Monomeric structures of the zymogen and active catalytic domain of complement protease c1r: further insights into the c1 activation mechanism.

PubWeight™: 0.98‹?› | Rank: Top 15%

🔗 View Article (PMID 12429092)

Published in Structure on November 01, 2002

Authors

Monika Budayova-Spano1, Wolfgang Grabarse, Nicole M Thielens, Heinz Hillen, Monique Lacroix, Martin Schmidt, Juan Carlos Fontecilla-Camps, Gérard J Arlaud, Christine Gaboriaud

Author Affiliations

1: LCCP, Institut de Biologie Structurale Jean-Pierre Ebel, CEA-CNRS, 41 rue Jules Horowitz, Grenoble, France.

Articles citing this

Complement System Part I - Molecular Mechanisms of Activation and Regulation. Front Immunol (2015) 1.52

Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor. Blood (2008) 1.25

Conformational selection in trypsin-like proteases. Curr Opin Struct Biol (2012) 1.20

Allostery in trypsin-like proteases suggests new therapeutic strategies. Trends Biotechnol (2011) 1.07

Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2. EMBO J (2003) 1.02

Crystallographic and kinetic evidence of allostery in a trypsin-like protease. Biochemistry (2011) 0.98

Prohaptoglobin is proteolytically cleaved in the endoplasmic reticulum by the complement C1r-like protein. Proc Natl Acad Sci U S A (2004) 0.98

Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex. J Biol Chem (2010) 0.94

Deciphering the fine details of c1 assembly and activation mechanisms: "mission impossible"? Front Immunol (2014) 0.90

Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r. J Biol Chem (2010) 0.90

A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4. J Biol Chem (2013) 0.83

Molecular determinants of the substrate specificity of the complement-initiating protease, C1r. J Biol Chem (2013) 0.81

The serine protease domain of MASP-3: enzymatic properties and crystal structure in complex with ecotin. PLoS One (2013) 0.76

Articles by these authors

Ambulatory blood pressure changes after renal sympathetic denervation in patients with resistant hypertension. Circulation (2013) 3.44

Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease. J Neurochem (2005) 3.06

Structural characterization of a soluble amyloid beta-peptide oligomer. Biochemistry (2009) 2.31

CDR3 loop flexibility contributes to the degeneracy of TCR recognition. Nat Immunol (2003) 2.10

The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties. J Biol Chem (2003) 2.02

Crystal structure of human iron regulatory protein 1 as cytosolic aconitase. Structure (2006) 2.01

C1q and tumor necrosis factor superfamily: modularity and versatility. Trends Immunol (2004) 1.98

A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex. Immunity (2002) 1.79

Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids. Pain (2009) 1.74

Randomized comparison between open irrigation technology and intracardiac-echo-guided energy delivery for pulmonary vein antrum isolation: procedural parameters, outcomes, and the effect on esophageal injury. J Cardiovasc Electrophysiol (2007) 1.73

The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma–associated herpesvirus. Nat Med (2012) 1.72

Structure and activation of the C1 complex of complement: unraveling the puzzle. Trends Immunol (2004) 1.59

C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition. J Immunol (2008) 1.59

Patients with rheumatoid arthritis and systemic lupus erythematosus have increased renal excretion of mitogenic estrogens in relation to endogenous antiestrogens. J Rheumatol (2004) 1.58

Structural insights into the Slit-Robo complex. Proc Natl Acad Sci U S A (2007) 1.54

Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents. J Neurosci (2008) 1.54

Predictors of treatment in acute coronary syndromes in the elderly: impact on decision making and clinical outcome after interventional versus conservative treatment. Catheter Cardiovasc Interv (2012) 1.53

Structural insights into the innate immune recognition specificities of L- and H-ficolins. EMBO J (2007) 1.53

Microcircuits of functionally identified neurons in the rat medial entorhinal cortex. Neuron (2011) 1.51

Schizophrenia and depression: challenging the paradigm of two separate diseases--a controlled study of schizophrenia, depression and healthy controls. Schizophr Res (2005) 1.44

Rescue-stenting of an occluded lateral coronary sinus branch for recanalization after dissection during cardiac resynchronization device implantation. Europace (2008) 1.38

Vaccine immunogenicity in injecting drug users. Lancet Infect Dis (2009) 1.37

Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition. J Biol Chem (2009) 1.29

The septation apparatus, an autonomous system in budding yeast. Mol Biol Cell (2002) 1.26

Antimicrobial effects of selected plant essential oils on the growth of a Pseudomonas putida strain isolated from meat. Meat Sci (2006) 1.25

Abeta-globulomers are formed independently of the fibril pathway. Neurobiol Dis (2008) 1.23

X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement. J Biol Chem (2003) 1.21

Interactions of the extracellular matrix proteoglycans decorin and biglycan with C1q and collectins. J Immunol (2005) 1.19

Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin. J Biol Chem (2009) 1.16

Human astrovirus coat protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation. Mol Immunol (2009) 1.14

The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex. EMBO J (2002) 1.13

Mechanism of action of Spanish oregano, Chinese cinnamon, and savory essential oils against cell membranes and walls of Escherichia coli O157:H7 and Listeria monocytogenes. J Food Prot (2006) 1.13

Identification of the C1q-binding Sites of Human C1r and C1s: a refined three-dimensional model of the C1 complex of complement. J Biol Chem (2009) 1.13

Antimicrobial and antioxidant effects of milk protein-based film containing essential oils for the preservation of whole beef muscle. J Agric Food Chem (2004) 1.12

Mechanical and barrier properties of nanocrystalline cellulose reinforced chitosan based nanocomposite films. Carbohydr Polym (2012) 1.11

Molecular organization of human Ficolin-2. Mol Immunol (2006) 1.11

Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin. J Immunol (2009) 1.11

Interaction of C1q and mannan-binding lectin with viruses. Immunobiology (2002) 1.09

Relating diffusion along the substrate tunnel and oxygen sensitivity in hydrogenase. Nat Chem Biol (2009) 1.08

Modified low density lipoproteins differentially bind and activate the C1 complex of complement. Mol Immunol (2006) 1.08

Morphology of far-field electrograms and antitachycardia pacing effectiveness among fast ventricular tachycardias occurring in ICD patients: the role of other discriminators. J Cardiovasc Electrophysiol (2014) 1.08

Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins. J Biol Chem (2008) 1.08

A randomized, multicenter, single-blinded trial comparing paclitaxel-coated balloon angioplasty with plain balloon angioplasty in drug-eluting stent restenosis: the PEPCAD-DES study. J Am Coll Cardiol (2012) 1.07

The early course of schizophrenia and depression*. Eur Arch Psychiatry Clin Neurosci (2005) 1.07

Magnet application in ICD patients. Pacing Clin Electrophysiol (2014) 1.07

Complement protein C1q induces maturation of human dendritic cells. Mol Immunol (2007) 1.06

Capacity of human nisin- and pediocin-producing lactic Acid bacteria to reduce intestinal colonization by vancomycin-resistant enterococci. Appl Environ Microbiol (2008) 1.06

Evidence that complement protein C1q interacts with C-reactive protein through its globular head region. J Immunol (2006) 1.05

Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch. J Biol Chem (2007) 1.04

N-acylated chitosan: hydrophobic matrices for controlled drug release. J Control Release (2003) 1.04

Increased estrogen formation and estrogen to androgen ratio in the synovial fluid of patients with rheumatoid arthritis. J Rheumatol (2003) 1.03

X-ray structure of the human calreticulin globular domain reveals a peptide-binding area and suggests a multi-molecular mechanism. PLoS One (2011) 1.02

Heteromeric complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate the complement system. J Immunol (2013) 1.01

Studies on the interactions between C-reactive protein and complement proteins. Immunology (2007) 1.01

Investigations on the C1q-calreticulin-phosphatidylserine interactions yield new insights into apoptotic cell recognition. J Mol Biol (2011) 1.00

Introduction of methionines in the gas channel makes [NiFe] hydrogenase aero-tolerant. J Am Chem Soc (2009) 1.00

The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases. J Immunol (2005) 1.00

Aortic valve calcium score as a predictor for outcome after TAVI using the CoreValve revalving system. Int J Cardiol (2011) 0.99

Identification of the site of human mannan-binding lectin involved in the interaction with its partner serine proteases: the essential role of Lys55. J Immunol (2007) 0.99

Myocardium: dynamic versus single-shot CT perfusion imaging. Radiology (2013) 0.99

Characterization of recombinant mannan-binding lectin-associated serine protease (MASP)-3 suggests an activation mechanism different from that of MASP-1 and MASP-2. J Immunol (2004) 0.98

Key physiological differences in Candida albicans CDR1 induction by steroid hormones and antifungal drugs. Yeast (2006) 0.97