Published in J Cell Sci on November 01, 2002
Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis. Mol Cell Biol (2005) 2.22
Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage. Mol Cell Biol (2005) 2.13
Differential expression of sex-linked and autosomal germ-cell-specific genes during spermatogenesis in the mouse. Hum Mol Genet (2005) 2.12
Genetic analysis of X-linked hybrid sterility in the house mouse. Mamm Genome (2004) 1.84
The X and Y chromosomes assemble into H2A.Z-containing [corrected] facultative heterochromatin [corrected] following meiosis. Mol Cell Biol (2006) 1.64
MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev (2011) 1.52
Two-step imprinted X inactivation: repeat versus genic silencing in the mouse. Mol Cell Biol (2010) 1.46
Dynamic histone modifications mark sex chromosome inactivation and reactivation during mammalian spermatogenesis. Proc Natl Acad Sci U S A (2004) 1.41
Sex chromosome silencing in the marsupial male germ line. Proc Natl Acad Sci U S A (2007) 1.34
Widespread over-expression of the X chromosome in sterile F₁hybrid mice. PLoS Genet (2010) 1.32
The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a mutation in the X-derived retrogene, mUtp14b. Proc Natl Acad Sci U S A (2004) 1.28
A new deletion of the mouse Y chromosome long arm associated with the loss of Ssty expression, abnormal sperm development and sterility. Genetics (2004) 1.26
New twists in X-chromosome inactivation. Curr Opin Cell Biol (2008) 1.22
X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells. Hum Genet (2011) 1.14
The search for a marsupial XIC reveals a break with vertebrate synteny. Chromosome Res (2007) 1.06
Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing. PLoS Genet (2013) 1.03
Live offspring from mice lacking the Y chromosome long arm gene complement. Biol Reprod (2009) 1.00
Unravelling the evolutionary origins of X chromosome inactivation in mammals: insights from marsupials and monotremes. Chromosome Res (2009) 0.99
Sex chromosome inactivation in the male. Epigenetics (2009) 0.97
Global transcriptome analysis of the C57BL/6J mouse testis by SAGE: evidence for nonrandom gene order. BMC Genomics (2005) 0.96
Protein immunolocalization supports the presence of identical mechanisms of XY body formation in eutherians and marsupials. Chromosome Res (2007) 0.85
HP1beta and HP1gamma, but not HP1alpha, decorate the entire XY body during human male meiosis. Chromosome Res (2003) 0.85
Evaluating the relationship between spermatogenic silencing of the X chromosome and evolution of the Y chromosome in chimpanzee and human. PLoS One (2010) 0.83
Epigenetic processes implemented during spermatogenesis distinguish the paternal pronucleus in the embryo. Reprod Biomed Online (2008) 0.83
Meiotic sex chromosome inactivation in Drosophila. J Genomics (2014) 0.82
Embryo manipulation via assisted reproductive technology and epigenetic asymmetry in mammalian early development. Philos Trans R Soc Lond B Biol Sci (2013) 0.81
Expression of XIST sense and antisense in bovine fetal organs and cell cultures. Chromosome Res (2004) 0.79
HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis. Mol Biol Cell (2014) 0.78
Heteromorphic sex chromosomes: navigating meiosis without a homologous partner. Mol Reprod Dev (2011) 0.78
The expression of Y-linked Zfy2 in XY mouse oocytes leads to frequent meiosis 2 defects, a high incidence of subsequent early cleavage stage arrest and infertility. Development (2014) 0.78
The evolutionary pathway of x chromosome inactivation in mammals. Acta Naturae (2013) 0.78
Unique sex chromosome systems in Ellobius: How do male XX chromosomes recombine and undergo pachytene chromatin inactivation? Sci Rep (2016) 0.78
Escape of X-linked miRNA genes from meiotic sex chromosome inactivation. Development (2015) 0.76
The characterization of macroH2A beyond vertebrates supports an ancestral origin and conserved role for histone variants in chromatin. Epigenetics (2016) 0.75
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature (2009) 35.48
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell (2013) 24.00
A chromatin landmark and transcription initiation at most promoters in human cells. Cell (2007) 23.41
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell (2007) 21.58
Dissecting direct reprogramming through integrative genomic analysis. Nature (2008) 16.47
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A (2010) 15.13
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell (2009) 13.02
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (2007) 12.41
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat Biotechnol (2009) 12.40
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29
Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell (2008) 12.29
Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol (2011) 11.76
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell (2008) 10.68
Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell (2005) 9.84
Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci U S A (2004) 9.33
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet (2007) 9.25
HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12
Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol (2007) 9.04
Induction of tumors in mice by genomic hypomethylation. Science (2003) 8.86
Direct cell reprogramming is a stochastic process amenable to acceleration. Nature (2009) 8.71
Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic Acids Res (2005) 8.69
Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science (2003) 8.48
c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell (2007) 8.46
YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol (2007) 8.11
One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell (2013) 7.99
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat Biotechnol (2008) 7.91
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A (2008) 7.52
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell (2012) 7.17
HDAC2 negatively regulates memory formation and synaptic plasticity. Nature (2009) 6.96
Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells. Genesis (2006) 6.64
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell (2011) 6.56
Chromosomal instability and tumors promoted by DNA hypomethylation. Science (2003) 6.02
Chromosomal silencing and localization are mediated by different domains of Xist RNA. Nat Genet (2002) 5.51
Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell (2008) 5.40
Oct4 expression is not required for mouse somatic stem cell self-renewal. Cell Stem Cell (2007) 5.29
Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell (2010) 5.13
Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci U S A (2010) 5.00
A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. Nat Genet (2004) 4.95
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell (2005) 4.83
The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron (2006) 4.74
Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression. Stem Cells (2008) 4.67
Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell (2010) 4.59
Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell (2002) 4.56
Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell (2011) 4.52
Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A (2005) 4.52
Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A (2008) 4.48
Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell (2008) 4.43
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol (2008) 4.41
Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell (2010) 4.32
Silencing of unsynapsed meiotic chromosomes in the mouse. Nat Genet (2004) 4.25
Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature (2002) 4.16
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res (2010) 3.94
Metastable pluripotent states in NOD-mouse-derived ESCs. Cell Stem Cell (2009) 3.92
H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell (2008) 3.90
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat Genet (2009) 3.73
Nuclear reprogramming and pluripotency. Nature (2006) 3.68
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system. Cell Res (2013) 3.50
Technical challenges in using human induced pluripotent stem cells to model disease. Cell Stem Cell (2009) 3.42
H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Dev Cell (2003) 3.42
Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development. Dev Cell (2013) 3.31
Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells. Cell Stem Cell (2011) 3.31
DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One (2007) 3.30
Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. Proc Natl Acad Sci U S A (2002) 3.29
Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice. Proc Natl Acad Sci U S A (2009) 3.23
Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development (2003) 3.22
Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells. Nat Mater (2010) 3.11
A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits. J Neurosci (2002) 3.09
Reprogramming of human peripheral blood cells to induced pluripotent stem cells. Cell Stem Cell (2010) 3.08
Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus. Stem Cells (2006) 3.07
Broader implications of defining standards for the pluripotency of iPSCs. Cell Stem Cell (2009) 3.03
Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev (2008) 2.99
The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression. Nat Genet (2008) 2.95
Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch. Science (2004) 2.93
Mice cloned from olfactory sensory neurons. Nature (2004) 2.90
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet (2013) 2.87
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice. Proc Natl Acad Sci U S A (2004) 2.87
Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proc Natl Acad Sci U S A (2010) 2.85
Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc Natl Acad Sci U S A (2009) 2.80
Rapid generation of inducible mouse mutants. Nucleic Acids Res (2003) 2.77
Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev (2004) 2.75
Molecular control of pluripotency. Curr Opin Genet Dev (2006) 2.75
Characterization of a highly variable eutherian microRNA gene. RNA (2005) 2.72
BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation. Curr Biol (2004) 2.67
Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science (2013) 2.61
Microfluidic control of cell pairing and fusion. Nat Methods (2009) 2.58
Nuclear transplantation, embryonic stem cells, and the potential for cell therapy. N Engl J Med (2003) 2.50
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat Med (2010) 2.50
Transgenic mice with defined combinations of drug-inducible reprogramming factors. Nat Biotechnol (2009) 2.46
Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res (2009) 2.44
Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients. EMBO J (2010) 2.43
Pachytene asynapsis drives meiotic sex chromosome inactivation and leads to substantial postmeiotic repression in spermatids. Dev Cell (2006) 2.40