Published in Circulation on October 15, 2002
Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha. Proc Natl Acad Sci U S A (2006) 2.71
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood (2007) 2.51
Energy metabolism in heart failure and remodelling. Cardiovasc Res (2008) 2.37
Energy metabolism in heart failure. J Physiol (2003) 2.10
Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A (2007) 1.92
Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation. J Clin Invest (2011) 1.84
Altered creatine kinase adenosine triphosphate kinetics in failing hypertrophied human myocardium. Circulation (2006) 1.84
Cardiac metabolism in heart failure: implications beyond ATP production. Circ Res (2013) 1.72
Lipid metabolism and toxicity in the heart. Cell Metab (2012) 1.71
Allopurinol acutely increases adenosine triphospate energy delivery in failing human hearts. J Am Coll Cardiol (2012) 1.66
Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis. Blood (2011) 1.64
Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes. Circ Res (2013) 1.56
Increased glucose uptake and oxidation in mouse hearts prevent high fatty acid oxidation but cause cardiac dysfunction in diet-induced obesity. Circulation (2009) 1.55
O-linked β-N-acetylglucosamine transferase is indispensable in the failing heart. Proc Natl Acad Sci U S A (2010) 1.43
Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage. J Clin Invest (2007) 1.40
Modulating fatty acid oxidation in heart failure. Cardiovasc Res (2011) 1.37
Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy. Circ Res (2012) 1.35
Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function. Mol Cell Biol (2006) 1.34
Glucose metabolism and cardiac hypertrophy. Cardiovasc Res (2011) 1.28
Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice. J Clin Invest (2010) 1.28
Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure. Cardiovasc Diabetol (2010) 1.21
Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy. Circulation (2010) 1.20
Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia/reperfusion injury. Circ Res (2010) 1.20
Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways. Circulation (2008) 1.20
Glucose regulation of load-induced mTOR signaling and ER stress in mammalian heart. J Am Heart Assoc (2013) 1.18
Switching metabolic genes to build a better heart. Circulation (2002) 1.13
Positive transcription elongation factor b activity in compensatory myocardial hypertrophy is regulated by cardiac lineage protein-1. Circ Res (2009) 1.12
Assessment of cardiac function and energetics in isolated mouse hearts using 31P NMR spectroscopy. J Vis Exp (2010) 1.03
GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle. Cardiovasc Diabetol (2012) 1.00
Metabolic therapy at the crossroad: how to optimize myocardial substrate utilization? Trends Cardiovasc Med (2009) 0.99
Causes and characteristics of diabetic cardiomyopathy. Rev Diabet Stud (2006) 0.99
Insulin resistance protects the heart from fuel overload in dysregulated metabolic states. Am J Physiol Heart Circ Physiol (2013) 0.97
Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice. Circulation (2008) 0.96
Cardiomyocyte ATP production, metabolic flexibility, and survival require calcium flux through cardiac ryanodine receptors in vivo. J Biol Chem (2013) 0.96
Energetics and metabolism in the failing heart: important but poorly understood. Curr Opin Clin Nutr Metab Care (2010) 0.94
Inducible overexpression of GLUT1 prevents mitochondrial dysfunction and attenuates structural remodeling in pressure overload but does not prevent left ventricular dysfunction. J Am Heart Assoc (2013) 0.93
Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mechanistic target of rapamycin. J Am Heart Assoc (2015) 0.92
The metabolic syndrome and the heart--a considered opinion. Clin Res Cardiol (2006) 0.92
Diacylglycerol acyl transferase 1 overexpression detoxifies cardiac lipids in PPARγ transgenic mice. J Lipid Res (2012) 0.91
The bHLH transcription factor CHF1/Hey2 regulates susceptibility to apoptosis and heart failure after pressure overload. Am J Physiol Heart Circ Physiol (2010) 0.91
Heart failure: a model of cardiac and skeletal muscle energetic failure. Pflugers Arch (2006) 0.90
Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults. Mech Dev (2013) 0.90
Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling. Mol Metab (2014) 0.89
Altered myocardial calcium cycling and energetics in heart failure-a rational approach for disease treatment. Cell Metab (2015) 0.89
Metabolic remodeling in the hypertrophic heart: fuel for thought. Circ Res (2012) 0.89
CHF1/Hey2 promotes physiological hypertrophy in response to pressure overload through selective repression and activation of specific transcriptional pathways. OMICS (2009) 0.88
Short-term akt activation in cardiac muscle cells improves contractile function in failing hearts. Am J Pathol (2012) 0.88
Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a. PLoS One (2009) 0.88
AMPK isoform expression in the normal and failing hearts. J Mol Cell Cardiol (2012) 0.87
The PPARalpha-PGC-1alpha Axis Controls Cardiac Energy Metabolism in Healthy and Diseased Myocardium. PPAR Res (2008) 0.86
Comparison of 18F-FDG uptake by right ventricular myocardium in idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with congenital heart disease. Pulm Circ (2012) 0.86
Cardiac metabolism in hypertrophy and heart failure: implications for therapy. Heart Fail Rev (2013) 0.85
Loss of NHE1 activity leads to reduced oxidative stress in heart and mitigates high-fat diet-induced myocardial stress. J Mol Cell Cardiol (2013) 0.84
Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice. PLoS One (2013) 0.84
Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6. Am J Physiol Heart Circ Physiol (2012) 0.84
In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy. J Cardiovasc Magn Reson (2013) 0.83
Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association. Circ Res (2016) 0.82
Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation. J Mol Cell Cardiol (2015) 0.82
Proteomic changes in the heart of diet-induced pre-diabetic mice. J Proteomics (2011) 0.82
Cardiac LXRα protects against pathological cardiac hypertrophy and dysfunction by enhancing glucose uptake and utilization. EMBO Mol Med (2015) 0.82
Glucose Transporters in Cardiac Metabolism and Hypertrophy. Compr Physiol (2015) 0.82
RNA-stabilizing proteins as molecular targets in cardiovascular pathologies. Trends Cardiovasc Med (2015) 0.81
Quantitative analysis of myocardial glucose utilization in patients with left ventricular dysfunction by means of 18F-FDG dynamic positron tomography and three-compartment analysis. Eur J Nucl Med Mol Imaging (2005) 0.81
Cardiac metabolic compensation to hypertension requires lipoprotein lipase. Am J Physiol Endocrinol Metab (2008) 0.81
Expression of SGLT1 in Human Hearts and Impairment of Cardiac Glucose Uptake by Phlorizin during Ischemia-Reperfusion Injury in Mice. PLoS One (2015) 0.81
Reduced cardiac fructose 2,6 bisphosphate increases hypertrophy and decreases glycolysis following aortic constriction. PLoS One (2013) 0.80
Rescue of neonatal cardiac dysfunction in mice by administration of cardiac progenitor cells in utero. Nat Commun (2015) 0.79
Proteomic analyses of transgenic LQT1 and LQT2 rabbit hearts elucidate an increase in expression and activity of energy producing enzymes. J Proteomics (2012) 0.79
Cardiac-specific hexokinase 2 overexpression attenuates hypertrophy by increasing pentose phosphate pathway flux. J Am Heart Assoc (2013) 0.78
GLUT1 deficiency in cardiomyocytes does not accelerate the transition from compensated hypertrophy to heart failure. J Mol Cell Cardiol (2014) 0.78
Sodium glucose cotransporter SGLT1 as a therapeutic target in diabetes mellitus. Expert Opin Ther Targets (2016) 0.77
DPP4 deficiency preserved cardiac function in abdominal aortic banding rats. PLoS One (2014) 0.77
Deletion of thioredoxin-interacting protein improves cardiac inotropic reserve in the streptozotocin-induced diabetic heart. Am J Physiol Heart Circ Physiol (2016) 0.77
Magnetic resonance imaging and spectroscopy of the murine cardiovascular system. Am J Physiol Heart Circ Physiol (2013) 0.77
Rescue of heart lipoprotein lipase-knockout mice confirms a role for triglyceride in optimal heart metabolism and function. Am J Physiol Endocrinol Metab (2013) 0.76
Molecular switches under TGFβ signalling during progression from cardiac hypertrophy to heart failure. Br J Pharmacol (2015) 0.76
Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury. Cell Metab (2017) 0.75
Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms. Amino Acids (2016) 0.75
Fuel availability and fate in cardiac metabolism: A tale of two substrates. Biochim Biophys Acta (2016) 0.75
c-Myc Alters Substrate Utilization and O-GlcNAc Protein Posttranslational Modifications without Altering Cardiac Function during Early Aortic Constriction. PLoS One (2015) 0.75
Metabolic Origins of Heart Failure. JACC Basic Transl Sci (2017) 0.75
Systematic identification of human mitochondrial disease genes through integrative genomics. Nat Genet (2006) 4.67
CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation. Circ Res (2005) 3.03
Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice. Diabetes (2011) 2.72
A randomized controlled trial of Licartin for preventing hepatoma recurrence after liver transplantation. Hepatology (2007) 2.66
Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling. Diabetes (2007) 2.45
A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1. Cell Res (2008) 2.38
An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry. Nature (2013) 2.31
Long-term effects of increased glucose entry on mouse hearts during normal aging and ischemic stress. Circulation (2007) 2.26
Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress. Circ Res (2004) 2.25
Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes. Mol Cell Biol (2011) 2.23
Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure. Circ Res (2008) 2.19
Restoration of cardiac progenitor cells after myocardial infarction by self-proliferation and selective homing of bone marrow-derived stem cells. Circ Res (2005) 2.18
Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects. Circ Res (2006) 2.15
Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase. J Biol Chem (2003) 2.07
Echocardiographic speckle-tracking based strain imaging for rapid cardiovascular phenotyping in mice. Circ Res (2011) 2.06
Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. Circ Res (2003) 1.99
Mechanisms for increased glycolysis in the hypertrophied rat heart. Hypertension (2004) 1.99
Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A (2007) 1.92
Peroxisome proliferator-activated receptor-gamma-mediated effects in the vasculature. Circ Res (2008) 1.88
Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality. J Clin Invest (2007) 1.85
PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility. Circ Res (2006) 1.80
Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice. Circ Res (2005) 1.80
Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice. J Clin Invest (2010) 1.78
Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure. Cell Metab (2013) 1.74
Impaired mitochondrial biogenesis precedes heart failure in right ventricular hypertrophy in congenital heart disease. Circ Heart Fail (2011) 1.72
Method development of efficient protein extraction in bone tissue for proteome analysis. J Proteome Res (2007) 1.71
AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin. Circulation (2009) 1.65
AMP-activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP-sensitive K(+) channels. J Cell Physiol (2007) 1.58
Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes. Circ Res (2013) 1.56
Increased glucose uptake and oxidation in mouse hearts prevent high fatty acid oxidation but cause cardiac dysfunction in diet-induced obesity. Circulation (2009) 1.55
Defective DNA replication impairs mitochondrial biogenesis in human failing hearts. Circ Res (2010) 1.55
Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling. J Biol Chem (2004) 1.52
Endovascular management as first therapy for chronic total occlusion of the lower extremity arteries: comparison of balloon angioplasty, stenting, and directional atherectomy. J Endovasc Ther (2011) 1.50
HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma. Mol Cancer Res (2007) 1.48
Construction and clinical application of a human tissue-engineered epidermal membrane. Plast Reconstr Surg (2010) 1.48
Collagen tissue engineering: development of novel biomaterials and applications. Pediatr Res (2008) 1.45
No gender influences on clinical outcomes or durability of repair following carotid angioplasty with stenting and carotid endarterectomy. Vasc Endovascular Surg (2008) 1.42
The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy. Mol Cell Biol (2006) 1.41
Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage. J Clin Invest (2007) 1.40
Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy. Circ Res (2012) 1.35
Repair of canine mandibular bone defects with bone marrow stromal cells and porous beta-tricalcium phosphate. Biomaterials (2006) 1.35
Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function. Mol Cell Biol (2006) 1.34
Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart. J Biol Chem (2004) 1.33
The polyphenols resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice. Circulation (2012) 1.32
Isolation, culture, and functional analysis of adult mouse cardiomyocytes. Methods Mol Med (2007) 1.31
Decreased contractile and metabolic reserve in peroxisome proliferator-activated receptor-alpha-null hearts can be rescued by increasing glucose transport and utilization. Circulation (2005) 1.31
Glucose metabolism and cardiac hypertrophy. Cardiovasc Res (2011) 1.28
PPARs: the vasculature, inflammation and hypertension. Curr Opin Nephrol Hypertens (2009) 1.28
Clonal analysis of nestin(-) vimentin(+) multipotent fibroblasts isolated from human dermis. J Cell Sci (2007) 1.26
Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy. J Biol Chem (2005) 1.25
Targeting radioimmunotherapy of hepatocellular carcinoma with iodine (131I) metuximab injection: clinical phase I/II trials. Int J Radiat Oncol Biol Phys (2006) 1.23
Myeloid-specific deletion of the mineralocorticoid receptor reduces infarct volume and alters inflammation during cerebral ischemia. Stroke (2010) 1.22
Effects of chronic Akt activation on glucose uptake in the heart. Am J Physiol Endocrinol Metab (2005) 1.22
Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation (2011) 1.22
Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury. J Clin Invest (2011) 1.21
Tissue engineering of blood vessel. J Cell Mol Med (2007) 1.20
RGS inhibition at G(alpha)i2 selectively potentiates 5-HT1A-mediated antidepressant effects. Proc Natl Acad Sci U S A (2010) 1.19
Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy. Circulation (2005) 1.18
Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute. Circulation (2010) 1.18
Proposed regulation of gene expression by glucose in rodent heart. Gene Regul Syst Bio (2007) 1.18
Acute bilateral angle-closure glaucoma and choroidal effusion associated with acetazolamide administration after cataract surgery. J Cataract Refract Surg (2011) 1.17
A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure. Circulation (2009) 1.12
Tissue engineering of cartilage with the use of chitosan-gelatin complex scaffolds. J Biomed Mater Res B Appl Biomater (2004) 1.11
Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress. J Mol Cell Cardiol (2011) 1.11
In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter. J Biol Chem (2008) 1.11
Titin determines the Frank-Starling relation in early diastole. J Gen Physiol (2003) 1.10
Microstructural impact of ischemia and bone marrow-derived cell therapy revealed with diffusion tensor magnetic resonance imaging tractography of the heart in vivo. Circulation (2014) 1.10
A comparative study of proliferation and osteogenic differentiation of adipose-derived stem cells on akermanite and beta-TCP ceramics. Biomaterials (2008) 1.10
The bone marrow--cardiac axis of myocardial regeneration. Prog Cardiovasc Dis (2007) 1.10
RGS-insensitive G-protein mutations to study the role of endogenous RGS proteins. Methods Enzymol (2004) 1.10
Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4. Am J Physiol Heart Circ Physiol (2006) 1.10
A small diameter elastic blood vessel wall prepared under pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated from adipose-derived stem cells. Biomaterials (2009) 1.09
Bridging tendon defects using autologous tenocyte engineered tendon in a hen model. Plast Reconstr Surg (2002) 1.09
Evaluation of the viability and osteogenic differentiation of cryopreserved human adipose-derived stem cells. Cryobiology (2008) 1.08
Identification of P2Y12-dependent and -independent mechanisms of glycoprotein VI-mediated Rap1 activation in platelets. Blood (2002) 1.08
Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium. Circ Cardiovasc Imaging (2011) 1.07
Rearrangement of energetic and substrate utilization networks compensate for chronic myocardial creatine kinase deficiency. J Physiol (2011) 1.07
Repair of tendon defect with dermal fibroblast engineered tendon in a porcine model. Tissue Eng (2006) 1.07
Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase. Circulation (2004) 1.07
Engineering human neo-tendon tissue in vitro with human dermal fibroblasts under static mechanical strain. Biomaterials (2009) 1.06
Notch1 in bone marrow-derived cells mediates cardiac repair after myocardial infarction. Circulation (2011) 1.06
Genetic determinants of nonmodulating hypertension. Hypertension (2003) 1.06
Deletion of cytosolic phospholipase A2 promotes striated muscle growth. Nat Med (2003) 1.05
Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial. J Nucl Med (2010) 1.04
Targeting AMPK for cardiac protection: opportunities and challenges. J Mol Cell Cardiol (2010) 1.04
Bifid liver in a patient with diaphragmatic hernia. Indian J Gastroenterol (2005) 1.04
Hydrogen peroxide-mediated SERCA cysteine 674 oxidation contributes to impaired cardiac myocyte relaxation in senescent mouse heart. J Am Heart Assoc (2013) 1.04
Bladder reconstruction with adipose-derived stem cell-seeded bladder acellular matrix grafts improve morphology composition. World J Urol (2010) 1.03
Clinical features, early treatment responses, and outcomes of pediatric acute lymphoblastic leukemia in China with or without specific fusion transcripts: a single institutional study of 1,004 patients. Am J Hematol (2012) 1.03
Assessment of cardiac function and energetics in isolated mouse hearts using 31P NMR spectroscopy. J Vis Exp (2010) 1.03
The value of ¹⁸F-FDG-PET/CT in the differential diagnosis of solitary pulmonary nodules in areas with a high incidence of tuberculosis. Ann Nucl Med (2011) 1.03
Differentiation of adipose-derived stem cells into contractile smooth muscle cells induced by transforming growth factor-beta1 and bone morphogenetic protein-4. Tissue Eng Part A (2010) 1.03