Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT.

Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy. Neuron (2010) 1.75

Ligand-dependent corepressor acts as a novel androgen receptor corepressor, inhibits prostate cancer growth, and is functionally inactivated by the Src protein kinase. J Biol Chem (2011) 1.60

The cell fate determination factor dachshund inhibits androgen receptor signaling and prostate cancer cellular growth. Cancer Res (2009) 1.58

Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors. Proc Natl Acad Sci U S A (2004) 1.47

Diverse roles of androgen receptor (AR) domains in AR-mediated signaling. Nucl Recept Signal (2008) 1.47

Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor. Mol Endocrinol (2007) 1.43

Transcriptional activity of androgen receptor is modulated by two RNA splicing factors, PSF and p54nrb. Mol Cell Biol (2007) 1.35

The silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressor is required for full estrogen receptor alpha transcriptional activity. Mol Cell Biol (2007) 1.34

Ligand-specific dynamics of the androgen receptor at its response element in living cells. Mol Cell Biol (2006) 1.28

The Dachshund gene in development and hormone-responsive tumorigenesis. Trends Endocrinol Metab (2009) 1.28

Negative modulation of androgen receptor transcriptional activity by Daxx. Mol Cell Biol (2004) 1.26

Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha. Mol Cell Biol (2004) 1.19

Emerging roles of the corepressors NCoR1 and SMRT in homeostasis. Genes Dev (2013) 1.18

Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer. Mol Cell Biol (2006) 1.12

Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes. Carcinogenesis (2008) 1.12

What goes on behind closed doors: physiological versus pharmacological steroid hormone actions. Bioessays (2008) 1.11

Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells. Mol Cell Biol (2004) 1.07

ARA67/PAT1 functions as a repressor to suppress androgen receptor transactivation. Mol Cell Biol (2004) 1.03

Characterization of nuclear import of the domain-specific androgen receptor in association with the importin alpha/beta and Ran-guanosine 5'-triphosphate systems. Endocrinology (2008) 1.01

Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotype. Oncogene (2013) 1.01

Structural basis for nuclear receptor corepressor recruitment by antagonist-liganded androgen receptor. Mol Cancer Ther (2008) 0.99

The stress response mediator ATF3 represses androgen signaling by binding the androgen receptor. Mol Cell Biol (2012) 0.98

Structural and functional analysis of domains of the progesterone receptor. Mol Cell Endocrinol (2011) 0.95

Elevated NCOR1 disrupts PPARalpha/gamma signaling in prostate cancer and forms a targetable epigenetic lesion. Carcinogenesis (2010) 0.95

MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling. Cancer Res (2011) 0.95

Nuclear compartmentalization of N-CoR and its interactions with steroid receptors. Mol Cell Biol (2006) 0.93

Differential modulation of androgen receptor transcriptional activity by the nuclear receptor co-repressor (N-CoR). Biochem J (2004) 0.92

ARF represses androgen receptor transactivation in prostate cancer. Mol Endocrinol (2013) 0.92

Regulation of a novel androgen receptor target gene, the cyclin B1 gene, through androgen-dependent E2F family member switching. Mol Cell Biol (2012) 0.91

Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patterns. Carcinogenesis (2012) 0.91

The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module. Cancer Res (2015) 0.87

Estrogen receptors recruit SMRT and N-CoR corepressors through newly recognized contacts between the corepressor N terminus and the receptor DNA binding domain. Mol Cell Biol (2010) 0.86

Inhibition of androgen receptor transcriptional activity as a novel mechanism of action of arsenic. Mol Endocrinol (2009) 0.84

Epigenetic distortion to VDR transcriptional regulation in prostate cancer cells. J Steroid Biochem Mol Biol (2012) 0.84

Corepressor effect on androgen receptor activity varies with the length of the CAG encoded polyglutamine repeat and is dependent on receptor/corepressor ratio in prostate cancer cells. Mol Cell Endocrinol (2011) 0.83

The PPARγ ligand ciglitazone regulates androgen receptor activation differently in androgen-dependent versus androgen-independent human prostate cancer cells. Exp Cell Res (2010) 0.83

Analysis of interdomain interactions of the androgen receptor. Methods Mol Biol (2011) 0.82

Nuclear receptor corepressor complexes in cancer: mechanism, function and regulation. Am J Clin Exp Urol (2014) 0.82

LANP mediates neuritic pathology in Spinocerebellar ataxia type 1. Neurobiol Dis (2012) 0.82

miR-125b Regulation of Androgen Receptor Signaling Via Modulation of the Receptor Complex Co-Repressor NCOR2. Biores Open Access (2012) 0.81

Proteomic analyses to identify novel therapeutic targets for the treatment of advanced prostate cancer. Cellscience (2006) 0.81

NBBS isolated from Pygeum africanum bark exhibits androgen antagonistic activity, inhibits AR nuclear translocation and prostate cancer cell growth. Invest New Drugs (2009) 0.81

Antiandrogen flutamide protects male mice from androgen-dependent toxicity in three models of spinal bulbar muscular atrophy. Endocrinology (2014) 0.81

New insights into the androgen-targeted therapies and epigenetic therapies in prostate cancer. Prostate Cancer (2011) 0.79

Different types of androgen receptor mutations in patients with complete androgen insensitivity syndrome. Intractable Rare Dis Res (2015) 0.78

Chromosome 12q24.31-q24.33 deletion causes multiple dysmorphic features and developmental delay: First mosaic patient and overview of the phenotype related to 12q24qter defects. Mol Cytogenet (2011) 0.78

Mechanism of androgen receptor corepression by CKβBP2/CRIF1, a multifunctional transcription factor coregulator expressed in prostate cancer. Mol Cell Endocrinol (2013) 0.77

Knockdown of AKR1C3 exposes a potential epigenetic susceptibility in prostate cancer cells. J Steroid Biochem Mol Biol (2015) 0.76

Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping. Mol Cell Proteomics (2017) 0.75

Pathogenesis of prostate cancer and hormone refractory prostate cancer. Indian J Urol (2007) 0.75

Mechanisms of Androgen-Independent Prostate Cancer. EJIFCC (2014) 0.75

Targeting of Androgen Receptor Expression by Andro-miRs as Novel Adjunctive Therapeutics in Prostate Cancer. J Cancer Ther (2013) 0.75

Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer. Oncotarget (2015) 0.75

Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. Proc Natl Acad Sci U S A (2008) 16.54

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07

The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study. Lancet (2008) 9.03

PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations. Nucleic Acids Res (2007) 7.07

Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection. J Exp Med (2009) 7.01

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet (2009) 6.42

Warfarin genotyping reduces hospitalization rates results from the MM-WES (Medco-Mayo Warfarin Effectiveness study). J Am Coll Cardiol (2010) 5.07

Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1. J Exp Med (2009) 4.79

Generation of induced pluripotent stem cell lines from adult rat cells. Cell Stem Cell (2008) 4.52

A TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell (2012) 4.49

Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell (2006) 4.13

Estimating medication persistency using administrative claims data. Am J Manag Care (2005) 3.95

Second messenger-mediated adjustment of bacterial swimming velocity. Cell (2010) 3.69

Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet (2009) 3.59

Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis. Mol Carcinog (2010) 3.44

Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proc Natl Acad Sci U S A (2005) 3.37

Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury. Biochem J (2003) 3.29

An effective method for accurate prediction of the first hyperpolarizability of alkalides. J Comput Chem (2011) 3.28

Role of HMGB1 in apoptosis-mediated sepsis lethality. J Exp Med (2006) 3.26

Myeloid-derived suppressor cells suppress antitumor immune responses through IDO expression and correlate with lymph node metastasis in patients with breast cancer. J Immunol (2013) 2.96

Genetic evidence supports demic diffusion of Han culture. Nature (2004) 2.92

An IAP-IAP complex inhibits apoptosis. J Biol Chem (2004) 2.82

Phenotypic properties of transmitted founder HIV-1. Proc Natl Acad Sci U S A (2013) 2.75

Late gastrointestinal toxicities following radiation therapy for prostate cancer. Eur Urol (2011) 2.69

Wide variation in the multiplicity of HIV-1 infection among injection drug users. J Virol (2010) 2.67

Collecting duct-specific deletion of peroxisome proliferator-activated receptor gamma blocks thiazolidinedione-induced fluid retention. Proc Natl Acad Sci U S A (2005) 2.56

Impact of comorbidity on survival among men with localized prostate cancer. J Clin Oncol (2011) 2.53

CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res (2012) 2.50

Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice. Endocrinology (2007) 2.40

Dementia subtypes in China: prevalence in Beijing, Xian, Shanghai, and Chengdu. Arch Neurol (2005) 2.39

Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys. J Virol (2010) 2.39

Biochemical and functional analysis of CTR1, a protein kinase that negatively regulates ethylene signaling in Arabidopsis. Plant J (2003) 2.37

Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy. J Am Coll Cardiol (2006) 2.37

NONCODEv4: exploring the world of long non-coding RNA genes. Nucleic Acids Res (2013) 2.37

Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. Nat Genet (2011) 2.32

Volumetric texture analysis of breast lesions on contrast-enhanced magnetic resonance images. Magn Reson Med (2007) 2.31

Programming human pluripotent stem cells into white and brown adipocytes. Nat Cell Biol (2012) 2.26

Is the 4 mm height of the vertebral artery groove really a limitation of C1 pedicle screw insertion? Eur Spine J (2014) 2.21

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito. Nature (2011) 2.20

Automation of protein purification for structural genomics. J Struct Funct Genomics (2004) 2.17

Autoreactive B cells in the marginal zone that express dual receptors. J Exp Med (2002) 2.16

Randomized study of autologous cytokine-induced killer cell immunotherapy in metastatic renal carcinoma. Clin Cancer Res (2012) 2.14

IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells. J Immunol (2010) 2.12

Vertical T cell immunodominance and epitope entropy determine HIV-1 escape. J Clin Invest (2012) 2.05

Insulin resistance in children with primary nephrotic syndrome and normal renal function. Pediatr Nephrol (2012) 2.03

Levels of prenatal mercury exposure and their relationships to neonatal anthropometry in Wujiang City, China. Environ Pollut (2013) 2.01

Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. J Clin Invest (2007) 1.99

Generation of pig induced pluripotent stem cells with a drug-inducible system. J Mol Cell Biol (2009) 1.99

Overweight patients achieve ideal body weight following curative gastrectomy resulting in better long-term prognosis. Obes Surg (2013) 1.97

CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses. J Immunol (2006) 1.94

Enhanced differential evolution with adaptive strategies for numerical optimization. IEEE Trans Syst Man Cybern B Cybern (2010) 1.91

A nation-wide multicenter 10-year (1999-2008) retrospective clinical epidemiological study of female breast cancer in China. BMC Cancer (2011) 1.88

Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes. J Mol Cell Cardiol (2002) 1.86

Responses of ecosystem carbon cycle to experimental warming: a meta-analysis. Ecology (2013) 1.80

Long-range ordered carbon clusters: a crystalline material with amorphous building blocks. Science (2012) 1.75

Activation of peroxisome proliferator-activated receptor-γ coactivator 1α ameliorates mitochondrial dysfunction and protects podocytes from aldosterone-induced injury. Kidney Int (2012) 1.75

Rational design of shepherdin, a novel anticancer agent. Cancer Cell (2005) 1.74

A multilevel adaptive finite element algorithm for bioluminescence tomography. Opt Express (2006) 1.71

Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription. J Biol Chem (2001) 1.70

Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. Proc Natl Acad Sci U S A (2011) 1.69

Golgi protein 73 (GOLPH2) is a valuable serum marker for hepatocellular carcinoma. Gut (2010) 1.67

Energy decomposition analysis of covalent bonds and intermolecular interactions. J Chem Phys (2009) 1.66

Chronic arsenic poisoning from burning high-arsenic-containing coal in Guizhou, China. Environ Health Perspect (2002) 1.65

The noncoding RNA expression profile and the effect of lncRNA AK126698 on cisplatin resistance in non-small-cell lung cancer cell. PLoS One (2013) 1.65

Laboratory diagnosis of four recent sporadic cases of community-acquired SARS, Guangdong Province, China. Emerg Infect Dis (2004) 1.65

Present Y chromosomes reveal the ancestry of Emperor CAO Cao of 1800 years ago. J Hum Genet (2011) 1.61

Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape. PLoS Pathog (2012) 1.61

Cancerous breast lesions on dynamic contrast-enhanced MR images: computerized characterization for image-based prognostic markers. Radiology (2010) 1.60

Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection. Mol Cell (2007) 1.60

Twelve-month frequency of drug-metabolizing enzyme and transporter-based drug-drug interaction potential in patients receiving oral enzyme-targeted kinase inhibitor antineoplastic agents. Mayo Clin Proc (2013) 1.60

Body iron stores and dietary iron intake in relation to diabetes in adults in North China. Diabetes Care (2007) 1.59

Mortality rates among prevalent hemodialysis patients in Beijing: a comparison with USRDS data. Nephrol Dial Transplant (2012) 1.59

Polarization-independent wide-angle triple-band metamaterial absorber. Opt Express (2011) 1.59

The role of miRNA-29 family in cancer. Eur J Cell Biol (2013) 1.58

Transcription factor AtMYB103 is required for anther development by regulating tapetum development, callose dissolution and exine formation in Arabidopsis. Plant J (2007) 1.58

A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation. J Biol Chem (2011) 1.57

Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections. PLoS Pathog (2011) 1.57

Analyses of genetic structure of Tibeto-Burman populations reveals sex-biased admixture in southern Tibeto-Burmans. Am J Hum Genet (2004) 1.57

Progress of genome wide association study in domestic animals. J Anim Sci Biotechnol (2012) 1.57

Safety and efficacy of biodegradable polymer-coated sirolimus-eluting stents in "real-world" practice: 18-month clinical and 9-month angiographic outcomes. JACC Cardiovasc Interv (2009) 1.56

Large-scale evaluation of protein reductive methylation for improving protein crystallization. Nat Methods (2008) 1.55

Does primary androgen-deprivation therapy delay the receipt of secondary cancer therapy for localized prostate cancer? Eur Urol (2012) 1.55

Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein. J Biol Chem (2011) 1.54

A randomised comparison of a novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent with a durable polymer everolimus-eluting stent: clinical and angiographic follow-up of the TARGET I trial. EuroIntervention (2013) 1.53

High-sensitivity C-reactive protein is within normal levels at the very onset of first ST-segment elevation acute myocardial infarction in 41% of cases: a multiethnic case-control study. J Am Coll Cardiol (2011) 1.53

Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. J Biol Chem (2004) 1.53

Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors. J Neurosci (2011) 1.52

Development of SNAP-tag fluorogenic probes for wash-free fluorescence imaging. Chembiochem (2011) 1.51

Contingent triple-screening for Down syndrome in the second trimester: a feasibility study in Mainland Chinese population. Prenat Diagn (2010) 1.51

TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs. Nat Struct Mol Biol (2009) 1.51

IDO inhibits T-cell function through suppressing Vav1 expression and activation. Cancer Biol Ther (2009) 1.51

The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs. J Biol Chem (2010) 1.48

miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3. Biochem Biophys Res Commun (2011) 1.48

Elf5 inhibits TGF-β-driven epithelial-mesenchymal transition in prostate cancer by repressing SMAD3 activation. Prostate (2015) 1.47

Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population. Nat Genet (2011) 1.46

Interferon-λs: special immunomodulatory agents and potential therapeutic targets. J Innate Immun (2012) 1.46

Interaction between regulatory T cells and cancer stem cells. Int J Cancer (2012) 1.46

Prospective randomized comparison of left atrial and biatrial radiofrequency ablation in the treatment of atrial fibrillation. Eur J Cardiothorac Surg (2008) 1.45

Candidate pathway-based genome-wide association studies identify novel associations of genomic variants in the complement system associated with coronary artery disease. Circ Cardiovasc Genet (2014) 1.45

Topological insulator nanostructures for near-infrared transparent flexible electrodes. Nat Chem (2012) 1.45