Published in J Immunol on May 15, 2002
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell (2007) 8.94
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci U S A (2003) 5.01
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol (2009) 4.31
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol (2003) 4.31
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A (2004) 3.93
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem J (2004) 3.92
Class I PI3K in oncogenic cellular transformation. Oncogene (2008) 3.90
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J Exp Med (2006) 3.78
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. J Clin Invest (2005) 3.66
FOXOs, cancer and regulation of apoptosis. Oncogene (2008) 3.02
An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. Immunity (2009) 2.82
Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction. J Exp Med (2006) 2.65
Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory. Immunity (2008) 2.56
The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol (2010) 2.53
Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells. Cancer Res (2010) 2.42
Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nat Immunol (2009) 2.32
Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A. Mol Cell Biol (2003) 2.20
Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell (2008) 2.16
Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1. Nat Immunol (2007) 1.97
Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. Mol Cell Biol (2007) 1.96
MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer. J Natl Cancer Inst (2010) 1.94
Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer. J Mol Signal (2010) 1.94
The cunning little vixen: Foxo and the cycle of life and death. Nat Immunol (2009) 1.91
A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection. Blood (2008) 1.69
Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival. Blood (2007) 1.64
FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70. Am J Physiol Cell Physiol (2009) 1.64
Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice. J Clin Invest (2012) 1.63
FOXO transcription factors throughout T cell biology. Nat Rev Immunol (2012) 1.60
Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis. Int J Oncol (2006) 1.58
Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma. Blood (2006) 1.58
The metabolic life and times of a T-cell. Immunol Rev (2010) 1.57
Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J Biol Chem (2008) 1.46
Organ size control by Hippo and TOR pathways. Curr Biol (2012) 1.45
FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf. Genes Dev (2007) 1.43
p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1. Proc Natl Acad Sci U S A (2004) 1.43
Cardiac aging: from molecular mechanisms to significance in human health and disease. Antioxid Redox Signal (2012) 1.40
Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia. Blood (2009) 1.40
IL-7 promotes T cell proliferation through destabilization of p27Kip1. J Exp Med (2006) 1.40
LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis. Dev Cell (2009) 1.39
Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a. Proc Natl Acad Sci U S A (2006) 1.37
Bim and Bmf in tissue homeostasis and malignant disease. Oncogene (2008) 1.36
PP2A regulates the pro-apoptotic activity of FOXO1. J Biol Chem (2008) 1.36
Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy. J Clin Invest (2004) 1.34
The FoxO family in cardiac function and dysfunction. Annu Rev Physiol (2010) 1.33
Forkhead box transcription factor FOXO3a suppresses estrogen-dependent breast cancer cell proliferation and tumorigenesis. Breast Cancer Res (2008) 1.30
Foxo3a induces motoneuron death through the Fas pathway in cooperation with JNK. BMC Neurosci (2004) 1.29
Forkhead transcription factors and cardiovascular biology. Circ Res (2008) 1.28
PUMA and BIM are required for oncogene inactivation-induced apoptosis. Sci Signal (2013) 1.28
Diabetic Cardiomyopathy: Mechanisms and Therapeutic Targets. Drug Discov Today Dis Mech (2010) 1.28
T cells require Foxo1 to populate the peripheral lymphoid organs. Eur J Immunol (2009) 1.27
Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis. J Clin Invest (2011) 1.27
The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells. Proc Natl Acad Sci U S A (2006) 1.23
STAT3 protein promotes T-cell survival and inhibits interleukin-2 production through up-regulation of Class O Forkhead transcription factors. J Biol Chem (2011) 1.22
FOXO3 regulates CD8 T cell memory by T cell-intrinsic mechanisms. PLoS Pathog (2012) 1.22
Regulation of expression of Bcl-2 protein family member Bim by T cell receptor triggering. Proc Natl Acad Sci U S A (2004) 1.20
Constitutively active Rheb induces oncogenic transformation. Oncogene (2008) 1.20
Apoptosis of CD4+ CD25(high) T cells in type 1 diabetes may be partially mediated by IL-2 deprivation. PLoS One (2009) 1.19
Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization. Am J Pathol (2005) 1.18
Evading apoptosis in cancer. Trends Cell Biol (2013) 1.17
ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation. Immunity (2015) 1.17
PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells. Cell Death Dis (2013) 1.16
Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cells. Curr Opin Immunol (2013) 1.16
A major role for Bim in regulatory T cell homeostasis. J Immunol (2010) 1.15
Autophagy and cell growth--the yin and yang of nutrient responses. J Cell Sci (2012) 1.14
Interlinking interleukin-7. Cytokine (2007) 1.14
FoxO tumor suppressors and BCR-ABL-induced leukemia: a matter of evasion of apoptosis. Biochim Biophys Acta (2007) 1.13
Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression. Mol Cell Biol (2007) 1.12
p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes. Circ Res (2009) 1.12
LY294002 and rapamycin co-operate to inhibit T-cell proliferation. Br J Pharmacol (2005) 1.11
ERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway: implication of p27kip1 in cell response to oxidative stress. Mol Biol Cell (2005) 1.11
Antagonism between FOXO and MYC Regulates Cellular Powerhouse. Front Oncol (2013) 1.10
Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death. EMBO Rep (2012) 1.10
Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad. Blood (2009) 1.10
Myc and PI3K/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45a gene expression. Nucleic Acids Res (2011) 1.09
Inhibition of IkappaB kinase alpha (IKKα) or IKKbeta (IKKβ) plus forkhead box O (Foxo) abolishes skeletal muscle atrophy. Biochem Biophys Res Commun (2011) 1.09
Synaptic activity and nuclear calcium signaling protect hippocampal neurons from death signal-associated nuclear translocation of FoxO3a induced by extrasynaptic N-methyl-D-aspartate receptors. J Biol Chem (2010) 1.09
Global remodeling of the vascular stem cell niche in bone marrow of diabetic patients: implication of the microRNA-155/FOXO3a signaling pathway. Circ Res (2012) 1.09
Highly specialized role of Forkhead box O transcription factors in the immune system. Antioxid Redox Signal (2010) 1.08
The Epstein-Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim. Proc Natl Acad Sci U S A (2009) 1.08
Content-based microarray search using differential expression profiles. BMC Bioinformatics (2010) 1.07
Regulation of B-cell entry into the cell cycle. Immunol Rev (2008) 1.06
Targeting Akt3 signaling in triple-negative breast cancer. Cancer Res (2013) 1.06
Endothelin-1 couples betaPix to p66Shc: role of betaPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt. Mol Biol Cell (2008) 1.04
Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus. Cell Death Differ (2009) 1.03
Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies. J Gerontol A Biol Sci Med Sci (2012) 1.02
Regulation of FOXO1 by TAK1-Nemo-like kinase pathway. J Biol Chem (2010) 1.02
Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2-mediated reversal of T-cell tolerance. Proc Natl Acad Sci U S A (2012) 1.02
Apoptosis in gingival overgrowth tissues. J Dent Res (2007) 1.01
Herpesvirus entry mediator (TNFRSF14) regulates the persistence of T helper memory cell populations. J Exp Med (2011) 1.01
Redox regulation of T-cell function: from molecular mechanisms to significance in human health and disease. Antioxid Redox Signal (2012) 1.01
Wnt/β-catenin signaling protects mouse liver against oxidative stress-induced apoptosis through the inhibition of forkhead transcription factor FoxO3. J Biol Chem (2013) 1.00
Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer. Cell Biosci (2014) 1.00
miR-93 promotes cell proliferation in gliomas through activation of PI3K/Akt signaling pathway. Oncotarget (2015) 0.99
Co-depletion of cathepsin B and uPAR induces G0/G1 arrest in glioma via FOXO3a mediated p27 upregulation. PLoS One (2010) 0.98
The phosphatidylinositol-3-kinase inhibitor NVP-BKM120 overcomes resistance signals derived from microenvironment by regulating the Akt/FoxO3a/Bim axis in chronic lymphocytic leukemia cells. Haematologica (2013) 0.98
Bimodal regulation of FoxO3 by AKT and 14-3-3. Biochim Biophys Acta (2011) 0.98
Oxidative stress stimulates testicular orphan receptor 4 through forkhead transcription factor forkhead box O3a. Endocrinology (2008) 0.98
Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects. J Immunol (2010) 0.98
Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations. Proc Natl Acad Sci U S A (2012) 0.97
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature (2002) 7.88
FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat Cell Biol (2005) 7.02
Cell cycle and death control: long live Forkheads. Trends Biochem Sci (2002) 4.87
Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol (2007) 4.73
Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science (2005) 4.61
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J (2004) 4.57
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature (2008) 4.33
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol (2003) 4.31
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP. Nat Cell Biol (2006) 4.14
Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates. Science (2009) 4.10
Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer (2010) 3.74
FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell (2011) 3.58
The decision to enter mitosis: feedback and redundancy in the mitotic entry network. J Cell Biol (2009) 3.48
FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem (2003) 3.41
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem (2004) 3.39
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell (2008) 3.38
Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science (2011) 3.29
Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Mol Cell Biol (2002) 3.20
Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J Cell Biol (2003) 3.15
FoxM1: at the crossroads of ageing and cancer. Biochim Biophys Acta (2006) 2.98
Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty. J Leukoc Biol (2003) 2.90
FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J Cell Biol (2002) 2.86
The Aurora kinase family in cell division and cancer. Biochim Biophys Acta (2008) 2.84
Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol Cell Biol (2002) 2.84
FOXOs: signalling integrators for homeostasis maintenance. Nat Rev Mol Cell Biol (2013) 2.83
Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. Oncogene (2005) 2.80
Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J (2003) 2.70
Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. Mol Cell (2004) 2.64
Forkhead-box transcription factors and their role in the immune system. Nat Rev Immunol (2004) 2.62
Polo-like kinases: a team in control of the division. Cell Cycle (2006) 2.62
Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization. Blood (2009) 2.49
Getting in and out of mitosis with Polo-like kinase-1. Oncogene (2005) 2.44
Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis. J Biol Chem (2004) 2.37
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol (2010) 2.26
Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins. EMBO J (2004) 2.19
Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt. Cancer Res (2006) 2.13
Kif15 cooperates with eg5 to promote bipolar spindle assembly. Curr Biol (2009) 2.10
The chromosomal passenger complex: guiding Aurora-B through mitosis. J Cell Biol (2006) 2.07
Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry. PLoS Biol (2010) 2.07
Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity. Immunity (2013) 2.05
The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. J Biol Chem (2009) 2.05
Unravelling the tumor-suppressive functions of FOXO proteins. Trends Cell Biol (2008) 2.05
Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells. Proc Natl Acad Sci U S A (2009) 2.04
Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery. Curr Biol (2006) 2.02
Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. EMBO Rep (2006) 1.82
Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly. EMBO J (2008) 1.81
Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis. J Cell Sci (2011) 1.79
Integration of kinase and phosphatase activities by BUBR1 ensures formation of stable kinetochore-microtubule attachments. Dev Cell (2012) 1.77
Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor. Immunity (2013) 1.75
Mechanisms of centrosome separation and bipolar spindle assembly. Dev Cell (2010) 1.70
Activation of FoxM1 during G2 requires cyclin A/Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain. Mol Cell Biol (2008) 1.67
Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy. Nat Cell Biol (2012) 1.63
FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism. Mol Cell Biol (2004) 1.63
Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy. Blood (2012) 1.61
The survivin/Aurora B complex: its role in coordinating tension and attachment. Cell Cycle (2003) 1.61
MAPK signaling pathways in the regulation of hematopoiesis. J Leukoc Biol (2009) 1.60
Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis. Nat Commun (2011) 1.59
The case for Survivin as mitotic regulator. Curr Opin Cell Biol (2006) 1.59
The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase. Dev Cell (2012) 1.55
The role of the PI3K-PKB signaling module in regulation of hematopoiesis. Cell Cycle (2009) 1.55
HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation. Blood (2008) 1.54
Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease. J Cell Biol (2011) 1.53
Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint. J Cell Biol (2013) 1.52
FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1. J Cell Biol (2004) 1.51
Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis. PLoS One (2010) 1.50
Ablation of the spindle assembly checkpoint by a compound targeting Mps1. EMBO Rep (2005) 1.49
The extending network of FOXO transcriptional target genes. Antioxid Redox Signal (2010) 1.49
CLIP-170 facilitates the formation of kinetochore-microtubule attachments. EMBO J (2005) 1.47
Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis. J Clin Invest (2014) 1.45
FOXO transcription factors as regulators of immune homeostasis: molecules to die for? J Immunol (2003) 1.44
RAMA1 is a novel kinetochore protein involved in kinetochore-microtubule attachment. J Cell Sci (2009) 1.44
Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes. PLoS One (2008) 1.43
A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis. Curr Biol (2011) 1.41
FOXO3a induces differentiation of Bcr-Abl-transformed cells through transcriptional down-regulation of Id1. J Biol Chem (2006) 1.40
Respiratory syncytial virus inhibits granulocyte apoptosis through a phosphatidylinositol 3-kinase and NF-kappaB-dependent mechanism. J Immunol (2006) 1.40
Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity. Nat Chem Biol (2009) 1.40
Phosphatidylinositol 4-kinasebeta is critical for functional association of rab11 with the Golgi complex. Mol Biol Cell (2004) 1.39
Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors. Mol Cell Biol (2007) 1.38
A TPR domain-containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B. J Cell Biol (2013) 1.38
The ins and outs of syntenin, a multifunctional intracellular adaptor protein. J Cell Sci (2008) 1.38
Evolution and function of the mitotic checkpoint. Dev Cell (2012) 1.38
FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner. Cell Cycle (2008) 1.37
A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. Curr Biol (2011) 1.36