Published in Nat Med on July 01, 2002
Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFN. J Exp Med (2004) 2.89
TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat Med (2005) 2.62
Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. J Biol Chem (2009) 2.33
An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages. Immunity (2012) 2.01
Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes. J Clin Invest (2004) 1.96
Borrelia burgdorferi changes its surface antigenic expression in response to host immune responses. Infect Immun (2004) 1.82
Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells. Proc Natl Acad Sci U S A (2006) 1.82
Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria. Immunology (2005) 1.75
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TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis. Cell Immunol (2009) 1.61
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Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guérin peptidoglycan. Infect Immun (2003) 1.55
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Borrelia garinii induces CXCL13 production in human monocytes through Toll-like receptor 2. Infect Immun (2007) 1.31
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Live Borrelia burgdorferi spirochetes elicit inflammatory mediators from human monocytes via the Toll-like receptor signaling pathway. Infect Immun (2009) 1.11
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FimH adhesin of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires TLR4 and type 1 interferon signalling. PLoS Pathog (2008) 1.06
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Inflammatory cytokine production predominates in early Lyme disease in patients with erythema migrans. Infect Immun (2003) 1.02
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Characterization of the B-cell inhibitory protein factor in Ixodes ricinus tick saliva: a potential role in enhanced Borrelia burgdoferi transmission. Immunology (2004) 0.99
TLR2 activation inhibits embryonic neural progenitor cell proliferation. J Neurochem (2010) 0.99
TRIF mediates Toll-like receptor 2-dependent inflammatory responses to Borrelia burgdorferi. Infect Immun (2012) 0.99
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Autoantigen, innate immunity, and T cells cooperate to break B cell tolerance during bacterial infection. J Clin Invest (2005) 0.97
The physiological regulation of toll-like receptor expression and function in humans. J Physiol (2005) 0.97
FimH can directly activate human and murine natural killer cells via TLR4. Mol Ther (2010) 0.97
Toll-like receptor 2 is required for LPS-induced Toll-like receptor 4 signaling and inhibition of ion transport in renal thick ascending limb. J Biol Chem (2012) 0.95
Interleukin-10 alters effector functions of multiple genes induced by Borrelia burgdorferi in macrophages to regulate Lyme disease inflammation. Infect Immun (2011) 0.94
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Differential effect of TLR2 and TLR4 on the immune response after immunization with a vaccine against Neisseria meningitidis or Bordetella pertussis. PLoS One (2010) 0.93
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Induction of IgG3 to LPS via Toll-like receptor 4 co-stimulation. PLoS One (2008) 0.92
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Human TLR8 is activated upon recognition of Borrelia burgdorferi RNA in the phagosome of human monocytes. J Leukoc Biol (2013) 0.91
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Lipoprotein-dependent and -independent immune responses to spirochetal infection. Clin Diagn Lab Immunol (2005) 0.90
Pan-vertebrate toll-like receptors during evolution. Curr Genomics (2008) 0.89
Roles for Treg expansion and HMGB1 signaling through the TLR1-2-6 axis in determining the magnitude of the antigen-specific immune response to MVA85A. PLoS One (2013) 0.89
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Nuclear presence of nuclear factor of activated T cells (NFAT) c3 and c4 is required for Toll-like receptor-activated innate inflammatory response of monocytes/macrophages. Cell Signal (2011) 0.88
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Increased TLR4 expression and downstream cytokine production in immunosuppressed adults compared to non-immunosuppressed adults. PLoS One (2010) 0.87
Dual role of MyD88 in rapid clearance of relapsing fever Borrelia spp. Infect Immun (2006) 0.87
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Interaction of Pattern Recognition Receptors with Mycobacterium Tuberculosis. J Clin Immunol (2014) 0.85
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A novel aminosaccharide compound blocks immune responses by Toll-like receptors and nucleotide-binding domain, leucine-rich repeat proteins. J Biol Chem (2010) 0.84
Different patterns of expression and of IL-10 modulation of inflammatory mediators from macrophages of Lyme disease-resistant and -susceptible mice. PLoS One (2012) 0.84
The role of immunostimulatory nucleic acids in septic shock. Int J Clin Exp Med (2012) 0.84
A nonproliferating parvovirus vaccine vector elicits sustained, protective humoral immunity following a single intravenous or intranasal inoculation. J Virol (2004) 0.84
Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity. Front Cell Infect Microbiol (2014) 0.84
Tripalmitoyl-S-glyceryl-cysteine-dependent OspA vaccination of toll-like receptor 2-deficient mice results in effective protection from Borrelia burgdorferi challenge. Infect Immun (2003) 0.84
Genetic determination of the effect of post-translational modification on the innate immune response to the 19 kDa lipoprotein of Mycobacterium tuberculosis. BMC Microbiol (2009) 0.83
Borrelia burgdorferi lipoprotein BmpA activates pro-inflammatory responses in human synovial cells through a protein moiety. Microbes Infect (2008) 0.83
Essential calcium-binding cluster of Leptospira LipL32 protein for inflammatory responses through the Toll-like receptor 2 pathway. J Biol Chem (2013) 0.83
Using distinct molecular signatures of human monocytes and dendritic cells to predict adjuvant activity and pyrogenicity of TLR agonists. Med Microbiol Immunol (2008) 0.83
A network of hydrogen bonds on the surface of TLR2 controls ligand positioning and cell signaling. J Biol Chem (2009) 0.83
Innate immunity and transplantation tolerance: the potential role of TLRs/NLRs in GVHD. Korean J Hematol (2011) 0.82
Toll-like receptor stimulation differentially regulates vasoactive intestinal peptide type 2 receptor in macrophages. J Cell Mol Med (2009) 0.82
MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi. PLoS Pathog (2014) 0.82
Novel toll-like receptor 2 ligands for targeted pancreatic cancer imaging and immunotherapy. J Med Chem (2012) 0.81
Toll-like receptor 2 mediates inhibition of HCO(3)(-) absorption by bacterial lipoprotein in medullary thick ascending limb. Am J Physiol Renal Physiol (2010) 0.81
Activation of the TLR1/2 pathway induces the shaping of the immune response status of peripheral blood leukocytes. Exp Ther Med (2014) 0.81
A plague on host defense. J Exp Med (2002) 0.81
Toll-like receptors 1 and 2 heterodimers alter Borrelia burgdorferi gene expression in mice and ticks. J Infect Dis (2009) 0.80
Dysregulation of Toll-Like Receptor 7 Compromises Innate and Adaptive T Cell Responses and Host Resistance to an Attenuated West Nile Virus Infection in Old Mice. J Virol (2015) 0.80
MyD88 negatively controls hypergammaglobulinemia with autoantibody production during bacterial infection. Infect Immun (2008) 0.79
The early activation of toll-like receptor (TLR)-3 initiates kidney injury after ischemia and reperfusion. PLoS One (2014) 0.79
Ikaros mediates the DNA methylation-independent silencing of MCJ/DNAJC15 gene expression in macrophages. Sci Rep (2015) 0.78
Antagonistic Interplay between MicroRNA-155 and IL-10 during Lyme Carditis and Arthritis. PLoS One (2015) 0.78
Upregulation of TLR1, TLR2, TLR4, and IRAK-2 Expression During ML-1 Cell Differentiation to Macrophages: Role in the Potentiation of Cellular Responses to LPS and LTA. ISRN Oncol (2012) 0.78
Presence of Arp specifically contributes to joint tissue edema associated with early-onset Lyme arthritis. Infect Immun (2013) 0.78
Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32
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Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science (2003) 14.04
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science (2005) 11.31
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature (2012) 10.74
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity (2006) 10.61
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity (2006) 10.58
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Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell (2008) 9.59
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Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature (2008) 9.16
Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A (2004) 9.00
Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med (2005) 8.49
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A (2006) 8.27
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The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell (2009) 7.88
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87
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Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med (2004) 7.49
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Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature (2007) 7.34
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IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79
Regulation of phagosome maturation by signals from toll-like receptors. Science (2004) 6.79
A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol (2008) 6.78
T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity (2007) 6.61
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature (2007) 6.58
Control of inducible gene expression by signal-dependent transcriptional elongation. Cell (2009) 6.57
Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science (2006) 6.55
Control of B-cell responses by Toll-like receptors. Nature (2005) 6.44
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol (2007) 6.20
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell (2006) 6.01
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity (2006) 6.00
Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc Natl Acad Sci U S A (2005) 5.96
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Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity (2006) 5.91
Toll-like receptor signaling pathways. Science (2003) 5.86
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity (2007) 5.73
The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci U S A (2008) 5.59
Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science (2007) 5.54
Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature (2006) 5.54
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell (2004) 5.50
Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature (2005) 5.32
A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol (2009) 5.26
A toll-like receptor that prevents infection by uropathogenic bacteria. Science (2004) 5.26
Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science (2009) 5.24
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest (2009) 5.09
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J Exp Med (2007) 4.95
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RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med (2005) 4.85
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The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nat Immunol (2006) 4.70
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Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J Exp Med (2007) 4.47
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Toll-like receptors and cancer. Nat Rev Cancer (2008) 4.29
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The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature (2002) 4.15
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MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab (2009) 3.64
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TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proc Natl Acad Sci U S A (2004) 3.26