Published in Nat Immunol on November 11, 2002
Up on the tightrope: natural killer cell activation and inhibition. Nat Immunol (2008) 7.88
A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules. Blood (2005) 4.64
Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion. Blood (2005) 3.99
Effect of NKG2D ligand expression on host immune responses. Immunol Rev (2010) 3.08
Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat Immunol (2005) 2.97
NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules. J Exp Med (2003) 2.75
Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity. J Exp Med (2003) 2.20
Reprogramming of CTLs into natural killer-like cells in celiac disease. J Exp Med (2006) 2.03
Continuous engagement of a self-specific activation receptor induces NK cell tolerance. J Exp Med (2008) 1.86
Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts. Nat Immunol (2005) 1.81
DAP10- and DAP12-associated receptors in innate immunity. Immunol Rev (2009) 1.76
Cytotoxic T lymphocytes form an antigen-independent ring junction. J Clin Invest (2004) 1.72
A role for NKG2D in NK cell-mediated resistance to poxvirus disease. PLoS Pathog (2008) 1.72
The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure. Proc Natl Acad Sci U S A (2005) 1.54
Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus. Proc Natl Acad Sci U S A (2007) 1.46
Chimeric NK-receptor-bearing T cells mediate antitumor immunotherapy. Blood (2005) 1.45
Vav1 phosphorylation is induced by beta2 integrin engagement on natural killer cells upstream of actin cytoskeleton and lipid raft reorganization. J Exp Med (2003) 1.44
Nasu-Hakola disease (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy--PLOSL): a dementia associated with bone cystic lesions. From clinical to genetic and molecular aspects. Cell Mol Neurobiol (2004) 1.44
Intraepithelial lymphocytes in celiac disease immunopathology. Semin Immunopathol (2012) 1.41
Multiplicity and plasticity of natural killer cell signaling pathways. Blood (2005) 1.40
Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity. J Exp Med (2004) 1.39
Membrane nanotubes facilitate long-distance interactions between natural killer cells and target cells. Proc Natl Acad Sci U S A (2010) 1.38
Costimulation of dendritic epidermal gammadelta T cells by a new NKG2D ligand expressed specifically in the skin. J Immunol (2009) 1.36
A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells. J Exp Med (2005) 1.35
NKG2D recognition and perforin effector function mediate effective cytokine immunotherapy of cancer. J Exp Med (2004) 1.35
NKG2D in NK and T cell-mediated immunity. J Clin Immunol (2005) 1.32
Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D. J Exp Med (2004) 1.32
Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production. Proc Natl Acad Sci U S A (2006) 1.30
Altered NK cell development and enhanced NK cell-mediated resistance to mouse cytomegalovirus in NKG2D-deficient mice. Immunity (2009) 1.29
Functions of skin-resident γδ T cells. Cell Mol Life Sci (2011) 1.27
Recognition of tumors by the innate immune system and natural killer cells. Adv Immunol (2014) 1.27
NKG2D ligands as therapeutic targets. Cancer Immun (2013) 1.26
NKG2D Receptor and Its Ligands in Host Defense. Cancer Immunol Res (2015) 1.25
Selective activation of the c-Jun NH2-terminal protein kinase signaling pathway by stimulatory KIR in the absence of KARAP/DAP12 in CD4+ T cells. J Exp Med (2003) 1.18
Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse. Mol Cell Biol (2007) 1.18
JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity. Proc Natl Acad Sci U S A (2008) 1.17
Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection. J Exp Med (2009) 1.16
Regulation of immune cell function and differentiation by the NKG2D receptor. Cell Mol Life Sci (2011) 1.12
NKG2D recognition mediates Toll-like receptor 3 signaling-induced breakdown of epithelial homeostasis in the small intestines of mice. Proc Natl Acad Sci U S A (2007) 1.12
Natural killer cell memory in infection, inflammation and cancer. Nat Rev Immunol (2016) 1.12
Brain and bone damage in KARAP/DAP12 loss-of-function mice correlate with alterations in microglia and osteoclast lineages. Am J Pathol (2005) 1.11
New prospects on the NKG2D/NKG2DL system for oncology. Oncoimmunology (2013) 1.10
Regulation of ITAM-positive receptors: role of IL-12 and IL-18. Blood (2005) 1.10
Obstructing shedding of the immunostimulatory MHC class I chain-related gene B prevents tumor formation. Clin Cancer Res (2009) 1.08
The role of natural killer cells in tumor control--effectors and regulators of adaptive immunity. Springer Semin Immunopathol (2005) 1.04
Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1. J Immunol (2010) 1.03
Natural killer cell responses to viral infection. J Innate Immun (2011) 1.03
A review of trafficking and activation of uterine natural killer cells. Am J Reprod Immunol (2005) 1.00
NKG2D Ligands in Tumor Immunity: Two Sides of a Coin. Front Immunol (2015) 0.98
Murine cytomegalovirus regulation of NKG2D ligands. Med Microbiol Immunol (2008) 0.95
NKG2D receptor signaling enhances cytolytic activity by virus-specific CD8+ T cells: evidence for a protective role in virus-induced encephalitis. J Virol (2007) 0.94
DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo. Eur J Immunol (2009) 0.93
NKG2D-independent suppression of T cell proliferation by H60 and MICA. Proc Natl Acad Sci U S A (2005) 0.92
NKG2D splice variants: a reexamination of adaptor molecule associations. Immunogenetics (2006) 0.92
Soluble NKG2D ligand promotes MDSC expansion and skews macrophage to the alternatively activated phenotype. J Hematol Oncol (2015) 0.91
Coronary artery disease from isolated non-H2-determined incompatibilities in transplanted mouse hearts. Transplantation (2011) 0.91
Beyond Stressed Self: Evidence for NKG2D Ligand Expression on Healthy Cells. Curr Immunol Rev (2009) 0.91
How the virus outsmarts the host: function and structure of cytomegalovirus MHC-I-like molecules in the evasion of natural killer cell surveillance. J Biomed Biotechnol (2011) 0.90
Manipulation of NKG2D ligands by cytomegaloviruses: impact on innate and adaptive immune response. Front Immunol (2011) 0.90
Differential activation of killer cells in the circulation and the lung: a study of current smoking status and chronic obstructive pulmonary disease (COPD). PLoS One (2013) 0.88
Fugu rubripes possesses genes for the entire set of the ITAM-bearing transmembrane signal subunits. Immunogenetics (2003) 0.87
Important roles for gamma interferon and NKG2D in gammadelta T-cell-induced demyelination in T-cell receptor beta-deficient mice infected with a coronavirus. J Virol (2005) 0.85
Versatile signaling through NKG2D. Nat Immunol (2002) 0.85
CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling. Eur J Immunol (2013) 0.85
Detecting the effects of selection at the population level in six bovine immune genes. BMC Genet (2008) 0.84
The role of NKG2D signaling in inhibition of cytotoxic T-lymphocyte lysis by the Murine cytomegalovirus immunoevasin m152/gp40. J Virol (2007) 0.83
NKG2D expression by CD8+ T cells contributes to GVHD and GVT effects in a murine model of allogeneic HSCT. Blood (2015) 0.83
A selective role of NKG2D in inflammatory and autoimmune diseases. Clin Immunol (2013) 0.82
Molecular cloning of KLRI1 and KLRI2, a novel pair of lectin-like natural killer-cell receptors with opposing signalling motifs. Immunogenetics (2005) 0.82
Activation or tolerance of natural killer cells is modulated by ligand quality in a nonmonotonic manner. Biophys J (2010) 0.81
Creation of the two isoforms of rodent NKG2D was driven by a B1 retrotransposon insertion. Nucleic Acids Res (2009) 0.81
A truncated human NKG2D splice isoform negatively regulates NKG2D-mediated function. J Immunol (2014) 0.81
Inhibition of Sophocarpine on Poly I: C/D-GalN-Induced Immunological Liver Injury in Mice. Front Pharmacol (2016) 0.79
Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition. Nat Commun (2016) 0.79
ADAPted secretion of cytokines in NK cells. Nat Immunol (2013) 0.79
Integrated immune responses to infection - cross-talk between human gammadelta T cells and dendritic cells. Immunology (2004) 0.79
Assay of T- and NK-cell subsets and the expression of NKG2A and NKG2D in patients with new-onset systemic lupus erythematosus. Clin Rheumatol (2009) 0.79
Complexity and Diversity of the NKR-P1:Clr (Klrb1:Clec2) Recognition Systems. Front Immunol (2014) 0.79
Cloning, sequencing, and cell surface expression pattern of bovine immunoreceptor NKG2D and adaptor molecules DAP10 and DAP12. Immunogenetics (2007) 0.78
NKG2D triggers cytotoxicity in murine epidermal γδ T cells via PI3K-dependent, Syk/ZAP70-independent signaling pathway. J Invest Dermatol (2013) 0.77
Self or nonself? That is the question: sensing of cytomegalovirus infection by innate immune receptors. Mamm Genome (2010) 0.77
CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1ε transgenic mice. Immunology (2014) 0.77
Polymeric delivery of therapeutic RAE-1 plasmid to the pancreatic islets for the prevention of type 1 diabetes. J Control Release (2012) 0.77
Modulation of NKG2D expression in human CD8(+) T cells corresponding with tuberculosis drug cure. PLoS One (2013) 0.77
CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72. PLoS One (2007) 0.77
NKG2D blockade attenuated cardiac allograft vasculopathy in a mouse model of cardiac transplantation. Clin Exp Immunol (2013) 0.76
NKG2D⁺ IFN-γ⁺ CD8⁺ T cells are responsible for palladium allergy. PLoS One (2014) 0.76
Depletion of IL-2 receptor β-positive cells protects from diabetes in non-obese diabetic mice. Immunol Cell Biol (2015) 0.75
Restricted expression of C-type lectin-like natural killer receptors by CD8 T cells in the murine small intestine. Immunology (2008) 0.75
The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy. Front Immunol (2017) 0.75
The unique surface molecules on intestinal intraepithelial lymphocytes: from tethering to recognizing. Dig Dis Sci (2013) 0.75
Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection. J Immunol (2017) 0.75
Chronic In Vivo Interaction of Dendritic Cells Expressing the Ligand Rae-1ε with NK Cells Impacts NKG2D Expression and Function. Immunohorizons (2017) 0.75
Functions of natural killer cells. Nat Immunol (2008) 9.88
Innate or adaptive immunity? The example of natural killer cells. Science (2011) 8.68
Innate lymphoid cells--a proposal for uniform nomenclature. Nat Rev Immunol (2013) 7.94
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature (2005) 7.18
Human NK cell education by inhibitory receptors for MHC class I. Immunity (2006) 6.73
TLR3 deficiency in patients with herpes simplex encephalitis. Science (2007) 5.86
NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. Immunity (2008) 5.35
Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin. Nat Immunol (2008) 4.78
A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules. Blood (2005) 4.64
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science (2013) 4.60
Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity (2004) 4.36
Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling. Genome Biol (2008) 3.93
The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity (2002) 3.85
Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46. Proc Natl Acad Sci U S A (2007) 3.60
Maturation of mouse NK cells is a 4-stage developmental program. Blood (2009) 3.31
A novel dendritic cell subset involved in tumor immunosurveillance. Nat Med (2006) 3.21
The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans. J Exp Med (2009) 3.17
Natural-killer cells and dendritic cells: "l'union fait la force". Blood (2005) 3.10
Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. Nat Med (2011) 3.03
CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner. J Exp Med (2005) 2.93
Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med (2007) 2.85
Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells. Blood (2009) 2.75
The trafficking of natural killer cells. Immunol Rev (2007) 2.62
Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors. Proc Natl Acad Sci U S A (2005) 2.55
Positive selection of dendritic epidermal gammadelta T cell precursors in the fetal thymus determines expression of skin-homing receptors. Immunity (2004) 2.19
Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases. Nat Immunol (2006) 2.15
NK cell responsiveness is tuned commensurate with the number of inhibitory receptors for self-MHC class I: the rheostat model. J Immunol (2009) 2.12
Germ-line and rearranged Tcrd transcription distinguish bona fide NK cells and NK-like gammadelta T cells. Eur J Immunol (2007) 2.11
Cutting edge: Priming of NK cells by IL-18. J Immunol (2008) 2.08
Turnover and proliferation of NK cells in steady state and lymphopenic conditions. J Immunol (2004) 2.07
Mature natural killer cells reset their responsiveness when exposed to an altered MHC environment. J Exp Med (2010) 2.06
Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future. Immunol Rev (2008) 2.05
Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor. Proc Natl Acad Sci U S A (2011) 2.01
Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor. Nat Immunol (2007) 2.00
Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses. Science (2012) 1.98
Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses. J Immunol (2011) 1.97
Natural killer cells promote early CD8 T cell responses against cytomegalovirus. PLoS Pathog (2007) 1.93
Redundant and unique roles of two enhancer elements in the TCRgamma locus in gene regulation and gammadelta T cell development. Immunity (2002) 1.88
A novel ligand for the NKG2D receptor activates NK cells and macrophages and induces tumor immunity. Eur J Immunol (2003) 1.78
Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc Natl Acad Sci U S A (2004) 1.76
Identity, regulation and in vivo function of gut NKp46+RORγt+ and NKp46+RORγt- lymphoid cells. EMBO J (2011) 1.74
Regulation of NK cell responsiveness to achieve self-tolerance and maximal responses to diseased target cells. Immunol Rev (2008) 1.74
Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. J Exp Med (2007) 1.73
The speed of change: towards a discontinuity theory of immunity? Nat Rev Immunol (2013) 1.72
Development and selection of gammadelta T cells. Immunol Rev (2007) 1.70
Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses. Blood (2007) 1.66
Natural killer cells: from CD3(-)NKp46(+) to post-genomics meta-analyses. Curr Opin Immunol (2007) 1.65
The innate immune response to tumors and its role in the induction of T-cell immunity. Immunol Rev (2002) 1.59
Sustained NKG2D engagement induces cross-tolerance of multiple distinct NK cell activation pathways. Blood (2008) 1.56
Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies. Blood (2013) 1.55
NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors. Nat Med (2012) 1.52
Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum. Proc Natl Acad Sci U S A (2005) 1.50
Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells. Blood (2005) 1.50
NK cells respond to pulmonary infection with Mycobacterium tuberculosis, but play a minimal role in protection. J Immunol (2003) 1.49
Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors. Eur J Immunol (2004) 1.48
Activation and self-tolerance of natural killer cells. Immunol Rev (2006) 1.46
Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells. J Immunol (2010) 1.46
Cytokine therapy reverses NK cell anergy in MHC-deficient tumors. J Clin Invest (2014) 1.45
Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells. J Immunol (2002) 1.44
Interferon-γ production by natural killer cells and cytomegalovirus in critically ill patients. Crit Care Med (2012) 1.43
Posttranslational regulation of the NKG2D ligand Mult1 in response to cell stress. J Exp Med (2009) 1.41
Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cells. J Exp Med (2004) 1.40
Multiplicity and plasticity of natural killer cell signaling pathways. Blood (2005) 1.40
Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis. J Exp Med (2012) 1.39
Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation. Proc Natl Acad Sci U S A (2002) 1.38
Membrane nanotubes facilitate long-distance interactions between natural killer cells and target cells. Proc Natl Acad Sci U S A (2010) 1.38
Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophila. PLoS Pathog (2009) 1.37
Costimulation of dendritic epidermal gammadelta T cells by a new NKG2D ligand expressed specifically in the skin. J Immunol (2009) 1.36
Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency. J Clin Invest (2012) 1.35
The DNA damage response arouses the immune system. Cancer Res (2006) 1.35
p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells. J Exp Med (2013) 1.34
Pivotal role of KARAP/DAP12 adaptor molecule in the natural killer cell-mediated resistance to murine cytomegalovirus infection. J Exp Med (2002) 1.33
Confinement of activating receptors at the plasma membrane controls natural killer cell tolerance. Sci Signal (2011) 1.30
Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases. Nat Immunol (2002) 1.29
Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse. J Neurosci (2004) 1.29
Syk regulation of phosphoinositide 3-kinase-dependent NK cell function. J Immunol (2002) 1.28
Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition? Curr Opin Immunol (2002) 1.28
Natural killer cells in human autoimmune diseases. Immunology (2010) 1.27