 1.44
Quantum mechanics simulation of protein dynamics on long timescale. Proteins (2001) 1.42
A model for SOS-lesion-targeted mutations in Escherichia coli. Nature (2001) 1.41
The metabolic effects of once daily extended-release metformin in patients with type 2 diabetes: a multicentre study. Int J Clin Pract (2008) 1.40
Site-directed mutagenesis of the hinge region of nisinZ and properties of nisinZ mutants. Appl Microbiol Biotechnol (2004) 1.40
miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes. Diabetologia (2013) 1.39
Obesity, coronary heart disease risk factors and diabetes in Chinese: an approach to the criteria of obesity in the Chinese population. Obes Rev (2002) 1.37
Comparison of vildagliptin and acarbose monotherapy in patients with Type 2 diabetes: a 24-week, double-blind, randomized trial. Diabet Med (2008) 1.37
PU box-binding transcription factors and a POU domain protein cooperate in the Epstein-Barr virus (EBV) nuclear antigen 2-induced transactivation of the EBV latent membrane protein 1 promoter. J Gen Virol (1995) 1.36
Unique misinsertion specificity of poliota may decrease the mutagenic potential of deaminated cytosines. EMBO J (2001) 1.36
An ATF/CRE element mediates both EBNA2-dependent and EBNA2-independent activation of the Epstein-Barr virus LMP1 gene promoter. J Virol (1998) 1.35
Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase. EMBO J (2001) 1.35
ARID5B SNP rs10821936 is associated with risk of childhood acute lymphoblastic leukemia in blacks and contributes to racial differences in leukemia incidence. Leukemia (2010) 1.34
The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake. J Biol Chem (2000) 1.33
Triphalangeal thumb-polysyndactyly syndrome and syndactyly type IV are caused by genomic duplications involving the long range, limb-specific SHH enhancer. J Med Genet (2008) 1.33
Identification of a motif in the carboxyl terminus of CXCR2 that is involved in adaptin 2 binding and receptor internalization. Biochemistry (2001) 1.32
The science of pterygia. Br J Ophthalmol (2009) 1.31
Special topics--Mitigation of methane and nitrous oxide emissions from animal operations: I. A review of enteric methane mitigation options. J Anim Sci (2013) 1.30
Substitution of mucAB or rumAB for umuDC alters the relative frequencies of the two classes of mutations induced by a site-specific T-T cyclobutane dimer and the efficiency of translesion DNA synthesis. J Bacteriol (1996) 1.29
Asymmetric recognition of DNA local distortion. Structure-based functional studies of eukaryotic Msh2-Msh6. J Biol Chem (2001) 1.28
Respiratory infections and the autumn increase in asthma morbidity. Eur Respir J (1996) 1.27
Roles of DNA polymerases V and II in SOS-induced error-prone and error-free repair in Escherichia coli. Proc Natl Acad Sci U S A (2001) 1.27
Expression and clinicopathological significance of oestrogen-responsive ezrin-radixin-moesin-binding phosphoprotein 50 in breast cancer. Histopathology (2007) 1.27
Reciprocal inhibition of mouse leukemia virus infection by Fv-1 allele cell extracts. Proc Natl Acad Sci U S A (1974) 1.27
1,25-Dihydroxyvitamin D3 and all-trans-retinoic acid sensitize breast cancer cells to chemotherapy-induced cell death. Cancer Res (2000) 1.26
The two-step model of bacterial UV mutagenesis. Mutat Res (1985) 1.25
In vivo stability of the Umu mutagenesis proteins: a major role for RecA. J Bacteriol (1996) 1.25