Published in Proc Natl Acad Sci U S A on May 14, 2002
Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system. Adv Anat Embryol Cell Biol (2012) 2.99
The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland. Invest Ophthalmol Vis Sci (2011) 2.44
Key role of CRF in the skin stress response system. Endocr Rev (2013) 1.77
Differential expression of HPA axis homolog in the skin. Mol Cell Endocrinol (2006) 1.72
Steroidogenesis in the skin: implications for local immune functions. J Steroid Biochem Mol Biol (2013) 1.71
Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation. Am J Physiol Endocrinol Metab (2011) 1.58
Differential expression of a cutaneous corticotropin-releasing hormone system. Endocrinology (2003) 1.46
Corticotropin releasing hormone and the skin. Front Biosci (2006) 1.45
CRH functions as a growth factor/cytokine in the skin. J Cell Physiol (2006) 1.38
Neuroendocrine system of the skin. Dermatology (2005) 1.24
Skin as an endocrine organ: implications for its function. Drug Discov Today Dis Mech (2008) 1.19
Culture, immortalization, and characterization of human meibomian gland epithelial cells. Invest Ophthalmol Vis Sci (2010) 1.11
On the role of the corticotropin-releasing hormone signalling system in the aetiology of inflammatory skin disorders. Br J Dermatol (2009) 1.02
An update on the role of the sebaceous gland in the pathogenesis of acne. Dermatoendocrinol (2011) 1.02
On the role of skin in the regulation of local and systemic steroidogenic activities. Steroids (2015) 1.01
Emerging role of alternative splicing of CRF1 receptor in CRF signaling. Acta Biochim Pol (2010) 0.97
Brain-skin connection: stress, inflammation and skin aging. Inflamm Allergy Drug Targets (2014) 0.95
CRH mediates inflammation induced by lipopolysaccharide in human adult epidermal keratinocytes. J Invest Dermatol (2006) 0.94
Modulation of the human hair follicle pigmentary unit by corticotropin-releasing hormone and urocortin peptides. FASEB J (2006) 0.90
Identification of biomarkers of human skin ageing in both genders. Wnt signalling - a label of skin ageing? PLoS One (2012) 0.90
"Sebocytes' makeup": novel mechanisms and concepts in the physiology of the human sebaceous glands. Pflugers Arch (2011) 0.87
The role of neuropeptides in the multifactorial pathogenesis of acne vulgaris. Dermatoendocrinol (2009) 0.84
Sebaceous gland receptors. Dermatoendocrinol (2009) 0.83
Hormones and the pilosebaceous unit. Dermatoendocrinol (2009) 0.81
Neuroendocrinology of the skin: An overview and selective analysis. Dermatoendocrinol (2011) 0.81
Dermatological problems of the puberty. Postepy Dermatol Alergol (2013) 0.81
New perspectives on antiacne plant drugs: contribution to modern therapeutics. Biomed Res Int (2014) 0.80
Commentary on the practical guide for the study of sebaceous glands. Exp Dermatol (2013) 0.78
Hormesis [biological effects of low level exposures (BELLE)] and dermatology. Dose Response (2008) 0.76
Cutaneous induction of corticotropin releasing hormone by Propionibacterium acnes extracts. Dermatoendocrinol (2009) 0.76
Acne and smoking. Dermatoendocrinol (2009) 0.76
The blemishes of modern society? Acne prevalence in the Dogon of Mali. Evol Med Public Health (2016) 0.75
Neuroendocrine regulators: Novel trends in sebaceous gland research with future perspectives for the treatment of acne and related disorders. Dermatoendocrinol (2009) 0.75
The scientific legacy of Stephen Rothman. J Invest Dermatol (2014) 0.75
Neuroendocrinology of the skin. Endocr Rev (2000) 3.34
Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev (2000) 2.98
Stressors, stress, and neuroendocrine integration of the adaptive response. The 1997 Hans Selye Memorial Lecture. Ann N Y Acad Sci (1998) 1.96
Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin, and CRH receptors. FASEB J (2001) 1.74
Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates. Proc Natl Acad Sci U S A (2000) 1.69
Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression. FASEB J (2001) 1.59
Intraadrenal interactions in the regulation of adrenocortical steroidogenesis. Endocr Rev (1998) 1.58
Role of hormones in pilosebaceous unit development. Endocr Rev (2000) 1.46
Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95). J Invest Dermatol (1999) 1.43
Cutaneous expression of CRH and CRH-R. Is there a "skin stress response system?". Ann N Y Acad Sci (1999) 1.18
Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls. Mol Psychiatry (2001) 1.09
Corticotropin-releasing hormone directly and preferentially stimulates dehydroepiandrosterone sulfate secretion by human fetal adrenal cortical cells. J Clin Endocrinol Metab (1998) 1.09
Sebocytes are the key regulators of androgen homeostasis in human skin. J Invest Dermatol (2001) 1.05
The skin produces urocortin. J Clin Endocrinol Metab (2000) 1.01
Mechanisms of androgen induction of sebocyte differentiation. Dermatology (1998) 1.00
Human skin: an independent peripheral endocrine organ. Horm Res (2000) 0.99
Hair cycle-dependent expression of corticotropin-releasing factor (CRF) and CRF receptors in murine skin. FASEB J (1998) 0.99
In situ expression of corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) genes in human skin. FASEB J (2001) 0.98
Growth hormone and insulin-like growth factors have different effects on sebaceous cell growth and differentiation. Endocrinology (1999) 0.97
Evidence for expression of melanocortin-1 receptor in human sebocytes in vitro and in situ. J Invest Dermatol (2002) 0.97
Molecular biology of the CRH receptors-- in the mood. Peptides (2001) 0.95
The melanocortin 5 receptor is expressed in human sebaceous glands and rat preputial cells. J Invest Dermatol (2000) 0.90
Role of the hypothalamic pituitary adrenal axis in the control of the response to stress and infection. Braz J Med Biol Res (2000) 0.90
Human umbilical vein endothelial cells: a new source and potential target for corticotropin-releasing factor. J Clin Endocrinol Metab (1999) 0.89
The genomic organization of the human corticotropin-releasing factor type-1 receptor. Gene (1998) 0.87
Altered proliferation, synthetic activity, and differentiation of cultured human sebocytes in the absence of vitamin A and their modulation by synthetic retinoids. J Invest Dermatol (1993) 0.85
Ligand-dependent activation of the melanocortin 5 receptor: cAMP production and ryanodine receptor-dependent elevations of [Ca(2+)](I). Biochem Biophys Res Commun (2002) 0.84
Regulation of pituitary corticotropin-releasing hormone-binding protein messenger ribonucleic acid levels by restraint stress and adrenalectomy. Endocrinology (1998) 0.84
A fluorometric rapid microassay to identify anti-proliferative compounds for human melanoma cells in vitro. Melanoma Res (1992) 0.82
Corticotropin-releasing factor (CRF) agonists stimulate testosterone production in mouse leydig cells through CRF receptor-1. Endocrinology (1998) 0.82
Expression of genes encoding corticotropin-releasing factor (CRF), type 1 CRF receptor, and CRF-binding protein and localization of the gene products in the human ovary. J Clin Endocrinol Metab (1997) 0.82
The role of melanocortins in skin homeostasis. Horm Res (2000) 0.80
Knocking out the stress response. Mol Psychiatry (1999) 0.79
Corticotropin-releasing hormone-binding protein and its possible role in neuroendocrinological research. Horm Metab Res (1997) 0.78
Adrenocortical atrophy of hypophysectomized rats can be reduced by corticotropin-releasing hormone (CRH). Cell Tissue Res (1990) 0.77
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Pheochromocytoma: recommendations for clinical practice from the First International Symposium. October 2005. Nat Clin Pract Endocrinol Metab (2007) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Biochemical diagnosis of phaeochromocytoma using plasma-free normetanephrine, metanephrine and methoxytyramine: importance of supine sampling under fasting conditions. Clin Endocrinol (Oxf) (2013) 3.12
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
The clinically inapparent adrenal mass: update in diagnosis and management. Endocr Rev (2004) 2.73
Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab (2013) 2.49
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes (2010) 2.44
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. Proc Natl Acad Sci U S A (2004) 2.41
Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells. FASEB J (2002) 2.26
Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma. Clin Chem (2011) 2.24
Congenital adrenal hyperplasia. Lancet (2005) 2.21
Malignant pheochromocytoma: current status and initiatives for future progress. Endocr Relat Cancer (2004) 2.20
Seasonal variation in plasma free normetanephrine concentrations: implications for biochemical diagnosis of pheochromocytoma. Eur J Endocrinol (2014) 2.13
Evaluation of a diabetes management system based on practice guidelines, integrated care, and continuous quality management in a Federal State of Germany: a population-based approach to health care research. Diabetes Care (2008) 2.00
Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes. Microbes Infect (2006) 1.91
A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
Top-down lipidomics reveals ether lipid deficiency in blood plasma of hypertensive patients. PLoS One (2009) 1.71
Neuroendocrine control of body fluid metabolism. Physiol Rev (2004) 1.67
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet (2009) 1.61
Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity. Proc Natl Acad Sci U S A (2004) 1.61
A novel informatics concept for high-throughput shotgun lipidomics based on the molecular fragmentation query language. Genome Biol (2011) 1.58
Adipocyte fatty acid-binding protein suppresses cardiomyocyte contraction: a new link between obesity and heart disease. Circ Res (2009) 1.58
Technical evaluation of the first fully automated assay for the detection of TSH receptor autoantibodies. Clin Chim Acta (2008) 1.56
A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria. Infect Immun (2005) 1.55
Adult-onset autoimmune diabetes in Europe is prevalent with a broad clinical phenotype: Action LADA 7. Diabetes Care (2012) 1.49
Plasma methoxytyramine: a novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status. Eur J Cancer (2011) 1.49
The Janus faces of allopurinol-allopurinol hypersensitivity syndrome. Am J Med (2008) 1.47
Levosimendan is superior to milrinone and dobutamine in selectively increasing microvascular gastric mucosal oxygenation in dogs. Crit Care Med (2005) 1.47
Toll-like receptor 2 signaling triggers fatal arrhythmias upon myocardial ischemia-reperfusion. Crit Care Med (2010) 1.45
Agonist of growth hormone-releasing hormone as a potential effector for survival and proliferation of pancreatic islets. Proc Natl Acad Sci U S A (2010) 1.42
Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes. Proc Natl Acad Sci U S A (2002) 1.36
Shotgun lipidomics on a LTQ Orbitrap mass spectrometer by successive switching between acquisition polarity modes. J Mass Spectrom (2012) 1.28
Development of a diabetes prevention management program for clinical practice. Public Health Rep (2007) 1.25
Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholia. Proc Natl Acad Sci U S A (2005) 1.24
Shotgun lipidomics on high resolution mass spectrometers. Cold Spring Harb Perspect Biol (2011) 1.24
Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response. Proc Natl Acad Sci U S A (2006) 1.23
Children with classic congenital adrenal hyperplasia have elevated serum leptin concentrations and insulin resistance: potential clinical implications. J Clin Endocrinol Metab (2002) 1.22
Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals. PLoS Biol (2013) 1.21
Catecholamine metabolomic and secretory phenotypes in phaeochromocytoma. Endocr Relat Cancer (2010) 1.21
Modulation of pancreatic islets-stress axis by hypothalamic releasing hormones and 11beta-hydroxysteroid dehydrogenase. Proc Natl Acad Sci U S A (2011) 1.20
Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes. FEBS Lett (2002) 1.19
Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans. Physiol Behav (2004) 1.17
Characterization of the influence of vildagliptin on model-assessed -cell function in patients with type 2 diabetes and mild hyperglycemia. J Clin Endocrinol Metab (2007) 1.16
miR-125b regulates calcification of vascular smooth muscle cells. Am J Pathol (2011) 1.15
Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Proc Natl Acad Sci U S A (2012) 1.14
Gout--current diagnosis and treatment. Dtsch Arztebl Int (2009) 1.14
LipidXplorer: a software for consensual cross-platform lipidomics. PLoS One (2012) 1.13
The Finnish Diabetes Risk Score is associated with insulin resistance and progression towards type 2 diabetes. J Clin Endocrinol Metab (2008) 1.13
Oxytocin in cardiac ontogeny. Proc Natl Acad Sci U S A (2004) 1.13
Primary human CD34+ hematopoietic stem and progenitor cells express functionally active receptors of neuromediators. Blood (2004) 1.12
Transplantation of human islets without immunosuppression. Proc Natl Acad Sci U S A (2013) 1.10
Adenoviral vectors can impair adrenocortical steroidogenesis: clinical implications for natural infections and gene therapy. Proc Natl Acad Sci U S A (2002) 1.10
IFN-alpha skews monocytes into CD56+-expressing dendritic cells with potent functional activities in vitro and in vivo. J Immunol (2008) 1.09
Impaired adrenal stress response in Toll-like receptor 2-deficient mice. Proc Natl Acad Sci U S A (2004) 1.09
Fat cells may be the obesity-hypertension link: human adipogenic factors stimulate aldosterone secretion from adrenocortical cells. Endocr Res (2004) 1.08
Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome. Proc Natl Acad Sci U S A (2006) 1.08
Gene expression profiling of benign and malignant pheochromocytoma. Ann N Y Acad Sci (2006) 1.08
Characterization of the vitamin D endocrine system in human sebocytes in vitro. J Steroid Biochem Mol Biol (2008) 1.08
Isolation of neural crest derived chromaffin progenitors from adult adrenal medulla. Stem Cells (2009) 1.07
Neuroendocrine neoplasms of the gastrointestinal tract. Dtsch Arztebl Int (2011) 1.05
Prevalence of parvovirus B19 and human bocavirus DNA in the heart of patients with no evidence of dilated cardiomyopathy or myocarditis. Clin Infect Dis (2009) 1.05
The value of training in communication skills for continuing medical education. Patient Educ Couns (2010) 1.05
Isolation, characterization, and differentiation of progenitor cells from human adult adrenal medulla. Stem Cells Transl Med (2012) 1.05
Expression of lipogenic factors galectin-12, resistin, SREBP-1, and SCD in human sebaceous glands and cultured sebocytes. J Invest Dermatol (2007) 1.04
Enhanced oxygen supply improves islet viability in a new bioartificial pancreas. Cell Transplant (2012) 1.03
NIH conference. Future directions in the study and management of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Ann Intern Med (2002) 1.03
[The quality of CME questions as a component part of continuing medical education--an empirical study]. Z Arztl Fortbild Qualitatssich (2007) 1.02
Identification of platelet-activating factor acetylhydrolase II in human skin. J Invest Dermatol (2002) 1.01
Differentiation and apoptosis in human immortalized sebocytes. J Invest Dermatol (2003) 1.00
Altered disease course after initiation of self-monitoring of blood glucose in noninsulin-treated type 2 diabetes (ROSSO 3). J Diabetes Sci Technol (2007) 1.00
Cortisol in hair and the metabolic syndrome. J Clin Endocrinol Metab (2013) 0.99
Transient receptor potential vanilloid-1 signaling as a regulator of human sebocyte biology. J Invest Dermatol (2008) 0.99
Involvement of PPARgamma in oxidative stress-mediated prostaglandin E(2) production in SZ95 human sebaceous gland cells. J Invest Dermatol (2006) 0.98
[PCSK9 Inhibitors - the magic bullet for LDL cholesterol reduction?]. Dtsch Med Wochenschr (2016) 0.98
Bottom-up shotgun lipidomics by higher energy collisional dissociation on LTQ Orbitrap mass spectrometers. Anal Chem (2011) 0.98
Evidence for expression of melanocortin-1 receptor in human sebocytes in vitro and in situ. J Invest Dermatol (2002) 0.97
Current aspects in the pathophysiology and treatment of chronic wounds in diabetes mellitus. Biomed Res Int (2013) 0.97
Efficient TRAIL-R1/DR4-mediated apoptosis in melanoma cells by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Invest Dermatol (2005) 0.96
Validation of a simple clinical diabetes prediction model in a middle-aged, white, German population. Arch Intern Med (2007) 0.96
Identification, characterization, and gene expression profiling of endotoxin-induced myocarditis. Proc Natl Acad Sci U S A (2003) 0.96
Novel insights into adipogenesis from omics data. Curr Med Chem (2009) 0.95
Thyrotropin receptor autoantibodies in Graves' disease. Trends Endocrinol Metab (2005) 0.95
Arterial flow reduces oxidative stress via an antioxidant response element and Oct-1 binding site within the NADPH oxidase 4 promoter in endothelial cells. Basic Res Cardiol (2011) 0.95
Cortical-chromaffin cell interactions in the adrenal gland. Endocr Pathol (2005) 0.95