Published in Adv Cancer Res on January 01, 2002
Genomic targets of the human c-Myc protein. Genes Dev (2003) 9.67
Modelling Myc inhibition as a cancer therapy. Nature (2008) 5.81
Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Mol Cell Biol (2005) 4.99
Characterization of the c-MYC-regulated transcriptome by SAGE: identification and analysis of c-MYC target genes. Proc Natl Acad Sci U S A (2002) 3.55
Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation. Proc Natl Acad Sci U S A (2007) 3.37
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev (2002) 3.16
Evidence of a large-scale functional organization of mammalian chromosomes. PLoS Genet (2005) 2.73
MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits. Nat Cell Biol (2012) 2.61
The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. Genes Dev (2007) 2.57
Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review. Front Pharmacol (2011) 2.24
Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP. EMBO Rep (2003) 2.21
Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays. Mol Cell Biol (2004) 2.19
Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation. Cancer Res (2008) 2.16
The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol (2004) 2.13
Global identification of Myc target genes reveals its direct role in mitochondrial biogenesis and its E-box usage in vivo. PLoS One (2008) 2.12
Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a). Proc Natl Acad Sci U S A (2006) 2.06
Developmental context determines latency of MYC-induced tumorigenesis. PLoS Biol (2004) 2.05
Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis. Mol Cell Biol (2006) 2.01
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. Proc Natl Acad Sci U S A (2011) 1.90
Quantitative proteomic analysis of Myc oncoprotein function. EMBO J (2002) 1.89
Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev (2003) 1.84
The interaction between Myc and Miz1 is required to antagonize TGFbeta-dependent autocrine signaling during lymphoma formation and maintenance. Genes Dev (2010) 1.81
A role for c-Myc in the regulation of ribosomal RNA processing. Nucleic Acids Res (2003) 1.80
Transcription-independent functions of MYC: regulation of translation and DNA replication. Nat Rev Mol Cell Biol (2008) 1.72
The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics. Nat Rev Cancer (2009) 1.71
Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. J Cell Biol (2005) 1.69
Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma. J Cancer Res Clin Oncol (2012) 1.66
A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of function. Proc Natl Acad Sci U S A (2005) 1.64
Glycogen synthase kinase 3 beta: can it be a target for oral cancer. Mol Cancer (2010) 1.59
GSK-3 as potential target for therapeutic intervention in cancer. Oncotarget (2014) 1.56
c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1. Mol Cell Biol (2007) 1.50
Functional validation of genes implicated in lymphomagenesis: an in vivo selection assay using a Myc-induced B-cell tumor. Ann N Y Acad Sci (2005) 1.44
Whole-genome analysis reveals a strong positional bias of conserved dMyc-dependent E-boxes. Mol Cell Biol (2005) 1.44
Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation. Proc Natl Acad Sci U S A (2008) 1.44
Nuclear receptor hepatocyte nuclear factor 4alpha1 competes with oncoprotein c-Myc for control of the p21/WAF1 promoter. Mol Endocrinol (2007) 1.40
Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover. Nat Cell Biol (2010) 1.39
dMyc functions downstream of Yorkie to promote the supercompetitive behavior of hippo pathway mutant cells. PLoS Genet (2010) 1.38
Loss of protooncogene c-Myc function impedes G1 phase progression both before and after the restriction point. Mol Biol Cell (2003) 1.34
Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-Myc. Neoplasia (2006) 1.34
Down-regulation of c-Myc following MEK/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors. Mol Cancer (2006) 1.33
Myc degradation: dancing with ubiquitin ligases. Proc Natl Acad Sci U S A (2004) 1.31
Subcellular localization of glycogen synthase kinase 3beta controls embryonic stem cell self-renewal. Mol Cell Biol (2009) 1.31
Down-regulation of Myc is essential for terminal erythroid maturation. J Biol Chem (2010) 1.30
Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis. EMBO J (2007) 1.29
Miz1 is required for early embryonic development during gastrulation. Mol Cell Biol (2003) 1.29
Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression. Proc Natl Acad Sci U S A (2003) 1.27
Deep sequencing of MYC DNA-binding sites in Burkitt lymphoma. PLoS One (2011) 1.22
Identification of novel Myc target genes with a potential role in lymphomagenesis. Nucleic Acids Res (2004) 1.20
Polycomb mediates Myc autorepression and its transcriptional control of many loci in Drosophila. Genes Dev (2005) 1.19
MYC and gastric adenocarcinoma carcinogenesis. World J Gastroenterol (2008) 1.17
The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis. J Cell Biol (2010) 1.16
Autoregulatory suppression of c-Myc by miR-185-3p. J Biol Chem (2011) 1.16
Drosophila growth and development in the absence of dMyc and dMnt. Dev Biol (2007) 1.13
Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation. Bioorg Med Chem Lett (2009) 1.11
The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster. Mol Cell Biol (2005) 1.11
Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding. Nucleic Acids Res (2012) 1.10
The Myc-nucleophosmin-ARF network: a complex web unveiled. Cell Cycle (2009) 1.10
Cellular target genes of Epstein-Barr virus nuclear antigen 2. J Virol (2006) 1.10
Low-level shRNA cytotoxicity can contribute to MYC-induced hepatocellular carcinoma in adult mice. Mol Ther (2009) 1.09
Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development. Proc Natl Acad Sci U S A (2005) 1.08
DNA-dependent protein kinase catalytic subunit modulates the stability of c-Myc oncoprotein. Mol Cancer (2008) 1.08
A therapeutic role for targeting c-Myc/Hif-1-dependent signaling pathways. Cell Cycle (2010) 1.07
Identification of small molecules that induce apoptosis in a Myc-dependent manner and inhibit Myc-driven transformation. Proc Natl Acad Sci U S A (2006) 1.05
Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure. PLoS One (2009) 1.04
Human c-Myc isoforms differentially regulate cell growth and apoptosis in Drosophila melanogaster. Mol Cell Biol (2005) 1.03
Myc inhibits p27-induced erythroid differentiation of leukemia cells by repressing erythroid master genes without reversing p27-mediated cell cycle arrest. Mol Cell Biol (2008) 1.01
Hepatotoxin-induced changes in the adult murine liver promote MYC-induced tumorigenesis. PLoS One (2008) 0.99
In silico identification of transcriptional regulators associated with c-Myc. Nucleic Acids Res (2004) 0.98
A curated database of miRNA mediated feed-forward loops involving MYC as master regulator. PLoS One (2011) 0.97
Recurrent RECQL4 imbalance and increased gene expression levels are associated with structural chromosomal instability in sporadic osteosarcoma. Neoplasia (2009) 0.97
A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation. Oncogene (2008) 0.97
The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer. BMC Cancer (2008) 0.96
Finding cancer's weakest link. Oncotarget (2011) 0.96
Targeting MYC-Regulated miRNAs to Combat Cancer. Genes Cancer (2010) 0.94
c-Myc-dependent formation of Robertsonian translocation chromosomes in mouse cells. Neoplasia (2007) 0.93
The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc. Proc Natl Acad Sci U S A (2015) 0.93
The Myc target gene JPO1/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo. Cancer Res (2005) 0.92
The impact of C-MYC gene expression on gastric cancer cell. Mol Cell Biochem (2010) 0.91
First siRNA library screening in hard-to-transfect HUVEC cells. J RNAi Gene Silencing (2009) 0.89
Deregulation of common genes by c-Myc and its direct target, MT-MC1. Proc Natl Acad Sci U S A (2005) 0.89
Modulation of cellular migration and survival by c-Myc through the downregulation of urokinase (uPA) and uPA receptor. Mol Cell Biol (2010) 0.89
MYC cofactors: molecular switches controlling diverse biological outcomes. Cold Spring Harb Perspect Med (2014) 0.88
Integrin α1β1 expression is controlled by c-MYC in colorectal cancer cells. Oncogene (2015) 0.87
Knockdown of TFIIS by RNA silencing inhibits cancer cell proliferation and induces apoptosis. BMC Cancer (2008) 0.87
Dose-dependent regulation of target gene expression and cell proliferation by c-Myc levels. Transcription (2013) 0.86
A systems biological approach to identify key transcription factors and their genomic neighborhoods in human sarcomas. Chin J Cancer (2011) 0.86
Drosophila Myc interacts with host cell factor (dHCF) to activate transcription and control growth. J Biol Chem (2010) 0.86
Promoter-binding and repression of PDGFRB by c-Myc are separable activities. Nucleic Acids Res (2004) 0.85
Growth-promoting and tumourigenic activity of c-Myc is suppressed by Hhex. Oncogene (2014) 0.85
The MYC-associated protein CDCA7 is phosphorylated by AKT to regulate MYC-dependent apoptosis and transformation. Mol Cell Biol (2012) 0.84
Polymorphisms cMyc-N11S and p27-V109G and breast cancer risk and prognosis. BMC Cancer (2007) 0.84
Regulation of the MAD1 promoter by G-CSF. Nucleic Acids Res (2008) 0.83
The world according to MYC. Conference on MYC and the transcriptional control of proliferation and oncogenesis. EMBO Rep (2007) 0.83
NLS-RARα promotes proliferation and inhibits differentiation in HL-60 cells. Int J Med Sci (2014) 0.83
Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma. Blood (2014) 0.82
Far upstream element-binding protein 1 is a prognostic biomarker and promotes nasopharyngeal carcinoma progression. Cell Death Dis (2015) 0.81
The molecular genetics of breast cancer and targeted therapy. Biologics (2007) 0.81
Methylation of DACT2 accelerates esophageal cancer development by activating Wnt signaling. Oncotarget (2016) 0.80
Alterations in c-Myc phenotypes resulting from dynamin-related protein 1 (Drp1)-mediated mitochondrial fission. Cell Death Dis (2013) 0.80
Indirect genomic effects on survival from gene expression data. Genome Biol (2008) 0.80
Reflecting on 25 years with MYC. Nat Rev Cancer (2008) 7.44
Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis. EMBO J (2005) 3.11
Prognostic gene signatures for non-small-cell lung cancer. Proc Natl Acad Sci U S A (2009) 2.84
The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis. Cancer Res (2006) 2.50
Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression. Curr Biol (2003) 2.47
Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues. Lab Invest (2009) 2.43
Three-gene prognostic classifier for early-stage non small-cell lung cancer. J Clin Oncol (2007) 2.10
Identifying genes regulated in a Myc-dependent manner. J Biol Chem (2002) 1.98
CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome. Nucleic Acids Res (2005) 1.89
Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis. Cancer Res (2004) 1.73
The Oscar-worthy role of Myc in apoptosis. Semin Cancer Biol (2006) 1.72
Dysregulation of the mevalonate pathway promotes transformation. Proc Natl Acad Sci U S A (2010) 1.71
Gene expression profiling in cervical cancer: an exploration of intratumor heterogeneity. Clin Cancer Res (2006) 1.65
Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry. EMBO J (2003) 1.59
Cancer therapeutics: targeting the dark side of Myc. Eur J Cancer (2005) 1.44
Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells. Proc Natl Acad Sci U S A (2007) 1.29
The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53. J Biol Chem (2007) 1.26
Involvement of Toso in activation of monocytes, macrophages, and granulocytes. Proc Natl Acad Sci U S A (2013) 1.19
Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function. Cancer Res (2008) 1.17
Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. Cancer Res (2005) 1.16
Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance. BMC Cancer (2010) 1.16
Functional analysis of the N-terminal domain of the Myc oncoprotein. Oncogene (2003) 1.13
Optimization of experimental design parameters for high-throughput chromatin immunoprecipitation studies. Nucleic Acids Res (2008) 1.12
Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. Neoplasia (2002) 1.11
Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding. Nucleic Acids Res (2012) 1.10
CUL7 is a novel antiapoptotic oncogene. Cancer Res (2007) 1.09
Myc: the beauty and the beast. Genes Cancer (2010) 1.07
Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma. Blood (2010) 1.05
c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism. Oncogene (2004) 1.04
A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants. J Mol Biol (2005) 1.03
Tumor cell kill by c-MYC depletion: role of MYC-regulated genes that control DNA double-strand break repair. Cancer Res (2010) 1.02
Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma. Mol Cancer Ther (2007) 0.97
Determination of the Plk4/Sak consensus phosphorylation motif using peptide spots arrays. FEBS Lett (2006) 0.95
Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells. Breast Cancer Res Treat (2013) 0.91
Promoter-binding and repression of PDGFRB by c-Myc are separable activities. Nucleic Acids Res (2004) 0.85
The role of INI1/hSNF5 in gene regulation and cancer. Biochem Cell Biol (2009) 0.84
Identifying gene locus associations with promyelocytic leukemia nuclear bodies using immuno-TRAP. J Cell Biol (2013) 0.84
The role of ligand density and size in mediating quantum dot nuclear transport. Small (2014) 0.83
Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents. Int J Cancer (2010) 0.83
Absence of caspase-3 protects pancreatic {beta}-cells from c-Myc-induced apoptosis without leading to tumor formation. J Biol Chem (2009) 0.83
MYC phosphorylation at novel regulatory regions suppresses transforming activity. Cancer Res (2013) 0.83
Characterization of the apoptotic response of human leukemia cells to organosulfur compounds. BMC Cancer (2010) 0.77
Identifying Myc interactors. Methods Mol Biol (2013) 0.77
Bcl-2 and c-Myc co-operate in the Epstein-Barr virus-immortalized human B-cell line GM607 but do not confer tumorigenicity. Leuk Lymphoma (2005) 0.75