Published in Anal Biochem on December 01, 1975
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[3H]-Clonidine binding to alpha-adrenoceptors in membranes prepared from regions of guinea-pig kidney: alteration by monovalent and divalent cations. Br J Pharmacol (1980) 0.75
Kinetic and genetic analyses of D-cycloserine inhibition and resistance in Escherichia coli. J Bacteriol (1965) 5.88
Chromosome replication in Escherichia coli. IV. Control of chromosome replication and cell division by an integrated episome. J Mol Biol (1971) 5.50
Escherichia coli K-12 auxotrophs induced by insertion of the transposable element Tn5. Genetics (1979) 5.49
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Transposition derivatives of an Hfr strain of Escherichia coli K-12. Genetics (1967) 4.39
RAPD (arbitrary primer) PCR is more sensitive than multilocus enzyme electrophoresis for distinguishing related bacterial strains. Nucleic Acids Res (1993) 3.10
Rapid sequencing of cloned DNA using a transposon for bidirectional priming: sequence of the Escherichia coli K-12 avtA gene. Nucleic Acids Res (1987) 2.17
Physiological characterization of polar Tn5-induced isoleucine-valine auxotrophs in Escherichia coli K.12: evidence for an internal promoter in the ilvOGEDA operon. Genetics (1979) 2.07
Ribozyme-mediated inhibition of HIV 1 suggests nucleolar trafficking of HIV-1 RNA. Proc Natl Acad Sci U S A (2000) 1.88
Salmonella typhimurium mutants defective in acetohydroxy acid synthases I and II. J Bacteriol (1980) 1.87
The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization. RNA (1997) 1.84
Direct detection of HIV-1 RNA from AIDS and ARC patient samples. DNA (1988) 1.79
Facilitation of hammerhead ribozyme catalysis by the nucleocapsid protein of HIV-1 and the heterogeneous nuclear ribonucleoprotein A1. EMBO J (1994) 1.77
Inhibition of human immunodeficiency virus by using an oligonucleoside methylphosphonate targeted to the tat-3 gene. J Virol (1988) 1.73
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Expression of small, therapeutic RNAs in human cell nuclei. Gene Ther (1997) 1.71
Unexpected point mutations activate cryptic 3' splice sites by perturbing a natural secondary structure within a yeast intron. Genes Dev (1991) 1.70
Structure and organization of the two tRNATyr gene clusters on the E. coli chromosome. Cell (1979) 1.68
Direct and crossover PCR amplification to facilitate Tn5supF-based sequencing of lambda phage clones. Nucleic Acids Res (1991) 1.68
Chromosome replication in some strains of Escherichia coli K12. Cold Spring Harb Symp Quant Biol (1968) 1.64
An alternate method for synthesis of double-stranded DNA segments. J Biol Chem (1982) 1.63
Use of arbitrarily primed polymerase chain reaction analysis to type disease and carrier strains of Neisseria meningitidis isolated during a university outbreak. J Infect Dis (1994) 1.63
The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex. RNA (1999) 1.62
Partial purification and some properties of delta1-pyrroline-5-carboxylate reductase from Escherichia coli. J Bacteriol (1977) 1.49
Medically supervised water-only fasting in the treatment of hypertension. J Manipulative Physiol Ther (2001) 1.49
Differential transcription of Pgk genes during spermatogenesis in the mouse. Dev Biol (1992) 1.41
Proline excretion and indirect suppression in Escherichia coli and Salmonella typhimurium. J Bacteriol (1974) 1.41
The ilvG gene is expressed in Escherichia coli K-12. Gene (1980) 1.40
Detection of drug resistance in human tumors by in vitro enzymatic amplification. Cancer Res (1988) 1.40
Differential recovery of auxotrophs after penicillin enrichment in Escherichia coli. J Bacteriol (1971) 1.39
Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein. Proc Natl Acad Sci U S A (1991) 1.37
Progress and prospects: RNA-based therapies for treatment of HIV infection. Gene Ther (2007) 1.34
Biological expression of an Escherichia coli consensus sequence promoter and some mutant derivatives. Proc Natl Acad Sci U S A (1983) 1.33
Engineering and optimization of the miR-106b cluster for ectopic expression of multiplexed anti-HIV RNAs. Gene Ther (2008) 1.32
Chromosome replication in Escherichia coli. II. Origin of replication in F- and F+ strains. J Mol Biol (1969) 1.32
Probe mapping to facilitate transposon-based DNA sequencing. Proc Natl Acad Sci U S A (1990) 1.29
Auxotroph accumulation in deoxyribonucleic acid polymeraseless strains of Escherichia coli K-12. J Bacteriol (1971) 1.29
Cloning and characterization of the Escherichia coli K-12 alanine-valine transaminase (avtA) gene. J Bacteriol (1987) 1.28
RNA accessibility prediction: a theoretical approach is consistent with experimental studies in cell extracts. Nucleic Acids Res (2000) 1.27
Foamy combinatorial anti-HIV vectors with MGMTP140K potently inhibit HIV-1 and SHIV replication and mediate selection in vivo. Gene Ther (2009) 1.27
A test for intron function in the yeast actin gene. Nature (1985) 1.24
Identification and characterization of yeast mutants that overcome an experimentally introduced block to splicing at the 3' splice site. RNA (1996) 1.24
Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo. Nucleic Acids Res (1992) 1.24
Yeast pre-messenger RNA splicing efficiency depends on critical spacing requirements between the branch point and 3' splice site. EMBO J (1986) 1.22
Organization and regulation of the ilvGEDA operon in Salmonella typhimurium LT2. J Bacteriol (1981) 1.22
Role of alanine-valine transaminase in Salmonella typhimurium and analysis of an avtA::Tn5 mutant. J Bacteriol (1983) 1.20
Intramolecular transposition by a synthetic IS50 (Tn5) derivative. J Bacteriol (1990) 1.16
Improved synthesis of the sodium salt of DL-alpha, beta-dihydroxyisovaleric acid. Anal Biochem (1980) 1.14
Inhibition of HIV-1 in human T-lymphocytes by retrovirally transduced anti-tat and rev hammerhead ribozymes. Gene (1994) 1.13
High frequency generalized transduction by miniMu plasmid phage. Genetics (1987) 1.13
Lentiviral-mediated delivery of siRNAs for antiviral therapy. Gene Ther (2006) 1.11
beta-Chloro-L-alanine inhibition of the Escherichia coli alanine-valine transaminase. J Bacteriol (1985) 1.10
Structural organization of Escherichia coli tRNAtyr gene clusters in four different transducing bacteriophages. J Mol Biol (1979) 1.10
Allogeneic bone marrow transplantation, zidovudine, and human immunodeficiency virus type 1 (HIV-1) infection. Studies in a patient with non-Hodgkin lymphoma. Ann Intern Med (1989) 1.08
Substrate channeling: alpha-ketobutyrate inhibition of acetohydroxy acid synthase in Salmonella typhimurium. J Bacteriol (1980) 1.07
Cloning of genes that suppress an Escherichia coli K-12 alanine auxotroph when present in multicopy plasmids. J Bacteriol (1987) 1.07
Mycoplasma gallisepticum strain differentiation by arbitrary primer PCR (RAPD) fingerprinting. Mol Cell Probes (1994) 1.06
Oligonucleotide probes for the detection of TEM-1 and TEM-2 beta-lactamase genes and their transposons. Can J Microbiol (1987) 1.06
Inhibition of bcr-abl oncogene expression by novel deoxyribozymes (DNAzymes). Hum Gene Ther (1999) 1.04
Isolation and functional analysis of a Kluyveromyces lactis RAP1 homologue. Gene (1994) 1.02
Detection of antisense and ribozyme accessible sites on native mRNAs: application to NCOA3 mRNA. Mol Ther (2001) 1.00
Inversions and deletions generated by a mini-gamma delta (Tn1000) transposon. J Bacteriol (1994) 0.99
Transductional instability of Tn5-induced mutations: generalized and specialized transduction of Tn5 by bacteriophage P1. Genetics (1983) 0.99
Kluyveromyces lactis maintains Saccharomyces cerevisiae intron-encoded splicing signals. Mol Cell Biol (1989) 0.98
pDUAL: a transposon-based cosmid cloning vector for generating nested deletions and DNA sequencing templates in vivo. Proc Natl Acad Sci U S A (1993) 0.98
Isolation of a mouse pseudo tRNA gene encoding CCA--a possible example of reverse flow of genetic information. Nature (1982) 0.97
Rapid determination and quantitation of the accessibility to native RNAs by antisense oligodeoxynucleotides in murine cell extracts. Nucleic Acids Res (1998) 0.97
Downregulation of the CCR5 beta-chemokine receptor and inhibition of HIV-1 infection by stable VA1-ribozyme chimeric transcripts. Antisense Nucleic Acid Drug Dev (2000) 0.97
Ribozyme-mediated inhibition of bcr-abl gene expression in a Philadelphia chromosome-positive cell line. Blood (1993) 0.95
Current progress in the development of RNAi-based therapeutics for HIV-1. Gene Ther (2011) 0.93
Intracellular applications of ribozymes. Methods Enzymol (2001) 0.92
Proline excretion in Escherichia coli: a comparison of an argD+ strain and a proline-excreting argD- derivative. Biochem Genet (1977) 0.91
Effect of enrichment procedure upon auxotroph recovery in Escherichia coli K-12. Antimicrob Agents Chemother (1975) 0.91
Ribozyme-mediated cleavage of an HIV-1 gag RNA: the effects of nontargeted sequences and secondary structure on ribozyme cleavage activity. Antisense Res Dev (1991) 0.91
Biological and functional aspects of catalytic RNAs. Crit Rev Eukaryot Gene Expr (1992) 0.91
Ribozyme-mediated inhibition of rat leukocyte-type 12-lipoxygenase prevents intimal hyperplasia in balloon-injured rat carotid arteries. Circulation (2001) 0.90
Use of polymerase chain reaction to detect the expression of the Mr 70,000 heat shock genes in control or heat shock leukemic cells as correlated to their heat response. Cancer Res (1990) 0.89
Gratuitous repression of avtA in Escherichia coli and Salmonella typhimurium. J Bacteriol (1984) 0.87
Adenoviral delivery of a leukocyte-type 12 lipoxygenase ribozyme inhibits effects of glucose and platelet-derived growth factor in vascular endothelial and smooth muscle cells. Circ Res (2001) 0.87
Radioenzymatic assay for the acetohydroxy acid synthase-catalyzed synthesis of alpha-aceto-alpha-hydroxybutyrate. Anal Biochem (1980) 0.87
Detection by enzymatic amplification of bcr-abl mRNA in peripheral blood and bone marrow cells of patients with chronic myelogenous leukemia. Blood (1989) 0.86
RNAi therapeutics: SNALPing siRNAs in vivo. Gene Ther (2006) 0.86
Ribozyme-mediated RNA degradation in nuclei suspension. Nucleic Acids Res (1995) 0.86
Redesigning, implementing and integrating Escherichia coli genome software tools with an object-oriented database system. Comput Appl Biosci (1992) 0.85
Status of ribozyme and antisense-based developmental approaches for anti-HIV-1 therapy. Ann N Y Acad Sci (1992) 0.85
Innate immunity confounds the clinical efficacy of small interfering RNAs (siRNAs). Gene Ther (2009) 0.85
Ribozymes: use as anti-HIV therapeutic molecules. Antisense Res Dev (1993) 0.85
Protecting from R5-tropic HIV: individual and combined effectiveness of a hammerhead ribozyme and a single-chain Fv antibody that targets CCR5. Gene Ther (2004) 0.85
Arginine side-chain dynamics in the HIV-1 rev-RRE complex. J Mol Biol (2000) 0.84
Monitoring retroviral RNA dimerization in vivo via hammerhead ribozyme cleavage. J Virol (1998) 0.84
Enhancement of ribozyme function by RNA binding proteins. Methods Mol Biol (1997) 0.84
Substitution of non-catalytic stem and loop regions of hammerhead ribozyme with DNA counterparts only increases KM without sacrificing the catalytic step (kcat): a way to improve substrate-specificity. Nucleic Acids Symp Ser (1992) 0.84
Oligonucleotide scanning of native mRNAs in extracts predicts intracellular ribozyme efficiency: ribozyme-mediated reduction of the murine DNA methyltransferase. Mol Ther (2000) 0.84