Published in Mol Cell Biol on April 01, 2002
A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell (2006) 6.96
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci U S A (2011) 5.53
Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev (2002) 4.30
The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc Natl Acad Sci U S A (2005) 3.72
High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature (2013) 3.32
Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proc Natl Acad Sci U S A (2009) 2.84
Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci U S A (2002) 2.82
Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer (2010) 2.68
Cyclin B2 and p53 control proper timing of centrosome separation. Nat Cell Biol (2014) 2.62
Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator. J Clin Invest (2011) 2.37
Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. Proc Natl Acad Sci U S A (2007) 2.34
Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation. Proc Natl Acad Sci U S A (2003) 2.25
Negative regulation of CHK2 activity by protein phosphatase 2A is modulated by DNA damage. Cell Cycle (2010) 2.12
The tumor suppressor PP2A Abeta regulates the RalA GTPase. Cell (2007) 2.10
Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol (2008) 2.04
Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation. Mol Cell Biol (2006) 2.00
Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. Proc Natl Acad Sci U S A (2008) 1.97
INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence. EMBO J (2002) 1.96
Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity. EMBO J (2009) 1.94
TGF-beta signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells. Proc Natl Acad Sci U S A (2011) 1.94
Stathmin 1, a marker of PI3K pathway activation and regulator of microtubule dynamics, is expressed in early pelvic serous carcinomas. Gynecol Oncol (2011) 1.87
Transformation of human and murine fibroblasts without viral oncoproteins. Mol Cell Biol (2005) 1.81
MicroRNA-374a activates Wnt/β-catenin signaling to promote breast cancer metastasis. J Clin Invest (2013) 1.76
Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12. Cell Cycle (2010) 1.63
Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens. Semin Cancer Biol (2009) 1.63
Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci. Mol Cell Biol (2007) 1.62
A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation. Genes Dev (2006) 1.58
miR-182 as a prognostic marker for glioma progression and patient survival. Am J Pathol (2010) 1.56
Regulation of G1 Cell Cycle Progression: Distinguishing the Restriction Point from a Nutrient-Sensing Cell Growth Checkpoint(s). Genes Cancer (2010) 1.53
The minimum replication origin of merkel cell polyomavirus has a unique large T-antigen loading architecture and requires small T-antigen expression for optimal replication. J Virol (2009) 1.52
EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice. PLoS Genet (2012) 1.47
Identification of PP2A complexes and pathways involved in cell transformation. Cancer Res (2010) 1.47
AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy. Oncogene (2011) 1.45
HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses. Cell Death Dis (2013) 1.37
Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus. Proc Natl Acad Sci U S A (2003) 1.35
Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts. Mol Cell Biol (2003) 1.32
Structural basis of PP2A inhibition by small t antigen. PLoS Biol (2007) 1.32
Myc degradation: dancing with ubiquitin ligases. Proc Natl Acad Sci U S A (2004) 1.31
Normal human fibroblasts are resistant to RAS-induced senescence. Mol Cell Biol (2004) 1.30
The Hsp90 cochaperone p23 is essential for perinatal survival. Mol Cell Biol (2006) 1.28
Lamin B1 fluctuations have differential effects on cellular proliferation and senescence. J Cell Biol (2013) 1.28
Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7. Cell Host Microbe (2013) 1.27
Merkel cell polyomavirus: a newly discovered human virus with oncogenic potential. Virology (2013) 1.27
Mammary epithelial cell transformation: insights from cell culture and mouse models. Breast Cancer Res (2005) 1.26
Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner. Proc Natl Acad Sci U S A (2007) 1.20
Simian virus 40 small T antigen activates AMPK and triggers autophagy to protect cancer cells from nutrient deprivation. J Virol (2009) 1.20
Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation. J Virol (2004) 1.19
Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation. Genes Dev (2013) 1.18
Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. Proc Natl Acad Sci U S A (2012) 1.18
Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression. Cancer Res (2012) 1.17
Molecular requirements for transformation of fallopian tube epithelial cells into serous carcinoma. Neoplasia (2011) 1.17
Akt1 deletion prevents lung tumorigenesis by mutant K-ras. Oncogene (2011) 1.17
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms. Mol Cell Biol (2007) 1.16
Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest. Genome Biol (2008) 1.15
Simian virus 40 small tumor antigen activates AKT and telomerase and induces anchorage-independent growth of human epithelial cells. J Virol (2002) 1.15
MCV and Merkel cell carcinoma: a molecular success story. Curr Opin Virol (2012) 1.14
A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins. Cancer Metastasis Rev (2008) 1.14
Merkel cell polyomavirus large T antigen has growth-promoting and inhibitory activities. J Virol (2013) 1.14
Insights from mouse models into human retinoblastoma. Cell Div (2008) 1.13
Simian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor. Mol Cell Biol (2005) 1.13
Culture, immortalization, and characterization of human meibomian gland epithelial cells. Invest Ophthalmol Vis Sci (2010) 1.11
Multi-faceted role of HSP40 in cancer. Clin Exp Metastasis (2009) 1.11
Emergent human pathogen simian virus 40 and its role in cancer. Clin Microbiol Rev (2004) 1.10
HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements. J Virol (2011) 1.10
Models of breast cancer: quo vadis, animal modeling? Breast Cancer Res (2003) 1.10
Intestinal hyperplasia induced by simian virus 40 large tumor antigen requires E2F2. J Virol (2007) 1.09
Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53. PLoS One (2011) 1.08
Blocking anaplerotic entry of glutamine into the TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs. Oncogene (2014) 1.08
Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53. J Virol (2006) 1.07
c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation. Cancer Res (2007) 1.07
T antigen transgenic mouse models. Semin Cancer Biol (2009) 1.06
Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesis. Proc Natl Acad Sci U S A (2005) 1.05
Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci. Cell Div (2010) 1.05
Mir-208 promotes cell proliferation by repressing SOX6 expression in human esophageal squamous cell carcinoma. J Transl Med (2014) 1.05
Mir-184 post-transcriptionally regulates SOX7 expression and promotes cell proliferation in human hepatocellular carcinoma. PLoS One (2014) 1.05
Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor viruses. Int J Biol Sci (2010) 1.05
Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover. EMBO J (2014) 1.04
The raccoon polyomavirus genome and tumor antigen transcription are stable and abundant in neuroglial tumors. J Virol (2014) 1.03
Dephosphorylation of JC virus agnoprotein by protein phosphatase 2A: inhibition by small t antigen. Virology (2008) 1.02
Intestinal dysplasia induced by simian virus 40 T antigen is independent of p53. J Virol (2005) 1.02
Mammary epithelial cell transformation is associated with deregulation of the vitamin D pathway. J Cell Biochem (2008) 1.02
Small tumor antigen of polyomaviruses: role in viral life cycle and cell transformation. J Cell Physiol (2008) 1.02
Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice. Mol Cell Biol (2011) 1.00
miR-93 promotes cell proliferation in gliomas through activation of PI3K/Akt signaling pathway. Oncotarget (2015) 0.99
Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells. PLoS One (2011) 0.99
The minimal set of genetic alterations required for conversion of primary human fibroblasts to cancer cells in the subrenal capsule assay. Neoplasia (2005) 0.99
In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene. Proc Natl Acad Sci U S A (2014) 0.99
Role for PP2A in ARF signaling to p53. Proc Natl Acad Sci U S A (2004) 0.98
Long telomeres bypass the requirement for telomere maintenance in human tumorigenesis. Cell Rep (2012) 0.98
Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation. Proc Natl Acad Sci U S A (2010) 0.97
Loss of the ciliary kinase Nek8 causes left-right asymmetry defects. J Am Soc Nephrol (2013) 0.97
Activation of the tumor-specific death effector apoptin and its kinase by an N-terminal determinant of simian virus 40 large T antigen. J Virol (2004) 0.97
Phosphatases: the new brakes for cancer development? Enzyme Res (2011) 0.97
Myc, mondo, and metabolism. Genes Cancer (2010) 0.97
Induction of interferon-stimulated genes by Simian virus 40 T antigens. Virology (2010) 0.97
Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model. Genes Dev (2012) 0.97
Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53. Mol Cell Biol (2004) 0.97
Cyclin E and SV40 small T antigen cooperate to bypass quiescence and contribute to transformation by activating CDK2 in human fibroblasts. J Biol Chem (2008) 0.96
Characterisation of telomerase immortalised normal human oesophageal squamous cells. Gut (2003) 0.96
Loss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC. Cancer Res (2013) 0.95
p53, the cellular gatekeeper for growth and division. Cell (1997) 31.04
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13
Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20
Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res (1990) 20.53
Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 20.48
Creation of human tumour cells with defined genetic elements. Nature (1999) 16.47
Monoclonal antibodies specific for simian virus 40 tumor antigens. J Virol (1981) 15.59
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell (1997) 12.41
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev (2001) 11.25
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J (2001) 9.40
Construction and analysis of viable deletion mutants of simian virus 40. J Virol (1976) 9.11
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature (1998) 7.81
Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell (1992) 7.61
The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev (1998) 7.46
Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. Cell (1990) 6.12
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science (1995) 5.46
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol (2000) 5.28
Mutants of SV40 with an altered small t protein are reduced in their ability to transform cells. Cell (1978) 5.23
Structure and function of simian virus 40 large tumor antigen. Annu Rev Biochem (1992) 4.84
Hypervariable ultra-long telomeres in mice. Nature (1990) 4.76
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol (1998) 4.59
Retracted Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity (1999) 4.42
Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem Sci (1999) 4.42
Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat Genet (1999) 4.22
Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP). Nucleic Acids Res (1997) 4.22
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc Natl Acad Sci U S A (1998) 4.11
A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res (1991) 4.07
p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts. Genes Dev (1991) 4.01
Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc Natl Acad Sci U S A (1995) 3.86
Defining the molecular mechanisms of human cell immortalization. Biochim Biophys Acta (1991) 3.73
Mutational analysis of simian virus 40 T antigen: isolation and characterization of mutants with deletions in the T-antigen gene. Mol Cell Biol (1983) 3.67
The roles of the simian virus 40 tumor antigens in transformation of Chinese hamster lung cells. Cell (1979) 3.57
In vitro mutagenesis of a putative DNA binding domain of SV40 large-T. Virology (1984) 3.50
Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding. Mol Cell Biol (1992) 3.37
The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation. Cell (1993) 3.27
Alterations of the PPP2R1B gene in human lung and colon cancer. Science (1998) 3.14
Cellular transformation by SV40 large T antigen: interaction with host proteins. Semin Cancer Biol (2001) 2.85
Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology. Nat Med (2000) 2.81
Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens. Mol Cell Biol (1986) 2.81
Control of protein phosphatase 2A by simian virus 40 small-t antigen. Mol Cell Biol (1991) 2.80
Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene. Nature (1983) 2.77
Senescence as a mode of tumor suppression. Environ Health Perspect (1991) 2.60
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci U S A (1999) 2.42
Human endothelial cell life extension by telomerase expression. J Biol Chem (1999) 2.38
The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain. Mol Cell Biol (1997) 2.33
Nucleotide sequence deletions within the coding region for small-t antigen of simian virus 40. J Virol (1979) 2.23
The p53 protein and its interactions with the oncogene products of the small DNA tumor viruses. Virology (1990) 2.15
SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen. Cell (1987) 2.13
Viral transactivating proteins. Annu Rev Genet (1997) 2.12
Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms. Oncogene (2000) 2.08
Derivation of human tumor cells in vitro without widespread genomic instability. Cancer Res (2001) 2.07
Role of the retinoblastoma protein in the pathogenesis of human cancer. J Clin Oncol (1997) 2.02
Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol Cell Biol (1997) 2.01
The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions. J Virol (1989) 2.00
The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest. J Virol (1994) 1.97
Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity. Proc Natl Acad Sci U S A (2000) 1.91
Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation. Mol Cell Biol (1995) 1.87
Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts. Cancer Res (1999) 1.86
Resistance of human cells to tumorigenesis induced by cloned transforming genes. Proc Natl Acad Sci U S A (1983) 1.79
Dissociation of Rb-binding and anchorage-independent growth from immortalization and tumorigenicity using SV40 mutants producing N-terminally truncated large T antigens. Virology (1990) 1.77
Role of T antigen interactions with p53 in tumorigenesis. Semin Cancer Biol (2001) 1.77
Role of small t antigen in the acute transforming activity of SV40. Cell (1982) 1.76
The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins. Mol Cell Biol (1998) 1.70
Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha. Proc Natl Acad Sci U S A (1998) 1.68
Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells. Virology (1991) 1.66
Signaling by integrins: implications for tumorigenesis. Cancer Res (1993) 1.66
Mutants with changes within or near a hydrophobic region of simian virus 40 large tumor antigen are defective for binding cellular protein p53. Virology (1989) 1.66
A genetically tractable model of human glioma formation. Cancer Res (2001) 1.63
Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products. Cancer Surv (1992) 1.63
Rescue of cells from ras oncogene-induced growth arrest by a second, complementing, oncogene. Proc Natl Acad Sci U S A (1988) 1.62
Can ends justify the means?: telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells. Proc Natl Acad Sci U S A (1998) 1.61
Transformation of a continuous rat embryo fibroblast cell line requires three separate domains of simian virus 40 large T antigen. J Virol (1992) 1.51
p16INK4A participates in a G1 arrest checkpoint in response to DNA damage. Mol Cell Biol (1998) 1.46
Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation. J Virol (1994) 1.42
Requirement for the simian virus 40 small tumor antigen in tumorigenesis in transgenic mice. Mol Cell Biol (1988) 1.40
Independent expression of the transforming amino-terminal domain of SV40 large I antigen from an alternatively spliced third SV40 early mRNA. EMBO J (1993) 1.39
Activated Ha-ras can cooperate with defective simian virus 40 in the transformation of nonestablished rat embryo fibroblasts. J Virol (1987) 1.36
Escape from premature senescence is not sufficient for oncogenic transformation by Ras. Nat Cell Biol (2001) 1.36
Functional expression of human PP2Ac in yeast permits the identification of novel C-terminal and dominant-negative mutant forms. J Biol Chem (1999) 1.35
The role of the SV40 ST antigen in cell growth promotion and transformation. Semin Cancer Biol (2001) 1.33
Simian virus 40 small tumor antigen and an amino-terminal domain of large tumor antigen share a common transforming function. Proc Natl Acad Sci U S A (1990) 1.27
Induction of immortality is an early event in malignant transformation of mammalian cells by carcinogens. Nature (1982) 1.26
Telomerase activity is sufficient to allow transformed cells to escape from crisis. Mol Cell Biol (1999) 1.19
The three transforming regions of SV40 T antigen are required for immortalization of primary mouse embryo fibroblasts. Oncogene (1995) 1.12
Mechanism of HPV E6 proteins in cellular transformation. Semin Cancer Biol (1996) 1.05
pRB-dependent, J domain-independent function of simian virus 40 large T antigen in override of p53 growth suppression. J Virol (2000) 1.03
The SV40 small t antigen is essential for the morphological transformation of human fibroblasts. Virology (1989) 1.00
Identification of structural elements involved in the interaction of simian virus 40 small tumor antigen with protein phosphatase 2A. J Biol Chem (1998) 1.00
New HPV E6 binding proteins: dangerous liaisons? Trends Microbiol (1998) 0.96
Cellular proteins that are targetted by DNA tumor viruses for transformation. Princess Takamatsu Symp (1989) 0.89
Malignant transformation of human fibroblasts by oncogene transfection or carcinogen treatment. Prog Clin Biol Res (1990) 0.81
Hallmarks of cancer: the next generation. Cell (2011) 140.01
The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99
The basics of epithelial-mesenchymal transition. J Clin Invest (2009) 32.82
CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol (2006) 32.51
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell (2004) 31.38
mTOR signaling in growth control and disease. Cell (2012) 29.21
Defining the role of mTOR in cancer. Cancer Cell (2007) 21.63
Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol (2008) 21.53
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature (2007) 21.53
mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell (2006) 18.81
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer (2009) 18.53
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell (2006) 18.36
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell (2002) 18.22
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell (2005) 18.20
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet (2008) 17.67
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol (2004) 16.83
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature (2007) 15.20
Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell (2008) 14.80
CellProfiler: free, versatile software for automated biological image analysis. Biotechniques (2007) 14.71
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science (2008) 14.08
A perspective on cancer cell metastasis. Science (2011) 13.31
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem (2009) 12.73
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell (2010) 12.24
Cancer cell metabolism: Warburg and beyond. Cell (2008) 11.80
Growing roles for the mTOR pathway. Curr Opin Cell Biol (2005) 11.66
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell (2006) 11.48
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature (2009) 11.46
Genetic screens in human cells using the CRISPR-Cas9 system. Science (2013) 10.75
Retracted A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell (2009) 10.51
Tumor metastasis: molecular insights and evolving paradigms. Cell (2011) 10.34
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell (2007) 9.68
A progression puzzle. Nature (2002) 9.56
mTOR signaling at a glance. J Cell Sci (2009) 8.66
Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA (2003) 8.07
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature (2011) 8.03
Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci U S A (2004) 7.96
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res (2008) 7.91
Ras oncogenes: split personalities. Nat Rev Mol Cell Biol (2008) 7.91
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell (2010) 7.59
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science (2011) 7.55
Highly parallel identification of essential genes in cancer cells. Proc Natl Acad Sci U S A (2008) 7.45
The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. Mol Cell Biol (2002) 7.44
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science (2011) 6.75
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science (2012) 6.69
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol (2010) 6.67
A unifying model for mTORC1-mediated regulation of mRNA translation. Nature (2012) 6.44
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A (2010) 6.15
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell (2009) 5.97
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci U S A (2011) 5.53
Modelling the molecular circuitry of cancer. Nat Rev Cancer (2002) 5.43
The pharmacology of mTOR inhibition. Sci Signal (2009) 5.36
Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A (2007) 5.24
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell (2003) 5.21
Cancer stem cells: mirage or reality? Nat Med (2009) 5.20
Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning. Proc Natl Acad Sci U S A (2009) 5.15
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr Biol (2006) 5.06
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J (2012) 5.03
The signals and pathways activating cellular senescence. Int J Biochem Cell Biol (2004) 5.00
Rules for making human tumor cells. N Engl J Med (2002) 4.84
Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol (2010) 4.80
Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell (2011) 4.79
Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77
The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Nat Genet (2005) 4.70
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell (2011) 4.70
Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle (2006) 4.67
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature (2012) 4.35
Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell (2007) 4.30
Species- and cell type-specific requirements for cellular transformation. Cancer Cell (2004) 4.25
Genome-scale loss-of-function screening with a lentiviral RNAi library. Nat Methods (2006) 4.12
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Curr Biol (2003) 4.01
Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin Cancer Biol (2012) 3.98
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science (2013) 3.96
Exploring a new twist on tumor metastasis. Cancer Res (2006) 3.96
The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med (2013) 3.96
Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell (2008) 3.95
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res (2010) 3.94
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature (2010) 3.81
Immortalization and transformation of primary human airway epithelial cells by gene transfer. Oncogene (2002) 3.80
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell (2009) 3.78
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell (2012) 3.77
Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Cell (2008) 3.75
The Spemann organizer gene, Goosecoid, promotes tumor metastasis. Proc Natl Acad Sci U S A (2006) 3.64
Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell (2013) 3.61
Tumours with PI3K activation are resistant to dietary restriction. Nature (2009) 3.60
Retracted Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. Cancer Cell (2003) 3.56
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature (2012) 3.51
An emerging role of mTOR in lipid biosynthesis. Curr Biol (2009) 3.50
An expanding role for mTOR in cancer. Trends Mol Med (2005) 3.40
Structure of the human mTOR complex I and its implications for rapamycin inhibition. Mol Cell (2010) 3.33
Telomerase maintains telomere structure in normal human cells. Cell (2003) 3.29