Published in Eur J Pharmacol on January 25, 2002
Sinoatrial node dysfunction induces cardiac arrhythmias in diabetic mice. Cardiovasc Diabetol (2014) 0.81
Pleiotropic effects of thyroid hormones: learning from hypothyroidism. J Thyroid Res (2011) 0.80
Drug-induced and postnatal hypothyroidism impairs the accumulation of diacylglycerol in liver and liver cell plasma membranes. BMC Physiol (2002) 0.77
Protection of the abnormal heart. Heart Fail Rev (2007) 0.77
The effect of streptozotocin-induced diabetes on the EDHF-type relaxation and cardiac function in rats. J Adv Res (2012) 0.75
Streptozotocin-induced diabetes disrupts the body temperature daily rhythm in rats. Diabetol Metab Syndr (2015) 0.75
EC4 European Syllabus for Post-Graduate Training in Clinical Chemistry and Laboratory Medicine: version 3 - 2005. Clin Chem Lab Med (2006) 2.14
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells. Cell Signal (2010) 1.73
The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells. J Biol Chem (2010) 1.42
FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells. J Biol Chem (2011) 1.37
Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules. Cancer Res (2011) 1.28
Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells. Mol Cell Biol (2010) 1.28
Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells. J Biol Chem (2002) 1.28
(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. Cell Signal (2011) 1.22
Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension. Br J Pharmacol (2002) 1.20
Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1-phosphate receptor-1. FASEB J (2005) 1.20
Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1. J Biol Chem (2008) 1.19
The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction. Semin Cell Dev Biol (2004) 1.13
Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. Cell Signal (2008) 1.12
Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools. Biochem J (2005) 1.11
Translational aspects of sphingosine 1-phosphate biology. Trends Mol Med (2011) 1.11
c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells. Cell Signal (2005) 1.10
(S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity. Cell Signal (2010) 1.07
Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors. Biochim Biophys Acta (2002) 1.06
Ryanodine receptors of pancreatic beta-cells mediate a distinct context-dependent signal for insulin secretion. FASEB J (2002) 1.05
Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase. PLoS One (2011) 1.05
Targeting sphingosine-1-phosphate signalling for cardioprotection. Curr Opin Pharmacol (2008) 1.04
The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells. Prostaglandins Other Lipid Mediat (2006) 1.03
Reactive oxygen species and endothelial function in diabetes. Eur J Pharmacol (2010) 1.02
The practice of clinical chemistry in the European Union. Clin Chem Lab Med (2002) 1.00
Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells. J Biol Chem (2010) 0.99
Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function. Biochem J (2008) 0.99
Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells. Stem Cells Dev (2009) 0.98
Cyclic AMP signaling in pancreatic islets. Adv Exp Med Biol (2010) 0.98
Ectopic expression of bovine type 5 phosphodiesterase confers a renal phenotype in Drosophila. J Biol Chem (2003) 0.96
Synthesis of selective inhibitors of sphingosine kinase 1. Chem Commun (Camb) (2013) 0.93
Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells. Biochem J (2006) 0.92
Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers. Front Oncol (2012) 0.92
The effect of RGS12 on PDGFbeta receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells. Cell Signal (2005) 0.90
Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b. Int J Biochem Cell Biol (2012) 0.90
Delayed cardioprotective effects of exercise in dogs are aminoguanidine sensitive: possible involvement of nitric oxide. Clin Sci (Lond) (2002) 0.89
Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival. Br J Pharmacol (2012) 0.89
The role of mitochondrial K(ATP) channels in antiarrhythmic effects of ischaemic preconditioning in dogs. Br J Pharmacol (2002) 0.89
The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division. Cell Signal (2009) 0.88
Sildenafil (Viagra) reduces arrhythmia severity during ischaemia 24 h after oral administration in dogs. Br J Pharmacol (2004) 0.88
Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration. Biochem J (2006) 0.87
The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells. Cell Signal (2013) 0.87
The functional PDGFbeta receptor-S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor. Prostaglandins Other Lipid Mediat (2006) 0.86
The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism. Br J Pharmacol (2013) 0.86
The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia. Br J Pharmacol (2009) 0.83
Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators. Bioorg Med Chem (2013) 0.82
Nitric oxide involvement in the delayed antiarrhythmic effect of treadmill exercise in dogs. Life Sci (2005) 0.82
Protean agonism of the lysophosphatidic acid receptor-1 with Ki16425 reduces nerve growth factor-induced neurite outgrowth in pheochromocytoma 12 cells. J Neurochem (2006) 0.81
New perspectives on the role of sphingosine 1-phosphate in cancer. Handb Exp Pharmacol (2013) 0.81
Noradrenaline, infused locally, reduces arrhythmia severity during coronary artery occlusion in anaesthetised dogs. Cardiovasc Res (2002) 0.80
An assessment of the role of the inhibitory gamma subunit of the retinal cyclic GMP phosphodiesterase and its effect on the p42/p44 mitogen-activated protein kinase pathway in animal and cellular models of pulmonary hypertension. Br J Pharmacol (2003) 0.80
Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1). Eur J Biochem (2003) 0.80
N-2-mercaptopropionylglycine, a scavanger of reactive oxygen species, does not modify the early antiarrhythmic effect of ischaemic preconditioning in anaesthetised dogs. Cardiovasc Drugs Ther (2004) 0.80
Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors. J Med Chem (2013) 0.79
Delayed exercise-induced protection against arrhythmias in dogs--effect of celecoxib. Eur J Pharmacol (2004) 0.79
Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease. Arch Toxicol (2014) 0.77
Comparison of urethane/chloralose and pentobarbitone anaesthesia for examining effects of bacterial lipopolysaccharide in mice. Fundam Clin Pharmacol (2006) 0.77
Lack of effect of proteinase-activated receptor-2 (PAR-2) deletion on the pathophysiological changes produced by lipopolysaccharide in the mouse: comparison with dexamethasone. J Pharm Pharmacol (2004) 0.77
Benzylguanidines and other galegine analogues inducing weight loss in mice. J Med Chem (2009) 0.76
Clinical Chemistry and Laboratory Medicine: an appreciation. Clin Chem Lab Med (2013) 0.76
A common mechanism in the protective effects of preconditioning, cardiac pacing and physical exercise against ischemia and reperfusion-induced arrhythmias. Exp Clin Cardiol (2005) 0.75
The antiarrhythmic effects of ischaemic preconditioning in anaesthetized dogs are prevented by atropine; role of changes in baroreceptor reflex sensitivity. Br J Pharmacol (2002) 0.75
The p.Arg86Gln change in GARP2 (glutamic acid-rich protein-2) is a common West African-related polymorphism. Gene (2012) 0.75
Report of the 11th EASD Islet Group meeting. Glasgow, UK, 13-15 September 2001. Diabetologia (2002) 0.75
The life and work of Dr. Robert Bittman (1942-2014). Biol Chem (2015) 0.75
Harmonisation of specialist training and continuing professional development in laboratory medicine: a long but necessary journey. Clin Chem Lab Med (2015) 0.75
Effects of delayed preconditioning on myocardial regional contractility during repeated episodes of low-flow ischaemia in anaesthetized dogs: possible role of nitric oxide. Clin Sci (Lond) (2004) 0.75
The new General Medical Services contract: opportunity or threat? Ann Clin Biochem (2005) 0.75
Cellular Signalling - Special issue to celebrate 75th birthday of Prof. Robert J. Lefkowitz. Cell Signal (2017) 0.75