Published in Nature on July 04, 2002
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Protection against lethal influenza virus challenge by RNA interference in vivo. Proc Natl Acad Sci U S A (2004) 1.91
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Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2004) 1.82
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Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. J Clin Invest (2004) 1.67
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An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons. Mol Pain (2005) 1.49
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Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting. RNA (2007) 1.46
Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake. BMC Neurosci (2002) 1.44
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Tissue-specific RNA interference in postimplantation mouse embryos with endoribonuclease-prepared short interfering RNA. Proc Natl Acad Sci U S A (2002) 1.23
Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells. Mol Ther (2011) 1.23
Optical imaging-guided cancer therapy with fluorescent nanoparticles. J R Soc Interface (2009) 1.22
Delivery systems for the direct application of siRNAs to induce RNA interference (RNAi) in vivo. J Biomed Biotechnol (2006) 1.21
Novel RNA-based strategies for therapeutic gene silencing. Mol Ther (2010) 1.20
Integrin alpha(v)beta(3)-Targeted Cancer Therapy. Drug Dev Res (2008) 1.17
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Small interfering RNA targeted to hepatitis C virus 5' nontranslated region exerts potent antiviral effect. J Virol (2006) 1.16
Gene silencing of complement C5a receptor using siRNA for preventing ischemia/reperfusion injury. Am J Pathol (2008) 1.14
Generation of Ski-knockdown mice by expressing a long double-strand RNA from an RNA polymerase II promoter. Genes Dev (2003) 1.12
Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference. EMBO Rep (2004) 1.11
Consensus siRNA for inhibition of HCV genotype-4 replication. Virol J (2009) 1.10
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Optimizing RNA interference for application in mammalian cells. Biochem J (2004) 1.09
Chemical inducers of targeted protein degradation. J Biol Chem (2010) 1.07
Engineering biomaterial systems to enhance viral vector gene delivery. Mol Ther (2011) 1.07
Characterizing proteins of unknown function: orphan cytochrome p450 enzymes as a paradigm. Mol Interv (2010) 1.07
Chemical modification of siRNA bases to probe and enhance RNA interference. J Org Chem (2011) 1.06
High doses of siRNAs induce eri-1 and adar-1 gene expression and reduce the efficiency of RNA interference in the mouse. Biochem J (2005) 1.06
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Variants of bcl-2 specific siRNA for silencing antiapoptotic bcl-2 in pancreatic cancer. Gut (2005) 1.02
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Amelioration of psoriasis by anti-TNF-alpha RNAi in the xenograft transplantation model. Mol Ther (2009) 1.01
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Use of RNA interference to inhibit integrin (alpha6beta4)-mediated invasion and migration of breast carcinoma cells. Clin Exp Metastasis (2003) 0.99
Concepts in in vivo siRNA delivery for cancer therapy. J Cell Physiol (2009) 0.98
Inhibition of hepatitis C virus replication by intracellular delivery of multiple siRNAs by nanosomes. Mol Ther (2012) 0.98
Cyclodextrin and polyethylenimine functionalized mesoporous silica nanoparticles for delivery of siRNA cancer therapeutics. Theranostics (2014) 0.97
Recombinant AAV as a platform for translating the therapeutic potential of RNA interference. Mol Ther (2013) 0.96
RNA interference: antiviral weapon and beyond. World J Gastroenterol (2003) 0.95
Cationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor. Nanomedicine (2013) 0.95
Inhibition of signal transducer and activator of transcription 3 expression by RNA interference suppresses invasion through inducing anoikis in human colon cancer cells. World J Gastroenterol (2008) 0.95
Hydrodynamic gene delivery and its applications in pharmaceutical research. Pharm Res (2010) 0.94
Therapeutic regulation of gene expression in the inner ear using RNA interference. Adv Otorhinolaryngol (2009) 0.94
Epigenetics and the transition from acute to chronic pain. Pain Med (2012) 0.93
Antiviral effects of human immunodeficiency virus type 1-specific small interfering RNAs against targets conserved in select neurotropic viral strains. J Virol (2004) 0.93
A critical role for Rac1 in tumor progression of human colorectal adenocarcinoma cells. Am J Pathol (2007) 0.93
Therapeutic potential of siRNA-mediated targeting of urokinase plasminogen activator, its receptor, and matrix metalloproteinases. Methods Mol Biol (2009) 0.93
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Gene regulation by non-coding RNAs. Crit Rev Biochem Mol Biol (2013) 0.92
Combining competition assays with genetic complementation strategies to dissect mouse embryonic stem cell self-renewal and pluripotency. Nat Protoc (2012) 0.91
Short interfering RNA-mediated inhibition of herpes simplex virus type 1 gene expression and function during infection of human keratinocytes. J Virol (2004) 0.90
Development and optimization of nanosomal formulations for siRNA delivery to the liver. Eur J Pharm Biopharm (2011) 0.89
Recent In Vivo Evidences of Particle-Based Delivery of Small-Interfering RNA (siRNA) into Solid Tumors. J Pharm Innov (2014) 0.89
Gene silencing by RNAi in mouse Sertoli cells. Reprod Biol Endocrinol (2008) 0.88
Expression strategies for short hairpin RNA interference triggers. Hum Gene Ther (2008) 0.88
Stop codon suppression via inhibition of eRF1 expression. RNA (2003) 0.87
siRNAs: potential therapeutic agents against hepatitis C virus. Virol J (2011) 0.87
Constitutive expression of short hairpin RNA in vivo triggers buildup of mature hairpin molecules. Hum Gene Ther (2011) 0.87
The role of Med19 in the proliferation and tumorigenesis of human hepatocellular carcinoma cells. Acta Pharmacol Sin (2011) 0.87
Electrically assisted delivery of macromolecules into the corneal epithelium. Exp Eye Res (2009) 0.87
New therapeutic opportunities for hepatitis C based on small RNA. World J Gastroenterol (2007) 0.86
Hemodynamics of a hydrodynamic injection. Mol Ther Methods Clin Dev (2014) 0.86
A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21
MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet (2004) 37.83
Argonaute2 is the catalytic engine of mammalian RNAi. Science (2004) 22.86
Genome-wide in situ exon capture for selective resequencing. Nat Genet (2007) 19.97
A microRNA component of the p53 tumour suppressor network. Nature (2007) 19.25
Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell (2007) 18.35
Dicer is essential for mouse development. Nat Genet (2003) 15.87
Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev (2006) 15.20
Processing of primary microRNAs by the Microprocessor complex. Nature (2004) 14.59
Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat Med (2006) 13.51
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell (2006) 12.72
Crystal structure of Argonaute and its implications for RISC slicer activity. Science (2004) 12.48
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol (2005) 12.12
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell (2003) 11.40
Adenovirus-associated virus vector-mediated gene transfer in hemophilia B. N Engl J Med (2011) 11.01
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature (2006) 10.95
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature (2008) 10.71
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev (2002) 10.71
A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature (2006) 9.88
The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science (2007) 9.36
Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. Cell (2008) 9.02
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat Genet (2005) 8.99
Small RNAs as guardians of the genome. Cell (2009) 8.88
Characterization of Dicer-deficient murine embryonic stem cells. Proc Natl Acad Sci U S A (2005) 8.35
Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet (2005) 8.23
An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88
Developmentally regulated piRNA clusters implicate MILI in transposon control. Science (2007) 7.68
MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev Cell (2007) 7.66
The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev (2002) 7.61
A role for the P-body component GW182 in microRNA function. Nat Cell Biol (2005) 7.54
Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet (2003) 6.95
The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol (2003) 6.90
Purified Argonaute2 and an siRNA form recombinant human RISC. Nat Struct Mol Biol (2005) 6.64
Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev (2002) 6.43
Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell (2009) 6.39
A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature (2010) 6.37
A resource for large-scale RNA-interference-based screens in mammals. Nature (2004) 6.36
A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell (2008) 6.35
A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. Cell (2007) 6.31
A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science (2010) 5.84
An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat Genet (2003) 5.82
Genome analysis of the platypus reveals unique signatures of evolution. Nature (2008) 5.74
Alta-Cyclic: a self-optimizing base caller for next-generation sequencing. Nat Methods (2008) 5.70
A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61
Systemic delivery of genes to striated muscles using adeno-associated viral vectors. Nat Med (2004) 5.59
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell (2008) 5.47
Cancer proliferation gene discovery through functional genomics. Science (2008) 5.41
microRNAs join the p53 network--another piece in the tumour-suppression puzzle. Nat Rev Cancer (2007) 5.38
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci U S A (2005) 5.29
A biochemical approach to identifying microRNA targets. Proc Natl Acad Sci U S A (2007) 5.16
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An epigenetic role for maternally inherited piRNAs in transposon silencing. Science (2008) 5.05
Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice. Nat Biotechnol (2007) 5.04
A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes Dev (2007) 4.95
miR-19 is a key oncogenic component of mir-17-92. Genes Dev (2009) 4.95
Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet (2011) 4.81
Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation. Nature (2006) 4.68
Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8. Mol Ther (2006) 4.64
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AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B. Blood (2002) 4.60
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell (2009) 4.57
Profiling essential genes in human mammary cells by multiplex RNAi screening. Science (2008) 4.51
Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing. Nat Protoc (2009) 4.45
A nonviral minicircle vector for deriving human iPS cells. Nat Methods (2010) 4.42
Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes. Genome Res (2007) 4.28
Small RNA sorting: matchmaking for Argonautes. Nat Rev Genet (2010) 4.27
A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nat Methods (2011) 4.24
Critical roles for Dicer in the female germline. Genes Dev (2007) 4.23
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14
RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Biol (2004) 4.01
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A (2008) 4.00
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Biological basis for restriction of microRNA targets to the 3' untranslated region in mammalian mRNAs. Nat Struct Mol Biol (2009) 3.70
A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell (2011) 3.69
A micrococcal nuclease homologue in RNAi effector complexes. Nature (2003) 3.67
Synthetic shRNAs as potent RNAi triggers. Nat Biotechnol (2004) 3.67
Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectors. J Virol (2004) 3.65
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol (2006) 3.64
Suppression of tumorigenesis by the p53 target PUMA. Proc Natl Acad Sci U S A (2004) 3.42
Human tRNA-derived small RNAs in the global regulation of RNA silencing. RNA (2010) 3.40
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Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates. Cell (2011) 3.39
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. Nat Biotechnol (2010) 3.33
Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice. J Virol (2005) 3.28
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Inhibition of hepatitis B virus in mice by RNA interference. Nat Biotechnol (2003) 3.15
rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice. Nat Med (2006) 3.13
High-resolution genome-wide mapping of transposon integration in mammals. Mol Cell Biol (2005) 3.10
High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. Genome Res (2009) 3.08
DNA Sudoku--harnessing high-throughput sequencing for multiplexed specimen analysis. Genome Res (2009) 3.05
RNAi: an ever-growing puzzle. Trends Biochem Sci (2003) 3.01
Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis. Nat Methods (2004) 3.01
Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo. Mol Ther (2003) 2.95
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