Published in J Neurosci on May 01, 2002
The GSK3 hypothesis of Alzheimer's disease. J Neurochem (2007) 3.16
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron (2009) 2.72
Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1. Proc Natl Acad Sci U S A (2003) 1.89
State-dependent Ras signaling and AMPA receptor trafficking. Genes Dev (2005) 1.86
AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli. Biol Psychiatry (2008) 1.60
Long-term potentiation: outstanding questions and attempted synthesis. Philos Trans R Soc Lond B Biol Sci (2003) 1.49
PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane. Nat Neurosci (2009) 1.36
Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity. Learn Mem (2008) 1.35
Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions. J Neurosci (2008) 1.34
PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility. Nat Neurosci (2011) 1.28
PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression. EMBO J (2010) 1.26
Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity. Cell Adh Migr (2008) 1.24
AMPA-receptor activation regulates the diffusion of a membrane marker in parallel with dendritic spine motility in the mouse hippocampus. J Physiol (2004) 1.22
NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. EMBO J (2011) 1.15
BDNF variant Val66Met interacts with estrous cycle in the control of hippocampal function. Proc Natl Acad Sci U S A (2010) 1.15
Leptin induces a novel form of NMDA receptor-dependent long-term depression. J Neurochem (2005) 1.14
Freud-1/Aki1, a novel PDK1-interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling. Mol Cell Biol (2008) 1.13
Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis. J Neurosci (2009) 1.12
NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia. Front Cell Neurosci (2013) 1.12
Small G protein signaling in neuronal plasticity and memory formation: the specific role of ras family proteins. Neuron (2010) 1.12
PKCλ is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP. EMBO J (2013) 1.10
Ca(2+) permeable AMPA receptor induced long-term potentiation requires PI3/MAP kinases but not Ca/CaM-dependent kinase II. PLoS One (2009) 1.09
Regulation of psychostimulant-induced signaling and gene expression in the striatum. J Neurochem (2008) 1.07
AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors. Biol Psychiatry (2011) 1.07
Estradiol acts via estrogen receptors alpha and beta on pathways important for synaptic plasticity in the mouse hippocampal formation. Neuroscience (2011) 1.05
Calpain-2-mediated PTEN degradation contributes to BDNF-induced stimulation of dendritic protein synthesis. J Neurosci (2013) 1.02
Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase. J Neurosci (2012) 1.01
A model of the roles of essential kinases in the induction and expression of late long-term potentiation. Biophys J (2006) 1.00
The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity. EMBO J (2007) 0.95
Signalling pathways underlying structural plasticity of dendritic spines. Br J Pharmacol (2011) 0.95
GSK3 Function in the Brain during Development, Neuronal Plasticity, and Neurodegeneration. Int J Alzheimers Dis (2011) 0.94
Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity. PLoS One (2012) 0.92
Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3. J Physiol (2005) 0.90
Simvastatin enhances hippocampal long-term potentiation in C57BL/6 mice. Neuroscience (2009) 0.90
Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase. PLoS One (2010) 0.89
PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression. EMBO J (2011) 0.89
Protein kinase B/Akt is required for complete Freund's adjuvant-induced upregulation of Nav1.7 and Nav1.8 in primary sensory neurons. J Pain (2013) 0.89
Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats. Mol Neurodegener (2014) 0.87
Role of phosphoinositides at the neuronal synapse. Subcell Biochem (2012) 0.87
Nucleotide sequence variation within the PI3K p85 alpha gene associates with alcohol risk drinking behaviour in adolescents. PLoS One (2008) 0.87
Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase. Front Mol Neurosci (2012) 0.86
A potential role for adiponectin receptor 2 (AdipoR2) in the regulation of alcohol intake. Brain Res (2010) 0.85
Effects of estrogen and aging on the synaptic distribution of phosphorylated Akt-immunoreactivity in the CA1 region of the female rat hippocampus. Brain Res (2010) 0.85
Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus. Proc Natl Acad Sci U S A (2013) 0.85
PI3K/Akt signaling pathway in the basolateral amygdala mediates the rapid antidepressant-like effects of trefoil factor 3. Neuropsychopharmacology (2012) 0.85
Effects of relative hypoglycemia on LTP and NADH imaging in rat hippocampal slices. Brain Res (2007) 0.83
Learning improvement after PI3K activation correlates with de novo formation of functional small spines. Front Mol Neurosci (2014) 0.82
Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes. Front Pharmacol (2015) 0.80
Molecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisal. World J Diabetes (2015) 0.80
The different roles of cyclinD1-CDK4 in STP and mGluR-LTD during the postnatal development in mice hippocampus area CA1. BMC Dev Biol (2007) 0.80
Signaling mechanisms involved in the acute effects of estradiol on 5-HT clearance. Int J Neuropsychopharmacol (2014) 0.80
Early growth response-1 induction by fibroblast growth factor-1 via increase of mitogen-activated protein kinase and inhibition of protein kinase B in hippocampal neurons. Br J Pharmacol (2010) 0.80
Genetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-γ (PI3Kγ). Mol Pain (2011) 0.79
Structural basis of PI(4,5)P2-dependent regulation of GluA1 by phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP5K2A). Pflugers Arch (2014) 0.79
Intrahippocampal wortmannin infusion enhances long-term spatial and contextual memories. Learn Mem (2002) 0.79
Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity. Mil Med Res (2016) 0.78
Expression profiling reveals differential gene induction underlying specific and non-specific memory for pheromones in mice. Neurochem Int (2011) 0.77
PTEN: A master regulator of neuronal structure, function, and plasticity. Commun Integr Biol (2014) 0.77
Function of insulin in snail brain in associative learning. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2015) 0.77
The Activity-Induced Long Non-Coding RNA Meg3 Modulates AMPA Receptor Surface Expression in Primary Cortical Neurons. Front Cell Neurosci (2017) 0.75
The PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia. Mol Cell Ther (2016) 0.75
Dynamical properties of gene regulatory networks involved in long-term potentiation. Front Mol Neurosci (2015) 0.75
PI3-kinase cascade has a differential role in acquisition and extinction of conditioned fear memory in juvenile and adult rats. Learn Mem (2016) 0.75
Modulation of BK channels contributes to activity-dependent increase of excitability through MTORC1 activity in CA1 pyramidal cells of mouse hippocampus. Front Cell Neurosci (2015) 0.75
15-deoxy-Δ12,14-prostaglandin J2 in neurodegenerative diseases and cancers. Oncotarget (2017) 0.75
Dynamic Akt/mTOR Signaling in Children with Autism Spectrum Disorder. Front Pediatr (2017) 0.75
Elevated RalA activity in the hippocampus of PI3Kγ knock-out mice lacking NMDAR-dependent long-term depression. BMB Rep (2013) 0.75
Mice deficient in lysophosphatidic acid acyltransferase δ (Lpaatδ)/ acylglycerophosphate acyltransferase 4 (Agpat4) have impairments in spatial learning and memory associated with reductions in NMDA and AMPA receptors. Mol Cell Biol (2017) 0.75
Synaptically driven phosphorylation of ribosomal protein S6 is differentially regulated at active synapses versus dendrites and cell bodies by MAPK and PI3K/mTOR signaling pathways. Learn Mem (2017) 0.75
Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2006) 3.61
Adult mouse brain gene expression patterns bear an embryologic imprint. Proc Natl Acad Sci U S A (2005) 2.46
Distribution of histone deacetylases 1-11 in the rat brain. J Mol Neurosci (2007) 2.44
Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1. Proc Natl Acad Sci U S A (2003) 1.89
Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis. Proc Natl Acad Sci U S A (2003) 1.86
Peripheral reduction of β-amyloid is sufficient to reduce brain β-amyloid: implications for Alzheimer's disease. J Neurosci Res (2011) 1.80
An integrative, multidisciplinary approach to the study of brain-behavior relations in the context of typical and atypical development. Dev Psychopathol (2002) 1.37
Amyloid deposition in the hippocampus and entorhinal cortex: quantitative analysis of a transgenic mouse model. Proc Natl Acad Sci U S A (2003) 1.37
ERK regulation in chronic ethanol exposure and withdrawal. Brain Res (2002) 1.27
Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: digital morphometric analyses. Proc Natl Acad Sci U S A (2004) 1.20
Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction. Proc Natl Acad Sci U S A (2005) 1.18
Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis. J Neurosci (2009) 1.12
Role of the adrenergic system in a mouse model of oxygen-induced retinopathy: antiangiogenic effects of beta-adrenoreceptor blockade. Invest Ophthalmol Vis Sci (2011) 1.01
Discriminators of mouse bladder response to intravesical Bacillus Calmette-Guerin (BCG). BMC Immunol (2007) 0.99
High-throughput morphometric analysis of individual neurons. Cereb Cortex (2004) 0.98
VEGF receptors and neuropilins are expressed in the urothelial and neuronal cells in normal mouse urinary bladder and are upregulated in inflammation. Am J Physiol Renal Physiol (2008) 0.98
The metabotropic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region. Brain Res (2004) 0.98
HIV secreted protein Tat prevents long-term potentiation in the hippocampal CA1 region. Brain Res (2004) 0.93
Regulatory network of inflammation downstream of proteinase-activated receptors. BMC Physiol (2007) 0.93
Discovery of 1,5-disubstituted pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor. ACS Chem Neurosci (2010) 0.93
Lymphatic vessel density and function in experimental bladder cancer. BMC Cancer (2007) 0.91
Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation. BMC Physiol (2007) 0.91
New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones. Bioorg Med Chem Lett (2010) 0.91
Increased expression of protein kinase A inhibitor alpha (PKI-alpha) and decreased PKA-regulated genes in chronic intermittent alcohol exposure. Brain Res (2007) 0.89
Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alpha. BMC Immunol (2008) 0.89
Neuropilin-VEGF signaling pathway acts as a key modulator of vascular, lymphatic, and inflammatory cell responses of the bladder to intravesical BCG treatment. Am J Physiol Renal Physiol (2010) 0.87
Intrinsic neuronal plasticity in the juxtacapsular nucleus of the bed nuclei of the stria terminalis (jcBNST). Prog Neuropsychopharmacol Biol Psychiatry (2009) 0.87
Consistency and diversity of spike dynamics in the neurons of bed nucleus of stria terminalis of the rat: a dynamic clamp study. PLoS One (2010) 0.86
Antiangiogenic role of somatostatin receptor 2 in a model of hypoxia-induced neovascularization in the retina: results from transgenic mice. Invest Ophthalmol Vis Sci (2007) 0.86
Bladder inflammatory transcriptome in response to tachykinins: neurokinin 1 receptor-dependent genes and transcription regulatory elements. BMC Urol (2007) 0.85
A potential role for adiponectin receptor 2 (AdipoR2) in the regulation of alcohol intake. Brain Res (2010) 0.85
Transcription factor network downstream of protease activated receptors (PARs) modulating mouse bladder inflammation. BMC Immunol (2007) 0.85
Presynaptic modulation of spontaneous inhibitory postsynaptic currents by gamma-hydroxybutyrate in the substantia nigra pars compacta. Neuropsychopharmacology (2004) 0.83
Mechanisms underlying somatostatin receptor 2 down-regulation of vascular endothelial growth factor expression in response to hypoxia in mouse retinal explants. J Pathol (2011) 0.82
Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor. J Med Chem (2012) 0.82
Repeated BCG treatment of mouse bladder selectively stimulates small GTPases and HLA antigens and inhibits single-spanning uroplakins. BMC Cancer (2007) 0.80
Effects of somatostatin analogues on retinal angiogenesis in a mouse model of oxygen-induced retinopathy: involvement of the somatostatin receptor subtype 2. Invest Ophthalmol Vis Sci (2009) 0.80
Binding and functional properties of the novel somatostatin analogue KE 108 at native mouse somatostatin receptors. Neuropharmacology (2005) 0.79
Excitability of jcBNST neurons is reduced in alcohol-dependent animals during protracted alcohol withdrawal. PLoS One (2012) 0.79
Gamma-hydroxybutyrate reduces GABA(A)-mediated inhibitory postsynaptic potentials in the CA1 region of hippocampus. Neuropsychopharmacology (2002) 0.79
Standardized quantitative in situ hybridization using radioactive oligonucleotide probes for detecting relative levels of mRNA transcripts verified by real-time PCR. Brain Res (2004) 0.78
Gamma-hydroxybutyrate and ethanol depress spontaneous excitatory postsynaptic currents in dopaminergic neurons of the substantia nigra. Brain Res (2004) 0.78
Involvement of the cAMP-dependent pathway in the reduction of epileptiform bursting caused by somatostatin in the mouse hippocampus. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.76
New prospects and strategies for drug target discovery in neurodegenerative disorders. NeuroRx (2005) 0.75
The cyclooxygenase-2/prostaglandin E2 pathway is involved in the somatostatin-induced decrease of epileptiform bursting in the mouse hippocampus. Neuropharmacology (2008) 0.75
Stress, coping, and disease. Brain Res (2009) 0.75
Nurse Practitioners bridge care gap, reduce ER visits for residents in supportive living. Alta RN (2013) 0.75
Keynote Address. Ann N Y Acad Sci (1998) 0.75