Published in Genes Cells on March 01, 2002
TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2. J Cell Biol (2002) 2.34
Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition. Mol Biol Cell (2006) 2.06
SARA-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rods. Cell (2007) 1.91
Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division. Nature (2009) 1.81
Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome. Am J Hum Genet (2008) 1.79
TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development. J Cell Biol (2003) 1.67
Role of transforming growth factor Beta in corneal function, biology and pathology. Curr Mol Med (2010) 1.39
The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor. J Cell Biol (2007) 1.38
Phosphatidylinositol 3-phosphate recognition and membrane docking by the FYVE domain. Biochim Biophys Acta (2006) 1.37
Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics. Mol Cell Biol (2009) 1.21
Specific activation of mitogen-activated protein kinase by transforming growth factor-beta receptors in lipid rafts is required for epithelial cell plasticity. Mol Biol Cell (2008) 1.18
TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling. EMBO J (2003) 1.16
SARA, a FYVE domain protein, affects Rab5-mediated endocytosis. J Cell Sci (2002) 1.15
Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA. Mol Biol Cell (2006) 1.06
Mechanistic similarities in docking of the FYVE and PX domains to phosphatidylinositol 3-phosphate containing membranes. Prog Lipid Res (2007) 1.02
A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. Biochem J (2006) 1.01
MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes. J Biol Chem (2010) 0.91
Defective autophagy in spastizin mutated patients with hereditary spastic paraparesis type 15. Brain (2013) 0.90
Cdx1 and Cdx2 function as tumor suppressors. J Biol Chem (2014) 0.90
Induction of palate epithelial mesenchymal transition by transforming growth factor β3 signaling. Dev Growth Differ (2012) 0.87
Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic. EMBO J (2016) 0.87
Directional Notch trafficking in Sara endosomes during asymmetric cell division in the spinal cord. Nat Cell Biol (2015) 0.84
Transforming growth factor Beta family: insight into the role of growth factors in regulation of fracture healing biology and potential clinical applications. Mediators Inflamm (2015) 0.84
Disruption of the murine Ap2β1 gene causes nonsyndromic cleft palate. Cleft Palate Craniofac J (2010) 0.83
C18 ORF1, a novel negative regulator of transforming growth factor-β signaling. J Biol Chem (2014) 0.82
Epithelial-to-Mesenchymal Plasticity Harnesses Endocytic Circuitries. Front Oncol (2015) 0.82
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of SMADS and TAK1 in early mouse embryo. Dev Dyn (2011) 0.79
TGFβ superfamily signaling regulators are differentially expressed in the developing and adult mouse testis. Spermatogenesis (2011) 0.79
Phosphatidylinositol 3-kinase and Rab5 GTPase inversely regulate the Smad anchor for receptor activation (SARA) protein independently of transforming growth factor-β1. J Biol Chem (2012) 0.79
Involvement of SARA in Axon and Dendrite Growth. PLoS One (2015) 0.78
Identification and structural characterization of FYVE domain-containing proteins of Arabidopsis thaliana. BMC Plant Biol (2010) 0.78
Optimal effector functions in human natural killer cells rely upon autocrine bone morphogenetic protein signaling. Cancer Res (2014) 0.77
Phosphatidylinositol 3-kinase class II α-isoform PI3K-C2α is required for transforming growth factor β-induced Smad signaling in endothelial cells. J Biol Chem (2015) 0.76
The FYVE domain of Smad Anchor for Receptor Activation (SARA) is required to prevent skin carcinogenesis, but not in mouse development. PLoS One (2014) 0.76
SARA regulates neuronal migration during neocortical development through L1 trafficking. Development (2016) 0.75
Single-Molecule Imaging Reveals the Activation Dynamics of Intracellular Protein Smad3 on Cell Membrane. Sci Rep (2016) 0.75
Nervous system development relies on endosomal trafficking. Neurogenesis (Austin) (2017) 0.75
TGF-β-target genes are differentially regulated in corneal epithelial cells and fibroblasts. New Front Ophthalmol (2017) 0.75
Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89
Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors. EMBO J (2002) 5.44
Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. Mol Cell (2003) 3.80
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell (2003) 3.36
Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin. J Cell Biol (2005) 3.17
Single-cell dynamics of genome-nuclear lamina interactions. Cell (2013) 3.03
Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity. Blood (2004) 2.61
Regulation of cell proliferation by Smad proteins. J Cell Physiol (2002) 2.55
Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning. J Cell Biol (2009) 2.45
Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis. J Biol Chem (2004) 2.37
Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells. Circulation (2002) 2.12
Vitamin K prophylaxis and late vitamin K deficiency bleeding in infants: fifth nationwide survey in Japan. Pediatr Int (2011) 2.06
Requirements for the localization of nesprin-3 at the nuclear envelope and its interaction with plectin. J Cell Sci (2007) 1.92
Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I. Immunity (2003) 1.89
Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L. J Cell Sci (2013) 1.79
Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J (2004) 1.78
Blood pressure influences end-stage renal disease of Cd151 knockout mice. J Clin Invest (2011) 1.75
PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions. J Cell Sci (2009) 1.75
Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape. Immunity (2005) 1.64
Integrin alpha3beta1 inhibits directional migration and wound re-epithelialization in the skin. J Cell Sci (2009) 1.60
PIP2 signaling in lipid domains: a critical re-evaluation. EMBO J (2005) 1.59
Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta. Mol Cell (2006) 1.55
Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency. Blood (2013) 1.51
Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis. Nature (2012) 1.48
The C-terminal domain of Rac1 contains two motifs that control targeting and signaling specificity. J Biol Chem (2003) 1.45
Visualization of PtdIns3P dynamics in living plant cells. Plant J (2006) 1.44
Supraphysiological nuclear export signals bind CRM1 independently of RanGTP and arrest at Nup358. EMBO J (2004) 1.44
TAL1/SCL relieves the E2-2-mediated repression of VEGFR2 promoter activity. J Biochem (2008) 1.41
Developmental changes of optical properties in neonates determined by near-infrared time-resolved spectroscopy. Pediatr Res (2005) 1.39
Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling. Cancer Res (2003) 1.32
Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice. J Cell Sci (2007) 1.31
TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling. Mol Cell (2010) 1.30
FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis. Blood (2006) 1.30
Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice. J Cell Sci (2005) 1.27
Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation. Blood (2006) 1.27
The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration. Blood (2009) 1.25
Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate. J Cell Biol (2007) 1.25
Intravital imaging of fluorescent markers and FRET probes by DNA tattooing. BMC Biotechnol (2007) 1.19
Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm. BMC Biol (2006) 1.19
A self-assembled multimodal complex for combined pre- and intraoperative imaging of the sentinel lymph node. Nanotechnology (2010) 1.18
Combinatorial SNARE complexes modulate the secretion of cytoplasmic granules in human neutrophils. J Immunol (2006) 1.16
Dual Role of alpha6beta4 integrin in epidermal tumor growth: tumor-suppressive versus tumor-promoting function. Mol Biol Cell (2007) 1.16
Evaluation and optimization of ZIC-HILIC-RP as an alternative MudPIT strategy. J Proteome Res (2007) 1.15
A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2) synthesis enzyme for asymmetric spindle positioning. Dev Cell (2008) 1.13
Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding. J Immunol (2007) 1.11
Localization of serglycin in human neutrophil granulocytes and their precursors. J Leukoc Biol (2004) 1.09
Linking lipids to chromatin. Curr Opin Genet Dev (2004) 1.09
Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells. J Biol Chem (2010) 1.08
Identification of human cysteine-rich secretory protein 3 (CRISP-3) as a matrix protein in a subset of peroxidase-negative granules of neutrophils and in the granules of eosinophils. J Leukoc Biol (2002) 1.07
PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha. Biochem J (2010) 1.07
Expression and subcellular localization of NRAMP1 in human neutrophil granules. Blood (2002) 1.05
An emerging role for PtdIns(4,5)P2-mediated signalling in human disease. Trends Pharmacol Sci (2005) 1.04
In vitro toxicity studies of polymer-coated gold nanorods. Nanotechnology (2010) 1.03
Direct antigen presentation and gap junction mediated cross-presentation during apoptosis. J Immunol (2009) 1.03
Synaptotagmin 3 deficiency in T cells impairs recycling of the chemokine receptor CXCR4 and thereby inhibits CXCL12 chemokine-induced migration. J Cell Sci (2006) 1.03
Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C. J Biol Chem (2005) 1.03
Nuclear phosphoinositides and their impact on nuclear functions. FEBS J (2013) 1.02
Essential role of type I(alpha) phosphatidylinositol 4-phosphate 5-kinase in neurite remodeling. Curr Biol (2002) 1.02
Vastus lateralis oxygenation and blood volume measured by near-infrared spectroscopy during whole body vibration. Clin Physiol Funct Imaging (2005) 1.02
B cell receptor-mediated internalization of salmonella: a novel pathway for autonomous B cell activation and antibody production. J Immunol (2009) 1.00
Control of mammary myoepithelial cell contractile function by α3β1 integrin signalling. EMBO J (2011) 0.99
Pharmacokinetics of prophylactic micafungin in very-low-birth-weight infants. Pediatr Infect Dis J (2009) 0.99
Identification of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins by neomycin extraction. Mol Cell Proteomics (2010) 0.99
Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics. J Cell Sci (2010) 0.98
A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis. Curr Biol (2006) 0.96
Requirement of TCF7L2 for TGF-beta-dependent transcriptional activation of the TMEPAI gene. J Biol Chem (2010) 0.96
Langerhans cells favor skin flora tolerance through limited presentation of bacterial antigens and induction of regulatory T cells. J Invest Dermatol (2013) 0.95
Flow cytometric analysis of lymphocyte subpopulations and TH1/TH2 balance in patients with polymyositis and dermatomyositis. Intern Med (2008) 0.95
Light interactions with gold nanorods and cells: implications for photothermal nanotherapeutics. Nano Lett (2011) 0.95
Methylation of Smad6 by protein arginine N-methyltransferase 1. FEBS Lett (2006) 0.95
Costimulatory ligand CD70 is delivered to the immunological synapse by shared intracellular trafficking with MHC class II molecules. Proc Natl Acad Sci U S A (2007) 0.94
Overexpression of PPK-1, the Caenorhabditis elegans Type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults. Dev Biol (2007) 0.93
Henoch-Schönlein purpura with intracerebral hemorrhage. Brain Dev (2002) 0.92
Structure-activity relationship of diacylglycerol kinase theta. Biochim Biophys Acta (2004) 0.92
Smad7 and protein phosphatase 1alpha are critical determinants in the duration of TGF-beta/ALK1 signaling in endothelial cells. BMC Cell Biol (2006) 0.92
SRD5B1 gene analysis needed for the accurate diagnosis of primary 3-oxo-Delta4-steroid 5beta-reductase deficiency. J Gastroenterol Hepatol (2008) 0.92
The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta. J Biol Chem (2005) 0.91
Estrogen actions on lactotroph proliferation are independent of a paracrine interaction with other pituitary cell types: a study using lactotroph-enriched cells. Endocrinology (2007) 0.91
Use of the GRP1 PH domain as a tool to measure the relative levels of PtdIns(3,4,5)P3 through a protein-lipid overlay approach. J Lipid Res (2006) 0.91
Measurement of cerebral oxygenation in neonates after vaginal delivery and cesarean section using full-spectrum near infrared spectroscopy. Comp Biochem Physiol A Mol Integr Physiol (2002) 0.91
Rab27a regulates exocytosis of tertiary and specific granules in human neutrophils. J Immunol (2008) 0.91
Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development. Proc Natl Acad Sci U S A (2013) 0.90
Highly glycosylated alpha1-acid glycoprotein is synthesized in myelocytes, stored in secondary granules, and released by activated neutrophils. J Leukoc Biol (2005) 0.90
Phosphatidylinositol 5-phosphate links dehydration stress to the activity of ARABIDOPSIS TRITHORAX-LIKE factor ATX1. PLoS One (2010) 0.90
Selective fusion of azurophilic granules with Leishmania-containing phagosomes in human neutrophils. J Biol Chem (2010) 0.89
Expression of the orphan protein Plet-1 during trichilemmal differentiation of anagen hair follicles. J Invest Dermatol (2010) 0.89
Noninvasive optical imaging in the visual cortex in young infants. Hum Brain Mapp (2004) 0.89
Low PIP4K2B expression in human breast tumors correlates with reduced patient survival: A role for PIP4K2B in the regulation of E-cadherin expression. Cancer Res (2013) 0.88
PtdIns5P is an oxidative stress-induced second messenger that regulates PKB activation. FASEB J (2012) 0.88
Prodefensins are matrix proteins of specific granules in human neutrophils. J Leukoc Biol (2005) 0.88