Published in J Clin Invest on June 01, 2002
Expression pattern of the orphan receptor LGR4/GPR48 gene in the mouse. Histochem Cell Biol (2005) 1.18
TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis. J Thyroid Res (2012) 0.96
Thyrotropin receptor stimulates internalization-independent persistent phosphoinositide signaling. Mol Pharmacol (2011) 0.93
Comparative structure analyses of cystine knot-containing molecules with eight aminoacyl ring including glycoprotein hormones (GPH) alpha and beta subunits and GPH-related A2 (GPA2) and B5 (GPB5) molecules. Reprod Biol Endocrinol (2009) 0.90
Evolutionary origin of a functional gonadotropin in the pituitary of the most primitive vertebrate, hagfish. Proc Natl Acad Sci U S A (2010) 0.89
Thyrostimulin, but not thyroid-stimulating hormone (TSH), acts as a paracrine regulator to activate the TSH receptor in mammalian ovary. J Biol Chem (2009) 0.89
Emergence and evolution of the glycoprotein hormone and neurotrophin gene families in vertebrates. BMC Evol Biol (2011) 0.87
Extended and structurally supported insights into extracellular hormone binding, signal transduction and organization of the thyrotropin receptor. PLoS One (2012) 0.86
Human TSH receptor ligands as pharmacological probes with potential clinical application. Expert Rev Endocrinol Metab (2009) 0.85
Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5. Proc Natl Acad Sci U S A (2005) 0.85
Transcriptomic identification of starfish neuropeptide precursors yields new insights into neuropeptide evolution. Open Biol (2016) 0.84
The heterodimeric glycoprotein hormone, GPA2/GPB5, regulates ion transport across the hindgut of the adult mosquito, Aedes aegypti. PLoS One (2014) 0.83
Neuropeptides encoded by the genomes of the Akoya pearl oyster Pinctata fucata and Pacific oyster Crassostrea gigas: a bioinformatic and peptidomic survey. BMC Genomics (2014) 0.82
Distinct expression patterns of glycoprotein hormone subunits in the lophotrochozoan Aplysia: implications for the evolution of neuroendocrine systems in animals. Endocrinology (2012) 0.82
Glycoprotein hormones and their receptors emerged at the origin of metazoans. Genome Biol Evol (2014) 0.81
Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development. Endocrinology (2015) 0.80
Thyrostimulin-TSHR signaling promotes the proliferation of NIH:OVCAR-3 ovarian cancer cells via trans-regulation of the EGFR pathway. Sci Rep (2016) 0.79
Hormone-like peptides in the venoms of marine cone snails. Gen Comp Endocrinol (2015) 0.78
Hypothalamic-pituitary-gonadal endocrine system in the hagfish. Front Endocrinol (Lausanne) (2013) 0.78
Human lutropin (hLH) and choriogonadotropin (CG) are assembled by different pathways: a model of hLH assembly. J Biol Chem (2014) 0.77
Structure-function relationships of glycoprotein hormones and their subunits' ancestors. Front Endocrinol (Lausanne) (2015) 0.76
Glycoprotein hormone in the pituitary of hagfish and its evolutionary implications. Fish Physiol Biochem (2012) 0.76
An Intimate Relationship between Thyroid Hormone and Skin: Regulation of Gene Expression. Front Endocrinol (Lausanne) (2013) 0.76
Multiple Transduction Pathways Mediate Thyrotropin Receptor Signaling in Preosteoblast-Like Cells. Endocrinology (2016) 0.76
Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms. Open Biol (2017) 0.76
The Activation Mechanism of Glycoprotein Hormone Receptors with Implications in the Cause and Therapy of Endocrine Diseases. J Biol Chem (2015) 0.75
The thyroid axis just got more complicated. J Clin Invest (2002) 0.75
Multigenic Delineation of Lower Jaw Deformity in Triploid Atlantic Salmon (Salmo salar L.). PLoS One (2016) 0.75
Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work. Front Endocrinol (Lausanne) (2017) 0.75
A novel genetic system to detect protein-protein interactions. Nature (1989) 43.83
Activation of orphan receptors by the hormone relaxin. Science (2002) 3.80
Graves' disease. N Engl J Med (2000) 3.50
Genome-wide protein interaction maps using two-hybrid systems. FEBS Lett (2000) 3.13
Crystal structure of human chorionic gonadotropin. Nature (1994) 3.06
Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc Natl Acad Sci U S A (1997) 2.45
The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. Mol Endocrinol (2000) 2.37
Molecular cloning of the thyrotropin receptor. Science (1989) 2.32
Adenyl cyclase in fat cells. II. Hormone receptors. J Biol Chem (1969) 2.20
A comparison of recombinant human thyrotropin and thyroid hormone withdrawal for the detection of thyroid remnant or cancer. J Clin Endocrinol Metab (1999) 1.92
Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules. Mol Endocrinol (2001) 1.70
Familial isolated thyrotropin deficiency with cretinism. N Engl J Med (1971) 1.65
Cystine knots. Curr Opin Struct Biol (1995) 1.60
Studies on the structure of thyrotropin: its relationship to luteinizing hormone. Recent Prog Horm Res (1971) 1.46
Three-dimensional structure of human follicle-stimulating hormone. Mol Endocrinol (2001) 1.41
Folliculostellate cell network: a route for long-distance communication in the anterior pituitary. Proc Natl Acad Sci U S A (2001) 1.40
Mitochondrial release of cytochrome c corresponds to the selective vulnerability of hippocampal CA1 neurons in rats after transient global cerebral ischemia. J Neurosci (1999) 1.39
Thyrotropin secretion in patients with central hypothyroidism: evidence for reduced biological activity of immunoreactive thyrotropin. J Clin Endocrinol Metab (1979) 1.36
Functional TSH receptor in human abdominal preadipocytes and orbital fibroblasts. Am J Physiol Cell Physiol (2000) 1.27
The thyrotropin receptor in thyroid diseases. N Engl J Med (1997) 1.24
The expression of thyrotropin receptor in the brain. Endocrinology (2001) 1.14
Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5. Mol Endocrinol (2002) 1.12
Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge region. J Biol Chem (2000) 1.00
Molecular biology of thyrotropin. Endocr Rev (1989) 0.97
A circulating, biologically inactive thyrotropin caused by a mutation in the beta subunit gene. J Clin Invest (1996) 0.96
Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney. Mol Endocrinol (1999) 0.95
Expression of the thyroid-stimulating hormone receptor in the folliculo-stellate cells of the human anterior pituitary. J Clin Endocrinol Metab (2000) 0.93
Evidence that adenosine 3',5'-monophosphate mediates stimulation of thyroid growth in FRTL5 cells. Endocrinology (1986) 0.92
A novel, nonradioactive in vivo bioassay of thyrotropin (TSH). Thyroid (1995) 0.92
Congenital central isolated hypothyroidism caused by a homozygous mutation in the TSH-beta subunit gene. Thyroid (2000) 0.90
Transmembrane regions V and VI of the human luteinizing hormone receptor are required for constitutive activation by a mutation in the third intracellular loop. J Biol Chem (1996) 0.90
Thyrotropin receptor messenger ribonucleic acid is expressed in most brown and white adipose tissues in the guinea pig. Endocrinology (1992) 0.90
Expression of thyroid-related genes in human thymus. Thyroid (1999) 0.87
Development and in vitro characterization of human recombinant thyrotropin. Thyroid (1999) 0.82
Novel recombinant gonadotropins. Trends Endocrinol Metab (2001) 0.82
Disulfide bond mutations in follicle-stimulating hormone result in uncoupling of biological activity from intracellular behavior. Endocrinology (2000) 0.78
Thyrotrophin receptor protein expression in normal and adenomatous human pituitary. J Endocrinol (2000) 0.77
The tie that binds: design of biologically active single-chain human chorionic gonadotropins and a gonadotropin-receptor complex using protein engineering. Biol Reprod (1998) 0.77
Interaction, signal generation, signal divergence, and signal transduction of LH/CG and the receptor. Recent Prog Horm Res (1997) 0.77
Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science (2005) 4.47
Activation of orphan receptors by the hormone relaxin. Science (2002) 3.80
Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes. J Biol Chem (2003) 1.89
Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension. Mol Cell Biol (2004) 1.89
Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2. Proc Natl Acad Sci U S A (2005) 1.73
Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists. Mol Endocrinol (2003) 1.72
INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. J Biol Chem (2002) 1.71
Activation of dormant ovarian follicles to generate mature eggs. Proc Natl Acad Sci U S A (2010) 1.66
Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality. Mol Endocrinol (2004) 1.66
Influence of endothelial nitric oxide synthase gene polymorphisms (-786T>C, 4a4b, 894G>T) in Korean patients with coronary artery disease. Thromb Res (2006) 1.63
Gene expression profiling of human endometrial receptivity on days LH+2 versus LH+7 by microarray technology. Mol Hum Reprod (2003) 1.62
The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis. J Biol Chem (2003) 1.59
Genetic and functional analyses of polymorphisms in the human FSH receptor gene. Mol Hum Reprod (2002) 1.56
Paracrine regulation of mammalian oocyte maturation and male germ cell survival. Proc Natl Acad Sci U S A (2004) 1.55
Signaling receptome: a genomic and evolutionary perspective of plasma membrane receptors involved in signal transduction. Sci STKE (2003) 1.47
Effect of controlled ovarian hyperstimulation in IVF on endometrial gene expression profiles. Mol Hum Reprod (2005) 1.46
Abnormal gene expression profiles in human ovaries from polycystic ovary syndrome patients. Mol Endocrinol (2004) 1.46
Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules. J Biol Chem (2006) 1.43
H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. J Biol Chem (2002) 1.38
Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene. Endocrinology (2004) 1.34
Uterine Msx-1 and Wnt4 signaling becomes aberrant in mice with the loss of leukemia inhibitory factor or Hoxa-10: evidence for a novel cytokine-homeobox-Wnt signaling in implantation. Mol Endocrinol (2004) 1.32
Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses. J Biol Chem (2005) 1.28
Growth differentiation factor-9 signaling is mediated by the type I receptor, activin receptor-like kinase 5. Mol Endocrinol (2003) 1.23
Growth differentiation factor-9 promotes the growth, development, and survival of human ovarian follicles in organ culture. J Clin Endocrinol Metab (2002) 1.23
Pre-ovulatory LH/hCG surge decreases C-type natriuretic peptide secretion by ovarian granulosa cells to promote meiotic resumption of pre-ovulatory oocytes. Hum Reprod (2011) 1.21
Ovarian brain-derived neurotrophic factor (BDNF) promotes the development of oocytes into preimplantation embryos. Proc Natl Acad Sci U S A (2005) 1.19
Neuronostatin encoded by the somatostatin gene regulates neuronal, cardiovascular, and metabolic functions. J Biol Chem (2008) 1.19
Impaired nipple development and parturition in LGR7 knockout mice. Mol Cell Biol (2004) 1.18
Bisphenol A induces apoptosis and G2-to-M arrest of ovarian granulosa cells. Biochem Biophys Res Commun (2002) 1.16
Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation. J Biol Chem (2004) 1.15
Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5. Mol Endocrinol (2002) 1.12
Paracrine regulation of ovarian granulosa cell differentiation by stanniocalcin (STC) 1: mediation through specific STC1 receptors. Mol Endocrinol (2004) 1.11
Bone morphogenetic protein receptor type II is a receptor for growth differentiation factor-9. Biol Reprod (2002) 1.10
Tankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis. J Biol Chem (2002) 1.10
Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis. Biochem Biophys Res Commun (2005) 1.05
Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative trait loci influencing variation in human menopausal age. Am J Hum Genet (2004) 1.04
Escherichia coli ribonuclease III activity is downregulated by osmotic stress: consequences for the degradation of bdm mRNA in biofilm formation. Mol Microbiol (2009) 1.03
A signaling-selective, nanomolar potent allosteric low molecular weight agonist for the human luteinizing hormone receptor. Naunyn Schmiedebergs Arch Pharmacol (2008) 1.03
Multi-functional norrin is a ligand for the LGR4 receptor. J Cell Sci (2013) 1.01
FOXL2 interacts with steroidogenic factor-1 (SF-1) and represses SF-1-induced CYP17 transcription in granulosa cells. Mol Endocrinol (2010) 1.00
Inhibitory effects of RraA and RraB on RNAse E-related enzymes imply conserved functions in the regulated enzymatic cleavage of RNA. FEMS Microbiol Lett (2008) 0.97
Regulation of preimplantation embryo development by brain-derived neurotrophic factor. Dev Biol (2007) 0.97
Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the Steroidogenic Acute Regulatory gene. Cell Signal (2009) 0.97
MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death. FEBS Lett (2009) 0.96
The hedgehog-patched signaling pathway and function in the mammalian ovary: a novel role for hedgehog proteins in stimulating proliferation and steroidogenesis of theca cells. Reproduction (2009) 0.95
Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary. Endocrinology (2004) 0.95
p19ras interacts with and activates p73 by involving the MDM2 protein. J Biol Chem (2006) 0.94
Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor, GPR39. Mol Endocrinol (2008) 0.94
Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects. Physiol Genomics (2004) 0.93
Role of Bcl2-like 10 (Bcl2l10) in Regulating Mouse Oocyte Maturation. Biol Reprod (2009) 0.93
Heterogeneous rRNAs are differentially expressed during the morphological development of Streptomyces coelicolor. FEMS Microbiol Lett (2007) 0.93
Delivery of shRNA using gold nanoparticle-DNA oligonucleotide conjugates as a universal carrier. Biochem Biophys Res Commun (2010) 0.92
Global gene expression profiling of human endometrial receptivity. J Reprod Immunol (2004) 0.92
Growth differentiation factor-9 induces Smad2 activation and inhibin B production in cultured human granulosa-luteal cells. J Clin Endocrinol Metab (2003) 0.92
Actin cytoskeleton regulates Hippo signaling. PLoS One (2013) 0.91
C-type natriuretic peptide stimulates ovarian follicle development. Mol Endocrinol (2012) 0.91
Growth differentiation factor-9 stimulates inhibin production and activates Smad2 in cultured rat granulosa cells. Endocrinology (2003) 0.91
Ligand selectivity of gonadotropin receptors. Role of the beta-strands of extracellular leucine-rich repeats 3 and 6 of the human luteinizing hormone receptor. J Biol Chem (2003) 0.91
Matching receptome genes with their ligands for surveying paracrine/autocrine signaling systems. Mol Endocrinol (2007) 0.91
Paracrine regulation of the resumption of oocyte meiosis by endothelin-1. Dev Biol (2008) 0.90
Oocyte-derived R-spondin2 promotes ovarian follicle development. FASEB J (2013) 0.89
A novel protein, MUDENG, induces cell death in cytotoxic T cells. Biochem Biophys Res Commun (2008) 0.89
A functionalized gold nanoparticles-assisted universal carrier for antisense DNA. Chem Commun (Camb) (2010) 0.89
Cross-Talk between Fas/Fas ligand system and nitric oxide in the pathway subserving granulosa cell apoptosis: a possible regulatory mechanism for ovarian follicle atresia. Endocrinology (2004) 0.88
Heterogeneous rRNA molecules encoded by Streptomyces coelicolor M145 genome are all expressed and assembled into ribosomes. J Microbiol Biotechnol (2007) 0.88
Effective delivery of anti-miRNA DNA oligonucleotides by functionalized gold nanoparticles. J Biotechnol (2011) 0.88
Genomic analyses of the evolution of LGR genes. Chang Gung Med J (2006) 0.88
Perspective: the ovarian kaleidoscope database-II. Functional genomic analysis of an organ-specific database. Endocrinology (2002) 0.88
Activation of the luteinizing hormone receptor in the extracellular domain. Mol Cell Endocrinol (2003) 0.87
Promotion of human early embryonic development and blastocyst outgrowth in vitro using autocrine/paracrine growth factors. PLoS One (2012) 0.87
Completion of Meiosis I of preovulatory oocytes and facilitation of preimplantation embryo development by glial cell line-derived neurotrophic factor. Dev Biol (2007) 0.86
HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death. Cell Physiol Biochem (2009) 0.86
Three's company: two or more unrelated receptors pair with the same ligand. Mol Endocrinol (2005) 0.85
Gonadotropin stimulation of ovarian fractalkine expression and fractalkine augmentation of progesterone biosynthesis by luteinizing granulosa cells. Endocrinology (2008) 0.85
Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands. Hum Reprod Update (2006) 0.84
Identification of amino acid residues in the catalytic domain of RNase E essential for survival of Escherichia coli: functional analysis of DNase I subdomain. Genetics (2008) 0.84
DUSP6 is a novel transcriptional target of p53 and regulates p53-mediated apoptosis by modulating expression levels of Bcl-2 family proteins. FEBS Lett (2012) 0.83
Autocrine regulation of early embryonic development by the artemin-GFRA3 (GDNF family receptor-alpha 3) signaling system in mice. FEBS Lett (2009) 0.83
Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway. Biochem Biophys Res Commun (2005) 0.83
Relaxin signaling in reproductive tissues. Mol Cell Endocrinol (2003) 0.83
Hormonal regulation of proprotein convertase subtilisin/kexin type 5 expression during ovarian follicle development in the rat. Mol Cell Endocrinol (2008) 0.83
Intraovarian tumor necrosis factor-related weak inducer of apoptosis/fibroblast growth factor-inducible-14 ligand-receptor system limits ovarian preovulatory follicles from excessive luteinization. Mol Endocrinol (2006) 0.82
Gonadotrophin-induced paracrine regulation of human oocyte maturation by BDNF and GDNF secreted by granulosa cells. Hum Reprod (2011) 0.82
Gene expression pattern and immunoreactive protein localization of LGR7 receptor in human endometrium throughout the menstrual cycle. Mol Hum Reprod (2004) 0.82
The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the transmembrane region: studies using chimeric human and fly receptors. J Biol Chem (2001) 0.82
Modulation of biological processes in the nucleus by delivery of DNA oligonucleotides conjugated with gold nanoparticles. Biomaterials (2011) 0.82
Genetic analysis of the invariant residue G791 in Escherichia coli 16S rRNA implicates RelA in ribosome function. J Bacteriol (2009) 0.81
Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism. Reprod Biomed Online (2003) 0.81
The apolipoprotein A-I level is downregulated in the granulosa cells of patients with polycystic ovary syndrome and affects steroidogenesis. J Proteome Res (2010) 0.81
NM23-H2 involves in negative regulation of Diva and Bcl2L10 in apoptosis signaling. Biochem Biophys Res Commun (2007) 0.81
IEX-1-induced cell death requires BIM and is modulated by MCL-1. Biochem Biophys Res Commun (2009) 0.81
Intraovarian thrombin and activated protein C signaling system regulates steroidogenesis during the periovulatory period. Mol Endocrinol (2011) 0.81
Antibiotic stress-induced modulation of the endoribonucleolytic activity of RNase III and RNase G confers resistance to aminoglycoside antibiotics in Escherichia coli. Nucleic Acids Res (2014) 0.80
Cellular mechanisms of growth inhibition of human epithelial ovarian cancer cell line by LH-releasing hormone antagonist Cetrorelix. J Clin Endocrinol Metab (2002) 0.80