Comprehensive human genome amplification using multiple displacement amplification.

PubWeight™: 13.58‹?› | Rank: Top 0.1% | All-Time Top 10000

🔗 View Article (PMC 122757)

Published in Proc Natl Acad Sci U S A on April 16, 2002

Authors

Frank B Dean1, Seiyu Hosono, Linhua Fang, Xiaohong Wu, A Fawad Faruqi, Patricia Bray-Ward, Zhenyu Sun, Qiuling Zong, Yuefen Du, Jing Du, Mark Driscoll, Wanmin Song, Stephen F Kingsmore, Michael Egholm, Roger S Lasken

Author Affiliations

1: Molecular Staging, Inc., 300 George Street, Suite 701, New Haven, CT 06511, USA.

Articles citing this

(truncated to the top 100)

Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23

RNA sequencing: advances, challenges and opportunities. Nat Rev Genet (2010) 8.96

CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein Cell (2015) 7.80

High-resolution whole-genome association study of Parkinson disease. Am J Hum Genet (2005) 6.86

Analysis of repetitive element DNA methylation by MethyLight. Nucleic Acids Res (2005) 6.49

Unbiased whole-genome amplification directly from clinical samples. Genome Res (2003) 6.29

Sensitive sequencing method for KRAS mutation detection by Pyrosequencing. J Mol Diagn (2005) 6.00

Efficient de novo assembly of single-cell bacterial genomes from short-read data sets. Nat Biotechnol (2011) 5.60

Assessment of whole genome amplification-induced bias through high-throughput, massively parallel whole genome sequencing. BMC Genomics (2006) 4.55

Genomic DNA amplification from a single bacterium. Appl Environ Microbiol (2005) 4.25

Whole genome analysis of genetic alterations in small DNA samples using hyperbranched strand displacement amplification and array-CGH. Genome Res (2003) 4.10

Chromothripsis from DNA damage in micronuclei. Nature (2015) 4.04

Single-cell sequencing-based technologies will revolutionize whole-organism science. Nat Rev Genet (2013) 4.03

Genomic sequencing of single microbial cells from environmental samples. Curr Opin Microbiol (2008) 3.99

Accurate whole-genome sequencing and haplotyping from 10 to 20 human cells. Nature (2012) 3.74

One bacterial cell, one complete genome. PLoS One (2010) 3.69

Multiplex amplification enabled by selective circularization of large sets of genomic DNA fragments. Nucleic Acids Res (2005) 3.59

Mosaic copy number variation in human neurons. Science (2013) 3.57

Metagenomic analysis of respiratory tract DNA viral communities in cystic fibrosis and non-cystic fibrosis individuals. PLoS One (2009) 3.41

Genome coverage and sequence fidelity of phi29 polymerase-based multiple strand displacement whole genome amplification. Nucleic Acids Res (2004) 3.37

Clonal dynamics of native haematopoiesis. Nature (2014) 3.15

Single-neuron sequencing analysis of L1 retrotransposition and somatic mutation in the human brain. Cell (2012) 3.13

Mechanism of chimera formation during the Multiple Displacement Amplification reaction. BMC Biotechnol (2007) 3.01

Genomic insights to SAR86, an abundant and uncultivated marine bacterial lineage. ISME J (2011) 2.97

Nanoliter reactors improve multiple displacement amplification of genomes from single cells. PLoS Genet (2007) 2.79

Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage. PLoS One (2011) 2.73

Insights into the genome of large sulfur bacteria revealed by analysis of single filaments. PLoS Biol (2007) 2.69

Partial genome assembly for a candidate division OP11 single cell from an anoxic spring (Zodletone Spring, Oklahoma). Appl Environ Microbiol (2011) 2.61

Matching phylogeny and metabolism in the uncultured marine bacteria, one cell at a time. Proc Natl Acad Sci U S A (2007) 2.52

A high-density screen for linkage in multiple sclerosis. Am J Hum Genet (2005) 2.50

The players in a mutualistic symbiosis: insects, bacteria, viruses, and virulence genes. Proc Natl Acad Sci U S A (2005) 2.46

Genomic sequencing of uncultured microorganisms from single cells. Nat Rev Microbiol (2012) 2.45

Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. Genes Dev (2005) 2.39

Microarray-based analysis of subnanogram quantities of microbial community DNAs by using whole-community genome amplification. Appl Environ Microbiol (2006) 2.31

Nearly finished genomes produced using gel microdroplet culturing reveal substantial intraspecies genomic diversity within the human microbiome. Genome Res (2013) 2.29

The dual origin of the Malagasy in Island Southeast Asia and East Africa: evidence from maternal and paternal lineages. Am J Hum Genet (2005) 2.27

Targeted metagenomics and ecology of globally important uncultured eukaryotic phytoplankton. Proc Natl Acad Sci U S A (2010) 2.26

Environmental whole-genome amplification to access microbial populations in contaminated sediments. Appl Environ Microbiol (2006) 2.24

Two methods of whole-genome amplification enable accurate genotyping across a 2320-SNP linkage panel. Genome Res (2004) 2.22

Complete genome of the uncultured Termite Group 1 bacteria in a single host protist cell. Proc Natl Acad Sci U S A (2008) 2.21

Single cell genomics: advances and future perspectives. PLoS Genet (2014) 2.16

Probing meiotic recombination and aneuploidy of single sperm cells by whole-genome sequencing. Science (2012) 2.14

Genomic mapping of RNA polymerase II reveals sites of co-transcriptional regulation in human cells. Genome Biol (2005) 2.11

The future is now: single-cell genomics of bacteria and archaea. FEMS Microbiol Rev (2013) 2.10

Sequence assembly demystified. Nat Rev Genet (2013) 2.09

A quantitative comparison of single-cell whole genome amplification methods. PLoS One (2014) 2.04

Quantitative evaluation by minisequencing and microarrays reveals accurate multiplexed SNP genotyping of whole genome amplified DNA. Nucleic Acids Res (2003) 1.99

The high-throughput protein sample production platform of the Northeast Structural Genomics Consortium. J Struct Biol (2010) 1.90

Metagenomic analysis indicates that stressors induce production of herpes-like viruses in the coral Porites compressa. Proc Natl Acad Sci U S A (2008) 1.86

New abundant microbial groups in aquatic hypersaline environments. Sci Rep (2011) 1.84

Digital transcriptome profiling from attomole-level RNA samples. Genome Res (2010) 1.83

Resolving the evolution of extant and extinct ruminants with high-throughput phylogenomics. Proc Natl Acad Sci U S A (2009) 1.79

Specific capture and whole-genome sequencing of viruses from clinical samples. PLoS One (2011) 1.78

Single-cell chromosomal imbalances detection by array CGH. Nucleic Acids Res (2006) 1.78

Preparation of protein samples for NMR structure, function, and small-molecule screening studies. Methods Enzymol (2011) 1.75

A procedure for highly specific, sensitive, and unbiased whole-genome amplification. Proc Natl Acad Sci U S A (2008) 1.73

Whole genome amplification of DNA from laser capture-microdissected tissue for high-throughput single nucleotide polymorphism and short tandem repeat genotyping. Am J Pathol (2004) 1.73

Linkage disequilibrium decay and haplotype block structure in the pig. Genetics (2008) 1.71

Cancer genomics: one cell at a time. Genome Biol (2014) 1.70

Candidate phylum TM6 genome recovered from a hospital sink biofilm provides genomic insights into this uncultivated phylum. Proc Natl Acad Sci U S A (2013) 1.69

Natural and engineered nicking endonucleases--from cleavage mechanism to engineering of strand-specificity. Nucleic Acids Res (2010) 1.66

Single-cell genomics reveals the lifestyle of Poribacteria, a candidate phylum symbiotically associated with marine sponges. ISME J (2010) 1.66

A sequence-independent strategy for detection and cloning of circular DNA virus genomes by using multiply primed rolling-circle amplification. J Virol (2004) 1.64

G&T-seq: parallel sequencing of single-cell genomes and transcriptomes. Nat Methods (2015) 1.56

High-throughput single-cell sequencing identifies photoheterotrophs and chemoautotrophs in freshwater bacterioplankton. ISME J (2011) 1.55

Impact of whole genome amplification on analysis of copy number variants. Nucleic Acids Res (2008) 1.55

Metagenomic detection of phage-encoded platelet-binding factors in the human oral cavity. Proc Natl Acad Sci U S A (2010) 1.53

Gene content and virtual gene order of barley chromosome 1H. Plant Physiol (2009) 1.53

Amplification of uncultured single-stranded DNA viruses from rice paddy soil. Appl Environ Microbiol (2008) 1.53

L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci (2016) 1.51

Comparison of multiple displacement amplification (MDA) and multiple annealing and looping-based amplification cycles (MALBAC) in single-cell sequencing. PLoS One (2014) 1.50

Detection of low-copy-number genomic DNA sequences in individual bacterial cells by using peptide nucleic acid-assisted rolling-circle amplification and fluorescence in situ hybridization. Appl Environ Microbiol (2007) 1.49

The Complete Genome Sequences, Unique Mutational Spectra, and Developmental Potency of Adult Neurons Revealed by Cloning. Neuron (2016) 1.48

Allelic imbalance analysis by high-density single-nucleotide polymorphic allele (SNP) array with whole genome amplified DNA. Nucleic Acids Res (2004) 1.46

Conducting a microbiome study. Cell (2014) 1.46

Coupling amplified DNA from flow-sorted chromosomes to high-density SNP mapping in barley. BMC Genomics (2008) 1.45

Whole-genome haplotyping by dilution, amplification, and sequencing. Proc Natl Acad Sci U S A (2013) 1.44

Capturing single cell genomes of active polysaccharide degraders: an unexpected contribution of Verrucomicrobia. PLoS One (2012) 1.44

Hot and cold spots of recombination in the human genome: the reason we should find them and how this can be achieved. Am J Hum Genet (2003) 1.42

Single virus genomics: a new tool for virus discovery. PLoS One (2011) 1.41

Cell lineage analysis in human brain using endogenous retroelements. Neuron (2015) 1.39

Ice-COLD-PCR enables rapid amplification and robust enrichment for low-abundance unknown DNA mutations. Nucleic Acids Res (2010) 1.38

Targeted resequencing of candidate genes using selector probes. Nucleic Acids Res (2010) 1.37

Structural variation on the short arm of the human Y chromosome: recurrent multigene deletions encompassing Amelogenin Y. Hum Mol Genet (2006) 1.36

Digital isothermal quantification of nucleic acids via simultaneous chemical initiation of recombinase polymerase amplification reactions on SlipChip. Anal Chem (2011) 1.36

Effects of DNA mass on multiple displacement whole genome amplification and genotyping performance. BMC Biotechnol (2005) 1.36

Genome of the pathogen Porphyromonas gingivalis recovered from a biofilm in a hospital sink using a high-throughput single-cell genomics platform. Genome Res (2013) 1.35

Molecular analysis of patients with polycythemia vera or essential thrombocythemia receiving pegylated interferon α-2a. Blood (2013) 1.33

Single nucleotide polymorphism seeking long term association with complex disease. Nucleic Acids Res (2002) 1.33

A specific subdomain in phi29 DNA polymerase confers both processivity and strand-displacement capacity. Proc Natl Acad Sci U S A (2005) 1.33

SNP high-throughput screening in grapevine using the SNPlex genotyping system. BMC Plant Biol (2008) 1.33

Performance of amplified DNA in an Illumina GoldenGate BeadArray assay. Cancer Epidemiol Biomarkers Prev (2008) 1.32

Exploring whole genome amplification as a DNA recovery tool for molecular genetic studies. J Biomol Tech (2005) 1.32

Single-cell whole-genome amplification technique impacts the accuracy of SNP microarray-based genotyping and copy number analyses. Mol Hum Reprod (2010) 1.31

Amplification of whole tumor genomes and gene-by-gene mapping of genomic aberrations from limited sources of fresh-frozen and paraffin-embedded DNA. J Mol Diagn (2005) 1.29

Advances and applications of single-cell sequencing technologies. Mol Cell (2015) 1.28

DNA amplification method tolerant to sample degradation. Genome Res (2004) 1.28

Performance of high-throughput DNA quantification methods. BMC Biotechnol (2003) 1.27

Detection of chromosomal structural alterations in single cells by SNP arrays: a systematic survey of amplification bias and optimized workflow. PLoS One (2007) 1.25

Circumventing heterozygosity: sequencing the amplified genome of a single haploid Drosophila melanogaster embryo. Genetics (2011) 1.24

Articles cited by this

Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol (1975) 503.08

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science (1988) 220.77

Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science (1992) 16.38

Rapid amplification of plasmid and phage DNA using Phi 29 DNA polymerase and multiply-primed rolling circle amplification. Genome Res (2001) 10.55

Mutation detection and single-molecule counting using isothermal rolling-circle amplification. Nat Genet (1998) 9.84

Whole genome amplification from a single cell: implications for genetic analysis. Proc Natl Acad Sci U S A (1992) 9.15

Degenerate oligonucleotide-primed PCR: general amplification of target DNA by a single degenerate primer. Genomics (1992) 9.06

Highly efficient DNA synthesis by the phage phi 29 DNA polymerase. Symmetrical mode of DNA replication. J Biol Chem (1989) 7.18

Fidelity of phi 29 DNA polymerase. Comparison between protein-primed initiation and DNA polymerization. J Biol Chem (1993) 5.42

DNA polymerase fidelity and the polymerase chain reaction. PCR Methods Appl (1991) 4.31

Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells. Proc Natl Acad Sci U S A (1999) 3.74

Whole genome amplification using a degenerate oligonucleotide primer allows hundreds of genotypes to be performed on less than one nanogram of genomic DNA. Proc Natl Acad Sci U S A (1996) 3.15

High-throughput genotyping of single nucleotide polymorphisms with rolling circle amplification. BMC Genomics (2001) 2.25

Preimplantation diagnosis by whole-genome amplification, PCR amplification, and solid-phase minisequencing of blastomere DNA. Clin Chem (1996) 1.97

Detailed chromosomal and molecular genetic analysis of single cells by whole genome amplification and comparative genomic hybridisation. Nucleic Acids Res (1999) 1.94

Loss of heterozygosity analysis using whole genome amplification, cell sorting, and fluorescence-based PCR. Genome Res (1999) 1.90

Preimplantation single-cell analysis of multiple genetic loci by whole-genome amplification. Proc Natl Acad Sci U S A (1994) 1.90

Multipoint linkage map of the human pseudoautosomal region, based on single-sperm typing: do double crossovers occur during male meiosis? Am J Hum Genet (1994) 1.78

Whole genome amplification and high-throughput allelotyping identified five distinct deletion regions on chromosomes 5 and 6 in microdissected early-stage ovarian tumors. Cancer Res (2001) 1.61

HLA class II typing of whole genome amplified mouth swab DNA. Tissue Antigens (2000) 1.37

Long DOP-PCR of rare archival anthropological samples. Hum Biol (2000) 1.30

Whole genome amplification and molecular genetic analysis of DNA from paraffin-embedded prostate adenocarcinoma tumor tissue. J Urol (1999) 1.28

Recent advances and future developments in PGD. Prenat Diagn (1999) 1.26

Generation of whole-chromosome painting probes specific to each chicken macrochromosome. Cytogenet Cell Genet (1999) 1.20

Articles by these authors

Genome sequencing in microfabricated high-density picolitre reactors. Nature (2005) 150.21

The complete genome of an individual by massively parallel DNA sequencing. Nature (2008) 52.81

Alternative isoform regulation in human tissue transcriptomes. Nature (2008) 52.76

A core gut microbiome in obese and lean twins. Nature (2008) 52.30

Paired-end mapping reveals extensive structural variation in the human genome. Science (2007) 30.46

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (2009) 16.35

A metagenomic survey of microbes in honey bee colony collapse disorder. Science (2007) 11.72

Carrier testing for severe childhood recessive diseases by next-generation sequencing. Sci Transl Med (2011) 8.20

The genome of the domesticated apple (Malus × domestica Borkh.). Nat Genet (2010) 8.07

A new arenavirus in a cluster of fatal transplant-associated diseases. N Engl J Med (2008) 7.73

Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twins. Proc Natl Acad Sci U S A (2010) 7.09

A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing. Cell (2008) 6.98

Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing. Nat Med (2006) 6.96

A highly annotated whole-genome sequence of a Korean individual. Nature (2009) 6.91

Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biol Psychiatry (2007) 6.59

Unbiased whole-genome amplification directly from clinical samples. Genome Res (2003) 6.29

Analysis of one million base pairs of Neanderthal DNA. Nature (2006) 6.17

High-yield production of graphene by liquid-phase exfoliation of graphite. Nat Nanotechnol (2008) 5.64

Efficient de novo assembly of single-cell bacterial genomes from short-read data sets. Nat Biotechnol (2011) 5.60

Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa. PLoS Pathog (2009) 4.88

Transcriptome sequencing of malignant pleural mesothelioma tumors. Proc Natl Acad Sci U S A (2008) 4.75

Measurement and clinical monitoring of human lymphocyte clonality by massively parallel VDJ pyrosequencing. Sci Transl Med (2009) 4.71

Assessment of whole genome amplification-induced bias through high-throughput, massively parallel whole genome sequencing. BMC Genomics (2006) 4.55

Low-abundance drug-resistant viral variants in chronically HIV-infected, antiretroviral treatment-naive patients significantly impact treatment outcomes. J Infect Dis (2009) 4.48

Genomic DNA amplification from a single bacterium. Appl Environ Microbiol (2005) 4.25

Genomic sequencing of single microbial cells from environmental samples. Curr Opin Microbiol (2008) 3.99

Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature (2010) 3.90

Mosaic copy number variation in human neurons. Science (2013) 3.57

Dynamic transcriptomes during neural differentiation of human embryonic stem cells revealed by short, long, and paired-end sequencing. Proc Natl Acad Sci U S A (2010) 3.28

Serum protein markers for early detection of ovarian cancer. Proc Natl Acad Sci U S A (2005) 3.22

Whole genome amplification: abundant supplies of DNA from precious samples or clinical specimens. Trends Biotechnol (2003) 3.15

Ultra-deep pyrosequencing of hepatitis B virus quasispecies from nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI)-treated patients and NRTI-naive patients. J Infect Dis (2009) 3.08

Genomic insights to SAR86, an abundant and uncultivated marine bacterial lineage. ISME J (2011) 2.97

Multiplexed protein profiling on microarrays by rolling-circle amplification. Nat Biotechnol (2002) 2.86

Nanoliter reactors improve multiple displacement amplification of genomes from single cells. PLoS Genet (2007) 2.79

Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Nat Genet (2003) 2.78

Insights into the genome of large sulfur bacteria revealed by analysis of single filaments. PLoS Biol (2007) 2.69

Astrovirus encephalitis in boy with X-linked agammaglobulinemia. Emerg Infect Dis (2010) 2.69

Wasp gene expression supports an evolutionary link between maternal behavior and eusociality. Science (2007) 2.60

Individual variation in the germline Ig gene repertoire inferred from variable region gene rearrangements. J Immunol (2010) 2.36

Nearly finished genomes produced using gel microdroplet culturing reveal substantial intraspecies genomic diversity within the human microbiome. Genome Res (2013) 2.29

Targeted metagenomics and ecology of globally important uncultured eukaryotic phytoplankton. Proc Natl Acad Sci U S A (2010) 2.26

An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med (2013) 2.23

Two methods of whole-genome amplification enable accurate genotyping across a 2320-SNP linkage panel. Genome Res (2004) 2.22

Genomic convergence analysis of schizophrenia: mRNA sequencing reveals altered synaptic vesicular transport in post-mortem cerebellum. PLoS One (2008) 2.22

Novel borna virus in psittacine birds with proventricular dilatation disease. Emerg Infect Dis (2008) 2.10

Just what the doctor ordered. Review of the evidence of the impact of computerized physician order entry system on medication errors. Health Serv Res (2008) 2.05

Specific single-cell isolation and genomic amplification of uncultured microorganisms. Appl Microbiol Biotechnol (2006) 2.01

Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees. PLoS Pathog (2009) 1.97

Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. J Exp Med (2011) 1.97

Expression and functional significance of Twist1 in hepatocellular carcinoma: its role in vasculogenic mimicry. Hepatology (2010) 1.96

Whole-genome comparison reveals novel genetic elements that characterize the genome of industrial strains of Saccharomyces cerevisiae. PLoS Genet (2011) 1.94

Low-abundance HIV drug-resistant viral variants in treatment-experienced persons correlate with historical antiretroviral use. PLoS One (2009) 1.91

Generation of an inbred miniature pig model of retinitis pigmentosa. Invest Ophthalmol Vis Sci (2012) 1.87

Management of High-Throughput DNA Sequencing Projects: Alpheus. J Comput Sci Syst Biol (2008) 1.85

Prevalence and clinical significance of HIV drug resistance mutations by ultra-deep sequencing in antiretroviral-naïve subjects in the CASTLE study. PLoS One (2010) 1.83

Something from (almost) nothing: the impact of multiple displacement amplification on microbial ecology. ISME J (2008) 1.79

Evidence for selective microRNAs and their effectors as common long-term targets for the actions of mood stabilizers. Neuropsychopharmacology (2008) 1.79

Minority variants associated with transmitted and acquired HIV-1 nonnucleoside reverse transcriptase inhibitor resistance: implications for the use of second-generation nonnucleoside reverse transcriptase inhibitors. J Acquir Immune Defic Syndr (2009) 1.73

Cerebral palsy is characterized by protein mediators in cord serum. Ann Neurol (2004) 1.73

A highly specific and discriminatory FISH assay for distinguishing between benign and malignant melanocytic neoplasms. Am J Surg Pathol (2012) 1.73

A full-coverage, high-resolution human chromosome 22 genomic microarray for clinical and research applications. Hum Mol Genet (2002) 1.69

Candidate phylum TM6 genome recovered from a hospital sink biofilm provides genomic insights into this uncultivated phylum. Proc Natl Acad Sci U S A (2013) 1.69

Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis. J Clin Microbiol (2009) 1.63

Identification of a severe acute respiratory syndrome coronavirus-like virus in a leaf-nosed bat in Nigeria. MBio (2010) 1.62

Genome sequencing and mapping reveal loss of heterozygosity as a mechanism for rapid adaptation in the vegetable pathogen Phytophthora capsici. Mol Plant Microbe Interact (2012) 1.59

Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus. PLoS One (2010) 1.58

Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis. Nat Genet (2013) 1.57

Disease progression in hemodynamically stable patients presenting to the emergency department with sepsis. Acad Emerg Med (2010) 1.54

Obesity-related upregulation of monocyte chemotactic factors in adipocytes: involvement of nuclear factor-kappaB and c-Jun NH2-terminal kinase pathways. Diabetes (2008) 1.52

Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion. J Clin Invest (2009) 1.48

In vitro fabrication of a tissue engineered human cardiovascular patch for future use in cardiovascular surgery. Ann Thorac Surg (2006) 1.47

A host-based RT-PCR gene expression signature to identify acute respiratory viral infection. Sci Transl Med (2013) 1.46

Erythropoietin protects against diabetes through direct effects on pancreatic beta cells. J Exp Med (2010) 1.44

The DnaC helicase loader is a dual ATP/ADP switch protein. EMBO J (2002) 1.42

Human metapneumovirus infection in wild mountain gorillas, Rwanda. Emerg Infect Dis (2011) 1.42

Identification of GBV-D, a novel GB-like flavivirus from old world frugivorous bats (Pteropus giganteus) in Bangladesh. PLoS Pathog (2010) 1.42

Single virus genomics: a new tool for virus discovery. PLoS One (2011) 1.41

Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula. Proc Natl Acad Sci U S A (2011) 1.40

Earliest evidence for commensal processes of cat domestication. Proc Natl Acad Sci U S A (2013) 1.40

High-resolution antibody dynamics of vaccine-induced immune responses. Proc Natl Acad Sci U S A (2014) 1.39

Ibrutinib treatment ameliorates murine chronic graft-versus-host disease. J Clin Invest (2014) 1.38

A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2. PLoS One (2013) 1.37

Progressive genome-wide introgression in agricultural Campylobacter coli. Mol Ecol (2012) 1.37

Genome of the pathogen Porphyromonas gingivalis recovered from a biofilm in a hospital sink using a high-throughput single-cell genomics platform. Genome Res (2013) 1.35

Protein microarray analysis of disease activity in pediatric inflammatory bowel disease demonstrates elevated serum PLGF, IL-7, TGF-beta1, and IL-12p40 levels in Crohn's disease and ulcerative colitis patients in remission versus active disease. Am J Gastroenterol (2005) 1.34

Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation. J Immunol (2004) 1.33

Site-directed recombination via bifunctional PNA-DNA conjugates. Proc Natl Acad Sci U S A (2002) 1.32

Cytokine expression patterns associated with systemic adverse events following smallpox immunization. J Infect Dis (2006) 1.29