The CCP4 molecular-graphics project.

Phaser crystallographic software. J Appl Crystallogr (2007) 108.34

Overview of the CCP4 suite and current developments. Acta Crystallogr D Biol Crystallogr (2011) 67.55

Presenting your structures: the CCP4mg molecular-graphics software. Acta Crystallogr D Biol Crystallogr (2011) 6.27

Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. EMBO J (2006) 2.16

Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily. Nat Chem Biol (2008) 1.96

The structure of the C-terminal actin-binding domain of talin. EMBO J (2007) 1.77

ABCA4 disease progression and a proposed strategy for gene therapy. Hum Mol Genet (2008) 1.69

Structural basis of cooperative ligand binding by the glycine riboswitch. Chem Biol (2011) 1.43

Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation. Nat Struct Mol Biol (2010) 1.40

Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance. J Biol Chem (2009) 1.37

Crystal structure of the Staphylococcus aureus pI258 CadC Cd(II)/Pb(II)/Zn(II)-responsive repressor. J Bacteriol (2005) 1.36

Evidence for a dual binding mode of dockerin modules to cohesins. Proc Natl Acad Sci U S A (2007) 1.36

Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains. PLoS Biol (2013) 1.35

Structural determinants of integrin binding to the talin rod. J Biol Chem (2009) 1.35

Structural basis for type VI secretion effector recognition by a cognate immunity protein. PLoS Pathog (2012) 1.28

Coupling of receptor conformation and ligand orientation determine graded activity. Nat Chem Biol (2010) 1.25

Molecular basis of histone H3K4me3 recognition by ING4. J Biol Chem (2008) 1.24

Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex. Proc Natl Acad Sci U S A (2011) 1.23

The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation. J Mol Biol (2007) 1.22

Central region of talin has a unique fold that binds vinculin and actin. J Biol Chem (2010) 1.21

Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme. J Biol Chem (2009) 1.20

Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10. J Virol (2006) 1.19

Molecular basis for the recognition and cleavages of IGF-II, TGF-alpha, and amylin by human insulin-degrading enzyme. J Mol Biol (2009) 1.17

The structure of the Myo4p globular tail and its function in ASH1 mRNA localization. J Cell Biol (2010) 1.17

The structure of the GAF A domain from phosphodiesterase 6C reveals determinants of cGMP binding, a conserved binding surface, and a large cGMP-dependent conformational change. J Biol Chem (2008) 1.15

Papillomavirus E1 helicase assembly maintains an asymmetric state in the absence of DNA and nucleotide cofactors. Nucleic Acids Res (2007) 1.14

The mechanism of prion inhibition by HET-S. Mol Cell (2010) 1.14

Crystal structure of the narrow-spectrum OXA-46 class D beta-lactamase: relationship between active-site lysine carbamylation and inhibition by polycarboxylates. Antimicrob Agents Chemother (2010) 1.13

Structural bases for substrate recognition and activity in Meaban virus nucleoside-2'-O-methyltransferase. Protein Sci (2007) 1.13

Structural basis for the selection of glycosylated substrates by SCF(Fbs1) ubiquitin ligase. Proc Natl Acad Sci U S A (2007) 1.12

New antiviral target revealed by the hexameric structure of mouse hepatitis virus nonstructural protein nsp15. J Virol (2006) 1.11

Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D β-lactamase OXA-10 by rational protein design. Proc Natl Acad Sci U S A (2011) 1.07

ClbP is a prototype of a peptidase subgroup involved in biosynthesis of nonribosomal peptides. J Biol Chem (2011) 1.07

Structural analysis of a dengue cross-reactive antibody complexed with envelope domain III reveals the molecular basis of cross-reactivity. J Immunol (2012) 1.07

Interactions between Ca2+-ATPase and the pentameric form of phospholamban in two-dimensional co-crystals. Biophys J (2006) 1.06

Crystal structure of the flavoprotein ArsH from Sinorhizobium meliloti. FEBS Lett (2007) 1.06

The bacterial effector VopL organizes actin into filament-like structures. Cell (2013) 1.04

Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution. Proc Natl Acad Sci U S A (2009) 1.01

The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site. J Biol Chem (2011) 1.00

Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells. J Med Chem (2014) 0.99

Phosphorylation and mutation of phospholamban alter physical interactions with the sarcoplasmic reticulum calcium pump. J Mol Biol (2010) 0.98

The "Phantom Effect" of the Rexinoid LG100754: structural and functional insights. PLoS One (2010) 0.98

Structural insights into complete metal ion coordination from ternary complexes of B family RB69 DNA polymerase. Biochemistry (2011) 0.97

Overproduction, purification and structure determination of human dual-specificity phosphatase 14. Acta Crystallogr D Biol Crystallogr (2009) 0.97

High-resolution crystal structure of the subclass B3 metallo-beta-lactamase BJP-1: rational basis for substrate specificity and interaction with sulfonamides. Antimicrob Agents Chemother (2010) 0.95

Translocation of Borrelia burgdorferi surface lipoprotein OspA through the outer membrane requires an unfolded conformation and can initiate at the C-terminus. Mol Microbiol (2010) 0.94

X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation. EMBO J (2006) 0.94

An acceptor-substrate binding site determining glycosyl transfer emerges from mutant analysis of a plant vacuolar invertase and a fructosyltransferase. Plant Mol Biol (2008) 0.92

Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions. EMBO J (2010) 0.92

Molecular dynamics simulations of the cardiac troponin complex performed with FRET distances as restraints. PLoS One (2014) 0.92

Surface localization determinants of Borrelia OspC/Vsp family lipoproteins. J Bacteriol (2011) 0.91

Crystal structure of the coat protein of the flexible filamentous papaya mosaic virus. J Mol Biol (2012) 0.90

Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2. Proc Natl Acad Sci U S A (2007) 0.90

Predicting protein function from structure--the roles of short-chain dehydrogenase/reductase enzymes in Bordetella O-antigen biosynthesis. J Mol Biol (2007) 0.88

Structure and function of PA4872 from Pseudomonas aeruginosa, a novel class of oxaloacetate decarboxylase from the PEP mutase/isocitrate lyase superfamily. Biochemistry (2007) 0.87

S1 pocket of a bacterially derived subtilisin-like protease underpins effective tissue destruction. J Biol Chem (2011) 0.87

First crystal structure of a fungal high-redox potential dye-decolorizing peroxidase: substrate interaction sites and long-range electron transfer. J Biol Chem (2012) 0.86

Structural studies of β-carbonic anhydrase from the green alga Coccomyxa: inhibitor complexes with anions and acetazolamide. PLoS One (2011) 0.86

Amsacta moorei entomopoxvirus expresses an active superoxide dismutase. J Virol (2004) 0.86

Structure and biochemical characterization of an adenylate kinase originating from the psychrophilic organism Marinibacillus marinus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.86

Structure and mechanism of the diiron benzoyl-coenzyme A epoxidase BoxB. J Biol Chem (2011) 0.85

Intersubunit linker length as a modifier of protein stability: crystal structures and thermostability of mutant TRAP. Protein Sci (2008) 0.85

Crystal structure of Bacteroides thetaiotaomicron TetX2: a tetracycline degrading monooxygenase at 2.8 Å resolution. Proteins (2011) 0.84

Structural, biochemical and genetic characterization of dissimilatory ATP sulfurylase from Allochromatium vinosum. PLoS One (2013) 0.84

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design. Oncotarget (2013) 0.82

Crystal structure of Bacillus cereus HlyIIR, a transcriptional regulator of the gene for pore-forming toxin hemolysin II. J Mol Biol (2006) 0.82

Phosphoinositides differentially regulate protrudin localization through the FYVE domain. J Biol Chem (2012) 0.82

Structural insights into vinyl reduction regiospecificity of phycocyanobilin:ferredoxin oxidoreductase (PcyA). J Biol Chem (2009) 0.81

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice. Nat Commun (2015) 0.80

Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme. J Mol Biol (2015) 0.80

Structural Insights on the bacteriolytic and self-protection mechanism of muramidase effector Tse3 in Pseudomonas aeruginosa. J Biol Chem (2013) 0.80

Order and disorder in the domain organization of the plasmid partition protein KorB. J Biol Chem (2010) 0.79

Structure of the extended-spectrum β-lactamase TEM-72 inhibited by citrate. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.79

Structure and genetic analysis of the arterivirus nonstructural protein 7alpha. J Virol (2011) 0.78

M. tuberculosis sliding β-clamp does not interact directly with the NAD+-dependent DNA ligase. PLoS One (2012) 0.78

1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells. Acta Crystallogr D Biol Crystallogr (2009) 0.78

Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme. Eur J Med Chem (2014) 0.78

Crystal structure of binary and ternary complexes of archaeal UDP-galactose 4-epimerase-like L-threonine dehydrogenase from Thermoplasma volcanium. J Biol Chem (2012) 0.78

Structural and functional characterization of ScsC, a periplasmic thioredoxin-like protein from Salmonella enterica serovar Typhimurium. Antioxid Redox Signal (2013) 0.78

Targeting class A and C serine β-lactamases with a broad-spectrum boronic acid derivative. J Med Chem (2014) 0.77

First crystal structure of L-lysine 6-dehydrogenase as an NAD-dependent amine dehydrogenase. J Biol Chem (2010) 0.77

Noncovalent complexes of an inactive mutant of CTX-M-9 with the substrate piperacillin and the corresponding product. Antimicrob Agents Chemother (2011) 0.77

Crystal structure of novel dye-linked L-proline dehydrogenase from hyperthermophilic archaeon Aeropyrum pernix. J Biol Chem (2012) 0.77

Structure of a multicopper oxidase from the hyperthermophilic archaeon Pyrobaculum aerophilum. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.76

Disruption of the putative vascular leak peptide sequence in the stabilized ricin vaccine candidate RTA1-33/44-198. Toxins (Basel) (2013) 0.76

Glycoblocks: a schematic three-dimensional representation for glycans and their interactions. Acta Crystallogr D Struct Biol (2016) 0.75

Prediction and evaluation of the lipase inhibitory activities of tea polyphenols with 3D-QSAR models. Sci Rep (2016) 0.75

Crystal structure of a novel two domain GH78 family α-rhamnosidase from Klebsiella oxytoca with rhamnose bound. Proteins (2015) 0.75

[Contraction of the disordered loop located within C-terminal domain of the transcriptional regulator HlyIIR causes its structural rearrangement]. Mol Biol (Mosk) (2009) 0.75

Purification, crystallization and preliminary X-ray diffraction analysis of ArsH from Synechocystis sp. strain PCC 6803. Acta Crystallogr F Struct Biol Commun (2014) 0.75

A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep (2016) 0.75

Structural studies on cytosolic domain of magnesium transporter MgtE from Enterococcus faecalis. Proteins (2010) 0.75

Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs. Biochem Pharmacol (2017) 0.75

Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01

REFMAC5 dictionary: organization of prior chemical knowledge and guidelines for its use. Acta Crystallogr D Biol Crystallogr (2004) 14.28

Developments in the CCP4 molecular-graphics project. Acta Crystallogr D Biol Crystallogr (2004) 13.53

Remediation of the protein data bank archive. Nucleic Acids Res (2007) 4.89

Structures of P. falciparum PfPK5 test the CDK regulation paradigm and suggest mechanisms of small molecule inhibition. Structure (2003) 1.68

Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction. Nat Struct Mol Biol (2007) 1.51

Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44. Mol Cell (2004) 1.38

The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis--an enzyme which inactivates the anti-tubercular drug, isoniazid. J Mol Biol (2002) 1.28

Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4. Mol Cell Biol (2002) 1.26

Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis. Protein Sci (2005) 1.01

Arylamine N-acetyltransferases in mycobacteria. Curr Drug Metab (2008) 0.98

Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design. Structure (2008) 0.94

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem (2003) 0.94

Molecular cloning, characterisation and ligand-bound structure of an azoreductase from Pseudomonas aeruginosa. J Mol Biol (2007) 0.93

Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site. Protein Cell (2010) 0.92

Substituted 4-(thiazol-5-yl)-2-(phenylamino)pyrimidines are highly active CDK9 inhibitors: synthesis, X-ray crystal structures, structure-activity relationship, and anticancer activities. J Med Chem (2013) 0.86

Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase. Protein Expr Purif (2003) 0.85

Erratum: Carbohydrate anomalies in the PDB. Nat Chem Biol (2015) 0.75

Catalysis and regulation. Curr Opin Struct Biol (2011) 0.75

Stay Out of Scientists' E-mails. Sci Am (2017) 0.75

Catalysis and regulation. Curr Opin Struct Biol (2009) 0.75