Published in J Immunol on February 01, 2002
Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock. Clin Microbiol Rev (2003) 3.70
A comprehensive map of the toll-like receptor signaling network. Mol Syst Biol (2006) 2.89
Genome-wide identification of Chlamydia trachomatis antigens associated with trachomatous trichiasis. Invest Ophthalmol Vis Sci (2012) 2.13
Bacterial virulence in the moonlight: multitasking bacterial moonlighting proteins are virulence determinants in infectious disease. Infect Immun (2011) 1.99
The chlamydial plasmid-encoded protein pgp3 is secreted into the cytosol of Chlamydia-infected cells. Infect Immun (2008) 1.97
Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis. J Immunol (2009) 1.83
Innate immune pattern recognition: a cell biological perspective. Annu Rev Immunol (2015) 1.66
Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection. J Immunol (2010) 1.61
The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection. PLoS Pathog (2009) 1.58
Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages. J Immunol (2008) 1.49
Killing me softly: chlamydial use of proteolysis for evading host defenses. Trends Microbiol (2009) 1.47
No longer an innocent bystander: epithelial toll-like receptor signaling in the development of mucosal inflammation. Mol Med (2008) 1.46
Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome. J Immunol (2010) 1.42
Porphyromonas gingivalis lipopolysaccharide antagonizes Escherichia coli lipopolysaccharide at toll-like receptor 4 in human endothelial cells. Infect Immun (2003) 1.34
The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF. J Immunol (2012) 1.31
Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4. J Biol Chem (2011) 1.27
The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor. J Immunol (2009) 1.25
Manifold mechanisms of Toll-like receptor-ligand recognition. J Clin Immunol (2005) 1.22
The role of sex hormones in immune protection of the female reproductive tract. Nat Rev Immunol (2015) 1.21
Chlamydial intracellular survival strategies. Cold Spring Harb Perspect Med (2013) 1.20
Critical role for interleukin-1beta (IL-1beta) during Chlamydia muridarum genital infection and bacterial replication-independent secretion of IL-1beta in mouse macrophages. Infect Immun (2009) 1.19
Metabolic syndrome: the danger signal in atherosclerosis. Vasc Health Risk Manag (2006) 1.13
Chlamydia trachomatis antigens recognized in women with tubal factor infertility, normal fertility, and acute infection. Obstet Gynecol (2012) 1.10
Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P. Am J Obstet Gynecol (2010) 1.09
CD14 and toll-like receptor 4: a link between infection and acute coronary events? Heart (2004) 1.08
The atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions? Cell Stress Chaperones (2009) 1.08
NADPH oxidases: an overview from structure to innate immunity-associated pathologies. Cell Mol Immunol (2014) 1.08
The expression and functions of toll-like receptors in atherosclerosis. Mediators Inflamm (2010) 1.07
Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5. J Rheumatol (2010) 1.05
Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation. J Immunol (2008) 1.02
TLR4-mediated activation of dendritic cells by the heat shock protein DnaK from Francisella tularensis. J Leukoc Biol (2008) 1.01
Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases. Pharmacol Ther (2013) 1.00
Nuclear receptor signaling inhibits HIV-1 replication in macrophages through multiple trans-repression mechanisms. J Virol (2011) 0.97
Role of infection in the development and exacerbation of asthma. Expert Rev Respir Med (2010) 0.95
MicroRNAs and toll-like receptor/interleukin-1 receptor signaling. J Hematol Oncol (2012) 0.95
Toll-like receptor polymorphisms, inflammatory and infectious diseases, allergies, and cancer. J Interferon Cytokine Res (2013) 0.93
Host-Cell Survival and Death During Chlamydia Infection. Curr Immunol Rev (2007) 0.93
Chlamydia trachomatis heat shock protein-60 induced interferon-gamma and interleukin-10 production in infertile women. Clin Exp Immunol (2003) 0.92
Comparative cell signalling activity of ultrapure recombinant chaperonin 60 proteins from prokaryotes and eukaryotes. Immunology (2005) 0.91
GroEL and lipopolysaccharide from Francisella tularensis live vaccine strain synergistically activate human macrophages. Infect Immun (2010) 0.90
Involvement of TLR2 and TLR4 in cell responses to Rickettsia akari. J Leukoc Biol (2010) 0.90
Heat shock proteins form part of a danger signal cascade in response to lipopolysaccharide and GroEL. Clin Exp Immunol (2006) 0.90
Chlamydial heat shock protein 60 induces acute pulmonary inflammation in mice via the Toll-like receptor 4- and MyD88-dependent pathway. Infect Immun (2009) 0.89
Maternal TLR4 and NOD2 gene variants, pro-inflammatory phenotype and susceptibility to early-onset preeclampsia and HELLP syndrome. PLoS One (2008) 0.88
Chlamydia pneumoniae GroEL1 protein is cell surface associated and required for infection of HEp-2 cells. J Bacteriol (2008) 0.88
Chlamydophila pneumoniae induces expression of toll-like receptor 4 and release of TNF-alpha and MIP-2 via an NF-kappaB pathway in rat type II pneumocytes. Respir Res (2005) 0.87
E3 ubiquitin ligases Pellinos as regulators of pattern recognition receptor signaling and immune responses. Immunol Rev (2015) 0.87
Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells. PLoS One (2012) 0.86
Toll-like receptors in atherosclerosis. Int J Mol Sci (2013) 0.86
Endocytosis of Mycobacterium tuberculosis heat shock protein 60 is required to induce interleukin-10 production in macrophages. J Biol Chem (2013) 0.86
Heat shock protein 60 is the major antigen which stimulates delayed-type hypersensitivity reaction in the macaque model of Chlamydia trachomatis salpingitis. Infect Immun (2004) 0.86
Type III secretion needle proteins induce cell signaling and cytokine secretion via Toll-like receptors. Infect Immun (2014) 0.85
Opposing roles for heat and heat shock proteins in macrophage functions during inflammation: a function of cell activation state? Front Immunol (2012) 0.85
Induction and function of IFNβ during viral and bacterial infection. Crit Rev Immunol (2011) 0.85
Molecular chaperones and heat shock proteins in atherosclerosis. Am J Physiol Heart Circ Physiol (2011) 0.84
Toll-like receptor 2-dependent activity of native major outer membrane protein proteosomes of Chlamydia trachomatis. Infect Immun (2012) 0.83
Combinatorial interference of toll-like receptor 2 and 4 synergistically stabilizes atherosclerotic plaque in apolipoprotein E-knockout mice. J Cell Mol Med (2011) 0.82
Mucosal immunity in the female genital tract, HIV/AIDS. Biomed Res Int (2014) 0.81
The Toll-like receptor 4 polymorphism Asp299Gly but not Thr399Ile influences TLR4 signaling and function. PLoS One (2014) 0.81
Toll-like receptor 4 implicated in acute lung injury induced by paraquat poisoning in mice. Int J Clin Exp Med (2014) 0.81
CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infection. J Immunol (2013) 0.81
Chlamydial Hsp60-2 is iron responsive in Chlamydia trachomatis serovar E-infected human endometrial epithelial cells in vitro. Infect Immun (2007) 0.80
Bacterial and host factors involved in the major histocompatibility complex class Ib-restricted presentation of Salmonella Hsp 60: novel pathway. Infect Immun (2004) 0.80
Balancing the immune system: Th1 and Th2. Ann Rheum Dis (2002) 0.80
Critical role of TLR4 in human metapneumovirus mediated innate immune responses and disease pathogenesis. PLoS One (2013) 0.79
Role of MyD88 and Toll-like receptors 2 and 4 in the sensing of Parachlamydia acanthamoebae. Infect Immun (2010) 0.79
Toll-like receptor signaling in primary immune deficiencies. Ann N Y Acad Sci (2015) 0.79
In vivo molecular imaging of vascular stress. Cell Stress Chaperones (2008) 0.78
Identification and characterization of Chlamydia pneumoniae-specific proteins that activate tumor necrosis factor alpha production in RAW 264.7 murine macrophages. Infect Immun (2008) 0.78
Interferons and interferon regulatory factors in malaria. Mediators Inflamm (2014) 0.77
Understanding the expression of Toll-like receptors in Asian Indians predisposed to coronary artery disease. Arch Med Sci (2011) 0.77
Therapeutic Developments Targeting Toll-like Receptor-4-Mediated Neuroinflammation. ChemMedChem (2015) 0.77
The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis. Int J Inflam (2016) 0.76
Outcome of urogenital infection with Chlamydia muridarum in CD14 gene knockout mice. BMC Infect Dis (2006) 0.75
Chlamydial Lipoproteins Stimulate Toll-Like Receptors 1/2 Mediated Inflammatory Responses through MyD88-Dependent Pathway. Front Microbiol (2017) 0.75
IRE1α mediates PKR activation in response to Chlamydia trachomatis infection. Microbes Infect (2016) 0.75
Eotaxin-2 increased toll-like receptor 4 expression in endothelial cells in vitro and exacerbates high-cholesterol diet-induced atherogenesis in vivo. Am J Transl Res (2016) 0.75
Toll-like receptor 4 gene is associated with recurrent spontaneous miscarriage in Uygur and Han women in Xinjiang. Exp Ther Med (2016) 0.75
Chlamydia trachomatis: The persistent pathogen. Clin Vaccine Immunol (2017) 0.75
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A (2004) 5.58
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity (2012) 5.08
Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am J Physiol Gastrointest Liver Physiol (2005) 4.28
TLR signaling in the gut in health and disease. J Immunol (2005) 3.51
Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut. J Immunol (2003) 2.96
The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis. J Immunol (2006) 2.83
Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine. Gastroenterology (2006) 2.78
HMGB1 mediates endogenous TLR2 activation and brain tumor regression. PLoS Med (2009) 2.56
TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells. J Biol Chem (2002) 2.37
A predominant role for antibody in acquired immunity to chlamydial genital tract reinfection. J Immunol (2005) 2.26
The tools to understand: community as co-researcher on culture-specific protective factors for Alaska Natives. J Prev Interv Community (2006) 2.18
Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid. J Clin Invest (2005) 2.07
TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. Gastroenterology (2008) 2.06
Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells. J Immunol (2004) 2.05
Risk, resilience, and natural recovery: a model of recovery from alcohol abuse for Alaska Natives. Addiction (2007) 2.03
Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling. J Immunol (2006) 1.88
Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection. J Infect Dis (2011) 1.86
Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections. J Exp Med (2003) 1.83
"Tied together like a woven hat:" Protective pathways to Alaska native sobriety. Harm Reduct J (2004) 1.79
Staphylococcus aureus Panton-Valentine leukocidin contributes to inflammation and muscle tissue injury. PLoS One (2009) 1.74
Interleukin-1β is crucial for the induction of coronary artery inflammation in a mouse model of Kawasaki disease. Circulation (2012) 1.70
TLR signaling: an emerging bridge from innate immunity to atherogenesis. J Immunol (2004) 1.62
The natural history of untreated Chlamydia trachomatis infection in the interval between screening and returning for treatment. Sex Transm Dis (2008) 1.60
The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection. PLoS Pathog (2009) 1.58
The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells. J Immunol (2007) 1.56
CsgA is a pathogen-associated molecular pattern of Salmonella enterica serotype Typhimurium that is recognized by Toll-like receptor 2. Mol Microbiol (2005) 1.51
Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease. J Immunol (2005) 1.49
Effects of recombinant human IGF-I and oral contraceptive administration on bone density in anorexia nervosa. J Clin Endocrinol Metab (2002) 1.48
MyD88 is pivotal for the early inflammatory response and subsequent bacterial clearance and survival in a mouse model of Chlamydia pneumoniae pneumonia. J Biol Chem (2005) 1.47
TLR signaling at the intestinal epithelial interface. J Endotoxin Res (2003) 1.47
Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling. J Biol Chem (2004) 1.46
IL-17A is proatherogenic in high-fat diet-induced and Chlamydia pneumoniae infection-accelerated atherosclerosis in mice. J Immunol (2010) 1.36
Mycobacterium tuberculosis heat shock proteins use diverse Toll-like receptor pathways to activate pro-inflammatory signals. J Biol Chem (2005) 1.34
Vaccination against Chlamydia genital infection utilizing the murine C. muridarum model. Infect Immun (2010) 1.33
Innate immunity and toll-like receptors: clinical implications of basic science research. J Pediatr (2004) 1.28
Dysphagia in the elderly: preliminary evidence of prevalence, risk factors, and socioemotional effects. Ann Otol Rhinol Laryngol (2007) 1.27
Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. PLoS One (2010) 1.26
Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection. PLoS One (2011) 1.25
Cross-reactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis. Arterioscler Thromb Vasc Biol (2003) 1.22
TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis. J Immunol (2008) 1.22
ERCC5 is a novel biomarker of ovarian cancer prognosis. J Clin Oncol (2008) 1.15
Bladder reconstitution with bone marrow derived stem cells seeded on small intestinal submucosa improves morphological and molecular composition. J Urol (2005) 1.15
Mastoparan, a G protein agonist peptide, differentially modulates TLR4- and TLR2-mediated signaling in human endothelial cells and murine macrophages. J Immunol (2005) 1.14
TLR2 and MyD88 contribute to Lactobacillus casei extract-induced focal coronary arteritis in a mouse model of Kawasaki disease. Circulation (2005) 1.14
Vitamin D and the regulation of placental inflammation. J Immunol (2011) 1.13
Toll-like receptors and innate immunity in gut homeostasis and pathology. Curr Opin Hematol (2007) 1.10
CD4+ T cells and antibody are required for optimal major outer membrane protein vaccine-induced immunity to Chlamydia muridarum genital infection. Infect Immun (2010) 1.08
Epidemiology of voice disorders in the elderly: preliminary findings. Laryngoscope (2007) 1.08
Activated myeloid dendritic cells accumulate and co-localize with CD3+ T cells in coronary artery lesions in patients with Kawasaki disease. Exp Mol Pathol (2007) 1.08
Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis. PLoS One (2011) 1.08
Involvement of innate and adaptive immunity in a murine model of coronary arteritis mimicking Kawasaki disease. J Immunol (2009) 1.07
Chlamydia heat shock protein 60 induces trophoblast apoptosis through TLR4. J Immunol (2006) 1.06
Phagosomal degradation increases TLR access to bacterial ligands and enhances macrophage sensitivity to bacteria. J Immunol (2011) 1.05
Urine proteomics for discovery of improved diagnostic markers of Kawasaki disease. EMBO Mol Med (2012) 1.05
Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation. J Immunol (2008) 1.02
TB, or not TB: that is the question -- does TLR signaling hold the answer? J Clin Invest (2004) 1.01
Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis. PLoS One (2010) 1.00
Macrophages mediate cardioprotective cellular postconditioning in acute myocardial infarction. J Clin Invest (2015) 1.00
Emerging role of IL-17 in atherosclerosis. J Innate Immun (2010) 0.99
Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells. Eur J Immunol (2008) 0.99
Role of Toll-like receptors in atherosclerosis. Circ Res (2004) 0.98
Murine Chlamydia trachomatis genital infection is unaltered by depletion of CD4+ T cells and diminished adaptive immunity. J Infect Dis (2011) 0.96
Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitization. J Allergy Clin Immunol (2008) 0.96
The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury. Am J Respir Cell Mol Biol (2014) 0.95
The induction of Toll-like receptor tolerance enhances rather than suppresses HIV-1 gene expression in transgenic mice. J Leukoc Biol (2003) 0.95
Immunoglobulin-specific responses to Chlamydia elementary bodies in individuals with and at risk for genital chlamydial infection. J Infect Dis (2012) 0.94
The protective effect of antibody in immunity to murine chlamydial genital tract reinfection is independent of immunoglobulin A. Infect Immun (2005) 0.94
Differential expression of Toll-like receptor 2 (TLR2) and responses to TLR2 ligands between human and murine vascular endothelial cells. J Endotoxin Res (2007) 0.94
Absence of lymphogranuloma venereum strains among rectal Chlamydia trachomatis outer membrane protein A genotypes infecting women and men who have sex with men in Birmingham, Alabama. Sex Transm Dis (2008) 0.92
TLR signaling and trapped vascular dendritic cells in the development of atherosclerosis. Trends Immunol (2006) 0.91
The role of innate immunity in the pathogenesis of asthma: evidence for the involvement of Toll-like receptor signaling. J Endotoxin Res (2007) 0.91
Dietary vitamin D restriction in pregnant female mice is associated with maternal hypertension and altered placental and fetal development. Endocrinology (2013) 0.90
Insights into TL1A and IBD pathogenesis. Adv Exp Med Biol (2011) 0.90
Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis. Am J Pathol (2011) 0.90
Ambivalence toward the body: death, neuroticism, and the flight from physical sensation. Pers Soc Psychol Bull (2006) 0.89
Innate immune responses to Chlamydia pneumoniae infection: role of TLRs, NLRs, and the inflammasome. Microbes Infect (2012) 0.89