Published in Science on October 26, 2001
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Human MicroRNA targets. PLoS Biol (2004) 34.51
A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (2002) 32.26
The microRNA Registry. Nucleic Acids Res (2004) 29.45
Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res (2005) 29.17
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A (2004) 28.29
Principles of microRNA-target recognition. PLoS Biol (2005) 23.70
MicroRNA targets in Drosophila. Genome Biol (2003) 23.59
Specificity of microRNA target selection in translational repression. Genes Dev (2004) 21.14
MicroRNA genes are transcribed by RNA polymerase II. EMBO J (2004) 20.65
A uniform system for microRNA annotation. RNA (2003) 20.28
MicroRNAs in plants. Genes Dev (2002) 20.12
Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol (2009) 19.99
MicroRNA maturation: stepwise processing and subcellular localization. EMBO J (2002) 19.47
miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev (2002) 19.24
The microRNAs of Caenorhabditis elegans. Genes Dev (2003) 17.70
Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet (2009) 16.58
siRNAs can function as miRNAs. Genes Dev (2003) 16.08
Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol (2004) 15.15
CARPEL FACTORY, a Dicer homolog, and HEN1, a novel protein, act in microRNA metabolism in Arabidopsis thaliana. Curr Biol (2002) 15.13
Identification of mammalian microRNA host genes and transcription units. Genome Res (2004) 14.63
MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proc Natl Acad Sci U S A (2004) 14.59
Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA (2005) 14.14
Small silencing RNAs: an expanding universe. Nat Rev Genet (2009) 13.88
An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. Proc Natl Acad Sci U S A (2004) 13.66
Identification of Drosophila MicroRNA targets. PLoS Biol (2003) 12.72
Genome regulation by long noncoding RNAs. Annu Rev Biochem (2012) 11.70
Regulation of flowering time and floral organ identity by a MicroRNA and its APETALA2-like target genes. Plant Cell (2003) 11.69
The colorectal microRNAome. Proc Natl Acad Sci U S A (2006) 11.59
Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA (2004) 11.52
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev (2002) 10.71
Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure. Proc Natl Acad Sci U S A (2004) 10.35
New microRNAs from mouse and human. RNA (2003) 10.35
Endogenous and silencing-associated small RNAs in plants. Plant Cell (2002) 10.07
A biochemical framework for RNA silencing in plants. Genes Dev (2003) 9.95
Computational identification of Drosophila microRNA genes. Genome Biol (2003) 9.86
A combined computational-experimental approach predicts human microRNA targets. Genes Dev (2004) 9.82
A microRNA array reveals extensive regulation of microRNAs during brain development. RNA (2003) 9.76
Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. Genome Res (2007) 9.61
Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev (2004) 9.32
MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc Natl Acad Sci U S A (2003) 8.73
The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR. Genes Dev (2004) 8.42
Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA (2004) 8.31
microRNAs exhibit high frequency genomic alterations in human cancer. Proc Natl Acad Sci U S A (2006) 8.24
Detection of microRNA expression in human peripheral blood microvesicles. PLoS One (2008) 8.04
Sequence-specific inhibition of small RNA function. PLoS Biol (2004) 7.98
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci U S A (2003) 7.95
Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5' UTR as in the 3' UTR. Proc Natl Acad Sci U S A (2007) 7.93
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. RNA (2004) 7.71
The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell (2007) 7.70
Sequence requirements for micro RNA processing and function in human cells. RNA (2003) 7.46
Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biol (2004) 7.33
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes Dev (2010) 7.14
mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene (2007) 7.02
MicroRNA expression detected by oligonucleotide microarrays: system establishment and expression profiling in human tissues. Genome Res (2004) 6.98
MicroRNAs in stress signaling and human disease. Cell (2012) 6.93
Post-transcriptional regulation of microRNA expression. RNA (2006) 6.76
The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development. Genes Dev (2004) 6.69
A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc Natl Acad Sci U S A (2005) 6.61
Expression profiling identifies microRNA signature in pancreatic cancer. Int J Cancer (2007) 6.57
Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev (2002) 6.43
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype. Genome Biol (2007) 6.41
Numerous microRNPs in neuronal cells containing novel microRNAs. RNA (2003) 6.28
Identification of microRNAs and other small regulatory RNAs using cDNA library sequencing. Methods (2008) 6.22
Inference of miRNA targets using evolutionary conservation and pathway analysis. BMC Bioinformatics (2007) 6.21
Myogenic factors that regulate expression of muscle-specific microRNAs. Proc Natl Acad Sci U S A (2006) 6.19
A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Genes Dev (2002) 6.10
miRNAs in human cancer. J Pathol (2010) 6.02
Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Proc Natl Acad Sci U S A (2005) 5.88
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res (2011) 5.83
Biological principles of microRNA-mediated regulation: shared themes amid diversity. Nat Rev Genet (2008) 5.83
Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs. Genes Dev (2005) 5.78
A large imprinted microRNA gene cluster at the mouse Dlk1-Gtl2 domain. Genome Res (2004) 5.77
The database of experimentally supported targets: a functional update of TarBase. Nucleic Acids Res (2008) 5.65
Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis. Lancet Oncol (2009) 5.56
MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. Proc Natl Acad Sci U S A (2005) 5.54
Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies. Mol Cancer (2006) 5.47
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med (2012) 5.46
Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference. Nucleic Acids Res (2004) 5.46
Chromatin structure analyses identify miRNA promoters. Genes Dev (2008) 5.40
Systematic analysis of microRNA expression of RNA extracted from fresh frozen and formalin-fixed paraffin-embedded samples. RNA (2007) 5.35
Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genet (2007) 5.33
Slicer function of Drosophila Argonautes and its involvement in RISC formation. Genes Dev (2005) 5.29
T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J Exp Med (2005) 5.26
Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. Genome Res (2006) 5.23
A high-throughput method to monitor the expression of microRNA precursors. Nucleic Acids Res (2004) 5.21
A novel class of small RNAs: tRNA-derived RNA fragments (tRFs). Genes Dev (2009) 5.04
Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. Genes Dev (2006) 4.97
The Arabidopsis double-stranded RNA-binding protein HYL1 plays a role in microRNA-mediated gene regulation. Proc Natl Acad Sci U S A (2004) 4.95
Processing of pre-microRNAs by the Dicer-1-Loquacious complex in Drosophila cells. PLoS Biol (2005) 4.93
Distance constraints between microRNA target sites dictate efficacy and cooperativity. Nucleic Acids Res (2007) 4.91
miRGen: a database for the study of animal microRNA genomic organization and function. Nucleic Acids Res (2006) 4.91
Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc Natl Acad Sci U S A (2004) 4.85
Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev (2007) 4.79
Clustering and conservation patterns of human microRNAs. Nucleic Acids Res (2005) 4.79
Ribonuclease activity and RNA binding of recombinant human Dicer. EMBO J (2002) 4.73
CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer. Nucleic Acids Res (2010) 4.68
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (2001) 57.23
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science (2001) 31.33
RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev (2001) 26.16
RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell (2000) 20.32
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J (2001) 12.88
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