Published in Neuron on October 11, 2001
Modelling schizophrenia using human induced pluripotent stem cells. Nature (2011) 7.41
Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines. Science (2008) 4.55
BDNF and activity-dependent synaptic modulation. Learn Mem (2003) 4.04
BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory? Neurobiol Learn Mem (2007) 2.96
Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biol Psychiatry (2007) 2.93
Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease. Dev Neurobiol (2010) 2.19
BDNF is essential to promote persistence of long-term memory storage. Proc Natl Acad Sci U S A (2008) 2.16
Toward predictive models of mammalian cells. Annu Rev Biophys Biomol Struct (2005) 1.82
TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat Neurosci (2012) 1.82
Oxidative neuronal injury. The dark side of ERK1/2. Eur J Biochem (2004) 1.81
Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction. Cell (2012) 1.75
Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory. Nat Neurosci (2014) 1.74
Selective modulation of some forms of schaffer collateral-CA1 synaptic plasticity in mice with a disruption of the CPEB-1 gene. Learn Mem (2004) 1.69
A simple role for BDNF in learning and memory? Front Mol Neurosci (2010) 1.68
Brain-derived neurotrophic factor-induced gene expression reveals novel actions of VGF in hippocampal synaptic plasticity. J Neurosci (2003) 1.64
BDNF activates mTOR to regulate GluR1 expression required for memory formation. PLoS One (2009) 1.63
MAPK, CREB and zif268 are all required for the consolidation of recognition memory. Philos Trans R Soc Lond B Biol Sci (2003) 1.56
BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses. Exp Brain Res (2009) 1.42
Daily intermittent hypoxia augments spinal BDNF levels, ERK phosphorylation and respiratory long-term facilitation. Exp Neurol (2009) 1.39
The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment. Mol Neurodegener (2016) 1.38
Brain-derived neurotrophic factor and epidermal growth factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylation. J Neurosci (2010) 1.33
Glucocorticoid effects on memory consolidation depend on functional interactions between the medial prefrontal cortex and basolateral amygdala. J Neurosci (2009) 1.31
Hippocampal Mek/Erk signaling mediates extinction of contextual freezing behavior. Neurobiol Learn Mem (2006) 1.29
In search of general mechanisms for long-lasting plasticity: Aplysia and the hippocampus. Philos Trans R Soc Lond B Biol Sci (2003) 1.27
Modulation of neurotransmitter release by the second messenger-activated protein kinases: implications for presynaptic plasticity. Pharmacol Ther (2005) 1.26
The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus. J Neurosci (2010) 1.26
Segregated populations of hippocampal principal CA1 neurons mediating conditioning and extinction of contextual fear. J Neurosci (2009) 1.24
Requirement of TORC1 for late-phase long-term potentiation in the hippocampus. PLoS One (2006) 1.22
AMPA receptor trafficking and learning. Eur J Neurosci (2010) 1.21
Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx. J Cell Biol (2003) 1.16
Neurotrophin-mediated dendrite-to-nucleus signaling revealed by microfluidic compartmentalization of dendrites. Proc Natl Acad Sci U S A (2011) 1.15
TrkB as a potential synaptic and behavioral tag. J Neurosci (2011) 1.11
Signaling mechanisms mediating BDNF modulation of memory formation in vivo in the hippocampus. Cell Mol Neurobiol (2002) 1.11
Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst late-phase long-term potentiation in hippocampal area CA1. J Neurosci (2010) 1.11
PKA has a critical role in synaptic delivery of GluR1- and GluR4-containing AMPARs during initial stages of acquisition of in vitro classical conditioning. J Neurophysiol (2009) 1.10
Memory impairments in healthy aging: Role of aging-induced microglial sensitization. Aging Dis (2010) 1.09
Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission. Proc Natl Acad Sci U S A (2005) 1.08
Forskolin induction of late-LTP and up-regulation of 5' TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells. J Neurochem (2008) 1.07
Cleavage of proBDNF to BDNF by a tolloid-like metalloproteinase is required for acquisition of in vitro eyeblink classical conditioning. J Neurosci (2009) 1.05
Brain-derived neurotrophic factor-dependent unmasking of "silent" synapses in the developing mouse barrel cortex. Proc Natl Acad Sci U S A (2003) 1.05
Pin1 and PKMzeta sequentially control dendritic protein synthesis. Sci Signal (2010) 1.00
A tropomyosin-related kinase B ligand is required for ERK activation, long-term synaptic facilitation, and long-term memory in aplysia. Proc Natl Acad Sci U S A (2006) 1.00
A form of long-lasting, learning-related synaptic plasticity in the hippocampus induced by heterosynaptic low-frequency pairing. Proc Natl Acad Sci U S A (2004) 1.00
A model of the roles of essential kinases in the induction and expression of late long-term potentiation. Biophys J (2006) 1.00
Cell biology of BDNF and its relevance to schizophrenia. Novartis Found Symp (2008) 0.99
The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value. Eur J Neurosci (2008) 0.98
Role of activity-dependent BDNF expression in hippocampal-prefrontal cortical regulation of behavioral perseverance. Proc Natl Acad Sci U S A (2013) 0.98
ERK in learning and memory: a review of recent research. Int J Mol Sci (2010) 0.97
Iron mediates N-methyl-D-aspartate receptor-dependent stimulation of calcium-induced pathways and hippocampal synaptic plasticity. J Biol Chem (2011) 0.97
Inhibition of calcineurin facilitates the induction of memory for sensitization in Aplysia: requirement of mitogen-activated protein kinase. Proc Natl Acad Sci U S A (2003) 0.97
Temporal phases of activity-dependent plasticity and memory are mediated by compartmentalized routing of MAPK signaling in aplysia sensory neurons. Neuron (2009) 0.95
BDNF facilitates L-LTP maintenance in the absence of protein synthesis through PKMζ. PLoS One (2011) 0.94
Gravin orchestrates protein kinase A and β2-adrenergic receptor signaling critical for synaptic plasticity and memory. J Neurosci (2012) 0.94
Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons. BMC Neurosci (2005) 0.91
Synaptic Network Activity Induces Neuronal Differentiation of Adult Hippocampal Precursor Cells through BDNF Signaling. Front Neurosci (2009) 0.90
The role of BDNF as a mediator of neuroplasticity in bipolar disorder. Psychiatry Investig (2010) 0.89
A model of late long-term potentiation simulates aspects of memory maintenance. PLoS One (2007) 0.88
Signaling from the cytoplasm to the nucleus in striatal medium-sized spiny neurons. Front Neuroanat (2011) 0.88
Altered WNT Signaling in Human Induced Pluripotent Stem Cell Neural Progenitor Cells Derived from Four Schizophrenia Patients. Biol Psychiatry (2015) 0.87
CPEB4 knockout mice exhibit normal hippocampus-related synaptic plasticity and memory. PLoS One (2013) 0.87
A new genetic model of activity-induced Ras signaling dependent pre-synaptic plasticity in Drosophila. Brain Res (2010) 0.87
Assessment of the role of MAP kinase in mediating activity-dependent transcriptional activation of the immediate early gene Arc/Arg3.1 in the dentate gyrus in vivo. Learn Mem (2010) 0.86
Modeling signal transduction in classical conditioning with network motifs. Front Mol Neurosci (2011) 0.86
The role of cytoplasmic serine residues of the cell adhesion molecule L1 in neurite outgrowth, endocytosis, and cell migration. Cell Mol Neurobiol (2006) 0.85
The characteristics of LTP induced in hippocampal slices are dependent on slice-recovery conditions. Learn Mem (2006) 0.85
Molecular constraints on synaptic tagging and maintenance of long-term potentiation: a predictive model. PLoS Comput Biol (2012) 0.85
Senescent-induced dysregulation of cAMP/CREB signaling and correlations with cognitive decline. Brain Res (2013) 0.85
Theta-burst LTP. Brain Res (2014) 0.83
A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF release. J Cell Biol (2015) 0.83
Directing traffic in neural cells: determinants of receptor tyrosine kinase localization and cellular responses. J Neurochem (2008) 0.81
Application of FRET probes in the analysis of neuronal plasticity. Front Neural Circuits (2013) 0.81
ERK-associated changes of AP-1 proteins during fear extinction. Mol Cell Neurosci (2011) 0.81
Involvement of TrkB- and p75(NTR)-signaling pathways in two contrasting forms of long-lasting synaptic plasticity. Sci Rep (2013) 0.81
Galpha(i2) inhibition of adenylate cyclase regulates presynaptic activity and unmasks cGMP-dependent long-term depression at Schaffer collateral-CA1 hippocampal synapses. Learn Mem (2008) 0.80
Behavior training reverses asymmetry in hippocampal transcriptome of the cav3.2 knockout mice. PLoS One (2015) 0.80
Mapping molecular memory: navigating the cellular pathways of learning. Cell Mol Neurobiol (2012) 0.79
Disorders of memory and plasticity in psychiatric disease. Dialogues Clin Neurosci (2013) 0.79
Differential activation of extracellular signal-regulated kinase 1 and a related complex in neuronal nuclei. Brain Cell Biol (2008) 0.78
Adenosine A(2A) receptors modulate BDNF both in normal conditions and in experimental models of Huntington's disease. Purinergic Signal (2007) 0.78
Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity. Mil Med Res (2016) 0.78
Transforming growth factor β recruits persistent MAPK signaling to regulate long-term memory consolidation in Aplysia californica. Learn Mem (2016) 0.77
BDNF-induced nitric oxide signals in cultured rat hippocampal neurons: time course, mechanism of generation, and effect on neurotrophin secretion. Front Cell Neurosci (2014) 0.77
Noradrenergic activation of the basolateral amygdala enhances object recognition memory and induces chromatin remodeling in the insular cortex. Front Behav Neurosci (2015) 0.76
NMDA-dependent switch of proBDNF actions on developing GABAergic synapses. Cereb Cortex (2012) 0.76
The requirement of BDNF for hippocampal synaptic plasticity is experience-dependent. Hippocampus (2016) 0.76
Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and Narp. Cell Rep (2015) 0.76
Mass Spectrometry-Based Approaches to Understand the Molecular Basis of Memory. Front Chem (2016) 0.75
Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome. Mol Brain (2016) 0.75
Cell-Specific PKM Isoforms Contribute to the Maintenance of Different Forms of Persistent Long-Term Synaptic Plasticity. J Neurosci (2017) 0.75
Social Isolation During Adolescence Strengthens Retention of Fear Memories and Facilitates Induction of Late-Phase Long-Term Potentiation. Mol Neurobiol (2014) 0.75
Potentiation of Schaffer-Collateral CA1 Synaptic Transmission by eEF2K and p38 MAPK Mediated Mechanisms. Front Cell Neurosci (2016) 0.75
Muscle Contraction Regulates BDNF/TrkB Signaling to Modulate Synaptic Function through Presynaptic cPKCα and cPKCβI. Front Mol Neurosci (2017) 0.75
Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior. Mol Psychiatry (2017) 0.75
Subregion- and cell type-restricted gene knockout in mouse brain. Cell (1996) 8.02
Control of memory formation through regulated expression of a CaMKII transgene. Science (1996) 7.56
Cognitive neuroscience and the study of memory. Neuron (1998) 6.22
Clinical and financial benefits of rapid bacterial identification and antimicrobial susceptibility testing. J Clin Microbiol (1999) 5.38
Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron (1996) 5.19
Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell (1997) 4.83
Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science (1992) 4.58
Molecular biology of learning: modulation of transmitter release. Science (1982) 4.44
Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science (1993) 4.31
Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage. Cell (1997) 3.93
Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell (1998) 3.90
Requirement of a critical period of transcription for induction of a late phase of LTP. Science (1994) 3.85
The long and the short of long-term memory--a molecular framework. Nature (1986) 3.68
Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones. Nature (1982) 3.61
A critical period for macromolecular synthesis in long-term heterosynaptic facilitation in Aplysia. Science (1986) 3.30
Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation. Nature (1993) 3.23
Hippocampal network patterns of activity in the mouse. Neuroscience (2003) 3.23
Clinical and financial benefits of rapid detection of respiratory viruses: an outcomes study. J Clin Microbiol (2000) 3.22
Anomalous rectification in the metacerebral giant cells and its consequences for synaptic transmission. J Physiol (1966) 3.18
Structural changes accompanying memory storage. Annu Rev Physiol (1993) 3.11
Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene. J Bacteriol (1995) 3.05
Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation. Nature (1990) 2.85
Toward a molecular definition of long-term memory storage. Proc Natl Acad Sci U S A (1996) 2.81
A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis. Cell (1999) 2.77
Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change. Cell (1995) 2.75
Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA. Learn Mem (1999) 2.72
Synaptic facilitation and behavioral sensitization in Aplysia: possible role of serotonin and cyclic AMP. Science (1976) 2.72
The 3'-untranslated region of CaMKII alpha is a cis-acting signal for the localization and translation of mRNA in dendrites. Proc Natl Acad Sci U S A (1996) 2.70
Presynaptic modulation of voltage-dependent Ca2+ current: mechanism for behavioral sensitization in Aplysia californica. Proc Natl Acad Sci U S A (1978) 2.68
Mortality among recent purchasers of handguns. N Engl J Med (1999) 2.64
Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger. Proc Natl Acad Sci U S A (1991) 2.64
Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin. Cell (2001) 2.62
cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase. Cell (1994) 2.59
Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. Science (1993) 2.51
MAP kinase translocates into the nucleus of the presynaptic cell and is required for long-term facilitation in Aplysia. Neuron (1997) 2.50
Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia. Cell (1997) 2.50
Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A (1997) 2.48
A functional role for intra-axonal protein synthesis during axonal regeneration from adult sensory neurons. J Neurosci (2001) 2.48
Neuronal mechanisms of habituation and dishabituation of the gill-withdrawal reflex in Aplysia. Science (1970) 2.43
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia. Cell (1994) 2.42
D1/D5 receptor agonists induce a protein synthesis-dependent late potentiation in the CA1 region of the hippocampus. Proc Natl Acad Sci U S A (1995) 2.42
The association of pre-treatment neutrophil to lymphocyte ratio with overall survival in patients with glioblastoma multiforme. J Neurooncol (2013) 2.41
Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization. Learn Mem (1999) 2.41
Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway. Proc Natl Acad Sci U S A (1999) 2.39
Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells. Nature (1987) 2.32
APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron (2001) 2.31
CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation. Cell (1998) 2.27
Presynaptic facilitation as a mechanism for behavioral sensitization in Aplysia. Science (1976) 2.27
Mechanism of calcium current modulation underlying presynaptic facilitation and behavioral sensitization in Aplysia. Proc Natl Acad Sci U S A (1980) 2.26
Abolition of long-term stability of new hippocampal place cell maps by NMDA receptor blockade. Science (1998) 2.25
A cellular mechanism of classical conditioning in Aplysia: activity-dependent amplification of presynaptic facilitation. Science (1983) 2.25
Intracellular injection of t he catalytic subunit of cyclic AMP-dependent protein kinase simulates facilitation of transmitter release underlying behavioral sensitization in Aplysia. Proc Natl Acad Sci U S A (1980) 2.24
Selective elimination of mRNAs in vivo: complementary oligodeoxynucleotides promote RNA degradation by an RNase H-like activity. Proc Natl Acad Sci U S A (1987) 2.23
Serotonin modulates a specific potassium current in the sensory neurons that show presynaptic facilitation in Aplysia. Proc Natl Acad Sci U S A (1982) 2.19
Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal LTP in the range of the theta frequency. Cell (1995) 2.19
CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP. Cell (1995) 2.16
Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway. Neuron (1998) 2.13
Cyclic AMP induces functional presynaptic boutons in hippocampal CA3-CA1 neuronal cultures. Nat Neurosci (1999) 2.08
Activation of cAMP-responsive genes by stimuli that produce long-term facilitation in Aplysia sensory neurons. Neuron (1993) 2.05
Presynaptic facilitation revisited: state and time dependence. J Neurosci (1996) 2.04
Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin. Cell (1998) 2.04
cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1991) 2.04
A quantal analysis of the synaptic depression underlying habituation of the gill-withdrawal reflex in Aplysia. Proc Natl Acad Sci U S A (1974) 2.04
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature (1991) 2.02
Mutation in the phosphorylation sites of MAP kinase blocks learning-related internalization of apCAM in Aplysia sensory neurons. Neuron (1997) 1.98
ERK plays a regulatory role in induction of LTP by theta frequency stimulation and its modulation by beta-adrenergic receptors. Neuron (1999) 1.97
Long-term sensitization of a defensive withdrawal reflex in Aplysia. Science (1973) 1.90
Long-term habituation of a defensive withdrawal reflex in aplysia. Science (1972) 1.89
Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus. Science (1993) 1.89
Postsynaptic induction and PKA-dependent expression of LTP in the lateral amygdala. Neuron (1998) 1.87
Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory. Cell (1998) 1.85
Inducible and reversible gene expression with the rtTA system for the study of memory. Neuron (1998) 1.81
Nitric oxide signaling contributes to late-phase LTP and CREB phosphorylation in the hippocampus. J Neurosci (1999) 1.79
Modulation of an NCAM-related adhesion molecule with long-term synaptic plasticity in Aplysia. Science (1992) 1.78
Functioning of identified neurons and synapses in abdominal ganglion of Aplysia in absence of protein synthesis. J Neurophysiol (1971) 1.77
Both protein kinase A and mitogen-activated protein kinase are required in the amygdala for the macromolecular synthesis-dependent late phase of long-term potentiation. J Neurosci (2000) 1.77
Memory suppressor genes: inhibitory constraints on the storage of long-term memory. Science (1998) 1.76
Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene. Proc Natl Acad Sci U S A (1997) 1.75
A macromolecular synthesis-dependent late phase of long-term potentiation requiring cAMP in the medial perforant pathway of rat hippocampal slices. J Neurosci (1996) 1.74
Cyclic AMP-dependent protein kinase closes the serotonin-sensitive K+ channels of Aplysia sensory neurones in cell-free membrane patches. Nature (1985) 1.73
Electrophysiological properties and functional interconnections of two symmetrical neurosecretory clusters (bag cells) in abdominal ganglion of Aplysia. J Neurophysiol (1970) 1.71
Depletion of serotonin in the nervous system of Aplysia reduces the behavioral enhancement of gill withdrawal as well as the heterosynaptic facilitation produced by tail shock. J Neurosci (1989) 1.69
Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation. Nature (1994) 1.68
Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus. Cell (1996) 1.67
Calcineurin-mediated LTD of GABAergic inhibition underlies the increased excitability of CA1 neurons associated with LTP. Neuron (2000) 1.67
Intrasomatic injection of radioactive precursors for studying transmitter synthesis in identified neurons of Aplysia californica. Proc Natl Acad Sci U S A (1973) 1.66
Direct and common connections among identified neurons in Aplysia. J Neurophysiol (1967) 1.65
Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons. Cell (1996) 1.63
Genetic approaches to memory storage. Trends Genet (1999) 1.63
Activity-dependent long-term enhancement of transmitter release by presynaptic 3',5'-cyclic GMP in cultured hippocampal neurons. Nature (1995) 1.63
The epidemiology of seatbelt-associated injuries. J Trauma (1991) 1.62
Serotonin-mediated endocytosis of apCAM: an early step of learning-related synaptic growth in Aplysia. Science (1992) 1.62
Heterosynaptic facilitation in neurones of the abdominal ganglion of Aplysia depilans. J Physiol (1965) 1.62