Published in Biochim Biophys Acta on October 31, 2001
Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells. Mol Cell Biol (2002) 4.50
Intersectin links WNK kinases to endocytosis of ROMK1. J Clin Invest (2007) 1.67
A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation. J Cell Biol (2010) 1.35
Intersectin 1L guanine nucleotide exchange activity is regulated by adjacent src homology 3 domains that are also involved in endocytosis. Mol Biol Cell (2003) 1.09
Intersecting pathways in cell biology. Sci Signal (2010) 1.01
Intersectin-2L regulates caveola endocytosis secondary to Cdc42-mediated actin polymerization. J Biol Chem (2009) 0.95
Caenorhabditis elegans intersectin: a synaptic protein regulating neurotransmission. Mol Biol Cell (2007) 0.91
Impaired caveolae function and upregulation of alternative endocytic pathways induced by experimental modulation of intersectin-1s expression in mouse lung endothelium. Biochem Res Int (2012) 0.91
The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin. PLoS One (2010) 0.87
Emerging roles for intersectin (ITSN) in regulating signaling and disease pathways. Int J Mol Sci (2013) 0.84
Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. PLoS One (2012) 0.81
MicroRNA-194 (miR-194) regulates ROMK channel activity by targeting intersectin 1. Am J Physiol Renal Physiol (2013) 0.79
Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins. PLoS One (2013) 0.79
ITSN2L Interacts with and Negatively Regulates RABEP1. Int J Mol Sci (2015) 0.76
Identification and comparative analysis of novel alternatively spliced transcripts of RhoGEF domain encoding gene in C. elegans and C. briggsae. Bioinformation (2007) 0.75
Rac1-mediated cytoskeleton rearrangements induced by intersectin-1s deficiency promotes lung cancer cell proliferation, migration and metastasis. Mol Cancer (2016) 0.75
A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands. Nature (1987) 7.88
Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes. Am J Hum Genet (1998) 5.24
The origin of the major cystic fibrosis mutation (delta F508) in European populations. Nat Genet (1994) 4.94
High carrier frequency of the 35delG deafness mutation in European populations. Genetic Analysis Consortium of GJB2 35delG. Eur J Hum Genet (2000) 4.63
Connexin26 mutations associated with the most common form of non-syndromic neurosensory autosomal recessive deafness (DFNB1) in Mediterraneans. Hum Mol Genet (1997) 3.39
DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum Mol Genet (2000) 2.93
Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus. Mol Cell Biol (2000) 2.48
Estimation of the mutation frequencies in Charcot-Marie-Tooth disease type 1 and hereditary neuropathy with liability to pressure palsies: a European collaborative study. Eur J Hum Genet (1996) 2.40
Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome. Hum Mol Genet (2001) 2.24
Mutations affecting mRNA splicing are the most common molecular defects in patients with neurofibromatosis type 1. Hum Mol Genet (2000) 2.20
Physical and genetic analysis of cosmids from the vicinity of the cystic fibrosis locus. Nucleic Acids Res (1987) 2.16
Mutations in GJB6 cause nonsyndromic autosomal dominant deafness at DFNA3 locus. Nat Genet (1999) 2.05
Reverse gyrase: a helicase-like domain and a type I topoisomerase in the same polypeptide. Proc Natl Acad Sci U S A (1993) 2.04
Complex structure of the nuclear translocation signal of influenza virus polymerase PA subunit. J Gen Virol (1994) 2.03
Individual expression of influenza virus PA protein induces degradation of coexpressed proteins. J Virol (1995) 2.02
Simultaneous on-line DNA sequencing on both strands with two fluorescent dyes. Anal Biochem (1995) 2.01
Clinical, neuropathologic, and genetic studies of a large spinocerebellar ataxia type 1 (SCA1) kindred: (CAG)n expansion and early premonitory signs and symptoms. Neurology (1995) 1.97
Monoclonal antibodies against influenza virus PB2 and NP polypeptides interfere with the initiation step of viral mRNA synthesis in vitro. J Virol (1994) 1.93
Schwann cells harbor the somatic NF1 mutation in neurofibromas: evidence of two different Schwann cell subpopulations. Hum Mol Genet (2000) 1.84
Synthesis of biologically active influenza virus core proteins using a vaccinia virus-T7 RNA polymerase expression system. J Gen Virol (1994) 1.83
The amino-terminal one-third of the influenza virus PA protein is responsible for the induction of proteolysis. J Virol (1996) 1.79
Influenza virus NS1 protein interacts with viral transcription-replication complexes in vivo. J Gen Virol (1997) 1.79
MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss. Am J Hum Genet (2001) 1.78
High positive supercoiling in vitro catalyzed by an ATP and polyethylene glycol-stimulated topoisomerase from Sulfolobus acidocaldarius. EMBO J (1985) 1.77
Indirect cystic fibrosis carrier detection. Lancet (1987) 1.76
A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders. Cell (2001) 1.75
A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart. Hum Mol Genet (1995) 1.68
Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene. Genomics (1997) 1.68
Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. EMBO J (1988) 1.67
Non-type I cystinuria caused by mutations in SLC7A9, encoding a subunit (bo,+AT) of rBAT. Nat Genet (1999) 1.65
Neurofibromatosis type 1 due to germ-line mosaicism in a clinically normal father. N Engl J Med (1994) 1.63
Concentrations of arsenic, cadmium, mercury, and lead in common foods and estimated daily intake by children, adolescents, adults, and seniors of Catalonia, Spain. J Agric Food Chem (2003) 1.60
A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region. Hum Mol Genet (1996) 1.60
Recurrent mutations in the NF1 gene are common among neurofibromatosis type 1 patients. J Med Genet (2003) 1.59
Nuclear transport of influenza virus polymerase PA protein. Virus Res (1992) 1.59
Confirmation of a double-hit model for the NF1 gene in benign neurofibromas. Am J Hum Genet (1997) 1.55
Utilization of cereal and fruit fibres in low fat dry fermented sausages. Meat Sci (2002) 1.55
Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome. Genomics (1999) 1.55
Structural determinants of KvLQT1 control by the KCNE family of proteins. J Biol Chem (2000) 1.54
Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with aging. Brain Res Mol Brain Res (1997) 1.53
Usefulness of transoesophageal echocardiography before circumferential pulmonary vein ablation in patients with atrial fibrillation: is it really mandatory? Europace (2010) 1.49
Molecular genetics of hearing impairment due to mutations in gap junction genes encoding beta connexins. Hum Mutat (2000) 1.49
Molecular basis of childhood deafness resulting from mutations in the GJB2 (connexin 26) gene. Hum Genet (2000) 1.48
Heterogeneity for mutations in the CFTR gene and clinical correlations in patients with congenital absence of the vas deferens. Hum Reprod (2000) 1.47
CA/GT microsatellite alleles within the cystic fibrosis transmembrane conductance regulator (CFTR) gene are not generated by unequal crossingover. Genomics (1991) 1.46
Reverse gyrase, a hallmark of the hyperthermophilic archaebacteria. J Bacteriol (1990) 1.44
[Molecular analysis of the IT15 gene in 79 Spanish families with Huntington's disease: diagnostic confirmation and presymptomatic diagnosis]. Med Clin (Barc) (1997) 1.44
Mutational analysis of the influenza virus A/Victoria/3/75 PA protein: studies of interaction with PB1 protein and identification of a dominant negative mutant. J Gen Virol (1996) 1.43
A patient with autistic disorder and a 20/22 chromosomal translocation. Dev Med Child Neurol (1998) 1.41
Detection of a cystic fibrosis modifier locus for meconium ileus on human chromosome 19q13. Nat Genet (1999) 1.41
The mouse brain transcriptome by SAGE: differences in gene expression between P30 brains of the partial trisomy 16 mouse model of Down syndrome (Ts65Dn) and normals. Genome Res (2000) 1.40
Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunit. J Virol (1996) 1.38
Experience with new DNA markers for the diagnosis of cystic fibrosis. N Engl J Med (1988) 1.37
Atretic cephalocele: the tip of the iceberg. J Neurosurg (1992) 1.34
Microsatellite haplotypes for cystic fibrosis: mutation frameworks and evolutionary tracers. Hum Mol Genet (1993) 1.31
Sex differences in mutational rate and mutational mechanism in the NF1 gene in neurofibromatosis type 1 patients. Hum Genet (1996) 1.31
Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells. Mol Cell Biol (1998) 1.30
Presymptomatic analysis of spinocerebellar ataxia type 1 (SCA1) via the expansion of the SCA1 CAG-repeat in a large pedigree displaying anticipation and parental male bias. Hum Mol Genet (1993) 1.29
A novel donor splice site in intron 11 of the CFTR gene, created by mutation 1811+1.6kbA-->G, produces a new exon: high frequency in Spanish cystic fibrosis chromosomes and association with severe phenotype. Am J Hum Genet (1995) 1.29
Predicting beauty: fractal dimension and visual complexity in art. Br J Psychol (2011) 1.27
Linkage, clinical features, and prognosis of autosomal dominant polycystic kidney disease types 1 and 2. J Am Soc Nephrol (1996) 1.24
The A1555G mutation in the 12S rRNA gene of human mtDNA: recurrent origins and founder events in families affected by sensorineural deafness. Am J Hum Genet (1999) 1.23
Inulin as fat substitute in low fat, dry fermented sausages. Meat Sci (2001) 1.22
Espin gene (ESPN) mutations associated with autosomal dominant hearing loss cause defects in microvillar elongation or organisation. J Med Genet (2005) 1.21
A highly informative CA/GT repeat polymorphism in intron 38 of the human neurofibromatosis type 1 (NF1) gene. Hum Genet (1993) 1.21
Temperature, template topology, and factor requirements of archaeal transcription. Proc Natl Acad Sci U S A (1998) 1.20
Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB. Mol Psychiatry (2007) 1.19
Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment. Cereb Cortex (2003) 1.18
Expression cloning of a human renal cDNA that induces high affinity transport of L-cystine shared with dibasic amino acids in Xenopus oocytes. J Biol Chem (1993) 1.18
Additional complexity on human chromosome 15q: identification of a set of newly recognized duplicons (LCR15) on 15q11-q13, 15q24, and 15q26. Genome Res (2001) 1.17
Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12. Cell Death Dis (2011) 1.17
Polybrominated diphenyl ethers (PBDEs) in foodstuffs: human exposure through the diet. J Agric Food Chem (2003) 1.16
A high-resolution physical map of human chromosome 21p using yeast artificial chromosomes. Genome Res (1999) 1.16
Chromosome assignment and restriction fragment length polymorphism analysis of the anonymous DNA probe B79a at 7q22 (HMG8 assignment D7S13). Hum Genet (1986) 1.14
Functional analysis of mutations in SLC7A9, and genotype-phenotype correlation in non-Type I cystinuria. Hum Mol Genet (2001) 1.13
Molecular studies in 20 submicroscopic neurofibromatosis type 1 gene deletions. Hum Mutat (1999) 1.13
WASP gene mutations in Wiskott-Aldrich syndrome and X-linked thrombocytopenia. Hum Mol Genet (1995) 1.12
Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis. FEBS Lett (2000) 1.12
Association of common copy number variants at the glutathione S-transferase genes and rare novel genomic changes with schizophrenia. Mol Psychiatry (2009) 1.11
Haplotype analysis to determine the position of a mutation among closely linked DNA markers. Hum Mol Genet (1993) 1.11
X-chromosome tiling path array detection of copy number variants in patients with chromosome X-linked mental retardation. BMC Genomics (2007) 1.11
PTOV1, a novel protein overexpressed in prostate cancer containing a new class of protein homology blocks. Oncogene (2001) 1.11
Two CA/GT repeat polymorphisms in intron 27 of the human neurofibromatosis (NF1) gene. Hum Genet (1994) 1.11
Next generation diagnostics of cystic fibrosis and CFTR-related disorders by targeted multiplex high-coverage resequencing of CFTR. J Med Genet (2013) 1.10
Haploinsufficiency of Dyrk1A in mice leads to specific alterations in the development and regulation of motor activity. Behav Neurosci (2004) 1.10
Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases. Biochem Biophys Res Commun (1999) 1.10
Continuous production of a hybrid antibiotic by Streptomyces lividans TK21 pellets in a three-phase fluidized-bed bioreactor. Biotechnol Bioeng (1997) 1.09
Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type. Mol Psychiatry (2003) 1.09
Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction. Neurobiol Dis (2004) 1.09
Reverse gyrase binding to DNA alters the double helix structure and produces single-strand cleavage in the absence of ATP. EMBO J (1989) 1.08