Published in J Biol Chem on May 20, 2002
Grb2 regulates internalization of EGF receptors through clathrin-coated pits. Mol Biol Cell (2003) 2.58
Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression. Mol Biol Cell (2007) 1.99
Endocytosis and intracellular trafficking of ErbBs. Exp Cell Res (2008) 1.96
EGF receptor ubiquitination is not necessary for its internalization. Proc Natl Acad Sci U S A (2007) 1.96
Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor. J Cell Biol (2010) 1.90
YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation. Blood (2008) 1.86
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits. Mol Biol Cell (2004) 1.82
The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells. PLoS Pathog (2010) 1.73
Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes. J Cell Sci (2008) 1.70
Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits. Mol Cell Biol (2006) 1.54
Bending a membrane: how clathrin affects budding. Proc Natl Acad Sci U S A (2006) 1.53
Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis. Mol Biol Cell (2005) 1.49
Control of epidermal growth factor receptor endocytosis by receptor dimerization, rather than receptor kinase activation. EMBO Rep (2005) 1.42
SRC-mediated phosphorylation of dynamin and cortactin regulates the "constitutive" endocytosis of transferrin. Mol Cell Biol (2009) 1.39
A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation. J Cell Biol (2010) 1.35
Epidermal growth factor receptor and cancer: control of oncogenic signalling by endocytosis. J Cell Mol Med (2008) 1.27
Molecular mechanisms of ubiquitin-dependent membrane traffic. Annu Rev Biophys (2011) 1.19
Shiga toxin regulates its entry in a Syk-dependent manner. Mol Biol Cell (2005) 1.17
The AP-2 adaptor beta2 appendage scaffolds alternate cargo endocytosis. Mol Biol Cell (2008) 1.05
Entry of feline calicivirus is dependent on clathrin-mediated endocytosis and acidification in endosomes. J Virol (2006) 1.04
EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation. Mol Biol Cell (2008) 1.01
Distinct recruitment of Eps15 via Its coiled-coil domain is required for efficient down-regulation of the met receptor tyrosine kinase. J Biol Chem (2008) 0.96
PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2. J Biol Chem (2010) 0.95
Functional roles of short sequence motifs in the endocytosis of membrane receptors. Front Biosci (Landmark Ed) (2009) 0.94
Novel outcomes and end points: biomarkers in chronic obstructive pulmonary disease clinical trials. Proc Am Thorac Soc (2011) 0.92
Flotillins regulate membrane mobility of the dopamine transporter but are not required for its protein kinase C dependent endocytosis. Traffic (2013) 0.87
Internalization of Met requires the co-receptor CD44v6 and its link to ERM proteins. PLoS One (2013) 0.87
Quantification and kinetic analysis of Grb2-EGFR interaction on micro-patterned surfaces for the characterization of EGFR-modulating substances. PLoS One (2014) 0.84
Polarised clathrin-mediated endocytosis of EGFR during chemotactic invasion. Traffic (2014) 0.83
Epidermal growth factor-stimulated Akt phosphorylation requires clathrin or ErbB2 but not receptor endocytosis. Mol Biol Cell (2015) 0.83
Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants. World J Clin Oncol (2014) 0.81
Adaptive coarse-grained Monte Carlo simulation of reaction and diffusion dynamics in heterogeneous plasma membranes. BMC Bioinformatics (2010) 0.78
Endocytosis of Ubiquitylation-Deficient EGFR Mutants via Clathrin-Coated Pits is Mediated by Ubiquitylation. Traffic (2015) 0.77
The effects of harvesting media on biological characteristics and repair potential of neural stem cells after traumatic brain injury. PLoS One (2014) 0.76
Effect of EGF-receptor tyrosine kinase inhibitor on Rab5 function during endocytosis. Arch Biochem Biophys (2012) 0.76
Chaperone-mediated destruction of erbB2: relevance to tyrosine kinase inhibitors. Breast Cancer Res (2002) 0.75
A phosphotyrosine switch for cargo sequestration at clathrin-coated buds. J Biol Chem (2014) 0.75
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol Cell (2006) 4.36
Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference. J Biol Chem (2004) 4.32
Grb2 regulates internalization of EGF receptors through clathrin-coated pits. Mol Biol Cell (2003) 2.58
Signaling on the endocytic pathway. Curr Opin Cell Biol (2007) 2.53
RNA interference screen reveals an essential role of Nedd4-2 in dopamine transporter ubiquitination and endocytosis. J Neurosci (2006) 2.08
Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines. J Biol Chem (2001) 2.06
Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation. Exp Cell Res (2004) 1.96
EGF receptor ubiquitination is not necessary for its internalization. Proc Natl Acad Sci U S A (2007) 1.96
Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor. J Cell Biol (2010) 1.90
Epidermal growth factor receptor internalization through clathrin-coated pits requires Cbl RING finger and proline-rich domains but not receptor polyubiquitylation. Traffic (2003) 1.82
Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells. Mol Biol Cell (2002) 1.77
Regulation of receptors and transporters by ubiquitination: new insights into surprisingly similar mechanisms. Mol Interv (2007) 1.77
Constitutive and protein kinase C-induced internalization of the dopamine transporter is mediated by a clathrin-dependent mechanism. Traffic (2005) 1.76
Three-chromophore FRET microscopy to analyze multiprotein interactions in living cells. Nat Methods (2004) 1.74
Conversion of the monomeric red fluorescent protein into a photoactivatable probe. Chem Biol (2005) 1.63
Oligomerization of dopamine transporters visualized in living cells by fluorescence resonance energy transfer microscopy. J Biol Chem (2003) 1.62
Endocytosis of receptor tyrosine kinases. Cold Spring Harb Perspect Biol (2013) 1.57
Three ubiquitin conjugation sites in the amino terminus of the dopamine transporter mediate protein kinase C-dependent endocytosis of the transporter. Mol Biol Cell (2006) 1.50
Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis. Mol Biol Cell (2005) 1.49
Enhanced ubiquitylation and accelerated degradation of the dopamine transporter mediated by protein kinase C. J Biol Chem (2005) 1.32
Rapid regulation of the dopamine transporter: role in stimulant addiction? Neuropharmacology (2004) 1.32
Visualization of Rab5 activity in living cells by FRET microscopy and influence of plasma-membrane-targeted Rab5 on clathrin-dependent endocytosis. J Cell Sci (2003) 1.27
The role of EGF receptor ubiquitination in regulating its intracellular traffic. Traffic (2011) 1.23
Multiple molecular determinants in the carboxyl terminus regulate dopamine transporter export from endoplasmic reticulum. J Biol Chem (2004) 1.16
Negative regulation of dopamine transporter endocytosis by membrane-proximal N-terminal residues. J Neurosci (2009) 1.16
Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes. J Biol Chem (2010) 1.13
Trafficking of dopamine transporters in psychostimulant actions. Semin Cell Dev Biol (2009) 1.11
Tyrosine phosphorylation of the beta2 subunit of clathrin adaptor complex AP-2 reveals the role of a di-leucine motif in the epidermal growth factor receptor trafficking. J Biol Chem (2003) 1.10
Calmodulin regulates intracellular trafficking of epidermal growth factor receptor and the MAPK signaling pathway. Mol Biol Cell (2002) 1.05
Usp18 regulates epidermal growth factor (EGF) receptor expression and cancer cell survival via microRNA-7. J Biol Chem (2011) 1.04
Differential subcellular distribution of endosomal compartments and the dopamine transporter in dopaminergic neurons. Mol Cell Neurosci (2010) 1.04
Endosomal targeting of MEK2 requires RAF, MEK kinase activity and clathrin-dependent endocytosis. Traffic (2008) 1.04
Protein kinase C-dependent ubiquitination and clathrin-mediated endocytosis of the cationic amino acid transporter CAT-1. J Biol Chem (2011) 1.03
RNA interference screen identifies Usp18 as a regulator of epidermal growth factor receptor synthesis. Mol Biol Cell (2009) 1.03
Lysine 63-linked polyubiquitination is required for EGF receptor degradation. Proc Natl Acad Sci U S A (2013) 0.96
Shoc2 is targeted to late endosomes and required for Erk1/2 activation in EGF-stimulated cells. PLoS One (2012) 0.95
Epitope-tagged dopamine transporter knock-in mice reveal rapid endocytic trafficking and filopodia targeting of the transporter in dopaminergic axons. FASEB J (2012) 0.95
HD-PTP inhibits endothelial migration through its interaction with Src. Int J Biochem Cell Biol (2008) 0.95
Live-cell fluorescence imaging reveals high stoichiometry of Grb2 binding to the EGF receptor sustained during endocytosis. J Cell Sci (2013) 0.91
Protein kinaseCdelta-calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomes. Mol Biol Cell (2004) 0.89
Mice expressing markedly reduced striatal dopamine transporters exhibit increased locomotor activity, dopamine uptake turnover rate, and cocaine responsiveness. Synapse (2013) 0.87
Flotillins regulate membrane mobility of the dopamine transporter but are not required for its protein kinase C dependent endocytosis. Traffic (2013) 0.87
A bifunctional converter: fluorescein quenching scFv/fluorogen activating protein for photostability and improved signal to noise in fluorescence experiments. Bioconjug Chem (2014) 0.84
Cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity. Mol Pharmacol (2009) 0.84
Recruitment of Uev1B to Hrs-containing endosomes and its effect on endosomal trafficking. Exp Cell Res (2010) 0.83
The relationship between ER-multivesicular body membrane contacts and the ESCRT machinery. Biochem Soc Trans (2012) 0.80
Visualization of Rab5 activity in living cells using FRET microscopy. Methods Enzymol (2005) 0.80
The tyrosine phosphatase HD-PTP is regulated by FGF-2 through proteasome degradation. Front Biosci (2006) 0.76
Feedforward regulation of mRNA stability by prolonged extracellular signal-regulated kinase activity. FEBS J (2015) 0.76
Improved precision of proteomic measurements in immunoprecipitation based purifications using relative quantitation. Anal Chem (2013) 0.76