Published in J Clin Invest on November 01, 2002
Ubiquitination in postsynaptic function and plasticity. Annu Rev Cell Dev Biol (2010) 1.94
Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking. Mol Biol Cell (2007) 1.75
The serine protease Corin is a novel modifier of the Agouti pathway. Development (2007) 1.69
Melanism in peromyscus is caused by independent mutations in agouti. PLoS One (2009) 1.31
Signaling pathways in melanosome biogenesis and pathology. Int J Biochem Cell Biol (2010) 1.27
Beta-catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching. Proc Natl Acad Sci U S A (2010) 1.19
Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides (2009) 1.16
Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice. PLoS Genet (2008) 1.10
Association of an Agouti allele with fawn or sable coat color in domestic dogs. Mamm Genome (2005) 0.97
Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas. J Biol Chem (2009) 0.95
Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein. J Biol Chem (2011) 0.93
Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing. PLoS Genet (2009) 0.89
Melanocortin 1 Receptor: Structure, Function, and Regulation. Front Genet (2016) 0.88
The ubiquitin-proteasome system in spongiform degenerative disorders. Biochim Biophys Acta (2008) 0.86
60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSH. J Mol Endocrinol (2016) 0.79
Biglycan deletion alters adiponectin expression in murine adipose tissue and 3T3-L1 adipocytes. PLoS One (2012) 0.77
The sequence of the human genome. Science (2001) 101.55
Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol (2001) 8.68
Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell (2000) 7.82
RING finger proteins: mediators of ubiquitin ligase activity. Cell (2000) 7.75
Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science (1997) 6.23
Does this have a familiar RING? Trends Biochem Sci (1996) 4.80
Molecular characterization of the mouse agouti locus. Cell (1992) 4.55
The pathogenic potential of endogenous retroviruses: facts and fantasies. Trends Microbiol (1999) 3.32
The RING finger domain: a recent example of a sequence-structure family. Curr Opin Struct Biol (1996) 2.97
Emerging roles of ubiquitin in transcription regulation. Science (2002) 2.92
Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev (1993) 2.67
The molecular genetics of rodent single gene obesities. J Biol Chem (1997) 2.32
A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27. Hum Mol Genet (2001) 2.17
Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res (1998) 1.74
A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation. Proc Natl Acad Sci U S A (1994) 1.67
Retroviral sequences located within an intron of the dilute gene alter dilute expression in a tissue-specific manner. EMBO J (1995) 1.66
Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway. Mol Cell Biol (2001) 1.54
AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor. Mol Endocrinol (2001) 1.52
A biochemical function for attractin in agouti-induced pigmentation and obesity. Nat Genet (2001) 1.49
The mouse mahogany locus encodes a transmembrane form of human attractin. Nature (1999) 1.37
Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor. Regul Pept (2001) 1.33
Genetic studies of the mouse mutations mahogany and mahoganoid. Genetics (1997) 1.32
Real-time RT-PCR quantification of insulin-like growth factor (IGF)-1, IGF-1 receptor, IGF-2, IGF-2 receptor, insulin receptor, growth hormone receptor, IGF-binding proteins 1, 2 and 3 in the bovine species. Domest Anim Endocrinol (2002) 1.31
Exonic and intronic sequence variation in the human leptin receptor gene (LEPR). Diabetes (1997) 1.16
Life without neuropeptide Y. Recent Prog Horm Res (1998) 1.15
The mahogany protein is a receptor involved in suppression of obesity. Nature (1999) 1.12
Attractin/mahogany/zitter plays a critical role in myelination of the central nervous system. Proc Natl Acad Sci U S A (2001) 1.09
The role of melanocortin signalling in the control of body weight: evidence from human and murine genetic models. QJM (2000) 1.00
Molecular and phenotypic analysis of Attractin mutant mice. Genetics (2001) 0.94
The ubiquitin protein catabolic disorders. Neuropathol Appl Neurobiol (2001) 0.90
Mahogany (mg) stimulates feeding and increases basal metabolic rate independent of its suppression of agouti. Proc Natl Acad Sci U S A (1998) 0.89
Phaeomelanin synthesis and obesity in mice. Interaction of the viable yellow (Avy) and sombre (eso) mutations. J Hered (1979) 0.87
Mice with mutations in the mahogany gene Atrn have cerebral spongiform changes. J Neuropathol Exp Neurol (2001) 0.81
Microdissection of proximal mouse chromosome 6: identification of RFLPs tightly linked to the ob mutation. Mamm Genome (1993) 0.78
Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22
CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest (2005) 10.44
Racial differences in incident heart failure among young adults. N Engl J Med (2009) 5.60
Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trial. Ann Intern Med (2003) 5.38
The long-term stability of the human gut microbiota. Science (2013) 5.15
De novo mutations in histone-modifying genes in congenital heart disease. Nature (2013) 5.15
Racial differences in the progression from chronic renal insufficiency to end-stage renal disease in the United States. J Am Soc Nephrol (2003) 4.28
Human oocytes reprogram somatic cells to a pluripotent state. Nature (2011) 4.03
Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell (2004) 4.00
The sensitivity and specificity of a simple test to distinguish between urge and stress urinary incontinence. Ann Intern Med (2006) 3.93
A public resource facilitating clinical use of genomes. Proc Natl Acad Sci U S A (2012) 3.72
Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol (2008) 3.49
Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci U S A (2009) 3.43
Enalapril in infants with single ventricle: results of a multicenter randomized trial. Circulation (2010) 3.13
Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest (2005) 3.10
Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: the Cholesterol and Pharmacogenetics (CAP) Study. Am J Cardiol (2006) 2.94
Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis. Blood (2008) 2.91
Determination of oestrogen-receptor status and ERBB2 status of breast carcinoma: a gene-expression profiling study. Lancet Oncol (2007) 2.90
Endoscopic and surgical treatments for achalasia: a systematic review and meta-analysis. Ann Surg (2009) 2.89
The incidence of end-stage renal disease is increasing faster than the prevalence of chronic renal insufficiency. Ann Intern Med (2004) 2.86
An HMM approach to genome-wide identification of differential histone modification sites from ChIP-seq data. Bioinformatics (2008) 2.85
Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab (2010) 2.79
Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab (2002) 2.76
A signal-noise model for significance analysis of ChIP-seq with negative control. Bioinformatics (2010) 2.66
A randomized comparison of total or supracervical hysterectomy: surgical complications and clinical outcomes. Obstet Gynecol (2003) 2.57
Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet-Biedl syndrome. Proc Natl Acad Sci U S A (2010) 2.45
Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J Clin Invest (2008) 2.44
Serum lipoprotein levels, statin use, and cognitive function in older women. Arch Neurol (2002) 2.41
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. PLoS Genet (2013) 2.39
Nonoptimal lipids commonly present in young adults and coronary calcium later in life: the CARDIA (Coronary Artery Risk Development in Young Adults) study. Ann Intern Med (2010) 2.37
Decay-accelerating factor modulates induction of T cell immunity. J Exp Med (2005) 2.34
Genetics and genomics of pulmonary arterial hypertension. J Am Coll Cardiol (2009) 2.31
Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects. Am J Physiol Regul Integr Comp Physiol (2003) 2.28
Models of consent to return of incidental findings in genomic research. Hastings Cent Rep (2014) 2.25
Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension. Circ Cardiovasc Genet (2012) 2.16
Genetic testing preferences in families containing multiple individuals with epilepsy. Epilepsia (2014) 2.15
Is the energy homeostasis system inherently biased toward weight gain? Diabetes (2003) 2.14
Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight. Am J Clin Nutr (2008) 2.13
Glycogen storage disease type III diagnosis and management guidelines. Genet Med (2010) 2.13
Association between marijuana exposure and pulmonary function over 20 years. JAMA (2012) 2.09
Hot flushes, coronary heart disease, and hormone therapy in postmenopausal women. Menopause (2009) 2.07
Effect of postmenopausal hormone therapy on cognitive function: the Heart and Estrogen/progestin Replacement Study. Am J Med (2002) 2.02
The motor neuron response to SMN1 deficiency in spinal muscular atrophy. Muscle Nerve (2014) 2.02
11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls. J Nucl Med (2009) 1.99
Effect of hysterectomy vs medical treatment on health-related quality of life and sexual functioning: the medicine or surgery (Ms) randomized trial. JAMA (2004) 1.97
Postmenopausal hormone therapy: does it cause incontinence? Obstet Gynecol (2005) 1.94
Control of hypertension in adults with chronic kidney disease in the United States. Hypertension (2005) 1.92
Pancreatic cancer screening in a prospective cohort of high-risk patients: a comprehensive strategy of imaging and genetics. Clin Cancer Res (2010) 1.92
EIF2AK4 mutations in pulmonary capillary hemangiomatosis. Chest (2014) 1.88
Waist Circumference and Cardiometabolic Risk: a Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Obesity (Silver Spring) (2007) 1.87
Genetic loss of SH2B3 in acute lymphoblastic leukemia. Blood (2013) 1.87
Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cells. Mol Cell Biol (2003) 1.78
Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells. Nat Immunol (2012) 1.74
Predictors of heart failure among women with coronary disease. Circulation (2004) 1.74
Responses of gut microbiota to diet composition and weight loss in lean and obese mice. Obesity (Silver Spring) (2011) 1.73
Prevalence and risk factors for urinary incontinence in women with type 2 diabetes and impaired fasting glucose: findings from the National Health and Nutrition Examination Survey (NHANES) 2001-2002. Diabetes Care (2006) 1.71
To eat or not to eat - how the gut talks to the brain. N Engl J Med (2003) 1.68
A recurrent PDGFRB mutation causes familial infantile myofibromatosis. Am J Hum Genet (2013) 1.66
A short Nur77-derived peptide converts Bcl-2 from a protector to a killer. Cancer Cell (2008) 1.66
The expression of CRM1 is associated with prognosis in human osteosarcoma. Oncol Rep (2009) 1.64
A 600 kb deletion syndrome at 16p11.2 leads to energy imbalance and neuropsychiatric disorders. J Med Genet (2012) 1.63
Copy-number disorders are a common cause of congenital kidney malformations. Am J Hum Genet (2012) 1.63
High prevalence of BRCA1 and BRCA2 germline mutations with loss of heterozygosity in a series of resected pancreatic adenocarcinoma and other neoplastic lesions. Clin Cancer Res (2013) 1.63
Association of TGFBR2 polymorphism with risk of sudden cardiac arrest in patients with coronary artery disease. Heart Rhythm (2009) 1.59
Decay accelerating factor can control T cell differentiation into IFN-gamma-producing effector cells via regulating local C5a-induced IL-12 production. J Immunol (2007) 1.59
Menopausal symptoms in older women and the effects of treatment with hormone therapy. Obstet Gynecol (2002) 1.57
Common beta-adrenergic receptor polymorphisms are not associated with risk of sudden cardiac death in patients with coronary artery disease. Heart Rhythm (2008) 1.56
A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. J Clin Invest (2011) 1.55
The "costs" of urinary incontinence for women. Obstet Gynecol (2006) 1.52
Hysterectomy versus expanded medical treatment for abnormal uterine bleeding: clinical outcomes in the medicine or surgery trial. Obstet Gynecol (2004) 1.52
Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nat Commun (2011) 1.49
Researchers' views on return of incidental genomic research results: qualitative and quantitative findings. Genet Med (2013) 1.48
Clinical significance of postvoid residual volume in older ambulatory women. J Am Geriatr Soc (2011) 1.48
Incarceration, incident hypertension, and access to health care: findings from the coronary artery risk development in young adults (CARDIA) study. Arch Intern Med (2009) 1.47
An eigenfunction method for reconstruction of large-scale and high-contrast objects. IEEE Trans Ultrason Ferroelectr Freq Control (2007) 1.47
Variants of the CFC1 gene in patients with laterality defects associated with congenital cardiac disease. Cardiol Young (2007) 1.47
Dietary fat is not a major determinant of body fat. Am J Med (2002) 1.46
IFN-gamma and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production. J Immunol (2008) 1.45
Determinants of leptin gene expression in fat depots of lean mice. Am J Physiol Regul Integr Comp Physiol (2002) 1.45
Biomarkers to predict recurrent cardiovascular disease: the Heart and Soul Study. Am J Med (2008) 1.45
Effect of ultra-low-dose transdermal estradiol on breast density in postmenopausal women. Menopause (2007) 1.44
Mutations in ZIC3 and ACVR2B are a common cause of heterotaxy and associated cardiovascular anomalies. Cardiol Young (2011) 1.44
Hepatic stellate cells regulate immune response by way of induction of myeloid suppressor cells in mice. Hepatology (2011) 1.44
Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics. J Gen Physiol (2013) 1.44
Comparison of endoscopic and clinical characteristics of patients with familial and sporadic Barrett's esophagus. Dig Dis Sci (2011) 1.43
Validation of the Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND). Pediatr Phys Ther (2011) 1.42
Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting. Mol Cell Biol (2004) 1.40
Novel splice mutation in microthalmia-associated transcription factor in Waardenburg Syndrome. Genet Test Mol Biomarkers (2011) 1.39
Generalized Detectability for Discrete Event Systems. Syst Control Lett (2011) 1.38
The NF-kappaB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes. J Hepatol (2010) 1.37
Body fat redistribution after weight gain in women with anorexia nervosa. Am J Clin Nutr (2005) 1.34
Statin therapy, cardiovascular events, and total mortality in the Heart and Estrogen/Progestin Replacement Study (HERS). Circulation (2002) 1.34
Genetic testing for dilated cardiomyopathy in clinical practice. J Card Fail (2012) 1.32