Published in Nature on July 11, 2002
Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol (2004) 7.17
Single-molecule transition-state analysis of RNA folding. Proc Natl Acad Sci U S A (2003) 2.31
RNA-polymerase-I-directed rDNA transcription, life and works. Trends Biochem Sci (2005) 2.13
An unexpected type of ribosomes induced by kasugamycin: a look into ancestral times of protein synthesis? Mol Cell (2009) 2.03
The RNA polymerase I transcription machinery. Biochem Soc Symp (2006) 1.46
Thermodynamic and kinetic aspects of RNA pulling experiments. Biophys J (2005) 1.38
Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing. Nat Struct Mol Biol (2008) 1.26
Eukaryotic ribosomal RNA determinants of aminoglycoside resistance and their role in translational fidelity. RNA (2007) 1.26
On the origin of the translation system and the genetic code in the RNA world by means of natural selection, exaptation, and subfunctionalization. Biol Direct (2007) 1.24
Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases. Proc Natl Acad Sci U S A (2008) 1.22
5 S rRNA: structure and interactions. Biochem J (2003) 1.20
UBF activates RNA polymerase I transcription by stimulating promoter escape. EMBO J (2006) 1.20
A method for helical RNA global structure determination in solution using small-angle x-ray scattering and NMR measurements. J Mol Biol (2009) 1.16
Metal ion dependence, thermodynamics, and kinetics for intramolecular docking of a GAAA tetraloop and receptor connected by a flexible linker. Biochemistry (2006) 1.15
The fragmented mitochondrial ribosomal RNAs of Plasmodium falciparum. PLoS One (2012) 1.04
Fast evolving 18S rRNA sequences from Solenogastres (Mollusca) resist standard PCR amplification and give new insights into mollusk substitution rate heterogeneity. BMC Evol Biol (2010) 0.99
Metalloprotein and metallo-DNA/RNAzyme design: current approaches, success measures, and future challenges. Inorg Chem (2006) 0.98
Non-coding RNA: a new frontier in regulatory biology. Natl Sci Rev (2014) 0.95
Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes. Subcell Biochem (2013) 0.94
The origin of life: chemical evolution of a metabolic system in a mineral honeycomb? J Mol Evol (2009) 0.93
Catalytic activity as a probe of native RNA folding. Methods Enzymol (2009) 0.93
Localization of spermine binding sites in 23S rRNA by photoaffinity labeling: parsing the spermine contribution to ribosomal 50S subunit functions. Nucleic Acids Res (2005) 0.92
Why is start codon selection so precise in eukaryotes? Translation (Austin) (2014) 0.92
Stiffened yeast telomerase RNA supports RNP function in vitro and in vivo. RNA (2012) 0.90
Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP. RNA (2010) 0.86
Montmorillonite protection of an UV-irradiated hairpin ribozyme: evolution of the RNA world in a mineral environment. BMC Evol Biol (2007) 0.86
Interaction between 25S rRNA A loop and eukaryotic translation initiation factor 5B promotes subunit joining and ensures stringent AUG selection. Mol Cell Biol (2013) 0.84
The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs. Nucleic Acids Res (2013) 0.82
Nucleolar proteins Bfr2 and Enp2 interact with DEAD-box RNA helicase Dbp4 in two different complexes. Nucleic Acids Res (2013) 0.79
The RNA world and the origin of metabolic enzymes. Biochem Soc Trans (2014) 0.77
Biochemical evidence of translational infidelity and decreased peptidyltransferase activity by a sarcin/ricin domain mutation of yeast 25S rRNA. Nucleic Acids Res (2004) 0.77
Ribozymes: catalytic RNAs that cut things, make things, and do odd and useful jobs. Biologist (London) (2002) 0.76
DEAD-box RNA helicase Dbp4 is required for small-subunit processome formation and function. Mol Cell Biol (2014) 0.75
Random mutagenesis of yeast 25S rRNA identify bases critical for 60S subunit structural integrity and function. Translation (Austin) (2013) 0.75
Expression of Distinct Maternal and Somatic 5.8S, 18S, and 28S rRNA Types during Zebrafish Development. RNA (2017) 0.75
Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase. Science (2002) 3.61
Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell (2005) 3.46
The structural mechanism of translocation and helicase activity in T7 RNA polymerase. Cell (2004) 3.33
An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA. Nature (2005) 3.18
The structures of four macrolide antibiotics bound to the large ribosomal subunit. Mol Cell (2002) 3.07
Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit. J Mol Biol (2003) 2.98
Structural insight into nascent polypeptide chain-mediated translational stalling. Science (2009) 2.89
Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction. Mol Cell (2005) 2.49
Structural insights into peptide bond formation. Proc Natl Acad Sci U S A (2002) 2.40
The hexameric helicase DnaB adopts a nonplanar conformation during translocation. Cell (2012) 2.37
A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits. Nat Struct Biol (2002) 2.36
Formation of the first peptide bond: the structure of EF-P bound to the 70S ribosome. Science (2009) 2.33
Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B-family polymerases. EMBO J (2007) 2.22
The contribution of metal ions to the structural stability of the large ribosomal subunit. RNA (2004) 2.17
Insights into strand displacement and processivity from the crystal structure of the protein-primed DNA polymerase of bacteriophage phi29. Mol Cell (2004) 2.00
Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase. Science (2007) 1.97
Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit. J Med Chem (2008) 1.96
Revisiting the structures of several antibiotics bound to the bacterial ribosome. Proc Natl Acad Sci U S A (2010) 1.82
The structural basis of large ribosomal subunit function. Annu Rev Biochem (2003) 1.82
The structure of T. aquaticus DNA polymerase III is distinct from eukaryotic replicative DNA polymerases. Cell (2006) 1.79
Poly(A) tail recognition by a viral RNA element through assembly of a triple helix. Science (2010) 1.73
Structure of a synaptic gammadelta resolvase tetramer covalently linked to two cleaved DNAs. Science (2005) 1.73
The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex. Mol Cell (2013) 1.73
The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation. Science (2009) 1.70
The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together. Cell (2007) 1.70
Structure of pyrrolysyl-tRNA synthetase, an archaeal enzyme for genetic code innovation. Proc Natl Acad Sci U S A (2007) 1.65
Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template. Nature (2004) 1.62
Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit. RNA (2003) 1.58
How hibernation factors RMF, HPF, and YfiA turn off protein synthesis. Science (2012) 1.55
The structure of the ankyrin-binding site of beta-spectrin reveals how tandem spectrin-repeats generate unique ligand-binding properties. Blood (2009) 1.54
The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome. Nat Struct Mol Biol (2010) 1.42
The initiation of mammalian protein synthesis and mRNA scanning mechanism. Nature (2013) 1.40
Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. Nat Struct Mol Biol (2009) 1.40
U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome. J Mol Biol (2009) 1.39
The structure of a transcribing T7 RNA polymerase in transition from initiation to elongation. Science (2008) 1.39
Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP. Cell (2002) 1.38
Insights into the replisome from the structure of a ternary complex of the DNA polymerase III alpha-subunit. J Mol Biol (2008) 1.37
Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding. Proc Natl Acad Sci U S A (2009) 1.36
Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J Mol Biol (2008) 1.35
A specific subdomain in phi29 DNA polymerase confers both processivity and strand-displacement capacity. Proc Natl Acad Sci U S A (2005) 1.33
The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition. EMBO J (2006) 1.31
Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome. Science (2012) 1.29
Insights into base selectivity from the 1.8 Å resolution structure of an RB69 DNA polymerase ternary complex. Biochemistry (2010) 1.29
Correction of X-ray intensities from single crystals containing lattice-translocation defects. Acta Crystallogr D Biol Crystallogr (2004) 1.26
The structure of LepA, the ribosomal back translocase. Proc Natl Acad Sci U S A (2008) 1.19
Structure of the base of the L7/L12 stalk of the Haloarcula marismortui large ribosomal subunit: analysis of L11 movements. J Mol Biol (2007) 1.19
Implications of structures of synaptic tetramers of gamma delta resolvase for the mechanism of recombination. Proc Natl Acad Sci U S A (2006) 1.17
A story with a good ending: tRNA 3'-end maturation by CCA-adding enzymes. Curr Opin Struct Biol (2005) 1.14
Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes. Mol Cell (2003) 1.12
A structural view on the mechanism of the ribosome-catalyzed peptide bond formation. Biochim Biophys Acta (2009) 1.08
The crystal structure of the Thermus aquaticus DnaB helicase monomer. Nucleic Acids Res (2007) 1.04
Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors. Proc Natl Acad Sci U S A (2004) 1.03
The roles of RNA in the synthesis of protein. Cold Spring Harb Perspect Biol (2011) 1.03
Structure of the calmodulin alphaII-spectrin complex provides insight into the regulation of cell plasticity. J Biol Chem (2006) 1.00
The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases. Proc Natl Acad Sci U S A (2003) 0.98
The structures of antibiotics bound to the E site region of the 50 S ribosomal subunit of Haloarcula marismortui: 13-deoxytedanolide and girodazole. J Mol Biol (2007) 0.97
Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui. Antimicrob Agents Chemother (2009) 0.95
Crystal structure of an intermediate of rotating dimers within the synaptic tetramer of the G-segment invertase. Nucleic Acids Res (2012) 0.94
Toward understanding phosphoseryl-tRNACys formation: the crystal structure of Methanococcus maripaludis phosphoseryl-tRNA synthetase. Proc Natl Acad Sci U S A (2007) 0.92
How the CCA-adding enzyme selects adenine over cytosine at position 76 of tRNA. Science (2010) 0.92
Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor. Proc Natl Acad Sci U S A (2013) 0.92
After the ribosome structures: how does peptidyl transferase work? RNA (2003) 0.91
The ribosome revealed. Trends Biochem Sci (2005) 0.91
Gene replacement in Haloarcula marismortui: construction of a strain with two of its three chromosomal rRNA operons deleted. Extremophiles (2005) 0.90
Initiation factor 2 crystal structure reveals a different domain organization from eukaryotic initiation factor 5B and mechanism among translational GTPases. Proc Natl Acad Sci U S A (2013) 0.90
The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge B2a of the ribosome. J Mol Biol (2012) 0.88
Elements of ribosomal drug resistance and specificity. Curr Opin Struct Biol (2012) 0.86
Structure of a helicase-helicase loader complex reveals insights into the mechanism of bacterial primosome assembly. Nat Commun (2013) 0.84
Structure of the PolIIIα-τc-DNA complex suggests an atomic model of the replisome. Structure (2013) 0.83
Cross-crystal averaging reveals that the structure of the peptidyl-transferase center is the same in the 70S ribosome and the 50S subunit. Proc Natl Acad Sci U S A (2008) 0.82
Rational design of 'water-soluble' bacteriorhodopsin variants. Protein Eng (2002) 0.81
Peptidyl-CCA deacylation on the ribosome promoted by induced fit and the O3'-hydroxyl group of A76 of the unacylated A-site tRNA. RNA (2008) 0.79
Assembly, purification and crystallization of an active HIV-1 reverse transcriptase initiation complex. Nucleic Acids Res (2002) 0.78
A novel method of determining the number of macromolecules per asymmetric unit from accurate crystal-volume measurements. Acta Crystallogr D Biol Crystallogr (2003) 0.75