Published in J Mol Biol on October 12, 2001
Changes in apparent free energy of helix-helix dimerization in a biological membrane due to point mutations. J Mol Biol (2007) 1.36
A novel cytology-based, two-hybrid screen for bacteria applied to protein-protein interaction studies of a type IV secretion system. J Bacteriol (2002) 1.30
Transmembrane helix dimerization: beyond the search for sequence motifs. Biochim Biophys Acta (2011) 1.26
Association of a model transmembrane peptide containing gly in a heptad sequence motif. Biophys J (2004) 0.98
Sequence determinants of GLUT1 oligomerization: analysis by homology-scanning mutagenesis. J Biol Chem (2013) 0.96
Identification and mapping of self-assembling protein domains encoded by the Escherichia coli K-12 genome by use of lambda repressor fusions. J Bacteriol (2004) 0.90
Helix packing and orientation in the transmembrane dimer of gp55-P of the spleen focus forming virus. Biophys J (2005) 0.87
Molecular dynamics studies of the transmembrane domain of gp41 from HIV-1. Biochim Biophys Acta (2009) 0.87
Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J Bacteriol (1995) 46.37
TnphoA: a transposon probe for protein export signals. Proc Natl Acad Sci U S A (1985) 21.06
Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins. Annu Rev Biophys Biophys Chem (1986) 11.00
Discrimination as a consequence of genetic testing. Am J Hum Genet (1992) 10.40
Mechanism of activation of catabolite-sensitive genes: a positive control system. Proc Natl Acad Sci U S A (1970) 9.37
A genetic approach to analyzing membrane protein topology. Science (1986) 9.01
Analysis of the regulation of Escherichia coli alkaline phosphatase synthesis using deletions and phi80 transducing phages. J Mol Biol (1975) 8.79
Identification of a protein required for disulfide bond formation in vivo. Cell (1991) 8.56
Protein localization in E. coli: is there a common step in the secretion of periplasmic and outer-membrane proteins? Cell (1981) 8.24
Mechanism of incorporation of cell envelope proteins in Escherichia coli. Annu Rev Microbiol (1982) 8.18
The spontaneous insertion of proteins into and across membranes: the helical hairpin hypothesis. Cell (1981) 7.77
E. coli mutant pleiotropically defective in the export of secreted proteins. Cell (1981) 7.72
Lipid bilayer thickness varies linearly with acyl chain length in fluid phosphatidylcholine vesicles. J Mol Biol (1983) 6.67
A transmembrane helix dimer: structure and implications. Science (1997) 6.46
An Escherichia coli mutation preventing degradation of abnormal periplasmic proteins. Proc Natl Acad Sci U S A (1988) 6.31
Mutations that alter the signal sequence of alkaline phosphatase in Escherichia coli. J Bacteriol (1983) 6.27
Mutations in a new chromosomal gene of Escherichia coli K-12, pcnB, reduce plasmid copy number of pBR322 and its derivatives. Mol Gen Genet (1986) 5.87
Determinants of membrane protein topology. Proc Natl Acad Sci U S A (1987) 5.76
Regulation of a membrane component required for protein secretion in Escherichia coli. Cell (1982) 5.70
Synthesis and processing of an Escherichia coli alkaline phosphatase precursor in vitro. Proc Natl Acad Sci U S A (1977) 5.29
The GxxxG motif: a framework for transmembrane helix-helix association. J Mol Biol (2000) 5.09
The use of transposon TnphoA to detect genes for cell envelope proteins subject to a common regulatory stimulus. Analysis of osmotically regulated genes in Escherichia coli. J Mol Biol (1987) 4.98
Localization of FtsI (PBP3) to the septal ring requires its membrane anchor, the Z ring, FtsA, FtsQ, and FtsL. J Bacteriol (1999) 4.87
Membrane protein folding and oligomerization: the two-stage model. Biochemistry (1990) 4.86
Mutations which alter the function of the signal sequence of the maltose binding protein of Escherichia coli. Nature (1980) 4.77
Path of the polypeptide in bacteriorhodopsin. Proc Natl Acad Sci U S A (1980) 4.76
Escherichia coli pleiotropic mutant that reduces amounts of several periplasmic and outer membrane proteins. J Bacteriol (1979) 4.69
New controlling element in the Lac operon of E. coli. Nature (1968) 4.63
Characterization of degP, a gene required for proteolysis in the cell envelope and essential for growth of Escherichia coli at high temperature. J Bacteriol (1989) 4.56
Mutations in a new gene, secB, cause defective protein localization in Escherichia coli. J Bacteriol (1983) 4.35
Sequence specificity in the dimerization of transmembrane alpha-helices. Biochemistry (1992) 4.19
Bilayer structure in membranes. Nat New Biol (1971) 4.12
Genetic characterization of mutations which affect catabolite-sensitive operons in Escherichia coli, including deletions of the gene for adenyl cyclase. J Bacteriol (1973) 4.03
Periodontal infection as a possible risk factor for preterm low birth weight. J Periodontol (1996) 4.02
Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants. Nature (1994) 3.97
Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions. J Mol Biol (2000) 3.95
Evidence for specificity at an early step in protein export in Escherichia coli. J Bacteriol (1985) 3.93
A pathway for disulfide bond formation in vivo. Proc Natl Acad Sci U S A (1993) 3.86
Isolation of pure lac operon DNA. Nature (1969) 3.79
Use of gene fusions to study outer membrane protein localization in Escherichia coli. Proc Natl Acad Sci U S A (1977) 3.78
Genetic analysis of protein export in Escherichia coli. Annu Rev Genet (1990) 3.73
Helical membrane protein folding, stability, and evolution. Annu Rev Biochem (2000) 3.63
Efficient folding of proteins with multiple disulfide bonds in the Escherichia coli cytoplasm. Proc Natl Acad Sci U S A (1999) 3.60
Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol-disulfide status. Proc Natl Acad Sci U S A (1999) 3.60
Alkaline phosphatase fusions: sensors of subcellular location. J Bacteriol (1990) 3.59
Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices. J Biol Chem (1992) 3.52
FtsL, an essential cytoplasmic membrane protein involved in cell division in Escherichia coli. J Bacteriol (1992) 3.50
Current models for the structure of biological membranes. J Cell Biol (1969) 3.47
Evidence for two sites in the lac promoter region. J Mol Biol (1972) 3.44
Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli. Nature (1984) 3.42
The role of the thioredoxin and glutaredoxin pathways in reducing protein disulfide bonds in the Escherichia coli cytoplasm. J Biol Chem (1997) 3.42
X-ray diffraction studies of phase transitions in the membrane of Mycoplasma laidlawii. J Mol Biol (1970) 3.31
Inactivation of FtsI inhibits constriction of the FtsZ cytokinetic ring and delays the assembly of FtsZ rings at potential division sites. Proc Natl Acad Sci U S A (1997) 3.25
The bonds that tie: catalyzed disulfide bond formation. Cell (1993) 3.20
The effect of point mutations on the free energy of transmembrane alpha-helix dimerization. J Mol Biol (1997) 3.16
The FtsQ protein of Escherichia coli: membrane topology, abundance, and cell division phenotypes due to overproduction and insertion mutations. J Bacteriol (1991) 3.15
Towards single-copy gene expression systems making gene cloning physiologically relevant: lambda InCh, a simple Escherichia coli plasmid-chromosome shuttle system. J Bacteriol (2000) 3.14
Interhelical hydrogen bonding drives strong interactions in membrane proteins. Nat Struct Biol (2000) 3.12
Escherichia coli mutants accumulating the precursor of a secreted protein in the cytoplasm. Nature (1979) 3.10
Deletion of the Escherichia coli crp gene. J Bacteriol (1975) 3.08
SecD and SecF facilitate protein export in Escherichia coli. EMBO J (1994) 3.04
A bacterial virulence determinant encoded by lysogenic coliphage lambda. Nature (1990) 3.02
An in vivo pathway for disulfide bond isomerization in Escherichia coli. Proc Natl Acad Sci U S A (1996) 2.98
The Calpha ---H...O hydrogen bond: a determinant of stability and specificity in transmembrane helix interactions. Proc Natl Acad Sci U S A (2001) 2.97
Regulation of Escherichia coli cell envelope proteins involved in protein folding and degradation by the Cpx two-component system. Genes Dev (1997) 2.96
Cloning and restriction mapping of the alkaline phosphatase structural gene (phoA) of Escherichia coli and generation of deletion mutants in vitro. J Bacteriol (1981) 2.88
secD, a new gene involved in protein export in Escherichia coli. J Bacteriol (1987) 2.84
A dimerization motif for transmembrane alpha-helices. Nat Struct Biol (1994) 2.82
Lipid bilayer structure in the membrane of Mycoplasma laidlawii. J Mol Biol (1971) 2.81
The nucleotide sequence of the gene for malF protein, an inner membrane component of the maltose transport system of Escherichia coli. Repeated DNA sequences are found in the malE-malF intercistronic region. J Biol Chem (1984) 2.79
TOXCAT: a measure of transmembrane helix association in a biological membrane. Proc Natl Acad Sci U S A (1999) 2.76
Mutations that allow disulfide bond formation in the cytoplasm of Escherichia coli. Science (1993) 2.73
Bacteriorhodopsin is an inside-out protein. Proc Natl Acad Sci U S A (1980) 2.72
A signal sequence is not required for protein export in prlA mutants of Escherichia coli. EMBO J (1993) 2.70
The planar organization of lecithin-cholesterol bilayers. J Biol Chem (1972) 2.62
Roles of thiol-redox pathways in bacteria. Annu Rev Microbiol (2001) 2.60
SecA membrane cycling at SecYEG is driven by distinct ATP binding and hydrolysis events and is regulated by SecD and SecF. Cell (1995) 2.58
Disulfide bond formation in the Escherichia coli cytoplasm: an in vivo role reversal for the thioredoxins. EMBO J (1998) 2.56
Polar residues drive association of polyleucine transmembrane helices. Proc Natl Acad Sci U S A (2001) 2.47
A complete mapping of the proteins in the small ribosomal subunit of Escherichia coli. Science (1987) 2.43
Escherichia coli alkaline phosphatase fails to acquire disulfide bonds when retained in the cytoplasm. J Bacteriol (1991) 2.42
The secD locus of E.coli codes for two membrane proteins required for protein export. EMBO J (1990) 2.40
Use of phoA fusions to study the topology of the Escherichia coli inner membrane protein leader peptidase. J Bacteriol (1989) 2.38
Deletion map of the Escherichia coli structural gene for alkaline phosphatase, phoA. J Bacteriol (1981) 2.38
Genetic analysis of the membrane insertion and topology of MalF, a cytoplasmic membrane protein of Escherichia coli. J Mol Biol (1988) 2.35
A mutation affecting the regulation of a secA-lacZ fusion defines a new sec gene. Genetics (1988) 2.34
FtsQ, FtsL and FtsI require FtsK, but not FtsN, for co-localization with FtsZ during Escherichia coli cell division. Mol Microbiol (2001) 2.32
Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor. Arteriosclerosis (1986) 2.32
Signal sequence of alkaline phosphatase of Escherichia coli. J Bacteriol (1982) 2.31
Use of gene fusions to determine a partial signal sequence of alkaline phosphatase. J Bacteriol (1979) 2.29
The secE gene encodes an integral membrane protein required for protein export in Escherichia coli. Genes Dev (1989) 2.27
Identification of a new gene (secA) and gene product involved in the secretion of envelope proteins in Escherichia coli. J Bacteriol (1982) 2.27
The effects of case definition in maternal screening and reporting criteria on rates of congenital syphilis. Am J Public Health (1990) 2.26
Refolding of bacteriorhodopsin in lipid bilayers. A thermodynamically controlled two-stage process. J Mol Biol (1987) 2.23
Septal localization of FtsQ, an essential cell division protein in Escherichia coli. J Bacteriol (1999) 2.22
Health care abuse. CMAJ (1994) 2.22
The role of charged amino acids in the localization of secreted and membrane proteins. Cell (1990) 2.19