Published in Nat Genet on December 01, 2001
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Pten regulates neuronal arborization and social interaction in mice. Neuron (2006) 6.11
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PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A (2005) 2.93
Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. J Neurosci (2009) 2.90
Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain. Cancer Cell (2011) 2.87
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Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function. Cell (2014) 2.25
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Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten. Proc Natl Acad Sci U S A (2004) 1.67
Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol (2005) 1.61
Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. Neuroscience (2007) 1.59
Role of the steroid receptor coactivator SRC-3 in cell growth. Mol Cell Biol (2003) 1.53
Pten knockdown in vivo increases excitatory drive onto dentate granule cells. J Neurosci (2011) 1.51
PTEN gene targeting reveals a radiation-induced size checkpoint in human cancer cells. Cancer Res (2004) 1.49
Germline inactivation of PTEN and dysregulation of the phosphoinositol-3-kinase/Akt pathway cause human Lhermitte-Duclos disease in adults. Am J Hum Genet (2003) 1.41
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Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice. Epilepsia (2011) 1.36
Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains. Genes Dev (2009) 1.34
PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia. Brain (2015) 1.33
MyosinV controls PTEN function and neuronal cell size. Nat Cell Biol (2009) 1.32
Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior. Proc Natl Acad Sci U S A (2009) 1.30
PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression. EMBO J (2010) 1.26
Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model. Eur J Hum Genet (2011) 1.25
Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration. J Physiol (2011) 1.24
Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells. Transgenic Res (2008) 1.23
Germline disruption of Pten localization causes enhanced sex-dependent social motivation and increased glial production. Hum Mol Genet (2014) 1.18
Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB. EMBO Mol Med (2014) 1.17
Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model. Cancer Res (2011) 1.17
NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. EMBO J (2011) 1.15
Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. J Cell Biol (2012) 1.13
ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons. J Neurosci (2010) 1.12
Critical role of integrin-linked kinase in granule cell precursor proliferation and cerebellar development. J Neurosci (2006) 1.11
Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells. Mol Cell Biol (2011) 1.11
A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice. Hum Mol Genet (2010) 1.11
Neural stem cells in the developing and adult brains. J Cell Physiol (2009) 1.11
Mammalian target of rapamycin (mTOR) inhibition: potential for antiseizure, antiepileptogenic, and epileptostatic therapy. Curr Neurol Neurosci Rep (2012) 1.09
Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex. J Neurosci (2011) 1.08
Phosphatase and tensin homologue deleted on chromosome 10: extending its PTENtacles. Int J Biochem Cell Biol (2008) 1.08
Inhibition of neuronal phenotype by PTEN in PC12 cells. Proc Natl Acad Sci U S A (2004) 1.05
Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission. J Neurosci (2012) 1.05
Hyperactivity of newborn Pten knock-out neurons results from increased excitatory synaptic drive. J Neurosci (2015) 1.00
Inactivation of neuronal forebrain A receptors protects dopaminergic neurons in a mouse model of Parkinson's disease. J Neurochem (2009) 0.98
Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins. Front Mol Neurosci (2014) 0.96
Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc. J Biol Chem (2010) 0.96
Pten deletion causes mTorc1-dependent ectopic neuroblast differentiation without causing uniform migration defects. Development (2012) 0.95
Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation. Front Mol Neurosci (2014) 0.95
The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia. Proc Natl Acad Sci U S A (2008) 0.95
Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders. Front Mol Neurosci (2014) 0.95
A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development. Development (2011) 0.94
Fatty acids increase neuronal hypertrophy of Pten knockdown neurons. Front Mol Neurosci (2014) 0.90
Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction. J Clin Invest (2009) 0.90
PTEN/PI3K and MAPK signaling in protection and pathology following CNS injuries. Front Biol (Beijing) (2013) 0.89
mTOR inhibition suppresses established epilepsy in a mouse model of cortical dysplasia. Epilepsia (2015) 0.89
Development and characterization of NEX- Pten, a novel forebrain excitatory neuron-specific knockout mouse. Dev Neurosci (2012) 0.89
Molecular mechanism of size control in development and human diseases. Cell Res (2011) 0.88
Will kinase inhibitors make it as glioblastoma drugs? Curr Top Microbiol Immunol (2012) 0.87
Analysis of transcriptional profiles and functional clustering of global cerebellar gene expression in PCD3J mice. Biochem Biophys Res Commun (2008) 0.87
Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder. Neurotherapeutics (2015) 0.86
Pten loss in Olig2 expressing neural progenitor cells and oligodendrocytes leads to interneuron dysplasia and leukodystrophy. Stem Cells (2014) 0.86
Tracking and transforming neocortical progenitors by CRISPR/Cas9 gene targeting and piggyBac transposase lineage labeling. Development (2015) 0.86
Neurobiology of autism gene products: towards pathogenesis and drug targets. Psychopharmacology (Berl) (2014) 0.86
Pten regulates collective cell migration during specification of the anterior-posterior axis of the mouse embryo. Dev Biol (2012) 0.86
Regulation of the postnatal development of dopamine neurons of the substantia nigra in vivo by Akt/protein kinase B. J Neurochem (2009) 0.86
A tale of tailless. Dev Neurosci (2010) 0.86
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Adenovirus mediated homozygous endometrial epithelial Pten deletion results in aggressive endometrial carcinoma. Exp Cell Res (2011) 0.85
Reduction of Pten dose leads to neoplastic development in multiple organs of Pten (shRNA) mice. Cancer Biol Ther (2010) 0.85
An AKT3-FOXG1-reelin network underlies defective migration in human focal malformations of cortical development. Nat Med (2015) 0.84
Conditional and inducible gene recombineering in the mouse inner ear. Brain Res (2006) 0.84
Impaired Pten expression in human malignant peripheral nerve sheath tumours. PLoS One (2012) 0.84
Cell-type specific roles for PTEN in establishing a functional retinal architecture. PLoS One (2012) 0.84
Developmental control of lateralized neuron size in the nematode Caenorhabditis elegans. Neural Dev (2010) 0.84
Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes. J Med Genet (2014) 0.84
The miR-183∼96∼182 cluster promotes tumorigenesis in a mouse model of medulloblastoma. J Biomed Res (2013) 0.83
Striking the balance between PTEN and PDK1: it all depends on the cell context. Genes Dev (2009) 0.83
Hydrocephalus caused by conditional ablation of the Pten or beta-catenin gene. Cerebrospinal Fluid Res (2008) 0.82
Lack of Connexin43-mediated bergmann glial gap junctional coupling does not affect cerebellar long-term depression, motor coordination, or eyeblink conditioning. Front Behav Neurosci (2008) 0.82
Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau. Mol Neurodegener (2006) 0.82
PTEN knockdown alters dendritic spine/protrusion morphology, not density. J Comp Neurol (2014) 0.82
PTEN regulates retinal interneuron morphogenesis and synaptic layer formation. Mol Cell Neurosci (2011) 0.81
Astroglial PTEN Loss Disrupts Neuronal Lamination by Dysregulating Radial Glia-guided Neuronal Migration. Aging Dis (2013) 0.81
The associations between Parkinson's disease and cancer: the plot thickens. Transl Neurodegener (2015) 0.81
Characterizing autism spectrum disorders by key biochemical pathways. Front Neurosci (2015) 0.80
Coordinate regulation of mature dopaminergic axon morphology by macroautophagy and the PTEN signaling pathway. PLoS Genet (2013) 0.80
Presenilins regulate the cellular level of the tumor suppressor PTEN. Neurobiol Aging (2007) 0.80
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