Published in Physiol Rev on January 01, 2002
Gating of CFTR by the STAS domain of SLC26 transporters. Nat Cell Biol (2004) 3.43
Intestinal barrier function: molecular regulation and disease pathogenesis. J Allergy Clin Immunol (2009) 2.63
Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol (2011) 2.03
Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia. Cell (2007) 1.89
Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity. PLoS One (2007) 1.86
WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia. Proc Natl Acad Sci U S A (2003) 1.82
Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6. J Gen Physiol (2006) 1.73
SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage. Proc Natl Acad Sci U S A (2009) 1.61
Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3- secretion: relevance to cystic fibrosis. EMBO J (2006) 1.56
The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. J Physiol (2004) 1.53
Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction. Proc Natl Acad Sci U S A (2006) 1.48
Calcium-dependent chloride conductance in epithelia: is there a contribution by Bestrophin? Pflugers Arch (2007) 1.47
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo. Proc Natl Acad Sci U S A (2007) 1.46
Enteropathogenic Escherichia coli (EPEC) inactivate innate immune responses prior to compromising epithelial barrier function. Cell Microbiol (2007) 1.44
Apical targeting of the P2Y(4) receptor is directed by hydrophobic and basic residues in the cytoplasmic tail. Am J Physiol Cell Physiol (2012) 1.42
Changes in ion transport in inflammatory disease. J Inflamm (Lond) (2006) 1.39
Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon. J Clin Invest (2010) 1.29
Anoctamins. Pflugers Arch (2011) 1.29
The cystic fibrosis transmembrane conductance regulator in reproductive health and disease. J Physiol (2008) 1.26
Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis. PLoS One (2012) 1.26
Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. J Med Chem (2011) 1.25
Aldosterone increases KCa1.1 (BK) channel-mediated colonic K+ secretion. J Physiol (2008) 1.24
Mechanistic insight into control of CFTR by AMPK. J Biol Chem (2008) 1.21
Keratins modulate colonocyte electrolyte transport via protein mistargeting. J Cell Biol (2004) 1.18
Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem (2009) 1.17
Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea. Am J Hum Genet (2009) 1.15
Regulation of electroneutral NaCl absorption by the small intestine. Annu Rev Physiol (2011) 1.15
Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells. J Cell Sci (2008) 1.13
Age-associated remodeling of the intestinal epithelial barrier. J Gerontol A Biol Sci Med Sci (2013) 1.13
The Type II heat-labile enterotoxins LT-IIa and LT-IIb and their respective B pentamers differentially induce and regulate cytokine production in human monocytic cells. Infect Immun (2004) 1.12
Abolition of Ca2+-mediated intestinal anion secretion and increased stool dehydration in mice lacking the intermediate conductance Ca2+-dependent K+ channel Kcnn4. J Physiol (2007) 1.11
Cftr and ENaC ion channels mediate NaCl absorption in the mouse submandibular gland. J Physiol (2009) 1.11
Nanomolar CFTR inhibition by pore-occluding divalent polyethylene glycol-malonic acid hydrazides. Chem Biol (2008) 1.09
Regulation of the epithelial Na+ channel and airway surface liquid volume by serine proteases. Pflugers Arch (2010) 1.08
Ion channels in inflammation. Pflugers Arch (2011) 1.08
Decreased expression of colonic Slc26a3 and carbonic anhydrase iv as a cause of fatal infectious diarrhea in mice. Infect Immun (2009) 1.08
Colonic potassium handling. Pflugers Arch (2010) 1.08
Carbonic anhydrases in normal gastrointestinal tract and gastrointestinal tumours. World J Gastroenterol (2005) 1.06
Cyclooxygenase 2 mediates post-inflammatory colonic secretory and barrier dysfunction. Gut (2003) 1.06
Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea. Am J Pathol (2007) 1.06
Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice. J Biol Chem (2010) 1.05
P2Y6 receptor mediates colonic NaCl secretion via differential activation of cAMP-mediated transport. J Clin Invest (2003) 1.04
Monomeric CFTR in plasma membranes in live cells revealed by single molecule fluorescence imaging. J Biol Chem (2008) 1.02
Transport properties of the human intestinal anion exchanger DRA (down-regulated in adenoma) in transfected HEK293 cells. Pflugers Arch (2004) 1.02
Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption. Pflugers Arch (2011) 1.00
Diarrhea as a cause of mortality in a mouse model of infectious colitis. Genome Biol (2008) 0.99
Adrenaline-induced colonic K+ secretion is mediated by KCa1.1 (BK) channels. J Physiol (2010) 0.97
Clinical potential of naloxegol in the management of opioid-induced bowel dysfunction. Clin Exp Gastroenterol (2014) 0.97
Intestinal epithelial CD98: an oligomeric and multifunctional protein. Biochim Biophys Acta (2008) 0.97
A model of Salmonella colitis with features of diarrhea in SLC11A1 wild-type mice. PLoS One (2008) 0.97
SPLUNC1 expression reduces surface levels of the epithelial sodium channel (ENaC) in Xenopus laevis oocytes. Channels (Austin) (2010) 0.97
The Vibrio cholerae cytolysin promotes chloride secretion from intact human intestinal mucosa. PLoS One (2009) 0.96
Function of K+ channels in the intestinal epithelium. J Membr Biol (2003) 0.95
AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. Am J Physiol Renal Physiol (2010) 0.95
Sexual dimorphism and oestrogen regulation of KCNE3 expression modulates the functional properties of KCNQ1 K⁺ channels. J Physiol (2011) 0.95
Neural influences on human intestinal epithelium in vitro. J Physiol (2015) 0.95
Vasopressin-stimulated CFTR Cl- currents are increased in the renal collecting duct cells of a mouse model of Liddle's syndrome. J Physiol (2004) 0.94
Mechanisms of renal control of potassium homeostasis in complete aldosterone deficiency. J Am Soc Nephrol (2014) 0.93
The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients. PLoS One (2011) 0.92
Potassium channels in epithelial transport. Pflugers Arch (2003) 0.92
Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts. Aging Cell (2009) 0.92
Electrolyte and acid-base disorders in inflammatory bowel disease. Ann Gastroenterol (2013) 0.92
Mechanism of action and toxicities of purgatives used for colonoscopy preparation. Expert Opin Drug Metab Toxicol (2011) 0.92
CFTR is activated through stimulation of purinergic P2Y2 receptors. Pflugers Arch (2008) 0.91
The role of epithelial P2Y2 and P2Y4 receptors in the regulation of intestinal chloride secretion. Br J Pharmacol (2005) 0.91
Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome. J Physiol (2007) 0.90
NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells. Pflugers Arch (2007) 0.90
Distal colonic Na(+) absorption inhibited by luminal P2Y(2) receptors. Pflugers Arch (2007) 0.90
Tissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial. BMC Med Genet (2015) 0.88
Colon-specific deletion of epithelial sodium channel causes sodium loss and aldosterone resistance. J Am Soc Nephrol (2014) 0.88
Severe defects in absorptive ion transport in distal colons of mice that lack ClC-2 channels. Gastroenterology (2011) 0.87
The {omega}-3 fatty acid eicosapentaenoic acid elicits cAMP generation in colonic epithelial cells via a "store-operated" mechanism. Am J Physiol Gastrointest Liver Physiol (2010) 0.87
Role of calcium and other trace elements in the gastrointestinal physiology. World J Gastroenterol (2006) 0.87
5-Fluorouracil induces diarrhea with changes in the expression of inflammatory cytokines and aquaporins in mouse intestines. PLoS One (2013) 0.86
Ezrin is required for the functional regulation of the epithelial sodium proton exchanger, NHE3. PLoS One (2013) 0.86
Localization of Ca2+ -activated big-conductance K+ channels in rabbit distal colon. Pflugers Arch (2003) 0.86
Segmental heterogeneity of electrogenic secretions in human ascending colon and rectum. Int J Colorectal Dis (2005) 0.86
Toxin mediated diarrhea in the 21 century: the pathophysiology of intestinal ion transport in the course of ETEC, V. cholerae and rotavirus infection. Toxins (Basel) (2010) 0.85
GFP-tagged CFTR transgene is functional in the G551D cystic fibrosis mouse colon. J Membr Biol (2003) 0.84
Increased colonic sodium absorption in rats with chronic renal failure is partially mediated by AT1 receptor agonism. Am J Physiol Gastrointest Liver Physiol (2008) 0.84
TASK-3 immunoreactivity shows differential distribution in the human gastrointestinal tract. Virchows Arch (2005) 0.83
Electrogenic transport, oxygen consumption, and sensitivity to acute hypoxia of human colonic epithelium. Int J Colorectal Dis (2011) 0.83
The Epac1 signaling pathway regulates Cl- secretion via modulation of apical KCNN4c channels in diarrhea. J Biol Chem (2013) 0.82
Inhibition of water absorption and selective damage to human colonic mucosa are induced by subtilase cytotoxin produced by Escherichia coli O113:H21. Infect Immun (2013) 0.82
Comparison of native or reformulated chicory fructans, or non-purified chicory, on rat cecal fermentation and mineral metabolism. Eur J Nutr (2008) 0.82
Chloride secretion in a morphologically differentiated human colonic cell line that expresses the epithelial Na+ channel. J Physiol (2003) 0.82
Oxygen in the regulation of intestinal epithelial transport. J Physiol (2014) 0.82
Bile acids increase the activity of the epithelial Na+ channel. Pflugers Arch (2013) 0.81
CFTR inhibitors. Curr Pharm Des (2013) 0.81
Saccharomyces boulardii inhibits water and electrolytes changes induced by castor oil in the rat colon. Dig Dis Sci (2005) 0.81
Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea. J Biol Chem (2015) 0.81
mRNA expression, functional profiling and multivariate classification of colon biopsy specimen by cDNA overall glass microarray. World J Gastroenterol (2006) 0.81
Human mini-guts: new insights into intestinal physiology and host-pathogen interactions. Nat Rev Gastroenterol Hepatol (2016) 0.80
An Adult Mouse Model of Vibrio cholerae-induced Diarrhea for Studying Pathogenesis and Potential Therapy of Cholera. PLoS Negl Trop Dis (2013) 0.80
The secretory KCa1.1 channel localises to crypts of distal mouse colon: functional and molecular evidence. Pflugers Arch (2011) 0.80
Tetramethylpyrazine stimulates cystic fibrosis transmembrane conductance regulator-mediated anion secretion in distal colon of rodents. World J Gastroenterol (2005) 0.80
Estrogen-dependent regulation of sodium/hydrogen exchanger-3 (NHE3) expression via estrogen receptor β in proximal colon of pregnant mice. Histochem Cell Biol (2012) 0.80
A quantitative analysis of electrolyte exchange in the salivary duct. Am J Physiol Gastrointest Liver Physiol (2012) 0.80
Benzamil sensitive ion channels contribute to volume regulation in canine chondrocytes. Br J Pharmacol (2013) 0.80
KCNE3 acts by promoting voltage sensor activation in KCNQ1. Proc Natl Acad Sci U S A (2015) 0.80
Characterization of wild-type and deltaF508 cystic fibrosis transmembrane regulator in human respiratory epithelia. Mol Biol Cell (2005) 2.13
Regulatory T-cell impairment in cystic fibrosis patients with chronic pseudomonas infection. Am J Respir Crit Care Med (2015) 1.51
CFTR Cl- channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis. Gastroenterology (2004) 1.04
Control of ion transport in mammalian airways by protease activated receptors type 2 (PAR-2). FASEB J (2005) 1.00
Ion transport induced by proteinase-activated receptors (PAR2) in colon and airways. Cell Biochem Biophys (2002) 0.91
Pharmacotherapy of the ion transport defect in cystic fibrosis: role of purinergic receptor agonists and other potential therapeutics. Am J Respir Med (2003) 0.89
Modelling dysregulated Na+ absorption in airway epithelial cells with mucosal nystatin treatment. Am J Respir Cell Mol Biol (2007) 0.83
Assessment of CFTR function in native epithelia for the diagnosis of cystic fibrosis. Pediatr Pulmonol Suppl (2004) 0.76