Published in Mol Cell on December 01, 2001
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev (2002) 13.08
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev (2002) 10.54
ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature (2006) 9.30
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell (2009) 8.69
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev (2002) 4.07
Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes. Mol Cell Biol (2004) 3.90
Modulation of p53 function by SET8-mediated methylation at lysine 382. Mol Cell (2007) 3.68
Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase. Cell (2002) 2.94
Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment. Mol Cell Biol (2005) 2.86
NSD1 is essential for early post-implantation development and has a catalytically active SET domain. EMBO J (2003) 2.72
Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. Mol Cell Biol (2003) 2.70
The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor. Blood (2007) 2.58
Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9. EMBO J (2003) 2.43
CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcription. Proc Natl Acad Sci U S A (2004) 2.38
Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Mol Cell (2008) 2.35
Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail. Diabetes (2009) 2.34
PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. Genes Dev (2007) 2.34
Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications. Nucleic Acids Res (2004) 2.28
Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells. Proc Natl Acad Sci U S A (2009) 2.18
Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation. J Biol Chem (2008) 2.17
Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci U S A (2006) 2.16
Regulation of NF-kappaB activity through lysine monomethylation of p65. Proc Natl Acad Sci U S A (2009) 2.10
Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes. Genes Dev (2002) 2.10
Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. Mol Cell (2007) 2.05
Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit. EMBO J (2009) 2.05
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99
Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet. EMBO J (2003) 1.89
Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast. Proc Natl Acad Sci U S A (2002) 1.87
Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes. Mol Cell Biol (2007) 1.84
Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes. Mol Cell Biol (2005) 1.78
Epigenetics in the placenta. Am J Reprod Immunol (2009) 1.77
The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Cell Host Microbe (2010) 1.76
Methylation-acetylation interplay activates p53 in response to DNA damage. Mol Cell Biol (2007) 1.75
Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure. Mol Cell Biol (2009) 1.74
H3K9 and H3K14 acetylation co-occur at many gene regulatory elements, while H3K14ac marks a subset of inactive inducible promoters in mouse embryonic stem cells. BMC Genomics (2012) 1.73
Comparative study of methyl-CpG-binding domain proteins. BMC Genomics (2003) 1.70
Histone code modifications on pluripotential nuclei of reprogrammed somatic cells. Mol Cell Biol (2004) 1.67
Trimethylation of histone H3 lysine 4 by Set1 in the lytic infection of human herpes simplex virus 1. J Virol (2006) 1.65
PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells. Mol Cell Biol (2006) 1.65
Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor. Mol Cell Biol (2002) 1.63
Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription. J Biol Chem (2005) 1.61
Mapping global histone methylation patterns in the coding regions of human genes. Mol Cell Biol (2005) 1.55
Epigenetic phenomena linked to diabetic complications. Nat Rev Endocrinol (2010) 1.51
Hematopoietic-specific activators establish an overlapping pattern of histone acetylation and methylation within a mammalian chromatin domain. Proc Natl Acad Sci U S A (2002) 1.51
An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B. Biochem J (2003) 1.48
Comparative analysis of SET domain proteins in maize and Arabidopsis reveals multiple duplications preceding the divergence of monocots and dicots. Plant Physiol (2003) 1.47
Biotinylation of histones represses transposable elements in human and mouse cells and cell lines and in Drosophila melanogaster. J Nutr (2008) 1.47
Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes. Diabetes (2008) 1.46
Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage. Mol Cell Biol (2006) 1.45
Dual role for the methyltransferase G9a in the maintenance of beta-globin gene transcription in adult erythroid cells. Proc Natl Acad Sci U S A (2009) 1.44
Epigenetic histone methylation modulates fibrotic gene expression. J Am Soc Nephrol (2010) 1.44
Lsh, a modulator of CpG methylation, is crucial for normal histone methylation. EMBO J (2003) 1.40
Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1. Eur J Cancer Prev (2016) 1.39
Cascade of distinct histone modifications during collagenase gene activation. Mol Cell Biol (2003) 1.36
An epigenetic perspective on the free radical theory of development. Free Radic Biol Med (2007) 1.35
Protein methylation: a new mechanism of p53 tumor suppressor regulation. Histol Histopathol (2008) 1.34
Quantitative proteomic analysis of histone modifications. Chem Rev (2015) 1.32
Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in Saccharomyces cerevisiae. Mol Cell Biol (2003) 1.32
S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation. Hepatology (2008) 1.30
Epigenetic aberrations and cancer. Mol Cancer (2006) 1.29
Regulation of secondary metabolism by chromatin structure and epigenetic codes. Fungal Genet Biol (2010) 1.28
A mosaic genetic screen reveals distinct roles for trithorax and polycomb group genes in Drosophila eye development. Genetics (2004) 1.25
Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability. Proc Natl Acad Sci U S A (2013) 1.24
Molecular landscape of modified histones in Drosophila heterochromatic genes and euchromatin-heterochromatin transition zones. PLoS Genet (2007) 1.21
Embryonic development following somatic cell nuclear transfer impeded by persisting histone methylation. Cell (2014) 1.18
Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation. Drug Discov Today (2011) 1.18
Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). Proc Natl Acad Sci U S A (2011) 1.17
A histone methyltransferase is required for maximal response to female sex hormones. Mol Cell Biol (2004) 1.17
Regulation of the androgen receptor by SET9-mediated methylation. Nucleic Acids Res (2010) 1.17
SET7/9 mediated methylation of non-histone proteins in mammalian cells. Epigenetics (2009) 1.16
The protein arginine methyltransferases CARM1 and PRMT1 cooperate in gene regulation. Nucleic Acids Res (2008) 1.16
Substrate and product specificities of SET domain methyltransferases. Epigenetics (2011) 1.15
Epigenetic factors in aging and longevity. Pflugers Arch (2009) 1.15
The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly. J Cell Biol (2011) 1.13
Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human. FEBS J (2010) 1.12
An unexpected journey: lysine methylation across the proteome. Biochim Biophys Acta (2014) 1.11
Biochemical characterization of metnase's endonuclease activity and its role in NHEJ repair. Biochemistry (2011) 1.10
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc Natl Acad Sci U S A (2014) 1.09
Histone H3 lysine 4 methyltransferases and demethylases in self-renewal and differentiation of stem cells. Cell Biosci (2013) 1.07
Deciphering the code for retroviral integration target site selection. PLoS Comput Biol (2010) 1.06
Neurotrophin-mediated degradation of histone methyltransferase by S-nitrosylation cascade regulates neuronal differentiation. Proc Natl Acad Sci U S A (2011) 1.04
Lysine-specific modifications of p53: a matter of life and death? Oncotarget (2013) 1.03
Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases. Antioxid Redox Signal (2012) 1.01
H3 K79 dimethylation marks developmental activation of the beta-globin gene but is reduced upon LCR-mediated high-level transcription. Blood (2008) 0.98
Targeting protein lysine methylation and demethylation in cancers. Acta Biochim Biophys Sin (Shanghai) (2012) 0.98
Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice. J Biol Chem (2008) 0.97
Control of gene expression and assembly of chromosomal subdomains by chromatin regulators with antagonistic functions. Chromosoma (2005) 0.96
PRDM6 is enriched in vascular precursors during development and inhibits endothelial cell proliferation, survival, and differentiation. J Mol Cell Cardiol (2007) 0.92
Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondria. J Biol Chem (2014) 0.92
smyd1 and smyd2 are expressed in muscle tissue in Xenopus laevis. Cytotechnology (2008) 0.92
The long non-coding RNA Fendrr links epigenetic control mechanisms to gene regulatory networks in mammalian embryogenesis. RNA Biol (2013) 0.92
cAMP prevents glucose-mediated modifications of histone H3 and recruitment of the RNA polymerase II holoenzyme to the L-PK gene promoter. J Mol Biol (2009) 0.91
Histone methyltransferases and demethylases: regulators in balancing osteogenic and adipogenic differentiation of mesenchymal stem cells. Int J Oral Sci (2015) 0.90
Chromatin regulation Tip(60)s the balance in embryonic stem cell self-renewal. Cell Cycle (2008) 0.90
Epigenetic Targeting of Transforming Growth Factor β Receptor II and Implications for Cancer Therapy. Mol Cell Pharmacol (2009) 0.90
Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells. Nucleic Acids Res (2002) 0.89
Turning on myogenin in muscle: a paradigm for understanding mechanisms of tissue-specific gene expression. Comp Funct Genomics (2012) 0.89
KMTase Set7/9 is a critical regulator of E2F1 activity upon genotoxic stress. Cell Death Differ (2014) 0.89
Transcriptional regulation by the Set7 lysine methyltransferase. Epigenetics (2013) 0.88
Electric field effect in atomically thin carbon films. Science (2004) 45.10
SNAP receptors implicated in vesicle targeting and fusion. Nature (1993) 18.57
Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell (2000) 17.44
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature (1999) 16.97
IntAct--open source resource for molecular interaction data. Nucleic Acids Res (2006) 13.82
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science (2000) 13.62
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol (2000) 11.62
Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med (2000) 11.12
Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell (2000) 11.09
Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol (2001) 10.20
Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nat Cell Biol (2001) 9.82
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell (1994) 9.48
Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. Cell (1990) 9.24
Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus. Nat Med (1996) 8.94
A cellular gene encodes scrapie PrP 27-30 protein. Cell (1985) 8.86
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell (1994) 8.71
Smoking in China: findings of the 1996 National Prevalence Survey. JAMA (1999) 8.67
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell (2001) 8.60
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med (1995) 8.51
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest (1999) 8.38
Mammalian sweet taste receptors. Cell (2001) 8.04
Disruption of IRS-2 causes type 2 diabetes in mice. Nature (1998) 7.94
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev (1999) 7.58
The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. Am J Public Health (1994) 7.38
Rapid modification of bacterial artificial chromosomes by ET-recombination. Nucleic Acids Res (1999) 6.85
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science (1998) 6.79
Significant acidification in major Chinese croplands. Science (2010) 6.68
DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell (1991) 6.63
TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal. Biochem Biophys Res Commun (1999) 6.33
Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. Lancet (2001) 6.23
RSC, an essential, abundant chromatin-remodeling complex. Cell (1996) 6.17
Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest (1999) 6.13
Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J (1998) 5.96
Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell (1997) 5.83
An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum (1998) 5.72
MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat Genet (1999) 5.61
The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system. J Biol Chem (1995) 5.36
Smads: transcriptional activators of TGF-beta responses. Cell (1998) 5.33
Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science (2001) 5.25
COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A (2001) 5.19
Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study. Ann Intern Med (1992) 5.05
Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit. Mol Cell Biol (1998) 5.01
The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell (1997) 4.99
Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology. Proc Natl Acad Sci U S A (2000) 4.79
A human telomeric protein. Science (1995) 4.77
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68
Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. Nature (1993) 4.68
Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science (1996) 4.59
Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem (1999) 4.56
Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Mol Cell (1999) 4.49
A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell (1994) 4.47
Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization. J Am Chem Soc (2001) 4.46
Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature (1999) 4.40
Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Natl Acad Sci U S A (1992) 4.32
Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci U S A (1997) 4.29
Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing. Genes Dev (1991) 4.28
PCR amplification and restriction endonuclease analysis of a 65-kilodalton heat shock protein gene sequence for taxonomic separation of rapidly growing mycobacteria. J Clin Microbiol (1995) 4.27
Orientation selectivity and the arrangement of horizontal connections in tree shrew striate cortex. J Neurosci (1997) 4.26
Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J Biol Chem (2001) 4.23
Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3. EMBO J (2001) 4.23
Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I. Proc Natl Acad Sci U S A (2000) 4.22
Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circ Res (2001) 4.22
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med (2001) 4.22
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci U S A (1994) 4.21
Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue. J Virol (1998) 4.17
Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs. Science (2013) 4.17
Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheum (1997) 4.08
The effect of postmenopausal estrogen therapy on bone density in elderly women. N Engl J Med (1993) 4.04
From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor. Proc Natl Acad Sci U S A (1998) 3.99
Multiattribute utility function for a comprehensive health status classification system. Health Utilities Index Mark 2. Med Care (1996) 3.96
I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B. Cell (1995) 3.95
The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum (1995) 3.93
A Drosophila Polycomb group complex includes Zeste and dTAFII proteins. Nature (2001) 3.90
Molecular dynamics simulations of a lipid bilayer and of hexadecane: an investigation of membrane fluidity. Science (1993) 3.81
The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol (2007) 3.81
A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme. Mol Cell (1999) 3.80
High-level semi-synthetic production of the potent antimalarial artemisinin. Nature (2013) 3.80