Published in Proc Natl Acad Sci U S A on July 29, 2002
Global transcriptional responses of fission yeast to environmental stress. Mol Biol Cell (2003) 6.04
Identification of a target RNA motif for RNA-binding protein HuR. Proc Natl Acad Sci U S A (2004) 5.15
Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes. Genome Res (2003) 4.07
High-resolution gene expression profiling for simultaneous kinetic parameter analysis of RNA synthesis and decay. RNA (2008) 3.13
Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha. EMBO J (2005) 2.33
Transient transcriptional responses to stress are generated by opposing effects of mRNA production and degradation. Mol Syst Biol (2008) 2.27
Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability. BMC Genomics (2005) 2.18
Importance of input perturbations and stochastic gene expression in the reverse engineering of genetic regulatory networks: insights from an identifiability analysis of an in silico network. Genome Res (2003) 2.09
Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR. Mol Cell Biol (2006) 2.05
Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes. Mol Cell Biol (2003) 1.93
Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2. Mol Biol Cell (2007) 1.89
RNAPol-ChIP: a novel application of chromatin immunoprecipitation to the analysis of real-time gene transcription. Nucleic Acids Res (2004) 1.86
Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells. Mol Cell Biol (2003) 1.83
Specific and global regulation of mRNA stability during osmotic stress in Saccharomyces cerevisiae. RNA (2009) 1.66
Gene expression profiling in Werner syndrome closely resembles that of normal aging. Proc Natl Acad Sci U S A (2003) 1.64
A complete set of nascent transcription rates for yeast genes. PLoS One (2010) 1.56
The BTG2 protein is a general activator of mRNA deadenylation. EMBO J (2008) 1.54
Global analysis of mRNA stability in the archaeon Sulfolobus. Genome Biol (2006) 1.53
Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J (2009) 1.52
Microarray analysis of newly synthesized RNA in cells and animals. Proc Natl Acad Sci U S A (2007) 1.44
Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis. Mol Cell Biol (2011) 1.42
Global mRNA stabilization preferentially linked to translational repression during the endoplasmic reticulum stress response. Mol Cell Biol (2004) 1.38
von Hippel-Lindau protein-mediated repression of tumor necrosis factor alpha translation revealed through use of cDNA arrays. Mol Cell Biol (2003) 1.37
RNA-binding protein Csx1 mediates global control of gene expression in response to oxidative stress. EMBO J (2003) 1.35
Nucleolin links to arsenic-induced stabilization of GADD45alpha mRNA. Nucleic Acids Res (2006) 1.23
A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells. Proc Natl Acad Sci U S A (2003) 1.23
Coordinated destruction of cellular messages in translation complexes by the gammaherpesvirus host shutoff factor and the mammalian exonuclease Xrn1. PLoS Pathog (2011) 1.21
Modification at HuR(S242) alters HuR localization and proliferative influence. Cell Cycle (2008) 1.20
Kaposi's sarcoma-associated herpesvirus ORF57 protein binds and protects a nuclear noncoding RNA from cellular RNA decay pathways. PLoS Pathog (2010) 1.18
Discovering structural cis-regulatory elements by modeling the behaviors of mRNAs. Mol Syst Biol (2009) 1.17
Transcriptome kinetics is governed by a genome-wide coupling of mRNA production and degradation: a role for RNA Pol II. PLoS Genet (2011) 1.16
Coupled pre-mRNA and mRNA dynamics unveil operational strategies underlying transcriptional responses to stimuli. Mol Syst Biol (2011) 1.13
Enhanced proliferation of cultured human vascular smooth muscle cells linked to increased function of RNA-binding protein HuR. J Biol Chem (2005) 1.12
Mechanisms coordinating ELAV/Hu mRNA regulons. Curr Opin Genet Dev (2013) 1.10
Chemokine transcripts as targets of the RNA-binding protein HuR in human airway epithelium. J Immunol (2011) 1.09
Time-dependent c-Myc transactomes mapped by Array-based nuclear run-on reveal transcriptional modules in human B cells. PLoS One (2010) 1.08
Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response? Cell Cycle (2011) 1.08
Relationship of GW/P-bodies with stress granules. Adv Exp Med Biol (2013) 1.07
Modulation of neoplastic gene regulatory pathways by the RNA-binding factor AUF1. Front Biosci (Landmark Ed) (2011) 1.06
Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3+/- mice. EMBO J (2011) 1.00
Proteomics, pathway array and signaling network-based medicine in cancer. Cell Div (2009) 0.99
The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1. J Virol (2012) 0.99
Life after transcription--revisiting the fate of messenger RNA. Trends Genet (2003) 0.98
Rck2 is required for reprogramming of ribosomes during oxidative stress. Mol Biol Cell (2005) 0.97
Novel DNA microarray system for analysis of nascent mRNAs. DNA Res (2008) 0.96
Cytoplasmic expression of HuR is related to cyclooxygenase-2 expression in colon cancer. Cancer Res Treat (2009) 0.96
The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated HuR from mRNP. Genes Dev (2013) 0.96
Gene autoregulation via intronic microRNAs and its functions. BMC Syst Biol (2012) 0.96
Reconsidering plant memory: Intersections between stress recovery, RNA turnover, and epigenetics. Sci Adv (2016) 0.93
Requirement of TFIIH kinase subunit Mat1 for RNA Pol II C-terminal domain Ser5 phosphorylation, transcription and mRNA turnover. Nucleic Acids Res (2011) 0.93
G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei--serpentine gateways to neuroendocrine homeostasis. Front Neuroendocrinol (2011) 0.92
Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2. Cell Rep (2015) 0.92
GSMA: Gene Set Matrix Analysis, An Automated Method for Rapid Hypothesis Testing of Gene Expression Data. Bioinform Biol Insights (2009) 0.90
En masse nascent transcription analysis to elucidate regulatory transcription factors. Nucleic Acids Res (2006) 0.90
The status of CDKN2A alpha (p16INK4A) and beta (p14ARF) transcripts in thyroid tumour progression. Br J Cancer (2006) 0.89
Nitric oxide activation of Erk1/2 regulates the stability and translation of mRNA transcripts containing CU-rich elements. Nucleic Acids Res (2006) 0.87
Ccr4 promotes resolution of the endoplasmic reticulum stress response during host temperature adaptation in Cryptococcus neoformans. Eukaryot Cell (2011) 0.87
Posttranscriptional regulation of gene expression-adding another layer of complexity to the DNA damage response. Front Genet (2012) 0.87
Prognostic value of increase in transcript levels of Tp73 DeltaEx2-3 isoforms in low-grade glioma patients. Br J Cancer (2006) 0.85
Nutrients and the Pkh1/2 and Pkc1 protein kinases control mRNA decay and P-body assembly in yeast. J Biol Chem (2010) 0.85
Post-transcriptional regulation of DNA damage-responsive gene expression. Antioxid Redox Signal (2013) 0.83
Modeling the basal dynamics of p53 system. PLoS One (2011) 0.83
Antigen-specific gene expression profiles of peripheral blood mononuclear cells do not reflect those of T-lymphocyte subsets. Clin Diagn Lab Immunol (2004) 0.83
Unstable transcripts in Arabidopsis allotetraploids are associated with nonadditive gene expression in response to abiotic and biotic stresses. PLoS One (2011) 0.82
Association of luteinizing hormone receptor (LHR) mRNA with its binding protein leads to decapping and degradation of the mRNA in the p bodies. Biochim Biophys Acta (2013) 0.81
Contributions of transcription and mRNA decay to gene expression dynamics of fission yeast in response to oxidative stress. RNA Biol (2014) 0.81
Perturbation analysis analyzed--athematical modeling of intact and perturbed gene regulatory circuits for animal development. Dev Biol (2010) 0.80
An evolutionarily conserved RNase-based mechanism for repression of transcriptional positive autoregulation. Mol Microbiol (2014) 0.80
Pat1 contributes to the RNA binding activity of the Lsm1-7-Pat1 complex. RNA (2014) 0.79
A novel cis-acting element from the 3'UTR of DNA damage-binding protein 2 mRNA links transcriptional and post-transcriptional regulation of gene expression. Nucleic Acids Res (2013) 0.78
Human promoter genomic composition demonstrates non-random groupings that reflect general cellular function. BMC Bioinformatics (2005) 0.78
Drosophila eyes absent is a novel mRNA target of the tristetraprolin (TTP) protein DTIS11. Int J Biol Sci (2012) 0.78
HuR function and translational state analysis following global brain ischemia and reperfusion. Transl Stroke Res (2013) 0.77
Genomic insights into the different layers of gene regulation in yeast. Genet Res Int (2011) 0.76
Widespread changes in mRNA stability contribute to quiescence-specific gene expression patterns in a fibroblast model of quiescence. BMC Genomics (2017) 0.75
The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis. Nucleic Acids Res (2016) 0.75
Array-based nuclear run-on analysis. Methods Mol Biol (2012) 0.75
Regulation of mRNA decay in plant responses to salt and osmotic stress. Cell Mol Life Sci (2016) 0.75
Stabilization of SMAR1 mRNA by PGA2 involves a stem loop structure in the 5' UTR. Nucleic Acids Res (2007) 0.75
MCPIP1, alias Regnase-1 binds and cleaves mRNA of C/EBPβ. PLoS One (2017) 0.75
Cip29 is phosphorylated following activation of the DNA damage response in Xenopus egg extracts. PLoS One (2017) 0.75
Rapid recovery gene downregulation during excess-light stress and recovery in Arabidopsis. Plant Cell (2017) 0.75
A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell (1986) 36.96
AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem Sci (1995) 14.81
mRNA stability in mammalian cells. Microbiol Rev (1995) 8.78
HuR and mRNA stability. Cell Mol Life Sci (2001) 8.06
The cap-to-tail guide to mRNA turnover. Nat Rev Mol Cell Biol (2001) 6.67
Messenger RNA degradation in eukaryotes. Cell (1993) 6.13
Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J Biol Chem (1996) 5.82
c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene. Cell (1984) 5.55
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Proc Natl Acad Sci U S A (2000) 5.38
HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol (2000) 4.96
Quantitative assessment of DNA microarrays--comparison with Northern blot analyses. Genomics (2001) 4.56
Regulation of mRNA stability in mammalian cells. Gene (2001) 4.55
HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation. EMBO J (2000) 4.11
Regulation of mRNA turnover in eukaryotic cells. Crit Rev Eukaryot Gene Expr (1991) 2.62
Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome and the proteome. Proc Natl Acad Sci U S A (2001) 2.51
Down-regulation of cyclin D1 expression by prostaglandin A(2) is mediated by enhanced cyclin D1 mRNA turnover. Mol Cell Biol (2000) 1.93
p53-dependent elevation of p21Waf1 expression by UV light is mediated through mRNA stabilization and involves a vanadate-sensitive regulatory system. Mol Cell Biol (1998) 1.89
Conditional expression of RNA polymerase II in mammalian cells. Deletion of the carboxyl-terminal domain of the large subunit affects early steps in transcription. J Biol Chem (2000) 1.65
Gene expression profile of herpesvirus-infected T cells obtained using immunomicroarrays: induction of proinflammatory mechanisms. J Virol (2001) 1.42
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
The genetic association database. Nat Genet (2004) 11.29
Analysis of microarray data using Z score transformation. J Mol Diagn (2003) 6.82
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell (2007) 5.29
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell (2009) 5.22
Identification of a target RNA motif for RNA-binding protein HuR. Proc Natl Acad Sci U S A (2004) 5.15
Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs. EMBO J (2004) 4.45
HuR recruits let-7/RISC to repress c-Myc expression. Genes Dev (2009) 4.41
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. Proc Natl Acad Sci U S A (2003) 4.34
LincRNA-p21 suppresses target mRNA translation. Mol Cell (2012) 3.87
RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron (2003) 3.58
Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet (2011) 3.56
Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet (2006) 3.34
miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell (2010) 3.27
AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22
p16(INK4a) translation suppressed by miR-24. PLoS One (2008) 3.08
White spot syndromes of the retina: a hypothesis based on the common genetic hypothesis of autoimmune/inflammatory disease. Am J Ophthalmol (2003) 2.97
Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1. Mol Cell Biol (2005) 2.83
Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. Biol Psychiatry (2005) 2.79
RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways. Proc Natl Acad Sci U S A (2008) 2.76
Role of the RNA-binding protein HuR in colon carcinogenesis. Oncogene (2003) 2.69
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A. J Biol Chem (2006) 2.67
miR-519 suppresses tumor growth by reducing HuR levels. Cell Cycle (2010) 2.63
Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence. Biol Chem (2008) 2.60
MicroRNA expression and identification of putative miRNA targets in ovarian cancer. PLoS One (2008) 2.60
Posttranscriptional regulation of cancer traits by HuR. Wiley Interdiscip Rev RNA (2010) 2.59
Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB. PLoS Genet (2013) 2.59
Application of z-score transformation to Affymetrix data. Appl Bioinformatics (2003) 2.56
P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling. J Biol Chem (2003) 2.38
HuR: post-transcriptional paths to malignancy. RNA Biol (2005) 2.38
Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha. EMBO J (2005) 2.33
miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels. Proc Natl Acad Sci U S A (2008) 2.29
MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90. Mol Cell Biol (2008) 2.26
Posttranscriptional orchestration of an anti-apoptotic program by HuR. Cell Cycle (2007) 2.25
Analysis of turnover and translation regulatory RNA-binding protein expression through binding to cognate mRNAs. Mol Cell Biol (2007) 2.24
RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol (2007) 2.20
Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability. BMC Genomics (2005) 2.18
Nuclear HuR accumulation through phosphorylation by Cdk1. Genes Dev (2008) 2.14
AMP-activated kinase regulates cytoplasmic HuR. Mol Cell Biol (2002) 2.14
Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells. Immunity (2009) 2.11
GU-rich RNA: expanding CUGBP1 function, broadening mRNA turnover. Mol Cell (2008) 2.08
Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR. Mol Cell Biol (2006) 2.05
Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron (2004) 1.99
Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs. Sci Signal (2009) 1.97
Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function. J Biol Chem (2003) 1.95
Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes. Mol Cell Biol (2003) 1.93
microRNA expression patterns reveal differential expression of target genes with age. PLoS One (2010) 1.92
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proc Natl Acad Sci U S A (2009) 1.91
The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis. Cancer Res (2009) 1.88
Translational repression by RNA-binding protein TIAR. Mol Cell Biol (2006) 1.87
Posttranscriptional gene regulation by long noncoding RNA. J Mol Biol (2012) 1.87
HuR function in disease. Front Biosci (Landmark Ed) (2012) 1.86
Stabilization of XIAP mRNA through the RNA binding protein HuR regulated by cellular polyamines. Nucleic Acids Res (2009) 1.86
Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res (2012) 1.85
Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells. Mol Cell Biol (2003) 1.83
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary study. Schizophr Res (2002) 1.76
miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol (2010) 1.75
Functional interplay between RNA-binding protein HuR and microRNAs. Curr Protein Pept Sci (2012) 1.71
Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs. J Biol Chem (2006) 1.69
VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats. J Clin Invest (2008) 1.68
Genetic and environmental pathways to complex diseases. BMC Syst Biol (2009) 1.67
Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination. Nat Commun (2013) 1.62
hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat Struct Mol Biol (2010) 1.61
Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess. Endocrinology (2007) 1.59
Regulation of eotaxin gene expression by TNF-alpha and IL-4 through mRNA stabilization: involvement of the RNA-binding protein HuR. J Immunol (2003) 1.57
Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information. BMC Med Genomics (2010) 1.57
MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence. Aging (Albany NY) (2010) 1.53
Graphene quantum dots: emergent nanolights for bioimaging, sensors, catalysis and photovoltaic devices. Chem Commun (Camb) (2012) 1.53
Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J (2009) 1.52