Published in J Biol Chem on June 25, 2002
Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol Mol Biol Rev (2002) 8.50
RecQ helicases: suppressors of tumorigenesis and premature aging. Biochem J (2003) 3.71
Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication. Proc Natl Acad Sci U S A (2002) 3.70
The Mus81/Mms4 endonuclease acts independently of double-Holliday junction resolution to promote a distinct subset of crossovers during meiosis in budding yeast. Genetics (2003) 3.22
Single Holliday junctions are intermediates of meiotic recombination. Cell (2006) 3.15
Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks. Mol Cell Biol (2005) 3.10
The Mus81 solution to resolution: generating meiotic crossovers without Holliday junctions. Genes Dev (2004) 2.89
SUMO-targeted ubiquitin ligases in genome stability. EMBO J (2007) 2.77
The mechanism of Mus81-Mms4 cleavage site selection distinguishes it from the homologous endonuclease Rad1-Rad10. Mol Cell Biol (2003) 2.59
Swi1 and Swi3 are components of a replication fork protection complex in fission yeast. Mol Cell Biol (2004) 2.55
Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3. Genes Dev (2003) 2.53
Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage. Proc Natl Acad Sci U S A (2002) 2.50
Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres. Mol Cell Biol (2003) 2.33
Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1. Mol Cell Biol (2003) 2.19
Repair of topoisomerase I-mediated DNA damage. Prog Nucleic Acid Res Mol Biol (2006) 2.16
Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities. EMBO J (2002) 2.09
Elg1 forms an alternative RFC complex important for DNA replication and genome integrity. EMBO J (2003) 2.03
Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis. Mol Cell Biol (2005) 2.00
Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes. Chromosoma (2011) 1.78
Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J (2003) 1.68
The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex. Mol Cell Biol (2006) 1.65
Mrc1 and Srs2 are major actors in the regulation of spontaneous crossover. EMBO J (2006) 1.65
RNase-sensitive DNA modification(s) initiates S. pombe mating-type switching. Genes Dev (2004) 1.64
More forks on the road to replication stress recovery. J Mol Cell Biol (2011) 1.64
Mus81 is essential for sister chromatid recombination at broken replication forks. EMBO J (2008) 1.63
Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures. Proc Natl Acad Sci U S A (2008) 1.62
Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress. Genes Dev (2005) 1.60
Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases. Mol Cell (2013) 1.57
Mechanism of Holliday junction resolution by the human GEN1 protein. Genes Dev (2010) 1.54
Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis. Mol Biol Cell (2004) 1.52
Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60. Mol Cell Biol (2003) 1.50
GEN1/Yen1 and the SLX4 complex: Solutions to the problem of Holliday junction resolution. Genes Dev (2010) 1.44
Saccharomyces cerevisiae Mus81-Mms4 is a catalytic, DNA structure-selective endonuclease. Nucleic Acids Res (2008) 1.44
The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair. Mol Biol Cell (2009) 1.44
Mus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates? EMBO J (2007) 1.42
The involvement of Srs2 in post-replication repair and homologous recombination in fission yeast. Nucleic Acids Res (2004) 1.41
Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4. Nucleic Acids Res (2012) 1.40
Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage. Mol Cell Biol (2005) 1.40
MUS81 promotes common fragile site expression. Nat Cell Biol (2013) 1.40
DNA repair by a Rad22-Mus81-dependent pathway that is independent of Rhp51. Nucleic Acids Res (2004) 1.38
Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes. J Cell Biol (2011) 1.36
Overlapping roles for Yen1 and Mus81 in cellular Holliday junction processing. J Biol Chem (2010) 1.34
Slx4 becomes phosphorylated after DNA damage in a Mec1/Tel1-dependent manner and is required for repair of DNA alkylation damage. Biochem J (2005) 1.32
Replication fork blockage by RTS1 at an ectopic site promotes recombination in fission yeast. EMBO J (2005) 1.32
Fission yeast Dna2 is required for generation of the telomeric single-strand overhang. Mol Cell Biol (2004) 1.31
Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway. J Cell Biol (2008) 1.31
The role of AtMUS81 in DNA repair and its genetic interaction with the helicase AtRecQ4A. Nucleic Acids Res (2006) 1.28
Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint. Mol Biol Cell (2007) 1.28
Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells. Nucleic Acids Res (2006) 1.26
RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe. Mol Biol Cell (2007) 1.25
Telomeres: structures in need of unwinding. FEBS Lett (2010) 1.21
RecQ helicases: lessons from model organisms. Nucleic Acids Res (2006) 1.19
Brc1-mediated DNA repair and damage tolerance. Genetics (2005) 1.18
Rad54, the motor of homologous recombination. DNA Repair (Amst) (2010) 1.18
Mus81 endonuclease localizes to nucleoli and to regions of DNA damage in human S-phase cells. Mol Biol Cell (2003) 1.17
RNA interference inhibition of Mus81 reduces mitotic recombination in human cells. Mol Biol Cell (2003) 1.17
Synthetic lethality of Drosophila in the absence of the MUS81 endonuclease and the DmBlm helicase is associated with elevated apoptosis. Genetics (2007) 1.16
Distinct roles of Mus81, Yen1, Slx1-Slx4, and Rad1 nucleases in the repair of replication-born double-strand breaks by sister chromatid exchange. Mol Cell Biol (2012) 1.15
Molecular mimicry of SUMO promotes DNA repair. Nat Struct Mol Biol (2009) 1.14
Archaeal Hel308 helicase targets replication forks in vivo and in vitro and unwinds lagging strands. Nucleic Acids Res (2005) 1.10
Molecular characterization of the Schizosaccharomyces pombe nbs1+ gene involved in DNA repair and telomere maintenance. Mol Cell Biol (2003) 1.09
A junction branch point adjacent to a DNA backbone nick directs substrate cleavage by Saccharomyces cerevisiae Mus81-Mms4. Nucleic Acids Res (2009) 1.06
Restriction of replication fork regression activities by a conserved SMC complex. Mol Cell (2014) 1.04
Crystal structure of the Mus81-Eme1 complex. Genes Dev (2008) 1.04
The dissolution of double Holliday junctions. Cold Spring Harb Perspect Biol (2014) 1.03
Three structure-selective endonucleases are essential in the absence of BLM helicase in Drosophila. PLoS Genet (2011) 1.03
The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant. Nucleic Acids Res (2009) 1.03
Holliday junction-containing DNA structures persist in cells lacking Sgs1 or Top3 following exposure to DNA damage. Proc Natl Acad Sci U S A (2011) 1.02
Genome stability roles of SUMO-targeted ubiquitin ligases. DNA Repair (Amst) (2009) 1.00
RAD5A, RECQ4A, and MUS81 have specific functions in homologous recombination and define different pathways of DNA repair in Arabidopsis thaliana. Plant Cell (2010) 0.99
Resolving branched DNA intermediates with structure-specific nucleases during replication in eukaryotes. Chromosoma (2013) 0.95
Sgs1 RecQ helicase inhibits survival of Saccharomyces cerevisiae cells lacking telomerase and homologous recombination. J Biol Chem (2008) 0.95
Holliday junction resolvases. Cold Spring Harb Perspect Biol (2014) 0.94
A postsynaptic role for Rhp55/57 that is responsible for cell death in Deltarqh1 mutants following replication arrest in Schizosaccharomyces pombe. Genetics (2005) 0.94
Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases. PLoS Genet (2012) 0.93
Genetic and functional interactions between Mus81-Mms4 and Rad27. Nucleic Acids Res (2010) 0.92
Meiotic DNA joint molecule resolution depends on Nse5-Nse6 of the Smc5-Smc6 holocomplex. Nucleic Acids Res (2012) 0.91
Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage. Nucleic Acids Res (2013) 0.91
Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant. Mol Cell Biol (2012) 0.89
Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage. Nat Struct Mol Biol (2013) 0.89
Mus81-Eme1-dependent and -independent crossovers form in mitotic cells during double-strand break repair in Schizosaccharomyces pombe. Mol Cell Biol (2007) 0.89
A Flp-nick system to study repair of a single protein-bound nick in vivo. Nat Methods (2009) 0.89
Meiotic Recombination in Schizosaccharomyces pombe: A Paradigm for Genetic and Molecular Analysis. Genome Dyn Stab (2008) 0.88
Two distinct MUS81-EME1 complexes from Arabidopsis process Holliday junctions. Plant Physiol (2009) 0.87
Role of Blm and collaborating factors in recombination and survival following replication stress in Ustilago maydis. DNA Repair (Amst) (2009) 0.87
The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast. Mol Cell Biol (2011) 0.87
DNA damage repair machinery and HIV escape from innate immune sensing. Front Microbiol (2014) 0.87
Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast. PLoS Genet (2010) 0.86
RusA Holliday junction resolvase: DNA complex structure--insights into selectivity and specificity. Nucleic Acids Res (2006) 0.84
Schizosaccharomyces pombe replication protein Cdc45/Sna41 requires Hsk1/Cdc7 and Rad4/Cut5 for chromatin binding. Chromosoma (2004) 0.84
Substrate specificity of the MUS81-EME2 structure selective endonuclease. Nucleic Acids Res (2013) 0.83
Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates. Genome Dyn Stab (2008) 0.83
Survival of the replication checkpoint deficient cells requires MUS81-RAD52 function. PLoS Genet (2013) 0.83
Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage. Genetics (2010) 0.83
Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress. Cell Rep (2015) 0.82
Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates. EMBO J (2014) 0.81
Control of structure-specific endonucleases to maintain genome stability. Nat Rev Mol Cell Biol (2017) 0.81
The role of DNA exonucleases in protecting genome stability and their impact on ageing. Age (Dordr) (2011) 0.81
Damage-dependent regulation of MUS81-EME1 by Fanconi anemia complementation group A protein. Nucleic Acids Res (2013) 0.81
Generating crossovers by resolution of nicked Holliday junctions: a role for Mus81-Eme1 in meiosis. Mol Cell (2003) 3.29
JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia. Blood (2010) 2.83
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Mol Cell (2010) 2.36
The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair. Mol Cell (2008) 2.19
The F-Box DNA helicase Fbh1 prevents Rhp51-dependent recombination without mediator proteins. Mol Cell Biol (2005) 1.82
Exploring the roles of Mus81-Eme1/Mms4 at perturbed replication forks. DNA Repair (Amst) (2007) 1.76
Cleavage of model replication forks by fission yeast Mus81-Eme1 and budding yeast Mus81-Mms4. J Biol Chem (2002) 1.76
Mus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates? EMBO J (2007) 1.42
The involvement of Srs2 in post-replication repair and homologous recombination in fission yeast. Nucleic Acids Res (2004) 1.41
DNA repair by a Rad22-Mus81-dependent pathway that is independent of Rhp51. Nucleic Acids Res (2004) 1.38
Replication fork blockage by RTS1 at an ectopic site promotes recombination in fission yeast. EMBO J (2005) 1.32
The fission yeast FANCM ortholog directs non-crossover recombination during meiosis. Science (2012) 1.26
Fbh1 limits Rad51-dependent recombination at blocked replication forks. Mol Cell Biol (2009) 1.13
The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability. Genes Dev (2012) 1.04
The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant. Nucleic Acids Res (2009) 1.03
Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier. Nucleic Acids Res (2011) 1.01
Biochemical characterization and DNA repair pathway interactions of Mag1-mediated base excision repair in Schizosaccharomyces pombe. Nucleic Acids Res (2005) 0.96
Correction of proliferation and drug sensitivity defects in the progeroid Werner's Syndrome by Holliday junction resolution. Rejuvenation Res (2007) 0.89
Alternative induction of meiotic recombination from single-base lesions of DNA deaminases. Genetics (2009) 0.89
The role of the SAP motif in promoting Holliday junction binding and resolution by SpCCE1. J Biol Chem (2003) 0.89
MHF1-2/CENP-S-X performs distinct roles in centromere metabolism and genetic recombination. Open Biol (2013) 0.88
Monitoring homologous recombination following replication fork perturbation in the fission yeast Schizosaccharomyces pombe. Methods Mol Biol (2009) 0.87
Junctions on the road to cancer. Nat Struct Mol Biol (2004) 0.85
UV irradiation causes the loss of viable mitotic recombinants in Schizosaccharomyces pombe cells lacking the G(2)/M DNA damage checkpoint. Genetics (2002) 0.83
Structure-specific endonucleases xpf and mus81 play overlapping but essential roles in DNA repair by homologous recombination. Cancer Res (2013) 0.83
Risk factors and seroprevalence of markers for hepatitis A, B and C in persons subject to homelessness in inner Sydney. Aust N Z J Public Health (2007) 0.83
Efficient second strand cleavage during Holliday junction resolution by RuvC requires both increased junction flexibility and an exposed 5' phosphate. PLoS One (2009) 0.83
A failure of meiotic chromosome segregation in a fbh1Delta mutant correlates with persistent Rad51-DNA associations. Nucleic Acids Res (2010) 0.83
The ATPase activity of Fml1 is essential for its roles in homologous recombination and DNA repair. Nucleic Acids Res (2012) 0.82
Nurse specialist treatment of eye emergencies: five year follow up study of quality and effectiveness. Int Emerg Nurs (2009) 0.80
SAR of a novel 'Anthranilamide Like' series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer. Bioorg Med Chem Lett (2007) 0.79
Emerging roles for centromere-associated proteins in DNA repair and genetic recombination. Biochem Soc Trans (2013) 0.79
Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability. PLoS One (2013) 0.77
How not to get cross(ed): a novel role for FANCM orthologs in meiotic recombination. Cell Cycle (2012) 0.76
Thinking the unthinkable: does mental health nursing have a future? J Psychiatr Ment Health Nurs (2009) 0.75
Patient perspective: what do palliative care patients think about their care? Int J Palliat Nurs (2008) 0.75