Published in FEBS Lett on February 20, 2002
Selective inhibition of BET bromodomains. Nature (2010) 18.79
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol (2007) 10.98
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev (2003) 7.91
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature (2006) 7.70
Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell (2011) 5.27
Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. Mol Cell Biol (2008) 3.74
The Yin and Yang of P-TEFb regulation: implications for human immunodeficiency virus gene expression and global control of cell growth and differentiation. Microbiol Mol Biol Rev (2006) 3.44
The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res (2004) 3.30
Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov (2013) 3.11
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia. Blood (2012) 2.91
Regulation of nucleosome dynamics by histone modifications. Nat Struct Mol Biol (2013) 2.71
Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell (2010) 2.44
The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3. Mol Cell Biol (2006) 2.29
Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein. Mol Cell Biol (2003) 2.22
KAP1 protein: an enigmatic master regulator of the genome. J Biol Chem (2011) 2.15
Structural basis for molecular recognition and presentation of histone H3 by WDR5. EMBO J (2006) 2.08
The role of human bromodomains in chromatin biology and gene transcription. Curr Opin Drug Discov Devel (2009) 1.99
Lysine succinylation and lysine malonylation in histones. Mol Cell Proteomics (2012) 1.95
Mechanisms of ATP dependent chromatin remodeling. Mutat Res (2007) 1.94
HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. Proc Natl Acad Sci U S A (2013) 1.82
Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function. J Virol (2006) 1.81
Association of the transcriptional corepressor TIF1beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiation. Genes Dev (2004) 1.76
Polybromo-1: the chromatin targeting subunit of the PBAF complex. Biochimie (2008) 1.68
Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites. J Med Chem (2012) 1.64
Chromatin and transcription in yeast. Genetics (2012) 1.61
Analysis of Myc-induced histone modifications on target chromatin. PLoS One (2008) 1.59
Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes. Proc Natl Acad Sci U S A (2011) 1.56
Molecular docking: a powerful approach for structure-based drug discovery. Curr Comput Aided Drug Des (2011) 1.53
The role of histone acetylation in memory formation and cognitive impairments. Neuropsychopharmacology (2012) 1.53
Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. EMBO J (2011) 1.52
Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse. Dev Dyn (2009) 1.51
E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia. Blood (2003) 1.51
Multi-tasking on chromatin with the SAGA coactivator complexes. Mutat Res (2007) 1.50
Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions. J Proteome Res (2007) 1.48
A protein-domain microarray identifies novel protein-protein interactions. Biochem J (2002) 1.42
Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus. Mol Cell Biol (2003) 1.37
SWI/SNF displaces SAGA-acetylated nucleosomes. Eukaryot Cell (2006) 1.36
Plant SET domain-containing proteins: structure, function and regulation. Biochim Biophys Acta (2007) 1.36
N-formylation of lysine in histone proteins as a secondary modification arising from oxidative DNA damage. Proc Natl Acad Sci U S A (2006) 1.32
A histone code in meiosis: the histone kinase, NHK-1, is required for proper chromosomal architecture in Drosophila oocytes. Genes Dev (2005) 1.30
Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. Proc Natl Acad Sci U S A (2011) 1.30
Roles of SWI/SNF and HATs throughout the dynamic transcription of a yeast glucose-repressible gene. EMBO J (2003) 1.30
Deciphering normal blood gene expression variation--The NOWAC postgenome study. PLoS Genet (2010) 1.29
The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3. EMBO Rep (2005) 1.28
Brd2 disruption in mice causes severe obesity without Type 2 diabetes. Biochem J (2009) 1.26
Chromatin-mediated epigenetic regulation in the malaria parasite Plasmodium falciparum. Eukaryot Cell (2010) 1.26
TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity. J Mol Biol (2013) 1.25
Structural basis for acetylated histone H4 recognition by the human BRD2 bromodomain. J Biol Chem (2010) 1.24
Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains. J Am Chem Soc (2014) 1.23
Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family. Bioorg Med Chem (2011) 1.23
Epigenomics and breast cancer. Pharmacogenomics (2008) 1.23
HDAC3 and the molecular brake pad hypothesis. Neurobiol Learn Mem (2011) 1.22
Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription. Genes Dev (2012) 1.21
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. Nat Med (2017) 1.21
Real-time imaging of histone H4 hyperacetylation in living cells. Proc Natl Acad Sci U S A (2009) 1.20
Multiple bromodomain genes are involved in restricting the spread of heterochromatic silencing at the Saccharomyces cerevisiae HMR-tRNA boundary. Genetics (2005) 1.20
Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27. Mol Cell Biol (2012) 1.20
The STAT3 NH2-terminal domain stabilizes enhanceosome assembly by interacting with the p300 bromodomain. J Biol Chem (2008) 1.17
The interplay of histone modifications - writers that read. EMBO Rep (2015) 1.15
An increasingly complex code. J Clin Invest (2002) 1.13
Regulation of P-TEFb elongation complex activity by CDK9 acetylation. Mol Cell Biol (2007) 1.13
In vitro transcription system delineates the distinct roles of the coactivators pCAF and p300 during MyoD/E47-dependent transactivation. Proc Natl Acad Sci U S A (2004) 1.12
The dual bromodomain and WD repeat-containing mouse protein BRWD1 is required for normal spermiogenesis and the oocyte-embryo transition. Dev Biol (2008) 1.12
Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation. Epigenetics Chromatin (2010) 1.10
Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J Med Chem (2013) 1.09
Histone modifications: from genome-wide maps to functional insights. Genome Biol (2005) 1.08
Use of epigenetic drugs in disease: an overview. Genet Epigenet (2014) 1.08
The BET family member BRD4 interacts with OCT4 and regulates pluripotency gene expression. Stem Cell Reports (2015) 1.06
Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery. Oncotarget (2015) 1.06
Multiple roles for acetylation in the interaction of p300 HAT with ATF-2. Biochemistry (2007) 1.05
The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation. Proc Natl Acad Sci U S A (2015) 1.05
Epigenetic control of immunity. Cold Spring Harb Perspect Biol (2014) 1.05
Combinatorial readout of dual histone modifications by paired chromatin-associated modules. J Biol Chem (2011) 1.04
Identification of pathways directly regulated by SHORT VEGETATIVE PHASE during vegetative and reproductive development in Arabidopsis. Genome Biol (2013) 1.04
Bromodomain coactivators in cancer, obesity, type 2 diabetes, and inflammation. Discov Med (2010) 1.03
Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins. J Virol (2005) 1.03
Identification of novel activation mechanisms for FLO11 regulation in Saccharomyces cerevisiae. Genetics (2008) 1.03
A combination of H2A.Z and H4 acetylation recruits Brd2 to chromatin during transcriptional activation. PLoS Genet (2012) 1.02
Transcription and post-transcriptional regulation of spermatogenesis. Philos Trans R Soc Lond B Biol Sci (2010) 1.02
Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2. Cell Res (2010) 1.02
Protein lysine acetylation by p300/CBP. Chem Rev (2015) 1.02
The bromodomain: from epigenome reader to druggable target. Biochim Biophys Acta (2014) 1.02
Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1. J Biol Chem (2014) 1.01
Intracellular delivery of acetyl-histone peptides inhibits native bromodomain-chromatin interactions and impairs mitotic progression. FEBS Lett (2008) 1.01
In vivo chromatin organization of mouse rod photoreceptors correlates with histone modifications. PLoS One (2010) 1.00
Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation. BMC Biol (2004) 1.00
Dissecting DNA-histone interactions in the nucleosome by molecular dynamics simulations of DNA unwrapping. Biophys J (2011) 0.99
Discovery of novel small-molecule inhibitors of BRD4 using structure-based virtual screening. J Med Chem (2013) 0.99
Small-molecule inhibitors of the Myc oncoprotein. Biochim Biophys Acta (2014) 0.98
Nanog requires BRD4 to maintain murine embryonic stem cell pluripotency and is suppressed by bromodomain inhibitor JQ1 together with Lefty1. Stem Cells Dev (2014) 0.97
Structural implications for K5/K12-di-acetylated histone H4 recognition by the second bromodomain of BRD2. FEBS Lett (2010) 0.97
Brd4 associates with mitotic chromosomes throughout early zebrafish embryogenesis. Dev Dyn (2008) 0.97
Chromatin configuration as a battlefield in plant-bacteria interactions. Plant Physiol (2011) 0.97
The CBP bromodomain and nucleosome targeting are required for Zta-directed nucleosome acetylation and transcription activation. Mol Cell Biol (2003) 0.96
A bromodomain-containing protein from tomato specifically binds potato spindle tuber viroid RNA in vitro and in vivo. J Virol (2003) 0.96
Metabolic control of epigenetics in cancer. Nat Rev Cancer (2016) 0.94
Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response. Genes Dev (2015) 0.94
Tudor: a versatile family of histone methylation 'readers'. Trends Biochem Sci (2013) 0.94
PTB or not PTB -- that is the question. FEBS Lett (2002) 0.99