Published in Nat Rev Immunol on June 01, 2002
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The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis. Immunity (2007) 4.74
c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses. Biochem J (2005) 2.16
Loss of Siglec expression on T lymphocytes during human evolution. Proc Natl Acad Sci U S A (2006) 1.75
State-based discovery: a multidimensional screen for small-molecule modulators of EGF signaling. Nat Methods (2006) 1.50
CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity. Proc Natl Acad Sci U S A (2008) 1.48
T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2. J Exp Med (2006) 1.22
A milk-free diet downregulates folate receptor autoimmunity in cerebral folate deficiency syndrome. Dev Med Child Neurol (2008) 1.19
Molecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy. Immunol Rev (2009) 1.19
CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis. Arthritis Res Ther (2003) 1.04
On-chip activation and subsequent detection of individual antigen-specific T cells. Anal Chem (2010) 1.02
TCR Signaling Emerges from the Sum of Many Parts. Front Immunol (2012) 0.99
Impaired T cell death and lupus-like autoimmunity in T cell-specific adapter protein-deficient mice. J Exp Med (2003) 0.94
Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation. Nat Commun (2015) 0.93
Crystallization and initial crystal characterization of the C-terminal phosphoglycerate mutase homology domain of Sts-1. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.93
MicroRNA regulation of lymphocyte tolerance and autoimmunity. J Clin Invest (2015) 0.92
T-lymphocyte signalling in systemic lupus erythematosus: a lipid raft perspective. Lupus (2004) 0.90
T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity. Int Rev Immunol (2006) 0.88
Early intervention with gene-modified mesenchymal stem cells overexpressing interleukin-4 enhances anti-inflammatory responses and functional recovery in experimental autoimmune demyelination. Cell Adh Migr (2012) 0.86
Fenofibrate inhibited the differentiation of T helper 17 cells in vitro. PPAR Res (2012) 0.86
The SWI/SNF chromatin-remodeling complex modulates peripheral T cell activation and proliferation by controlling AP-1 expression. J Biol Chem (2009) 0.85
Effects of triptolide from Radix Tripterygium wilfordii (Leigongteng) on cartilage cytokines and transcription factor NF-kappaB: a study on induced arthritis in rats. Chin Med (2009) 0.84
Therapeutic blockade of T-cell antigen receptor signal transduction and costimulation in autoimmune disease. Adv Exp Med Biol (2008) 0.82
A phase II multicenter rabbit anti-thymocyte globulin trial in patients with myelodysplastic syndromes identifying a novel model for response prediction. Haematologica (2014) 0.81
Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes. Immunology (2004) 0.80
Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes. Cell Physiol Biochem (2015) 0.80
Estradiol targets T cell signaling pathways in human systemic lupus. Clin Immunol (2009) 0.80
IL-2 mediates CD4+ T cell help in the breakdown of memory-like CD8+ T cell tolerance under lymphopenic conditions. PLoS One (2010) 0.80
The E3 ubiquitin ligase Cbl-b regulates expansion but not functional activity of self-reactive CD4 T cells. J Immunol (2009) 0.79
Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice. J Cell Biol (2011) 0.79
Early growth response-2 signaling mediates immunomodulatory effects of human multipotential stromal cells. Stem Cells Dev (2013) 0.78
Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. J Exp Med (2016) 0.78
Histone acetylation at the Ifng promoter in tolerized CD4 cells is associated with increased IFN-gamma expression during subsequent immunization to the same antigen. J Immunol (2007) 0.78
TCR signaling to NF-κB and mTORC1: Expanding roles of the CARMA1 complex. Mol Immunol (2015) 0.77
Low expression of estrogen receptor β in T lymphocytes and high serum levels of anti-estrogen receptor α antibodies impact disease activity in female patients with systemic lupus erythematosus. Biol Sex Differ (2016) 0.77
Compound heterozygosity for Pten and SHIP augments T-dependent humoral immune responses and cytokine production by CD(4+) T cells. Immunology (2004) 0.76
The role for protein tyrosine phosphatase non-receptor type 22 in regulating intestinal homeostasis. United European Gastroenterol J (2015) 0.75
Extracellular Vesicles: Evolving Contributors in Autoimmunity. For Immunopathol Dis Therap (2015) 0.75
CD8αα+MHC Class II+ Cell with the Capacity To Terminate Autoimmune Inflammation Is a Novel Antigen-Presenting NK-like Cell in Rats. J Immunol (2016) 0.75
New insights into the catalytic mechanism of histidine phosphatases revealed by a functionally essential arginine residue within the active site of the Sts phosphatases. Biochem J (2013) 0.75
Evaluation of artificial selection in Standard Poodles using whole-genome sequencing. Mamm Genome (2016) 0.75
Dual non-contiguous peptide occupancy of HLA class I evoke antiviral human CD8 T cell response and form neo-epitopes with self-antigens. Sci Rep (2017) 0.75