Published in Nature on July 18, 2002
Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol Mol Biol Rev (2002) 8.50
Requirement of the MRN complex for ATM activation by DNA damage. EMBO J (2003) 6.23
Endonucleolytic processing of covalent protein-linked DNA double-strand breaks. Nature (2005) 4.53
The Mre11 complex is required for ATM activation and the G2/M checkpoint. EMBO J (2003) 3.91
The MRE11 complex: starting from the ends. Nat Rev Mol Cell Biol (2011) 3.83
DNA end resection: many nucleases make light work. DNA Repair (Amst) (2009) 3.28
Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer (2010) 2.68
Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation. PLoS Pathog (2009) 2.21
DNA repair proteins affect the lifecycle of herpes simplex virus 1. Proc Natl Acad Sci U S A (2005) 2.20
Heterochromatin silencing of p53 target genes by a small viral protein. Nature (2010) 2.12
Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA. Mol Cell (2009) 2.12
The MRN complex: coordinating and mediating the response to broken chromosomes. EMBO Rep (2003) 1.97
Adenovirus E4 34k and E1b 55k oncoproteins target host DNA ligase IV for proteasomal degradation. J Virol (2007) 1.80
Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. Cell Host Microbe (2007) 1.71
Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production. Nat Immunol (2014) 1.67
Relocalization of the Mre11-Rad50-Nbs1 complex by the adenovirus E4 ORF3 protein is required for viral replication. J Virol (2005) 1.63
Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection. J Virol (2006) 1.61
Relationship of herpes simplex virus genome configuration to productive and persistent infections. Proc Natl Acad Sci U S A (2003) 1.59
The MRN complex in double-strand break repair and telomere maintenance. FEBS Lett (2010) 1.53
Adenovirus type 5 E4orf3 protein targets the Mre11 complex to cytoplasmic aggresomes. J Virol (2005) 1.50
Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53. Mol Cell Biol (2004) 1.48
The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication. J Virol (2007) 1.46
Adenovirus exploits the cellular aggresome response to accelerate inactivation of the MRN complex. J Virol (2005) 1.46
Herpes simplex virus type I disrupts the ATR-dependent DNA-damage response during lytic infection. J Cell Sci (2006) 1.43
Distinct roles of the Adenovirus E4 ORF3 protein in viral DNA replication and inhibition of genome concatenation. J Virol (2003) 1.42
Herpes simplex virus type 1 DNA polymerase requires the mammalian chaperone hsp90 for proper localization to the nucleus. J Virol (2005) 1.40
The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression. EMBO J (2006) 1.38
Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export. J Virol (2006) 1.37
The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev (2005) 1.37
Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins. Proc Natl Acad Sci U S A (2006) 1.37
Viral manipulation of DNA repair and cell cycle checkpoints. DNA Repair (Amst) (2009) 1.37
The role of DNA-PKcs and artemis in opening viral DNA hairpin termini in various tissues in mice. J Virol (2007) 1.35
Serotype-specific reorganization of the Mre11 complex by adenoviral E4orf3 proteins. J Virol (2005) 1.33
Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells. J Virol (2008) 1.32
Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase. Proc Natl Acad Sci U S A (2009) 1.29
Structural and functional analysis of Mre11-3. Nucleic Acids Res (2004) 1.28
Interplay between viruses and host sumoylation pathways. Nat Rev Microbiol (2013) 1.26
Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection. EMBO J (2009) 1.24
Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase. J Virol (2009) 1.24
A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors. Cell (2012) 1.23
Proteasome-dependent degradation of Daxx by the viral E1B-55K protein in human adenovirus-infected cells. J Virol (2010) 1.23
Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen. J Virol (2010) 1.23
Identification of integrin alpha3 as a new substrate of the adenovirus E4orf6/E1B 55-kilodalton E3 ubiquitin ligase complex. J Virol (2009) 1.22
Cell polarity proteins: common targets for tumorigenic human viruses. Oncogene (2008) 1.22
Cellular proteins PML and Daxx mediate an innate antiviral defense antagonized by the adenovirus E4 ORF3 protein. J Virol (2008) 1.22
Interaction of the adenovirus type 5 E4 Orf3 protein with promyelocytic leukemia protein isoform II is required for ND10 disruption. J Virol (2006) 1.21
Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation. Proc Natl Acad Sci U S A (2010) 1.17
Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes. J Immunol (2010) 1.16
Innate immunity to adenovirus. Hum Gene Ther (2014) 1.15
The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection. J Virol (2010) 1.15
Adenovirus E1B 55-kilodalton protein: multiple roles in viral infection and cell transformation. J Virol (2009) 1.14
Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex. Mol Biol Cell (2008) 1.14
Genetic identification of adenovirus type 5 genes that influence viral spread. J Virol (2006) 1.14
Papillomaviruses use recombination-dependent replication to vegetatively amplify their genomes in differentiated cells. PLoS Pathog (2013) 1.13
The DNA damage response induces IFN. J Immunol (2011) 1.13
Intranuclear targeting and nuclear export of the adenovirus E1B-55K protein are regulated by SUMO1 conjugation. Proc Natl Acad Sci U S A (2007) 1.13
A glycine-arginine domain in control of the human MRE11 DNA repair protein. Mol Cell Biol (2008) 1.13
Identification of cellular proteins that interact with the adeno-associated virus rep protein. J Virol (2008) 1.12
A role for E1B-AP5 in ATR signaling pathways during adenovirus infection. J Virol (2008) 1.11
Control of mRNA export by adenovirus E4orf6 and E1B55K proteins during productive infection requires E4orf6 ubiquitin ligase activity. J Virol (2008) 1.11
Adenovirus E4 ORF3 protein inhibits the interferon-mediated antiviral response. J Virol (2007) 1.11
Human papillomavirus (HPV) E7 induces prolonged G2 following S phase reentry in differentiated human keratinocytes. J Biol Chem (2011) 1.11
Pharmacologic and chemical adjuvants in tumor virotherapy. Chem Rev (2009) 1.10
Adenovirus core protein VII protects the viral genome from a DNA damage response at early times after infection. J Virol (2011) 1.09
Small-scale extracts for the study of nucleotide excision repair and non-homologous end joining. Nucleic Acids Res (2007) 1.08
Diverse roles for E4orf3 at late times of infection revealed in an E1B 55-kilodalton protein mutant background. J Virol (2004) 1.08
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation. J Virol (2008) 1.08
Adenovirus E1B 55-kilodalton protein is required for both regulation of mRNA export and efficient entry into the late phase of infection in normal human fibroblasts. J Virol (2006) 1.08
The adenovirus E4 ORF3 protein binds and reorganizes the TRIM family member transcriptional intermediary factor 1 alpha. J Virol (2007) 1.06
Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising. Front Oncol (2014) 1.06
Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection. J Virol (2009) 1.04
An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus. PLoS Pathog (2011) 1.04
The Role of Elongin BC-Containing Ubiquitin Ligases. Front Oncol (2012) 1.04
Deregulation of DNA damage signal transduction by herpesvirus latency-associated M2. J Virol (2006) 1.04
Bocavirus infection induces a DNA damage response that facilitates viral DNA replication and mediates cell death. J Virol (2010) 1.03
Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication. PLoS Pathog (2010) 1.03
The E4orf6/E1B55K E3 ubiquitin ligase complexes of human adenoviruses exhibit heterogeneity in composition and substrate specificity. J Virol (2010) 1.03
Adenovirus E1B 55-kilodalton protein is a p53-SUMO1 E3 ligase that represses p53 and stimulates its nuclear export through interactions with promyelocytic leukemia nuclear bodies. J Virol (2010) 1.01
Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates. J Virol (2008) 1.01
What's the damage? The impact of pathogens on pathways that maintain host genome integrity. Cell Host Microbe (2014) 1.00
Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection. J Virol (2010) 0.98
DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions. Cancer Res (2008) 0.97
Chromatin at the intersection of viral infection and DNA damage. Biochim Biophys Acta (2009) 0.97
Tip60 degradation by adenovirus relieves transcriptional repression of viral transcriptional activator EIA. Oncogene (2012) 0.96
Molecular cross-talk among chromosome fragility syndromes. Genes Dev (2004) 0.96
Ancient and recent adaptive evolution of primate non-homologous end joining genes. PLoS Genet (2010) 0.96
E4orf3 is necessary for enhanced S-phase replication of cell cycle-restricted subgroup C adenoviruses. J Virol (2003) 0.96
Adenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cells. J Virol (2011) 0.95
E4Orf6-E1B-55k-dependent degradation of de novo-generated adeno-associated virus type 5 Rep52 and capsid proteins employs a cullin 5-containing E3 ligase complex. J Virol (2008) 0.95
DNA virus replication compartments. J Virol (2013) 0.94
A role for MRE11, NBS1, and recombination junctions in replication and stable maintenance of EBV episomes. PLoS One (2007) 0.94
Activation of protein kinase Tel1 through recognition of protein-bound DNA ends. Mol Cell Biol (2011) 0.93
Nbs1-dependent binding of Mre11 to adenovirus E4 mutant viral DNA is important for inhibiting DNA replication. Virology (2008) 0.93
Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication. J Virol (2009) 0.93
Adenovirus late-phase infection is controlled by a novel L4 promoter. J Virol (2010) 0.93
Control of human adenovirus type 5 gene expression by cellular Daxx/ATRX chromatin-associated complexes. Nucleic Acids Res (2013) 0.93
Expression of the adenovirus E4 34k oncoprotein inhibits repair of double strand breaks in the cellular genome of a 293-based inducible cell line. Nucleic Acids Res (2004) 0.93
The DNA damage response in viral-induced cellular transformation. Br J Cancer (2012) 0.92
The timing of neural stem cell-based virotherapy is critical for optimal therapeutic efficacy when applied with radiation and chemotherapy for the treatment of glioblastoma. Stem Cells Transl Med (2013) 0.91
Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell (2008) 8.41
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature (2012) 5.47
A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell (2009) 4.60
The Mre11 complex is required for ATM activation and the G2/M checkpoint. EMBO J (2003) 3.91
APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons. Curr Biol (2006) 3.57
Custom zinc-finger nucleases for use in human cells. Mol Ther (2005) 3.04
Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors. Nat Biotechnol (2003) 3.01
Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Nature (2012) 2.98
Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. PLoS One (2011) 2.74
Alternative splicing events identified in human embryonic stem cells and neural progenitors. PLoS Comput Biol (2007) 2.71
Gene therapy: twenty-first century medicine. Annu Rev Biochem (2005) 2.59
DNA repair proteins affect the lifecycle of herpes simplex virus 1. Proc Natl Acad Sci U S A (2005) 2.20
A hybrid vector for ligand-directed tumor targeting and molecular imaging. Cell (2006) 2.20
Using or abusing: viruses and the cellular DNA damage response. Trends Microbiol (2007) 2.12
APOBEC3A can activate the DNA damage response and cause cell-cycle arrest. EMBO Rep (2011) 2.07
Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks. Mol Cell Biol (2003) 2.01
A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses. EMBO J (2010) 1.75
Interactions of viruses with the cellular DNA repair machinery. DNA Repair (Amst) (2004) 1.72
Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase. PLoS Pathog (2009) 1.65
The MRN complex in double-strand break repair and telomere maintenance. FEBS Lett (2010) 1.53
Adenovirus type 5 E4orf3 protein targets the Mre11 complex to cytoplasmic aggresomes. J Virol (2005) 1.50
The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication. J Virol (2007) 1.46
Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells. Proc Natl Acad Sci U S A (2011) 1.45
Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities. J Virol (2010) 1.40
The intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0. PLoS Pathog (2011) 1.37
Viral manipulation of DNA repair and cell cycle checkpoints. DNA Repair (Amst) (2009) 1.37
Serotype-specific reorganization of the Mre11 complex by adenoviral E4orf3 proteins. J Virol (2005) 1.33
Structural and functional analysis of Mre11-3. Nucleic Acids Res (2004) 1.28
Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection. EMBO J (2009) 1.24
Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase. J Virol (2009) 1.24
The Rep protein of adeno-associated virus type 2 interacts with single-stranded DNA-binding proteins that enhance viral replication. J Virol (2004) 1.17
The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection. J Virol (2010) 1.15
The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. J Clin Invest (2003) 1.14
Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins. J Cell Sci (2008) 1.13
Differential myocardial gene delivery by recombinant serotype-specific adeno-associated viral vectors. Mol Ther (2004) 1.09
SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication. J Virol (2013) 1.09
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation. J Virol (2008) 1.08
Viral E3 ubiquitin ligase-mediated degradation of a cellular E3: viral mimicry of a cellular phosphorylation mark targets the RNF8 FHA domain. Mol Cell (2012) 1.06
ZFX controls the self-renewal of human embryonic stem cells. PLoS One (2012) 1.03
Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication. PLoS Pathog (2010) 1.03
Direct comparison of efficiency and stability of gene transfer into the mammalian heart using adeno-associated virus versus adenovirus vectors. J Thorac Cardiovasc Surg (2003) 1.03
The ROCK inhibitor Y-27632 improves recovery of human embryonic stem cells after fluorescence-activated cell sorting with multiple cell surface markers. PLoS One (2010) 1.02
Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates. J Virol (2008) 1.01
Stem cells: the good, bad and barely in control. Nat Med (2006) 0.98
OncomiR addiction is generated by a miR-155 feedback loop in Theileria-transformed leukocytes. PLoS Pathog (2013) 0.98
Chromatin at the intersection of viral infection and DNA damage. Biochim Biophys Acta (2009) 0.97
A role for MRE11, NBS1, and recombination junctions in replication and stable maintenance of EBV episomes. PLoS One (2007) 0.94
A new animal model for pulmonary hypertension based on the overexpression of a single gene, angiopoietin-1. Ann Thorac Surg (2004) 0.93
APOBEC3 proteins and genomic stability: the high cost of a good defense. Cell Cycle (2012) 0.88
Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection. J Virol (2011) 0.81
Multiplex flow cytometry barcoding and antibody arrays identify surface antigen profiles of primary and metastatic colon cancer cell lines. PLoS One (2013) 0.81
Caveolin-1 mediates inflammatory breast cancer cell invasion via the Akt1 pathway and RhoC GTPase. J Cell Biochem (2015) 0.81
Characterization of a nuclear localization signal in the C-terminus of the adeno-associated virus Rep68/78 proteins. Virology (2004) 0.79
Enhancement of green fluorescent protein expression in adeno-associated virus with the woodchuck hepatitis virus post-transcriptional regulatory element. Methods Mol Biol (2002) 0.78
A core viral protein binds host nucleosomes to sequester immune danger signals. Nature (2016) 0.78
Keeping viruses in Chk: DNA damage signaling puts the brakes on transformation. Cell Host Microbe (2010) 0.77
Breaking the barriers to global gene delivery. Nat Biotechnol (2005) 0.75
Caveolin-1 Mediates Inflammatory Breast Cancer Cell Invasion via the Akt1 Pathway and RhoC GTPase. J Cell Biochem (2017) 0.75
Gene delivery to the mammalian heart using AAV vectors. Methods Mol Biol (2004) 0.75