Published in J Immunol on July 15, 2002
Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin. Proc Natl Acad Sci U S A (2003) 2.30
The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction. Semin Immunopathol (2009) 2.12
Molecular mechanisms involved in T cell migration across the blood-brain barrier. J Neural Transm (Vienna) (2006) 1.96
Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res (2012) 1.85
Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain. J Clin Invest (2010) 1.67
The blood-brain barrier, chemokines and multiple sclerosis. Biochim Biophys Acta (2010) 1.40
Inflammatory cell trafficking across the blood-brain barrier: chemokine regulation and in vitro models. Immunol Rev (2012) 1.30
Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle. Fluids Barriers CNS (2011) 1.21
Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain. Nat Med (2009) 1.10
Immune privilege of the CNS is not the consequence of limited antigen sampling. Sci Rep (2014) 1.09
Leukocyte integrins: role in leukocyte recruitment and as therapeutic targets in inflammatory disease. Pharmacol Ther (2014) 1.08
Modeling multiple sclerosis in laboratory animals. Semin Immunopathol (2009) 0.94
Endothelial histamine H1 receptor signaling reduces blood-brain barrier permeability and susceptibility to autoimmune encephalomyelitis. Proc Natl Acad Sci U S A (2010) 0.94
Human cerebrospinal fluid contains CD4+ memory T cells expressing gut- or skin-specific trafficking determinants: relevance for immunotherapy. BMC Immunol (2006) 0.93
The central nervous system is a target of acute graft versus host disease in mice. Blood (2013) 0.93
SAP suppresses the development of experimental autoimmune encephalomyelitis in C57BL/6 mice. Immunol Cell Biol (2011) 0.92
Knocking at the brain's door: intravital two-photon imaging of autoreactive T cell interactions with CNS structures. Semin Immunopathol (2010) 0.91
Absence of Fer protein tyrosine kinase exacerbates endotoxin induced intestinal epithelial barrier dysfunction in vivo. Gut (2005) 0.91
Cerebral leucocyte infiltration in lupus-prone MRL/MpJ-fas lpr mice--roles of intercellular adhesion molecule-1 and P-selectin. Clin Exp Immunol (2006) 0.89
The movers and shapers in immune privilege of the CNS. Nat Immunol (2017) 0.88
CD44 and HCELL: preventing hematogenous metastasis at step 1. FEBS Lett (2011) 0.88
Kinin B2 receptor regulates chemokines CCL2 and CCL5 expression and modulates leukocyte recruitment and pathology in experimental autoimmune encephalomyelitis (EAE) in mice. J Neuroinflammation (2008) 0.87
Hyaluronan anchored to activated CD44 on central nervous system vascular endothelial cells promotes lymphocyte extravasation in experimental autoimmune encephalomyelitis. J Biol Chem (2012) 0.87
VCAM-1/α4β1 integrin interaction is crucial for prompt recruitment of immune T cells into the brain during the early stage of reactivation of chronic infection with Toxoplasma gondii to prevent toxoplasmic encephalitis. Infect Immun (2014) 0.86
T cell-antigen-presenting cell interactions visualized in vivo in a model of antigen-specific inflammation. Clin Immunol (2008) 0.84
Intravital microscopy identifies selectins that regulate T cell traffic into allografts. J Clin Invest (2003) 0.83
Mesenchymal stem cells engineered to express selectin ligands and IL-10 exert enhanced therapeutic efficacy in murine experimental autoimmune encephalomyelitis. Biomaterials (2015) 0.83
Shining a light on intestinal traffic. Clin Dev Immunol (2011) 0.82
Enlargement of cerebral ventricles as an early indicator of encephalomyelitis. PLoS One (2013) 0.82
Gene deletion of P-Selectin and ICAM-1 does not inhibit neutrophil infiltration into peritoneal cavity following cecal ligation-puncture. BMC Clin Pathol (2004) 0.81
Absence of CCR5 increases neutrophil recruitment in severe herpetic encephalitis. BMC Neurosci (2013) 0.79
LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis. J Exp Med (2016) 0.78
Early treatment with anti-VLA-4 mAb can prevent the infiltration and/or development of pathogenic CD11b+CD4+ T cells in the CNS during progressive EAE. PLoS One (2014) 0.76
Monocyte behaviour and tissue transglutaminase expression during experimental autoimmune encephalomyelitis in transgenic CX3CR1(gfp/gfp) mice. Amino Acids (2016) 0.75
A Novel Cervical Spinal Cord Window Preparation Allows for Two-Photon Imaging of T-Cell Interactions with the Cervical Spinal Cord Microvasculature during Experimental Autoimmune Encephalomyelitis. Front Immunol (2017) 0.75
Development of central nervous system autoimmunity is impaired in the absence of Wiskott-Aldrich syndrome protein. PLoS One (2014) 0.75
Complement component C3a plays a critical role in endothelial activation and leukocyte recruitment into the brain. J Neuroinflammation (2016) 0.75
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med (2007) 8.58
Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol (2013) 7.10
Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science (2010) 5.84
Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade. J Exp Med (2006) 3.38
Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo. Nat Med (2012) 3.38
A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus. J Immunol (2010) 3.20
Metabolic profiling of serum samples by 1H nuclear magnetic resonance spectroscopy as a potential diagnostic approach for septic shock. Crit Care Med (2014) 2.97
Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs. J Clin Invest (2003) 2.89
PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils. Nat Immunol (2008) 2.88
The neutrophil in vascular inflammation. Nat Med (2011) 2.84
Enhanced S-nitroso-albumin formation from inhaled NO during ischemia/reperfusion. Circ Res (2004) 2.75
An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients. J Cell Biol (2002) 2.48
Functional innervation of hepatic iNKT cells is immunosuppressive following stroke. Science (2011) 2.44
Platelets express functional Toll-like receptor-4. Blood (2005) 2.37
TNF-alpha-secreting monocytes are recruited into the brain of cholestatic mice. Hepatology (2006) 2.23
Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis. Cell Host Microbe (2012) 2.17
NETosis: how vital is it? Blood (2013) 2.11
An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells. Nat Immunol (2010) 2.03
Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis. J Clin Invest (2013) 2.03
Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res (2012) 1.85
Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids. J Exp Med (2008) 1.84
The physiology of leukocyte recruitment: an in vivo perspective. J Immunol (2008) 1.84
Immune surveillance by the liver. Nat Immunol (2013) 1.79
LSP1 is an endothelial gatekeeper of leukocyte transendothelial migration. J Exp Med (2005) 1.72
Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic Gram-negative bacterial infection. J Clin Invest (2009) 1.70
TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease. J Immunol (2004) 1.70
Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain. J Clin Invest (2010) 1.67
Immune surveillance in the central nervous system. Nat Neurosci (2012) 1.63
IVIg therapy in brain inflammation: etiology-dependent differential effects on leucocyte recruitment. Brain (2004) 1.61
Targeting adhesion molecules as a potential mechanism of action for intravenous immunoglobulin. Circulation (2005) 1.60
Intravascular immunity: the host-pathogen encounter in blood vessels. Nat Rev Immunol (2009) 1.60
Toll gates and traffic arteries: from endothelial TLR2 to atherosclerosis. Circ Res (2004) 1.59
Real-time high resolution 3D imaging of the lyme disease spirochete adhering to and escaping from the vasculature of a living host. PLoS Pathog (2008) 1.59
PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP. J Cell Sci (2008) 1.54
Endothelial paxillin and focal adhesion kinase (FAK) play a critical role in neutrophil transmigration. Eur J Immunol (2012) 1.53
Role of CD44 and hyaluronan in neutrophil recruitment. J Immunol (2004) 1.53
Measuring chemotaxis and chemokinesis: the under-agarose cell migration assay. Sci STKE (2003) 1.50
Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitis. J Immunol (2004) 1.49
A requirement for microglial TLR4 in leukocyte recruitment into brain in response to lipopolysaccharide. J Immunol (2006) 1.49
Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance. Nat Immunol (2013) 1.46
Leukocyte migration is regulated by L-selectin endoproteolytic release. Immunity (2003) 1.42
Lipopolysaccharide-induced leukocyte-endothelial cell interactions: a role for CD14 versus toll-like receptor 4 within microvessels. J Immunol (2002) 1.38
Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection. Nat Immunol (2013) 1.37
Molecular mechanisms of leukocyte recruitment: organ-specific mechanisms of action. Thromb Haemost (2003) 1.36
Immune cell Toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia. Circ Res (2004) 1.35
Depletion of Ly6G/Gr-1 leukocytes after spinal cord injury in mice alters wound healing and worsens neurological outcome. J Neurosci (2009) 1.35
Molecular mechanisms involved in vascular interactions of the Lyme disease pathogen in a living host. PLoS Pathog (2008) 1.34
The role of TLR2 in vivo following challenge with Staphylococcus aureus and prototypic ligands. J Immunol (2006) 1.34
Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps. Cell Host Microbe (2013) 1.33
Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo. Blood (2007) 1.33
Neutrophils promote liver metastasis via Mac-1-mediated interactions with circulating tumor cells. Cancer Res (2012) 1.30
Modulating leukocyte recruitment in inflammation. J Allergy Clin Immunol (2007) 1.30
Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome. Nat Med (2009) 1.29
Chemokines: sirens of neutrophil recruitment-but is it just one song? Immunity (2010) 1.24
Anti-adhesive effect of nitric oxide on Plasmodium falciparum cytoadherence under flow. Am J Pathol (2003) 1.23
Role of endothelial TLR4 for neutrophil recruitment into central nervous system microvessels in systemic inflammation. J Immunol (2009) 1.23
Rules of recruitment for Th1 and Th2 lymphocytes in inflamed liver: a role for alpha-4 integrin and vascular adhesion protein-1. Immunity (2005) 1.23
Vav1 is essential for mechanotactic crawling and migration of neutrophils out of the inflamed microvasculature. J Immunol (2009) 1.23
Antibodies against neutrophil LY6G do not inhibit leukocyte recruitment in mice in vivo. Blood (2013) 1.23
Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow. J Exp Med (2013) 1.21
Macrophages eliminate circulating tumor cells after monoclonal antibody therapy. J Clin Invest (2014) 1.21
Rod-Shaped monocytes patrol the brain vasculature and give rise to perivascular macrophages under the influence of proinflammatory cytokines and angiopoietin-2. J Neurosci (2008) 1.20
The use of spinning-disk confocal microscopy for the intravital analysis of platelet dynamics in response to systemic and local inflammation. PLoS One (2011) 1.17
Endothelial LSP1 is involved in endothelial dome formation, minimizing vascular permeability changes during neutrophil transmigration in vivo. Blood (2010) 1.15
Cytotoxic CD4+ T cells use granulysin to kill Cryptococcus neoformans, and activation of this pathway is defective in HIV patients. Blood (2006) 1.15
Fundamentally different roles for LFA-1, Mac-1 and alpha4-integrin in neutrophil chemotaxis. J Cell Sci (2005) 1.15
Leukocyte adhesion in the liver: distinct adhesion paradigm from other organs. J Hepatol (2007) 1.12
Molecular regulators of leucocyte chemotaxis during inflammation. Cardiovasc Res (2010) 1.11
Integrin-induced PIP5K1C kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration. Immunity (2010) 1.10
P-selectin can support both Th1 and Th2 lymphocyte rolling in the intestinal microvasculature. Am J Pathol (2005) 1.09
Use of CD44 by CD4+ Th1 and Th2 lymphocytes to roll and adhere. Blood (2006) 1.09
Neutrophil-active chemokines in in vivo imaging of neutrophil trafficking. Eur J Immunol (2012) 1.08
Reevaluation of P-selectin and alpha 4 integrin as targets for the treatment of experimental autoimmune encephalomyelitis. J Immunol (2006) 1.06
Cellular and molecular choreography of neutrophil recruitment to sites of sterile inflammation. J Mol Med (Berl) (2011) 1.05
Endothelial domes encapsulate adherent neutrophils and minimize increases in vascular permeability in paracellular and transcellular emigration. PLoS One (2008) 1.05
Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules. Mol Microbiol (2012) 1.05
Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10. J Immunol (2009) 1.04
Inducible nitric oxide synthase (iNOS) in endotoxemia: chimeric mice reveal different cellular sources in various tissues. FASEB J (2002) 1.03
Multichannel fluorescence spinning disk microscopy reveals early endogenous CD4 T cell recruitment in contact sensitivity via complement. J Immunol (2008) 1.03
Mast cell-expressed complement receptor, not TLR2, is the main detector of zymosan in peritonitis. Eur J Immunol (2007) 1.03
Profound differences in leukocyte-endothelial cell responses to lipopolysaccharide versus lipoteichoic acid. J Immunol (2002) 1.03
Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability. J Immunol (2009) 1.03
Local coordination verses systemic disregulation: complexities in leukocyte recruitment revealed by local and systemic activation of TLR4 in vivo. J Leukoc Biol (2005) 1.01
Different domains of Pseudomonas aeruginosa exoenzyme S activate distinct TLRs. J Immunol (2004) 1.01
Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis. J Immunol (2009) 1.01
Varying importance of soluble and membrane CD14 in endothelial detection of lipopolysaccharide. J Immunol (2008) 1.00
Cellular and molecular mechanisms underlying LPS-associated myocyte impairment. Am J Physiol Heart Circ Physiol (2005) 1.00
A critical temporal window for selectin-dependent CD4+ lymphocyte homing and initiation of late-phase inflammation in contact sensitivity. J Exp Med (2004) 0.99
Mast cells regulate the magnitude and the cytokine microenvironment of the contact hypersensitivity response. Am J Pathol (2008) 0.97
The role of selectins and integrins in adenovirus vector-induced neutrophil recruitment to the liver. Eur J Immunol (2002) 0.97
Damage-associated molecular patterns control neutrophil recruitment. J Innate Immun (2013) 0.96
Neutrophils and intravascular immunity in the liver during infection and sterile inflammation. Toxicol Pathol (2011) 0.96
Recombinant PfEMP1 peptide inhibits and reverses cytoadherence of clinical Plasmodium falciparum isolates in vivo. Blood (2002) 0.95
Preventing the activation or cycling of the Rap1 GTPase alters adhesion and cytoskeletal dynamics and blocks metastatic melanoma cell extravasation into the lungs. Cancer Res (2010) 0.95
Lipoteichoic acid induces unique inflammatory responses when compared to other toll-like receptor 2 ligands. PLoS One (2009) 0.95
Complexity of inducible nitric oxide synthase: cellular source determines benefit versus toxicity. Circulation (2003) 0.93
Assessment of the safety and feasibility of administering antipyretic therapy in critically ill adults: a pilot randomized clinical trial. J Crit Care (2012) 0.93
GPI-linked endothelial CD14 contributes to the detection of LPS. Am J Physiol Heart Circ Physiol (2006) 0.93
Active Negative Pressure Peritoneal Therapy After Abbreviated Laparotomy: The Intraperitoneal Vacuum Randomized Controlled Trial. Ann Surg (2015) 0.93
Divergent roles of Toll-like receptor 2 in response to lipoteichoic acid and Staphylococcus aureus in vivo. Eur J Immunol (2010) 0.92