Published in J Biol Chem on June 17, 2002
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell (2007) 5.78
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev (2003) 5.13
Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast. Genes Dev (2003) 4.93
Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation. Curr Opin Cell Biol (2008) 4.25
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell (2009) 3.82
The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Annu Rev Biochem (2012) 3.61
Histone H2B ubiquitylation is associated with elongating RNA polymerase II. Mol Cell Biol (2005) 3.20
Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation. Mol Cell (2009) 2.91
Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation. Genes Dev (2007) 2.81
Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proc Natl Acad Sci U S A (2004) 2.80
Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. Mol Cell Biol (2003) 2.70
Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner. J Biol Chem (2006) 2.59
Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Genes Dev (2010) 2.53
The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis. Cancer Cell (2010) 2.50
The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes Dev (2008) 2.48
Functional maps of protein complexes from quantitative genetic interaction data. PLoS Comput Biol (2008) 2.46
Np95 is a histone-binding protein endowed with ubiquitin ligase activity. Mol Cell Biol (2004) 2.35
Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol Cell Biol (2008) 2.34
Chromatin signaling to kinetochores: transregulation of Dam1 methylation by histone H2B ubiquitination. Cell (2011) 2.30
The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3. Mol Cell Biol (2006) 2.29
dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing. Genes Dev (2008) 2.29
Histone H3 lysine 4 (H3K4) methylation in development and differentiation. Dev Biol (2009) 2.24
A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation. Nat Struct Mol Biol (2008) 2.22
Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis. Mol Cell Biol (2005) 2.22
Functional interplay between histone demethylase and deacetylase enzymes. Mol Cell Biol (2006) 2.20
Drosophila stem cells share a common requirement for the histone H2B ubiquitin protease scrawny. Science (2008) 2.19
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol Cell (2011) 2.16
The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes. Mol Cell (2010) 2.06
Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. Mol Cell (2007) 2.05
Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B. Genes Dev (2004) 2.04
The SAGA continues: expanding the cellular role of a transcriptional co-activator complex. Oncogene (2007) 2.04
A 1-megadalton ESC/E(Z) complex from Drosophila that contains polycomblike and RPD3. Mol Cell Biol (2003) 2.03
Methylation of histone H4 by arginine methyltransferase PRMT1 is essential in vivo for many subsequent histone modifications. Genes Dev (2005) 2.01
A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. Mol Cell (2007) 1.98
The pathogenesis of mixed-lineage leukemia. Annu Rev Pathol (2011) 1.95
Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation. Genes Dev (2008) 1.87
The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11. Mol Biol Cell (2006) 1.83
H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex. Mol Cell Biol (2005) 1.82
Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability. Proc Natl Acad Sci U S A (2009) 1.75
The ubiquitin-proteasome system of Saccharomyces cerevisiae. Genetics (2012) 1.73
Control of transcriptional elongation and cotranscriptional histone modification by the yeast BUR kinase substrate Spt5. Proc Natl Acad Sci U S A (2009) 1.73
Chromatin and transcription in yeast. Genetics (2012) 1.61
SWI/SNF is required for transcriptional memory at the yeast GAL gene cluster. Genes Dev (2007) 1.61
A charge-based interaction between histone H4 and Dot1 is required for H3K79 methylation and telomere silencing: identification of a new trans-histone pathway. Genes Dev (2007) 1.60
A 'higher order' of telomere regulation: telomere heterochromatin and telomeric RNAs. EMBO J (2009) 1.56
Genome-wide function of H2B ubiquitylation in promoter and genic regions. Genes Dev (2011) 1.56
Ubp10/Dot4p regulates the persistence of ubiquitinated histone H2B: distinct roles in telomeric silencing and general chromatin. Mol Cell Biol (2005) 1.55
Histone trimethylation by Set1 is coordinated by the RRM, autoinhibitory, and catalytic domains. EMBO J (2005) 1.55
Mapping global histone methylation patterns in the coding regions of human genes. Mol Cell Biol (2005) 1.55
Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling. Proc Natl Acad Sci U S A (2006) 1.54
Histone H2B monoubiquitination in the chromatin of FLOWERING LOCUS C regulates flowering time in Arabidopsis. Plant Cell (2008) 1.54
Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1. J Cell Biol (2009) 1.52
Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression. Genes Dev (2009) 1.52
The Spt4p subunit of yeast DSIF stimulates association of the Paf1 complex with elongating RNA polymerase II. Mol Cell Biol (2006) 1.52
Ctk complex-mediated regulation of histone methylation by COMPASS. Mol Cell Biol (2006) 1.50
Comparative analysis of SET domain proteins in maize and Arabidopsis reveals multiple duplications preceding the divergence of monocots and dicots. Plant Physiol (2003) 1.47
How eukaryotic genes are transcribed. Crit Rev Biochem Mol Biol (2009) 1.46
H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation. PLoS Genet (2011) 1.43
A novel proteomics approach for the discovery of chromatin-associated protein networks. Mol Cell Proteomics (2008) 1.42
The requirements for COMPASS and Paf1 in transcriptional silencing and methylation of histone H3 in Saccharomyces cerevisiae. Genetics (2006) 1.41
Histone H3K4 and K36 methylation, Chd1 and Rpd3S oppose the functions of Saccharomyces cerevisiae Spt4-Spt5 in transcription. Genetics (2009) 1.39
Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase. J Biol Chem (2004) 1.38
Altered nucleosome occupancy and histone H3K4 methylation in response to 'transcriptional stress'. EMBO J (2005) 1.35
The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states. Biochim Biophys Acta (2012) 1.32
Splitting the task: Ubp8 and Ubp10 deubiquitinate different cellular pools of H2BK123. Genes Dev (2011) 1.30
CCR4/NOT complex associates with the proteasome and regulates histone methylation. Proc Natl Acad Sci U S A (2007) 1.30
The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice. Mol Cell Biol (2004) 1.29
Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4. Genes Dev (2008) 1.28
A systems-level approach to mapping the telomere length maintenance gene circuitry. Mol Syst Biol (2008) 1.27
A conserved role for human Nup98 in altering chromatin structure and promoting epigenetic transcriptional memory. PLoS Biol (2013) 1.27
Protein modifications in transcription elongation. Biochim Biophys Acta (2008) 1.26
Ubp8p, a histone deubiquitinase whose association with SAGA is mediated by Sgf11p, differentially regulates lysine 4 methylation of histone H3 in vivo. Mol Cell Biol (2006) 1.23
BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. Mol Cell (2009) 1.23
Regulation of histone H3K4 tri-methylation and PAF complex recruitment by the Ccr4-Not complex. Nucleic Acids Res (2007) 1.23
A novel non-SET domain multi-subunit methyltransferase required for sequential nucleosomal histone H3 methylation by the mixed lineage leukemia protein-1 (MLL1) core complex. J Biol Chem (2010) 1.21
Two distinct repressive mechanisms for histone 3 lysine 4 methylation through promoting 3'-end antisense transcription. PLoS Genet (2012) 1.21
Chromatin-associated genes protect the yeast genome from Ty1 insertional mutagenesis. Genetics (2008) 1.19
The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation. Mol Cell (2013) 1.19
Regulation of H3K4 trimethylation via Cps40 (Spp1) of COMPASS is monoubiquitination independent: implication for a Phe/Tyr switch by the catalytic domain of Set1. Mol Cell Biol (2009) 1.18
Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase. Mol Cell Biol (2003) 1.17
Polyubiquitylation of histone H2B. Mol Biol Cell (2008) 1.17
UBE2A, which encodes a ubiquitin-conjugating enzyme, is mutated in a novel X-linked mental retardation syndrome. Am J Hum Genet (2006) 1.14
Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells. Radiat Res (2010) 1.12
Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human. FEBS J (2010) 1.12
Novel trans-tail regulation of H2B ubiquitylation and H3K4 methylation by the N terminus of histone H2A. Mol Cell Biol (2010) 1.11
Tax recruitment of CBP/p300, via the KIX domain, reveals a potent requirement for acetyltransferase activity that is chromatin dependent and histone tail independent. Mol Cell Biol (2003) 1.09
The RAD6/BRE1 histone modification pathway in Saccharomyces confers radiation resistance through a RAD51-dependent process that is independent of RAD18. Genetics (2006) 1.09
The role of histone ubiquitylation and deubiquitylation in gene expression as determined by the analysis of an HTB1(K123R) Saccharomyces cerevisiae strain. Mol Genet Genomics (2007) 1.09
Codependency of H2B monoubiquitination and nucleosome reassembly on Chd1. Genes Dev (2012) 1.09
Dynamic loss of H2B ubiquitylation without corresponding changes in H3K4 trimethylation during myogenic differentiation. Mol Cell Biol (2012) 1.06
Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability. Cancer Res (2012) 1.06
Controlling histone methylation via trans-histone pathways. Epigenetics (2008) 1.06
A modified "cross-talk" between histone H2B Lys-120 ubiquitination and H3 Lys-79 methylation. J Biol Chem (2010) 1.02
Histone ubiquitination and deubiquitination in transcription, DNA damage response, and cancer. Front Oncol (2012) 1.02
H2B monoubiquitylation is a 5'-enriched active transcription mark and correlates with exon-intron structure in human cells. Genome Res (2012) 1.02
The yeast SR-like protein Npl3 links chromatin modification to mRNA processing. PLoS Genet (2012) 1.01
The cap binding complex influences H2B ubiquitination by facilitating splicing of the SUS1 pre-mRNA. RNA (2009) 1.01
Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation. J Biol Chem (2015) 0.99
Symmetrical modification within a nucleosome is not required globally for histone lysine methylation. EMBO Rep (2011) 0.99
Functional profiling of the Saccharomyces cerevisiae genome. Nature (2002) 36.10
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
Finding functional features in Saccharomyces genomes by phylogenetic footprinting. Science (2003) 16.49
Knockout rats via embryo microinjection of zinc-finger nucleases. Science (2009) 12.33
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol Cell (2003) 7.47
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79
New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell (2006) 5.14
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev (2003) 5.13
RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Mol Cell Biol (2002) 5.04
AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. Mol Cell (2010) 4.99
Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol Cell (2003) 4.49
Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS. Cell (2007) 4.49
An operational definition of epigenetics. Genes Dev (2009) 4.26
Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol (2007) 4.17
COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem (2002) 4.05
Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature (2009) 3.83
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell (2009) 3.82
The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p. J Biol Chem (2003) 3.81
Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Cell (2005) 3.66
Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes. Nat Struct Mol Biol (2006) 3.54
Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II. Mol Cell Biol (2009) 3.26
The language of histone crosstalk. Cell (2010) 3.18
Dysplasia and cancer in a large multicenter cohort of patients with Barrett's esophagus. Clin Gastroenterol Hepatol (2006) 3.06
Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation. Mol Cell (2009) 2.91
Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression. Mol Cell (2005) 2.89
Histone modification: cause or cog? Trends Genet (2011) 2.85
Transcriptional elongation by RNA polymerase II and histone methylation. J Biol Chem (2003) 2.76
The super elongation complex (SEC) and MLL in development and disease. Genes Dev (2011) 2.63
Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Genes Dev (2010) 2.53
Human mediator subunit MED26 functions as a docking site for transcription elongation factors. Cell (2011) 2.53
Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II. J Biol Chem (2006) 2.45
Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol Cell Biol (2008) 2.34
Benchmarking next-generation transcriptome sequencing for functional and evolutionary genomics. Mol Biol Evol (2009) 2.32
Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. Cell (2007) 2.29
Histone H3 lysine 4 (H3K4) methylation in development and differentiation. Dev Biol (2009) 2.24
Cse4 is part of an octameric nucleosome in budding yeast. Mol Cell (2009) 2.23
A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation. Nat Struct Mol Biol (2008) 2.22
Remarkably ancient balanced polymorphisms in a multi-locus gene network. Nature (2010) 2.18
Glucose sensing and signaling in Saccharomyces cerevisiae through the Rgt2 glucose sensor and casein kinase I. Proc Natl Acad Sci U S A (2004) 2.10
The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes. Mol Cell (2010) 2.06
The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase. Nat Struct Mol Biol (2007) 2.05
Microbe domestication and the identification of the wild genetic stock of lager-brewing yeast. Proc Natl Acad Sci U S A (2011) 2.04
Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Genes Dev (2012) 2.04
The Bur1/Bur2 complex is required for histone H2B monoubiquitination by Rad6/Bre1 and histone methylation by COMPASS. Mol Cell (2005) 1.99
Regulatory network connecting two glucose signal transduction pathways in Saccharomyces cerevisiae. Eukaryot Cell (2004) 1.99
Comparative genomics of protoploid Saccharomycetaceae. Genome Res (2009) 1.96
Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription. J Biol Chem (2009) 1.94
Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II. Mol Cell Biol (2007) 1.89
A COMPASS in the voyage of defining the role of trithorax/MLL-containing complexes: linking leukemogensis to covalent modifications of chromatin. J Cell Biochem (2005) 1.88
The Awesome Power of Yeast Evolutionary Genetics: New Genome Sequences and Strain Resources for the Saccharomyces sensu stricto Genus. G3 (Bethesda) (2011) 1.86
Yeast genome duplication was followed by asynchronous differentiation of duplicated genes. Nature (2003) 1.84
New roles for model genetic organisms in understanding and treating human disease: report from the 2006 Genetics Society of America meeting. Genetics (2006) 1.83
The super elongation complex (SEC) family in transcriptional control. Nat Rev Mol Cell Biol (2012) 1.78
A site to remember: H3K36 methylation a mark for histone deacetylation. Mutat Res (2007) 1.77
Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC). Genes Dev (2011) 1.77
Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis. Nat Rev Cancer (2010) 1.77
Specificity and regulation of DNA binding by the yeast glucose transporter gene repressor Rgt1. Mol Cell Biol (2003) 1.77
Comparative analysis of two complete Corynebacterium ulcerans genomes and detection of candidate virulence factors. BMC Genomics (2011) 1.75
ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL. Proc Natl Acad Sci U S A (2005) 1.69
The relation of body mass index to depressive symptoms. Can J Public Health (2004) 1.67
Leveraging skewed transcript abundance by RNA-Seq to increase the genomic depth of the tree of life. Proc Natl Acad Sci U S A (2010) 1.55
The COMPASS family of H3K4 methylases in Drosophila. Mol Cell Biol (2011) 1.54
Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling. Proc Natl Acad Sci U S A (2006) 1.54
Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1. J Cell Biol (2009) 1.52
WDR5, a complexed protein. Nat Struct Mol Biol (2009) 1.51
Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. Mol Cell (2005) 1.51
Ctk complex-mediated regulation of histone methylation by COMPASS. Mol Cell Biol (2006) 1.50
The super elongation complex family of RNA polymerase II elongation factors: gene target specificity and transcriptional output. Mol Cell Biol (2012) 1.49
Leaving a mark: the many footprints of the elongating RNA polymerase II. Curr Opin Genet Dev (2006) 1.46
Cell biology. Whither model organism research? Science (2005) 1.42
Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment. Mol Genet Genomics (2006) 1.42
After the duplication: gene loss and adaptation in Saccharomyces genomes. Genetics (2005) 1.40
Are figure legends sufficient? Evaluating the contribution of associated text to biomedical figure comprehension. J Biomed Discov Collab (2009) 1.37
High-quality genome sequence of Pichia pastoris CBS7435. J Biotechnol (2011) 1.36
The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers. Mol Cell Biol (2013) 1.35
Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient. BMC Genomics (2012) 1.35
dELL is an essential RNA polymerase II elongation factor with a general role in development. Proc Natl Acad Sci U S A (2002) 1.34
The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation. Cell (2012) 1.33
Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice. Mol Cell Biol (2008) 1.32