Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression.

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Published in Blood on September 26, 2002


Andrea M Woltman1, Sandra W van der Kooij, Paul J Coffer, Rienk Offringa, Mohamed R Daha, Cees van Kooten

Author Affiliations

1: Department of Nephrology, Leiden University Medical Center, The Netherlands. a.m.woltman@lumc.nl

Associated clinical trials:

Prevention of the Graft-Versus-Host-Disease in Patients After Stem Cell Transplantation With Tacrolimus and Everolimus | NCT00117702

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