PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B.

PubWeight™: 2.88‹?› | Rank: Top 1%

🔗 View Article (PMID 11786556)

Published in J Biol Chem on January 10, 2002

Authors

Gulam A Manji1, Lin Wang, Brad J Geddes, Melissa Brown, Sarah Merriam, Amal Al-Garawi, Simona Mak, Jose M Lora, Michael Briskin, Mark Jurman, Jie Cao, Peter S DiStefano, John Bertin

Author Affiliations

1: Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, USA.

Articles citing this

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature (2009) 13.23

Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition. N Engl J Med (2006) 6.17

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum (2002) 4.98

Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. Am J Hum Genet (2002) 4.84

Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet (2004) 4.23

Inflammasomes: too big to miss. J Clin Invest (2009) 2.51

New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes. Am J Hum Genet (2002) 2.39

Discovery of a viral NLR homolog that inhibits the inflammasome. Science (2011) 2.36

Familial cold autoinflammatory syndrome: phenotype and genotype of an autosomal dominant periodic fever. J Allergy Clin Immunol (2001) 2.33

The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation. Biochem J (2003) 2.25

Inflammasomes: current understanding and open questions. Cell Mol Life Sci (2010) 1.87

The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways. J Exp Med (2002) 1.76

NLR proteins: integral members of innate immunity and mediators of inflammatory diseases. J Leukoc Biol (2007) 1.73

The NLRP12 inflammasome recognizes Yersinia pestis. Immunity (2012) 1.70

CARD games in apoptosis and immunity. EMBO Rep (2002) 1.63

Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. Cell (2013) 1.60

Initial description of the human NLRP3 promoter. Genes Immun (2008) 1.52

Expression and regulation of cryopyrin and related proteins in rheumatoid arthritis synovium. Ann Rheum Dis (2004) 1.48

Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy. Br J Haematol (2009) 1.46

Therapy of autoinflammatory syndromes. J Allergy Clin Immunol (2009) 1.45

Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease. Blood (2006) 1.44

A Shope Fibroma virus PYRIN-only protein modulates the host immune response. Virus Genes (2007) 1.41

Unleashing the therapeutic potential of NOD-like receptors. Nat Rev Drug Discov (2009) 1.39

Methylation mediated silencing of TMS1/ASC gene in prostate cancer. Mol Cancer (2006) 1.38

Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria. J Exp Med (2009) 1.36

Structural, expression, and evolutionary analysis of mouse CIAS1. Gene (2004) 1.33

The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment. Blood (2008) 1.27

Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res (2003) 1.26

Expression analysis of the NLRP gene family suggests a role in human preimplantation development. PLoS One (2008) 1.25

Cross-regulation between the IL-1β/IL-18 processing inflammasome and other inflammatory cytokines. Curr Opin Immunol (2011) 1.17

Evolution and functional divergence of NLRP genes in mammalian reproductive systems. BMC Evol Biol (2009) 1.14

Evaluation of Nod-like receptor (NLR) effector domain interactions. PLoS One (2009) 1.08

Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome. Proc Natl Acad Sci U S A (2014) 1.04

Intracellular sensing of microbes and danger signals by the inflammasomes. Immunol Rev (2011) 1.03

Inflammatory cytokine response to Bacillus anthracis peptidoglycan requires phagocytosis and lysosomal trafficking. Infect Immun (2010) 0.99

Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death. J Bone Miner Res (2008) 0.95

Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection. PLoS Pathog (2014) 0.95

Inflammasome-associated nucleotide-binding domain, leucine-rich repeat proteins and inflammatory diseases. J Immunol (2009) 0.93

Unsolved Mysteries in NLR Biology. Front Immunol (2013) 0.92

Structural and functional analysis of the NLRP4 pyrin domain. Biochemistry (2012) 0.92

Immunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activation. Clin Exp Immunol (2012) 0.90

NLRs, inflammasomes, and viral infection. J Leukoc Biol (2012) 0.88

The role of NLRP3 and AIM2 in inflammasome activation during Brucella abortus infection. Semin Immunopathol (2016) 0.86

The PYRIN domain in signal transduction. Curr Protein Pept Sci (2007) 0.85

NOD-Like Receptors in Infection, Immunity, and Diseases. Yonsei Med J (2016) 0.83

CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction. Arthritis Res Ther (2014) 0.81

Virulent Mycobacterium bovis Beijing Strain Activates the NLRP7 Inflammasome in THP-1 Macrophages. PLoS One (2016) 0.78

In vitro analysis of the functional effects of an NLRP3 G809S variant with the co-existence of MEFV haplotype variants in atypical autoinflammatory syndrome. J Clin Immunol (2012) 0.77

TLR4 activation induces IL-1β release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung. Respir Res (2014) 0.77

Busulfan and cyclosphamide induce liver inflammation through NLRP3 activation in mice after hematopoietic stem cell transplantation. Sci Rep (2015) 0.77

High Frequency of Inherited Variants in the MEFV Gene in Acute Lymphocytic Leukemia. Indian J Hematol Blood Transfus (2011) 0.76

Familial Mediterranean fever, inflammation and nephrotic syndrome: fibrillary glomerulopathy and the M680I missense mutation. BMC Nephrol (2003) 0.76

Chronic infantile neurological cutaneous articular syndrome: CD10 over-expression in neutrophils is a possible key to the pathogenesis of the disease. Eur J Pediatr (2003) 0.75

Increased frequency of Mediterranean fever gene variants in multiple myeloma. Oncol Lett (2014) 0.75

Inflammasomes in Myeloid Cells: Warriors Within. Microbiol Spectr (2017) 0.75

Enzymatically Inactive Procaspase 1 stabilizes the ASC Pyroptosome and Supports Pyroptosome Spreading during Cell Division. J Biol Chem (2016) 0.75

NLRP3 mediates NF-κB activation and cytokine induction in microbially induced and sterile inflammation. PLoS One (2015) 0.75

[Genetics of cryopyrin-associated periodic syndrome]. Z Rheumatol (2017) 0.75

Articles by these authors

The mutational landscape of head and neck squamous cell carcinoma. Science (2011) 16.88

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity (2006) 10.58

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat Immunol (2006) 10.55

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 9.77

NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell (2011) 9.75

Suppression of inflammation by a synthetic histone mimic. Nature (2010) 8.80

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science (2003) 7.49

Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol (2004) 7.22

Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med (2013) 5.29

Substrate-specific activation of sirtuins by resveratrol. J Biol Chem (2005) 5.28

Randomized trial of oral teriflunomide for relapsing multiple sclerosis. N Engl J Med (2011) 4.93

DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science (2002) 4.88

The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev (2004) 4.84

The NLR gene family: a standard nomenclature. Immunity (2008) 4.77

The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell (2009) 4.47

The developmental dynamics of the maize leaf transcriptome. Nat Genet (2010) 4.02

Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J Exp Med (2006) 3.76

TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature (2002) 3.55

A requirement for CARMA1 in TCR-induced NF-kappa B activation. Nat Immunol (2002) 3.38

Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol (2006) 3.37

A first-generation multiplex biomarker analysis of urine for the early detection of prostate cancer. Cancer Res (2008) 3.35

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. J Biol Chem (2002) 3.28

Reference genome sequence of the model plant Setaria. Nat Biotechnol (2012) 3.21

Priming in systemic plant immunity. Science (2009) 3.11

Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues. J Exp Med (2005) 3.02

Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis. Clin Cancer Res (2004) 2.96

Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease. Blood (2009) 2.91

The relationship of eosinophilia to intravenous immunoglobulin treatment failure in Kawasaki disease. Pediatr Allergy Immunol (2007) 2.81

Genetic and histopathologic evaluation of BRCA1 and BRCA2 DNA sequence variants of unknown clinical significance. Cancer Res (2006) 2.79

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem (2005) 2.77

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses. Nat Biotechnol (2009) 2.76

Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. FEBS Lett (2002) 2.66

Triple versus dual antiplatelet therapy in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Circulation (2009) 2.62

Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2. J Neurosci (2003) 2.58

Significant pulmonary toxicity associated with interferon and ribavirin therapy for hepatitis C. Am J Gastroenterol (2002) 2.55

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system. Proc Natl Acad Sci U S A (2007) 2.46

Inferring reputation promotes the evolution of cooperation in spatial social dilemma games. PLoS One (2012) 2.41

Potential markers that complement expression of CA125 in epithelial ovarian cancer. Gynecol Oncol (2005) 2.34

Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster. Proc Natl Acad Sci U S A (2002) 2.33

KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain. J Neurosci (2004) 2.31

First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy. Cancer Discov (2012) 2.31

Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers. Cancer Discov (2013) 2.29

The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Proc Natl Acad Sci U S A (2002) 2.24

Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem (2013) 2.24

Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes. J Immunol (2006) 2.21

Tunneling and coupled motion in the Escherichia coli dihydrofolate reductase catalysis. J Am Chem Soc (2004) 2.21

Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma. Am J Gastroenterol (2010) 2.20

The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell (2011) 2.18

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat Genet (2012) 2.17

Re-emerging superconductivity at 48 kelvin in iron chalcogenides. Nature (2012) 2.13

Low-molecular-weight heparin versus unfractionated heparin in acute ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention with drug-eluting stents. Am Heart J (2010) 2.09

Enzyme millisecond conformational dynamics do not catalyze the chemical step. Proc Natl Acad Sci U S A (2009) 2.08

Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways. Aging Cell (2006) 2.06

Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II. Gastroenterology (2003) 2.01

Effects of estrogen depletion on angiogenesis in estrogen-receptor-positive breast carcinoma--an immunohistochemical study of vasohibin-1 and CD31 with correlation to pathobiological response of the patients in neoadjuvant aromatase inhibitor therapy. Expert Opin Ther Targets (2012) 2.00

Nucleation and growth of nanoparticles in the atmosphere. Chem Rev (2011) 1.99

A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J Immunol (2011) 1.98

Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions. Proc Natl Acad Sci U S A (2011) 1.94

NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury. J Biol Chem (2009) 1.91

Targeting Stat3 abrogates EGFR inhibitor resistance in cancer. Clin Cancer Res (2012) 1.89

Functional characterization of Narc 1, a novel proteinase related to proteinase K. Arch Biochem Biophys (2003) 1.88

Hepatic resection as a safe and effective treatment for hepatocellular carcinoma involving a single large tumor, multiple tumors, or macrovascular invasion. Medicine (Baltimore) (2015) 1.88

Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats. Gastroenterology (2011) 1.85

AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function. J Clin Invest (2013) 1.84

Prospective study of tailoring whole-body dual-modality [18F]fluorodeoxyglucose positron emission tomography/computed tomography with plasma Epstein-Barr virus DNA for detecting distant metastasis in endemic nasopharyngeal carcinoma at initial staging. J Clin Oncol (2013) 1.81

Bionanotechnology based on silica nanoparticles. Med Res Rev (2004) 1.81

Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes. Dev Cell (2012) 1.76

Solid-state packing of conjugated oligomers: from pi-stacks to the herringbone structure. J Am Chem Soc (2004) 1.75

Transcriptional profiling of bone regeneration. Insight into the molecular complexity of wound repair. J Biol Chem (2002) 1.73

Setaria viridis: a model for C4 photosynthesis. Plant Cell (2010) 1.72

The NLRP12 inflammasome recognizes Yersinia pestis. Immunity (2012) 1.70

Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI). J Biol Chem (2005) 1.68

MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3. J Leukoc Biol (2007) 1.67

Formation of nanoparticles of blue haze enhanced by anthropogenic pollution. Proc Natl Acad Sci U S A (2009) 1.67

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. J Biol Chem (2002) 1.66

Decompressive hemicraniectomy in malignant middle cerebral artery infarct: a randomized controlled trial enrolling patients up to 80 years old. Neurocrit Care (2012) 1.65

DelPhi: a comprehensive suite for DelPhi software and associated resources. BMC Biophys (2012) 1.64

Interferon-gamma induces major histocompatibility class II transactivator (CIITA), which mediates collagen repression and major histocompatibility class II activation by human aortic smooth muscle cells. Circ Res (2006) 1.64

Correlation of pandemic (H1N1) 2009 viral load with disease severity and prolonged viral shedding in children. Emerg Infect Dis (2010) 1.64

Risk of MDM2 SNP309 alone or in combination with the p53 codon 72 polymorphism in acute myeloid leukemia. Leuk Res (2009) 1.64

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature (2012) 1.63