Published in Cell on July 26, 2002
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell (2012) 2.87
Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells. Genes Dev (2005) 2.40
Regulation of motor neuron specification by phosphorylation of neurogenin 2. Neuron (2008) 2.20
LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system. Dev Biol (2003) 1.98
LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteins. EMBO Rep (2003) 1.86
Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. Mol Ther (2011) 1.85
The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain. Proc Natl Acad Sci U S A (2003) 1.85
Role of LDB1 in the transition from chromatin looping to transcription activation. Genes Dev (2014) 1.71
Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells. J Neurosci (2007) 1.69
Single-stranded DNA-binding proteins regulate the abundance of LIM domain and LIM domain-binding proteins. Genes Dev (2007) 1.57
Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord. Neuron (2007) 1.52
cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes. EMBO J (2013) 1.42
A regulatory network to segregate the identity of neuronal subtypes. Dev Cell (2008) 1.41
LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum. Proc Natl Acad Sci U S A (2007) 1.41
Tobacco WLIM1 is a novel F-actin binding protein involved in actin cytoskeleton remodeling. Plant Cell (2006) 1.38
Expression of Terminal Effector Genes in Mammalian Neurons Is Maintained by a Dynamic Relay of Transient Enhancers. Neuron (2016) 1.37
Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron (2012) 1.37
Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity. Nat Neurosci (2013) 1.36
The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones. Genes Dev (2005) 1.30
Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex. EMBO J (2004) 1.28
Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development. Proc Natl Acad Sci U S A (2002) 1.28
Transcriptional control of axonal guidance and sorting in dorsal interneurons by the Lim-HD proteins Lhx9 and Lhx1. Neural Dev (2009) 1.28
LIM homeodomain transcription factor-dependent specification of bipotential MGE progenitors into cholinergic and GABAergic striatal interneurons. Development (2009) 1.22
An actin-binding protein, LlLIM1, mediates calcium and hydrogen regulation of actin dynamics in pollen tubes. Plant Physiol (2008) 1.20
Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity. Development (2009) 1.19
Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes. EMBO J (2008) 1.19
The LIM-only protein, LMO4, and the LIM domain-binding protein, LDB1, expression in squamous cell carcinomas of the oral cavity. Br J Cancer (2003) 1.18
Proteasomal selection of multiprotein complexes recruited by LIM homeodomain transcription factors. Proc Natl Acad Sci U S A (2007) 1.16
LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons. Neuron (2009) 1.16
Isl1 directly controls a cholinergic neuronal identity in the developing forebrain and spinal cord by forming cell type-specific complexes. PLoS Genet (2014) 1.12
Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer. Cancer Res (2009) 1.12
Human embryonic stem cell differentiation toward regional specific neural precursors. Stem Cells (2009) 1.10
Mechanisms underlying pituitary hypoplasia and failed cell specification in Lhx3-deficient mice. Dev Biol (2007) 1.07
How do genes regulate simple behaviours? Understanding how different neurons in the vertebrate spinal cord are genetically specified. Philos Trans R Soc Lond B Biol Sci (2006) 1.07
Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord. Proc Natl Acad Sci U S A (2005) 1.07
Lmo4 and Clim1 progressively delineate cortical projection neuron subtypes during development. Cereb Cortex (2009) 1.04
Fusion protein Isl1-Lhx3 specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs. Proc Natl Acad Sci U S A (2012) 1.02
The role of the proline-rich domain of Ssdp1 in the modular architecture of the vertebrate head organizer. Proc Natl Acad Sci U S A (2006) 1.01
Diverse expression patterns of LIM-homeodomain transcription factors (LIM-HDs) in mammalian inner ear development. Dev Dyn (2008) 1.01
The homeobox transcription factor Even-skipped regulates acquisition of electrical properties in Drosophila neurons. Neural Dev (2006) 1.00
Transient expression of LIM-domain transcription factors is coincident with delayed maturation of photoreceptors in the chicken retina. J Comp Neurol (2008) 0.99
GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling. Neuron (2011) 0.99
Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development. Mol Cell Endocrinol (2007) 0.98
Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification. J Biol Chem (2011) 0.98
Paired and LIM class homeodomain proteins coordinate differentiation of the C. elegans ALA neuron. Development (2010) 0.97
Lhx1 maintains synchrony among circadian oscillator neurons of the SCN. Elife (2014) 0.96
Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor. Diabetes (2012) 0.95
Drosophila, a genetic model system to study cocaine-related behaviors: a review with focus on LIM-only proteins. Neuropharmacology (2008) 0.95
The Ldb1 and Ldb2 transcriptional cofactors interact with the Ste20-like kinase SLK and regulate cell migration. Mol Biol Cell (2009) 0.94
Crystallization of an Lhx3-Isl1 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.93
STAT3 promotes motor neuron differentiation by collaborating with motor neuron-specific LIM complex. Proc Natl Acad Sci U S A (2013) 0.92
SEUSS and SEUSS-LIKE transcriptional adaptors regulate floral and embryonic development in Arabidopsis. Plant Physiol (2009) 0.92
Isl1 is required for multiple aspects of motor neuron development. Mol Cell Neurosci (2011) 0.92
Gbx2 regulates thalamocortical axon guidance by modifying the LIM and Robo codes. Development (2012) 0.91
Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients. Cell Rep (2015) 0.90
The LIM-homeodomain protein islet dictates motor neuron electrical properties by regulating K(+) channel expression. Neuron (2012) 0.90
Mutations in the LHX3 gene cause dysregulation of pituitary and neural target genes that reflect patient phenotypes. Gene (2007) 0.90
Nolz1 is induced by retinoid signals and controls motoneuron subtype identity through distinct repressor activities. Development (2008) 0.89
Transcription factors and effectors that regulate neuronal morphology. Development (2014) 0.89
Implications of activity-dependent neurotransmitter-receptor matching. Philos Trans R Soc Lond B Biol Sci (2008) 0.88
Model of pediatric pituitary hormone deficiency separates the endocrine and neural functions of the LHX3 transcription factor in vivo. Proc Natl Acad Sci U S A (2010) 0.88
LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells. J Clin Invest (2016) 0.87
LMO4 functions as a co-activator of neurogenin 2 in the developing cortex. Development (2011) 0.87
miR-218 is essential to establish motor neuron fate as a downstream effector of Isl1-Lhx3. Nat Commun (2015) 0.87
Hair cell overexpression of Islet1 reduces age-related and noise-induced hearing loss. J Neurosci (2013) 0.87
The E3 ligase Mind bomb-1 (Mib1) modulates Delta-Notch signaling to control neurogenesis and gliogenesis in the developing spinal cord. J Biol Chem (2012) 0.86
Lhx2 regulates a cortex-specific mechanism for barrel formation. Proc Natl Acad Sci U S A (2013) 0.85
Generation of v2a interneurons from mouse embryonic stem cells. Stem Cells Dev (2014) 0.85
Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution. PLoS Genet (2015) 0.84
The transcription factors islet and Lim3 combinatorially regulate ion channel gene expression. J Neurosci (2014) 0.84
Lmo4 in the basolateral complex of the amygdala modulates fear learning. PLoS One (2012) 0.84
Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nat Neurosci (2016) 0.83
Zebrafish Mnx proteins specify one motoneuron subtype and suppress acquisition of interneuron characteristics. Neural Dev (2012) 0.83
Prediction of active nodes in the transcriptional network of neural tube patterning. Proc Natl Acad Sci U S A (2006) 0.82
The Met receptor tyrosine kinase prevents zebrafish primary motoneurons from expressing an incorrect neurotransmitter. Neural Dev (2008) 0.82
Motor neurons and the generation of spinal motor neuron diversity. Front Cell Neurosci (2014) 0.82
Molecular and cellular development of spinal cord locomotor circuitry. Front Mol Neurosci (2015) 0.82
Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus. F1000Res (2013) 0.82
GATA4/FOG2 transcriptional complex regulates Lhx9 gene expression in murine heart development. BMC Dev Biol (2008) 0.82
Ldb1 is essential for development of Nkx2.1 lineage derived GABAergic and cholinergic neurons in the telencephalon. Dev Biol (2013) 0.81
The transcriptional co-factor Chip acts with LIM-homeodomain proteins to set the boundary of the eye field in Drosophila. Development (2010) 0.81
Crystallization and diffraction of an Lhx4-Isl2 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.81
GABAergic neuron specification in the spinal cord, the cerebellum, and the cochlear nucleus. Neural Plast (2012) 0.81
Blurring the boundaries: developmental and activity-dependent determinants of neural circuits. Trends Neurosci (2013) 0.81
Nkx6 genes pattern the frog neural plate and Nkx6.1 is necessary for motoneuron axon projection. Dev Biol (2010) 0.80
Chromatin looping as a target for altering erythroid gene expression. Ann N Y Acad Sci (2016) 0.79
Characterization of homeobox genes reveals sophisticated regionalization of the central nervous system in the European cuttlefish Sepia officinalis. PLoS One (2014) 0.79
The Olig family affects central nervous system development and disease. Neural Regen Res (2014) 0.79
Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube. Exp Neurol (2015) 0.79
Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactions. PLoS One (2012) 0.79
Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation. Mol Cell Biol (2003) 0.79
Regulation of LIM-domain-binding 1 protein expression by ubiquitination of Lys134. Biochem J (2010) 0.79
Cell-specific actions of a human LHX3 gene enhancer during pituitary and spinal cord development. Mol Endocrinol (2013) 0.78
A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions. J Biol Chem (2013) 0.78
LHX3 interacts with inhibitor of histone acetyltransferase complex subunits LANP and TAF-1β to modulate pituitary gene regulation. PLoS One (2013) 0.78
Enhancer-bound LDB1 regulates a corticotrope promoter-pausing repression program. Proc Natl Acad Sci U S A (2015) 0.78
A Multi-step Transcriptional and Chromatin State Cascade Underlies Motor Neuron Programming from Embryonic Stem Cells. Cell Stem Cell (2016) 0.78
From induction to conduction: how intrinsic transcriptional priming of extrinsic neuronal connectivity shapes neuronal identity. Open Biol (2014) 0.77
SSDP cofactors regulate neural patterning and differentiation of specific axonal projections. Dev Biol (2010) 0.76
Spinal neurons require Islet1 for subtype-specific differentiation of electrical excitability. Neural Dev (2014) 0.76
Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell (2003) 8.00
The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. Genes Dev (2007) 5.16
Embryonic stem cell potency fluctuates with endogenous retrovirus activity. Nature (2012) 3.96
Transcriptional codes and the control of neuronal identity. Annu Rev Neurosci (2002) 3.48
A functional study of miR-124 in the developing neural tube. Genes Dev (2007) 3.21
YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes Dev (2008) 3.16
Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors. Neuron (2003) 3.08
Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains. Cell (2005) 2.88
Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay. Mol Cell (2011) 2.73
Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells. Genes Dev (2005) 2.40
Small CTD phosphatases function in silencing neuronal gene expression. Science (2005) 2.23
Regulation of motor neuron specification by phosphorylation of neurogenin 2. Neuron (2008) 2.20
The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics. Neuron (2007) 2.19
Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci U S A (2006) 2.16
A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4. Proc Natl Acad Sci U S A (2009) 2.06
Segregation of axial motor and sensory pathways via heterotypic trans-axonal signaling. Science (2008) 2.01
Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals. Cell (2007) 2.00
A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem (2003) 1.93
Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A. Genes Dev (2011) 1.86
Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. Mol Ther (2011) 1.85
Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci U S A (2008) 1.80
Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits. Neuron (2005) 1.77
Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohorts. Biol Psychiatry (2005) 1.76
Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell (2006) 1.71
Inhibition of retroviral pathogenesis by RNA interference. Curr Biol (2002) 1.70
UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program. Dev Cell (2011) 1.66
Analysis of embryonic motoneuron gene regulation: derepression of general activators function in concert with enhancer factors. Development (2004) 1.60
Development of circuits that generate simple rhythmic behaviors in vertebrates. Curr Opin Neurobiol (2005) 1.59
Changes in body weight and fat mass of men and women in the first year of college: A study of the "freshman 15". J Am Coll Health (2006) 1.59
The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Dev Biol (2006) 1.58
Endosomal localization and function of sorting nexin 1. Proc Natl Acad Sci U S A (2002) 1.57
SnapShot: spinal cord development. Cell (2011) 1.56
A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity. Neuron (2004) 1.54
Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord. Neuron (2007) 1.52
The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface. Mol Biol Cell (2004) 1.48
Magnitude of binocular vision controlled by islet-2 repression of a genetic program that specifies laterality of retinal axon pathfinding. Cell (2004) 1.47
Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptors. Mol Endocrinol (2008) 1.45
Electroconvulsive seizures regulate gene expression of distinct neurotrophic signaling pathways. J Neurosci (2004) 1.44
A regulatory network to segregate the identity of neuronal subtypes. Dev Cell (2008) 1.41
Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation. J Biol Chem (2002) 1.37
Group distal movement of teeth using microscrew implant anchorage. Angle Orthod (2005) 1.35
Motor axon pathfinding. Cold Spring Harb Perspect Biol (2010) 1.31
TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells. Genome Res (2012) 1.29
Novel transcription coactivator complex containing activating signal cointegrator 1. Mol Cell Biol (2002) 1.29
Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections. J Neurosci (2006) 1.27
Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. J Neurosci (2010) 1.25
FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code. Neuron (2006) 1.25
Presenilin-dependent receptor processing is required for axon guidance. Cell (2011) 1.22
Axon fasciculation defects and retinal dysplasias in mice lacking the immunoglobulin superfamily adhesion molecule BEN/ALCAM/SC1. Mol Cell Neurosci (2004) 1.20
Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity. Development (2009) 1.19
T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration. Development (2006) 1.18
Developmental neuroscience: Hox and Fox. Nature (2008) 1.16
LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons. Neuron (2009) 1.16
Determinants of the endosomal localization of sorting nexin 1. Mol Biol Cell (2005) 1.15
Ret is a multifunctional coreceptor that integrates diffusible- and contact-axon guidance signals. Cell (2012) 1.12
Transposable elements as genetic regulatory substrates in early development. Trends Cell Biol (2013) 1.12
Beta1 integrins in muscle, but not in motor neurons, are required for skeletal muscle innervation. J Neurosci (2004) 1.11
Retinoid signaling and neurogenin2 function are coupled for the specification of spinal motor neurons through a chromatin modifier CBP. Neuron (2009) 1.11
Instructive role of aPKCzeta subcellular localization in the assembly of adherens junctions in neural progenitors. Proc Natl Acad Sci U S A (2007) 1.08
The LIM domain-only protein LMO4 is required for neural tube closure. Mol Cell Neurosci (2005) 1.07
Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation. Mol Endocrinol (2009) 1.06
Fusion protein Isl1-Lhx3 specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs. Proc Natl Acad Sci U S A (2012) 1.02
Reduced expression of the LIM-homeobox gene Lhx3 impairs growth and differentiation of Rathke's pouch and increases cell apoptosis during mouse pituitary development. Mech Dev (2006) 1.00
Protease regulation: the Yin and Yang of neural development and disease. Neuron (2011) 1.00
Defining rhythmic locomotor burst patterns using a continuous wavelet transform. Ann N Y Acad Sci (2010) 0.98
Homeodomain transcription factors in the development of subsets of hindbrain reticulospinal neurons. Mol Cell Neurosci (2005) 0.97
A Korean herbal medicine, Panax notoginseng, prevents liver fibrosis and hepatic microvascular dysfunction in rats. Life Sci (2005) 0.96
Physicochemical characterization of poly(L-lactic acid) and poly(D,L-lactide-co-glycolide) nanoparticles with polyethylenimine as gene delivery carrier. Int J Pharm (2005) 0.95
Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1. Protein Sci (2010) 0.94
Decoding the LIM development code. Trans Am Clin Climatol Assoc (2003) 0.94
STAT3 promotes motor neuron differentiation by collaborating with motor neuron-specific LIM complex. Proc Natl Acad Sci U S A (2013) 0.92
Isl1 is required for multiple aspects of motor neuron development. Mol Cell Neurosci (2011) 0.92
Insulin, IGF-1, and muscarinic agonists modulate schizophrenia-associated genes in human neuroblastoma cells. Biol Psychiatry (2008) 0.92
Dynamic inhibition of nuclear receptor activation by corepressor binding. Mol Endocrinol (2002) 0.89
Crucial roles of histone-modifying enzymes in mediating neural cell-type specification. Curr Opin Neurobiol (2010) 0.89
Factors influencing fast food consumption behaviors of middle-school students in Seoul: an application of theory of planned behaviors. Nutr Res Pract (2011) 0.88
LMO4 functions as a co-activator of neurogenin 2 in the developing cortex. Development (2011) 0.87
Spatial organization of cortical and spinal neurons controlling motor behavior. Curr Opin Neurobiol (2012) 0.86
Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation. J Biol Chem (2003) 0.86
Mammalian two-hybrid assay for detecting protein-protein interactions in vivo. Methods Mol Biol (2004) 0.84
Tumor initiation inhibition through inhibition COX-1 activity of a traditional Korean herbal prescription, Geiji-Bokryung-Hwan, in human hepatocarcinoma cells. Immunopharmacol Immunotoxicol (2005) 0.84
Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice. Hepatology (2015) 0.83
Histone H3K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes. Mol Cell Biol (2013) 0.83
Brain-specific homeobox factor as a target selector for glucocorticoid receptor in energy balance. Mol Cell Biol (2013) 0.82
Microscopy ambient ionization top-down mass spectrometry reveals developmental patterning. Proc Natl Acad Sci U S A (2013) 0.82
The prevalence of wasting, but not stunting, has improved in the Democratic People's Republic of Korea. J Nutr (2005) 0.82
Viewing serine/threonine protein phosphatases through the eyes of drug designers. FEBS J (2013) 0.81
Restriction of television food advertising in South Korea: impact on advertising of food companies. Health Promot Int (2012) 0.80
Hypolipidemic effect of Salicornia herbacea in animal model of type 2 diabetes mellitus. Nutr Res Pract (2007) 0.80
Fine-tuning motor neuron properties: signaling from the periphery. Neuron (2002) 0.80