Published in Gene on January 09, 2002
Muscle giants: molecular scaffolds in sarcomerogenesis. Physiol Rev (2009) 1.92
Isoform diversity of giant proteins in relation to passive and active contractile properties of rabbit skeletal muscles. J Gen Physiol (2005) 1.91
Obscurin is a ligand for small ankyrin 1 in skeletal muscle. Mol Biol Cell (2003) 1.80
Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles. J Cell Biol (2003) 1.72
Cytoskeletal protein kinases: titin and its relations in mechanosensing. Pflugers Arch (2011) 1.46
Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly. Mol Biol Cell (2009) 1.23
Titin: physiological function and role in cardiomyopathy and failure. Heart Fail Rev (2005) 1.22
Different obscurin isoforms localize to distinct sites at sarcomeres. FEBS Lett (2007) 1.20
Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin. Genomics (2007) 1.19
A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans. Mol Biol Cell (2008) 1.14
Essential role of obscurin in cardiac myofibrillogenesis and hypertrophic response: evidence from small interfering RNA-mediated gene silencing. Histochem Cell Biol (2005) 1.14
Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases. Dev Genes Evol (2004) 1.09
Early de novo DNA methylation and prolonged demethylation in the muscle lineage. Epigenetics (2013) 1.00
The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle. Mol Biol Cell (2009) 0.99
Early incorporation of obscurin into nascent sarcomeres: implication for myofibril assembly during cardiac myogenesis. Histochem Cell Biol (2008) 0.95
Loss of giant obscurins promotes breast epithelial cell survival through apoptotic resistance. FASEB J (2012) 0.94
A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain. Biochem J (2002) 0.94
Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity. J Cell Biol (2013) 0.94
The function of the M-line protein obscurin in controlling the symmetry of the sarcomere in the flight muscle of Drosophila. J Cell Sci (2012) 0.94
Targeted deletion of the zebrafish obscurin A RhoGEF domain affects heart, skeletal muscle and brain development. Dev Biol (2009) 0.93
The kinase domains of obscurin interact with intercellular adhesion proteins. FASEB J (2013) 0.92
Localization of ank1.5 in the sarcoplasmic reticulum precedes that of SERCA and RyR: relationship with the organization of obscurin in developing sarcomeres. Histochem Cell Biol (2008) 0.92
Obscurins: Goliaths and Davids take over non-muscle tissues. PLoS One (2014) 0.91
Developmental expression and differential cellular localization of obscurin and obscurin-associated kinase in cardiac muscle cells. J Cell Biochem (2008) 0.90
Obscurins: unassuming giants enter the spotlight. IUBMB Life (2013) 0.89
Electrostatic interactions mediate binding of obscurin to small ankyrin 1: biochemical and molecular modeling studies. J Mol Biol (2011) 0.86
Obscurin depletion impairs organization of skeletal muscle in developing zebrafish embryos. J Biomed Biotechnol (2011) 0.83
Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis. Oncogene (2014) 0.82
Exercise-induced alterations and loss of sarcomeric M-line organization in the diaphragm muscle of obscurin knockout mice. Am J Physiol Cell Physiol (2016) 0.78
Loss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cells. Oncotarget (2014) 0.78
Binding partners of the kinase domains in Drosophila obscurin and their effect on the structure of the flight muscle. J Cell Sci (2015) 0.77
Obscurin variants and inherited cardiomyopathies. Biophys Rev (2017) 0.77
Titin and obscurin: giants holding hands and discovery of a new Ig domain subset. J Mol Biol (2014) 0.76
Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness. Oncotarget (2016) 0.76
Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit. Oncotarget (2016) 0.75
Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin. Genomics (2007) 1.19
Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases. Dev Genes Evol (2004) 1.09
Rapid response of cardiac obscurin gene cluster to aortic stenosis: differential activation of Rho-GEF and MLCK and involvement in hypertrophic growth. Biochem Biophys Res Commun (2003) 1.08
Developmental expression and differential cellular localization of obscurin and obscurin-associated kinase in cardiac muscle cells. J Cell Biochem (2008) 0.90