A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR.

PubWeight™: 9.55‹?› | Rank: Top 0.1%

🔗 View Article (PMC 139214)

Published in Proc Natl Acad Sci U S A on December 12, 2002

Authors

Aneta T Petkova1, Yoshitaka Ishii, John J Balbach, Oleg N Antzutkin, Richard D Leapman, Frank Delaglio, Robert Tycko

Author Affiliations

1: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA.

Articles citing this

(truncated to the top 100)

Structure of the cross-beta spine of amyloid-like fibrils. Nature (2005) 11.56

3D structure of Alzheimer's amyloid-beta(1-42) fibrils. Proc Natl Acad Sci U S A (2005) 8.60

Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils. Biochemistry (2006) 6.54

The amyloid state of proteins in human diseases. Cell (2012) 4.53

In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A (2011) 4.38

Structural classification of toxic amyloid oligomers. J Biol Chem (2008) 4.16

Evidence for assembly of prions with left-handed beta-helices into trimers. Proc Natl Acad Sci U S A (2004) 3.64

High-resolution molecular structure of a peptide in an amyloid fibril determined by magic angle spinning NMR spectroscopy. Proc Natl Acad Sci U S A (2004) 3.58

Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR. Biochemistry (2007) 3.57

Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR. Proc Natl Acad Sci U S A (2005) 3.37

Structure determination of membrane proteins by NMR spectroscopy. Chem Rev (2004) 3.25

AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides. BMC Bioinformatics (2007) 3.02

The amyloid state and its association with protein misfolding diseases. Nat Rev Mol Cell Biol (2014) 2.99

The 3D profile method for identifying fibril-forming segments of proteins. Proc Natl Acad Sci U S A (2006) 2.88

Amyloid of the prion domain of Sup35p has an in-register parallel beta-sheet structure. Proc Natl Acad Sci U S A (2006) 2.88

Molecular architecture of human prion protein amyloid: a parallel, in-register beta-structure. Proc Natl Acad Sci U S A (2007) 2.55

On the nucleation of amyloid beta-protein monomer folding. Protein Sci (2005) 2.47

Characterization of the nanoscale properties of individual amyloid fibrils. Proc Natl Acad Sci U S A (2006) 2.46

Prion generation in vitro: amyloid of Ure2p is infectious. EMBO J (2005) 2.42

Solid-state NMR studies of amyloid fibril structure. Annu Rev Phys Chem (2011) 2.38

The Alzheimer's peptides Abeta40 and 42 adopt distinct conformations in water: a combined MD / NMR study. J Mol Biol (2007) 2.35

FTIR reveals structural differences between native beta-sheet proteins and amyloid fibrils. Protein Sci (2004) 2.31

Seeded growth of beta-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure. Proc Natl Acad Sci U S A (2009) 2.15

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers. Nat Chem Biol (2011) 2.08

Monomer adds to preformed structured oligomers of Abeta-peptides by a two-stage dock-lock mechanism. Proc Natl Acad Sci U S A (2006) 2.01

Amyloid beta-protein monomer structure: a computational and experimental study. Protein Sci (2006) 1.99

Folding versus aggregation: polypeptide conformations on competing pathways. Arch Biochem Biophys (2007) 1.97

Myoglobin forms amyloid fibrils by association of unfolded polypeptide segments. Proc Natl Acad Sci U S A (2003) 1.93

Paired beta-sheet structure of an Abeta(1-40) amyloid fibril revealed by electron microscopy. Proc Natl Acad Sci U S A (2008) 1.89

Template-assisted filament growth by parallel stacking of tau. Proc Natl Acad Sci U S A (2004) 1.89

Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42. Biochemistry (2006) 1.88

Molecular conformation and dynamics of the Y145Stop variant of human prion protein in amyloid fibrils. Proc Natl Acad Sci U S A (2008) 1.86

Polymorphic fibril formation by residues 10-40 of the Alzheimer's beta-amyloid peptide. Biophys J (2006) 1.84

Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register beta-sheet structure. Proc Natl Acad Sci U S A (2008) 1.80

Parallel beta-sheets and polar zippers in amyloid fibrils formed by residues 10-39 of the yeast prion protein Ure2p. Biochemistry (2005) 1.79

Molecular basis for amyloid-beta polymorphism. Proc Natl Acad Sci U S A (2011) 1.76

Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proc Natl Acad Sci U S A (2013) 1.75

Abeta(1-40) forms five distinct amyloid structures whose beta-sheet contents and fibril stabilities are correlated. J Mol Biol (2010) 1.74

General structural motifs of amyloid protofilaments. Proc Natl Acad Sci U S A (2006) 1.72

Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR. Nature (2011) 1.70

3D structure of amyloid protofilaments of beta2-microglobulin fragment probed by solid-state NMR. Proc Natl Acad Sci U S A (2006) 1.70

Structure and properties of alpha-synuclein and other amyloids determined at the amino acid level. Proc Natl Acad Sci U S A (2005) 1.65

Molecular dynamics simulation of amyloid beta dimer formation. Biophys J (2004) 1.63

Two-dimensional infrared spectra of isotopically diluted amyloid fibrils from Abeta40. Proc Natl Acad Sci U S A (2008) 1.63

Bacterial inclusion bodies contain amyloid-like structure. PLoS Biol (2008) 1.63

Polymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape. Chem Rev (2010) 1.62

A model for Ure2p prion filaments and other amyloids: the parallel superpleated beta-structure. Proc Natl Acad Sci U S A (2004) 1.62

Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures. Proc Natl Acad Sci U S A (2009) 1.61

Towards a pharmacophore for amyloid. PLoS Biol (2011) 1.58

Amyloid structure: conformational diversity and consequences. Annu Rev Biochem (2011) 1.57

Insight into the structure of amyloid fibrils from the analysis of globular proteins. PLoS Comput Biol (2006) 1.55

Applications of 2D IR spectroscopy to peptides, proteins, and hydrogen-bond dynamics. J Phys Chem B (2009) 1.54

Toxic fibrillar oligomers of amyloid-β have cross-β structure. Proc Natl Acad Sci U S A (2012) 1.53

Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril. Proc Natl Acad Sci U S A (2016) 1.51

Structure of the 21-30 fragment of amyloid beta-protein. Protein Sci (2006) 1.51

A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice. Am J Pathol (2004) 1.50

Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils. J Am Chem Soc (2016) 1.49

A role for helical intermediates in amyloid formation by natively unfolded polypeptides? Phys Biol (2009) 1.49

2D IR provides evidence for mobile water molecules in beta-amyloid fibrils. Proc Natl Acad Sci U S A (2009) 1.49

The structural biology of protein aggregation diseases: Fundamental questions and some answers. Acc Chem Res (2006) 1.47

Structure and dynamics of the Abeta(21-30) peptide from the interplay of NMR experiments and molecular simulations. J Am Chem Soc (2008) 1.47

Misfolded proteins in Alzheimer's disease and type II diabetes. Chem Soc Rev (2011) 1.45

Evidence for novel beta-sheet structures in Iowa mutant beta-amyloid fibrils. Biochemistry (2009) 1.45

Interprotofilament interactions between Alzheimer's Abeta1-42 peptides in amyloid fibrils revealed by cryoEM. Proc Natl Acad Sci U S A (2009) 1.45

Modeling the Alzheimer Abeta17-42 fibril architecture: tight intermolecular sheet-sheet association and intramolecular hydrated cavities. Biophys J (2007) 1.44

Kinetics of amyloid beta monomer-to-oligomer exchange by NMR relaxation. J Am Chem Soc (2010) 1.43

Folding events in the 21-30 region of amyloid beta-protein (Abeta) studied in silico. Proc Natl Acad Sci U S A (2005) 1.43

Energy landscape of amyloidogenic peptide oligomerization by parallel-tempering molecular dynamics simulation: significant role of Asn ladder. Proc Natl Acad Sci U S A (2005) 1.43

Linking folding with aggregation in Alzheimer's beta-amyloid peptides. Proc Natl Acad Sci U S A (2007) 1.42

Aβ(1-42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease. Nat Struct Mol Biol (2015) 1.42

Structural insights into functional and pathological amyloid. J Biol Chem (2011) 1.39

A critical assessment of the role of helical intermediates in amyloid formation by natively unfolded proteins and polypeptides. Protein Eng Des Sel (2009) 1.38

Solvent and mutation effects on the nucleation of amyloid beta-protein folding. Proc Natl Acad Sci U S A (2005) 1.37

Beta arcades: recurring motifs in naturally occurring and disease-related amyloid fibrils. FASEB J (2009) 1.37

Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Abeta into off-pathway conformers. J Biol Chem (2010) 1.35

Structural polymorphism of Alzheimer Abeta and other amyloid fibrils. Prion (2009) 1.35

Prediction of "hot spots" of aggregation in disease-linked polypeptides. BMC Struct Biol (2005) 1.34

Microwave field distribution in a magic angle spinning dynamic nuclear polarization NMR probe. J Magn Reson (2011) 1.34

Structural stability and dynamics of an amyloid-forming peptide GNNQQNY from the yeast prion sup-35. Biophys J (2006) 1.33

Exploring beta-sheet structure and interactions with chemical model systems. Acc Chem Res (2008) 1.31

Protein inheritance (prions) based on parallel in-register beta-sheet amyloid structures. Bioessays (2008) 1.31

alphaB-crystallin: a hybrid solid-state/solution-state NMR investigation reveals structural aspects of the heterogeneous oligomer. J Mol Biol (2008) 1.31

The functional curli amyloid is not based on in-register parallel beta-sheet structure. J Biol Chem (2009) 1.30

Two prion variants of Sup35p have in-register parallel beta-sheet structures, independent of hydration. Biochemistry (2009) 1.30

Single-molecule atomic force microscopy force spectroscopy study of Aβ-40 interactions. Biochemistry (2011) 1.30

Magic angle spinning NMR analysis of beta2-microglobulin amyloid fibrils in two distinct morphologies. J Am Chem Soc (2010) 1.30

Molecular-level examination of Cu2+ binding structure for amyloid fibrils of 40-residue Alzheimer's β by solid-state NMR spectroscopy. J Am Chem Soc (2011) 1.27

Structural basis for increased toxicity of pathological aβ42:aβ40 ratios in Alzheimer disease. J Biol Chem (2011) 1.26

Structure and dynamics of parallel beta-sheets, hydrophobic core, and loops in Alzheimer's A beta fibrils. Biophys J (2007) 1.26

Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins. J Am Chem Soc (2011) 1.25

High-resolution MAS NMR analysis of PI3-SH3 amyloid fibrils: backbone conformation and implications for protofilament assembly and structure . Biochemistry (2010) 1.24

Effects of familial Alzheimer's disease mutations on the folding nucleation of the amyloid beta-protein. J Mol Biol (2008) 1.24

Amide solvent protection analysis demonstrates that amyloid-beta(1-40) and amyloid-beta(1-42) form different fibrillar structures under identical conditions. Biochem J (2007) 1.24

Recent progress in understanding Alzheimer's β-amyloid structures. Trends Biochem Sci (2011) 1.24

Sequence determinants of bacterial amyloid formation. J Mol Biol (2008) 1.24

Determining the critical nucleus and mechanism of fibril elongation of the Alzheimer's Abeta(1-40) peptide. J Mol Biol (2006) 1.23

Solid-state NMR spectroscopy of human immunodeficiency virus fusion peptides associated with host-cell-like membranes: 2D correlation spectra and distance measurements support a fully extended conformation and models for specific antiparallel strand registries. J Am Chem Soc (2008) 1.23

Simulation of two-dimensional infrared spectroscopy of amyloid fibrils. Proc Natl Acad Sci U S A (2007) 1.23

Atomic-level characterization of the ensemble of the Aβ(1-42) monomer in water using unbiased molecular dynamics simulations and spectral algorithms. J Mol Biol (2010) 1.23

A simple algorithm locates beta-strands in the amyloid fibril core of alpha-synuclein, Abeta, and tau using the amino acid sequence alone. Protein Sci (2007) 1.22

Articles cited by this

MOLMOL: a program for display and analysis of macromolecular structures. J Mol Graph (1996) 39.73

Protein backbone angle restraints from searching a database for chemical shift and sequence homology. J Biomol NMR (1999) 26.99

Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun (1984) 20.07

1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects. J Biomol NMR (1995) 7.43

Common core structure of amyloid fibrils by synchrotron X-ray diffraction. J Mol Biol (1997) 7.27

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron (1994) 6.41

The protofilament structure of insulin amyloid fibrils. Proc Natl Acad Sci U S A (2002) 4.08

Amyloid fibers are water-filled nanotubes. Proc Natl Acad Sci U S A (2002) 3.78

Propagating structure of Alzheimer's beta-amyloid(10-35) is parallel beta-sheet with residues in exact register. Proc Natl Acad Sci U S A (1998) 3.74

Amyloid fibril formation by A beta 16-22, a seven-residue fragment of the Alzheimer's beta-amyloid peptide, and structural characterization by solid state NMR. Biochemistry (2000) 3.65

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease. J Biol Chem (1993) 3.52

Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease. J Mol Biol (1991) 3.33

Frequency selective heteronuclear dipolar recoupling in rotating solids: accurate (13)C-(15)N distance measurements in uniformly (13)C,(15)N-labeled peptides. J Am Chem Soc (2001) 3.26

Stabilities and conformations of Alzheimer's beta -amyloid peptide oligomers (Abeta 16-22, Abeta 16-35, and Abeta 10-35): Sequence effects. Proc Natl Acad Sci U S A (2002) 3.06

Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer's disease amyloid-beta protein. Chem Biol (1997) 3.05

Structure of Bordetella pertussis virulence factor P.69 pertactin. Nature (1996) 3.02

Molecular determinants of amyloid deposition in Alzheimer's disease: conformational studies of synthetic beta-protein fragments. Biochemistry (1990) 2.93

Structural studies of the scrapie prion protein by electron crystallography. Proc Natl Acad Sci U S A (2002) 2.91

Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease. Biochemistry (1999) 2.87

Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of beta-sheets in Alzheimer's beta-amyloid fibrils. Proc Natl Acad Sci U S A (2000) 2.84

Amyloidosis. Annu Rev Biochem (1992) 2.78

Supramolecular structure in full-length Alzheimer's beta-amyloid fibrils: evidence for a parallel beta-sheet organization from solid-state nuclear magnetic resonance. Biophys J (2002) 2.78

Structure of beta-crystallite assemblies formed by Alzheimer beta-amyloid protein analogues: analysis by x-ray diffraction. Biophys J (1993) 2.77

Structural features of the Abeta amyloid fibril elucidated by limited proteolysis. Biochemistry (2001) 2.64

Secondary and tertiary structural effects on protein NMR chemical shifts: an ab initio approach. Science (1993) 2.61

Supramolecular structural constraints on Alzheimer's beta-amyloid fibrils from electron microscopy and solid-state nuclear magnetic resonance. Biochemistry (2002) 2.37

Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein. Biochemistry (1992) 2.36

Structural analysis of Alzheimer's beta(1-40) amyloid: protofilament assembly of tubular fibrils. Biophys J (1998) 2.22

Studies on the in vitro assembly of a beta 1-40: implications for the search for a beta fibril formation inhibitors. J Struct Biol (2000) 2.19

Two-dimensional structure of beta-amyloid(10-35) fibrils. Biochemistry (2000) 2.16

A molecular model of Alzheimer amyloid beta-peptide fibril formation. J Biol Chem (1999) 2.12

Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides. J Mol Biol (1992) 1.90

Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain. Neurosci Lett (1996) 1.78

C alpha and C beta carbon-13 chemical shifts in proteins from an empirical database. J Biomol NMR (1999) 1.74

An atomic model for the pleated beta-sheet structure of Abeta amyloid protofilaments. Biophys J (1999) 1.71

Amyloid fibrils may be assembled from beta-helical protofibrils. Biochemistry (1998) 1.67

Solid-state NMR evidence for an antibody-dependent conformation of the V3 loop of HIV-1 gp120. Nat Struct Biol (1999) 1.56

Sensitivity enhancement in structural measurements by solid state NMR through pulsed spin locking. J Magn Reson (2002) 1.45

Molecular modeling of the Abeta1-42 peptide from Alzheimer's disease. Protein Eng (1998) 1.37

Ionization equilibria for side-chain carboxyl groups in oxidized and reduced human thioredoxin and in the complex with its target peptide from the transcription factor NF kappa B. Biochemistry (1996) 1.31

Computationally derived structural models of the beta-amyloid found in Alzheimer's disease plaques and the interaction with possible aggregation inhibitors. Biopolymers (1999) 1.30

N-terminus and lysine side chain pKa values of melittin in aqueous solutions and micellar dispersions measured by 15N NMR. Biochemistry (1995) 1.08

Articles by these authors

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts. J Biomol NMR (2009) 16.09

Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science (2005) 8.86

Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell (2012) 6.83

Consistent blind protein structure generation from NMR chemical shift data. Proc Natl Acad Sci U S A (2008) 6.76

Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils. Biochemistry (2006) 6.54

Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils. Proc Natl Acad Sci U S A (2008) 4.84

Molecular structure of β-amyloid fibrils in Alzheimer's disease brain tissue. Cell (2013) 4.02

Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR. Biochemistry (2007) 3.57

Evaluation of backbone proton positions and dynamics in a small protein by liquid crystal NMR spectroscopy. J Am Chem Soc (2003) 3.32

Protein oxidation implicated as the primary determinant of bacterial radioresistance. PLoS Biol (2007) 3.22

Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid. Nat Struct Mol Biol (2007) 3.06

Amyloid of the prion domain of Sup35p has an in-register parallel beta-sheet structure. Proc Natl Acad Sci U S A (2006) 2.88

Supramolecular structure in full-length Alzheimer's beta-amyloid fibrils: evidence for a parallel beta-sheet organization from solid-state nuclear magnetic resonance. Biophys J (2002) 2.78

Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. ACS Nano (2009) 2.39

Supramolecular structural constraints on Alzheimer's beta-amyloid fibrils from electron microscopy and solid-state nuclear magnetic resonance. Biochemistry (2002) 2.37

Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast. Proc Natl Acad Sci U S A (2010) 2.33

Synthesis and solid-state NMR structural characterization of 13C-labeled graphite oxide. Science (2008) 2.31

Seeded growth of beta-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure. Proc Natl Acad Sci U S A (2009) 2.15

Organization of the core structure of the postsynaptic density. Proc Natl Acad Sci U S A (2008) 2.06

Molecular dynamics simulations of Alzheimer's beta-amyloid protofilaments. J Mol Biol (2005) 1.99

Nanomole-scale protein solid-state NMR by breaking intrinsic 1HT1 boundaries. Nat Methods (2009) 1.93

Polymorphic fibril formation by residues 10-40 of the Alzheimer's beta-amyloid peptide. Biophys J (2006) 1.84

Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register beta-sheet structure. Proc Natl Acad Sci U S A (2008) 1.80

Parallel beta-sheets and polar zippers in amyloid fibrils formed by residues 10-39 of the yeast prion protein Ure2p. Biochemistry (2005) 1.79

Abeta40-Lactam(D23/K28) models a conformation highly favorable for nucleation of amyloid. Biochemistry (2005) 1.78

Characterization of beta-sheet structure in Ure2p1-89 yeast prion fibrils by solid-state nuclear magnetic resonance. Biochemistry (2007) 1.73

Oligomeric structure of the human immunodeficiency virus type 1 envelope protein on the virion surface. J Virol (2002) 1.69

Mass of the postsynaptic density and enumeration of three key molecules. Proc Natl Acad Sci U S A (2005) 1.67

Antiparallel β-sheet architecture in Iowa-mutant β-amyloid fibrils. Proc Natl Acad Sci U S A (2012) 1.60

Biomolecular solid state NMR with magic-angle spinning at 25K. J Magn Reson (2008) 1.60

Impact of brachial-ankle pulse wave velocity and ankle-brachial blood pressure index on mortality in hemodialysis patients. Am J Kidney Dis (2005) 1.59

Probing site-specific conformational distributions in protein folding with solid-state NMR. Proc Natl Acad Sci U S A (2005) 1.57

Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells. J Transl Med (2008) 1.54

Overall structure and sugar dynamics of a DNA dodecamer from homo- and heteronuclear dipolar couplings and 31P chemical shift anisotropy. J Biomol NMR (2003) 1.53

Low-temperature dynamic nuclear polarization at 9.4 T with a 30 mW microwave source. J Magn Reson (2010) 1.49

Sensitivity enhancement in structural measurements by solid state NMR through pulsed spin locking. J Magn Reson (2002) 1.45

Measurement of sample temperatures under magic-angle spinning from the chemical shift and spin-lattice relaxation rate of 79Br in KBr powder. J Magn Reson (2008) 1.44

Increasing the amphiphilicity of an amyloidogenic peptide changes the beta-sheet structure in the fibrils from antiparallel to parallel. Biophys J (2004) 1.41

Synthesis, physicochemical, and tribological characterization of S-Di-n-octoxyboron-O,O'-di-n-octyldithiophosphate. ACS Appl Mater Interfaces (2009) 1.39

Molecular fragment replacement approach to protein structure determination by chemical shift and dipolar homology database mining. Methods Enzymol (2005) 1.37

Capturing intermediate structures of Alzheimer's beta-amyloid, Abeta(1-40), by solid-state NMR spectroscopy. J Am Chem Soc (2005) 1.37

Constraints on supramolecular structure in amyloid fibrils from two-dimensional solid-state NMR spectroscopy with uniform isotopic labeling. J Am Chem Soc (2003) 1.37

PSD-95 is required to sustain the molecular organization of the postsynaptic density. J Neurosci (2011) 1.33

Nanoscale 3D cellular imaging by axial scanning transmission electron tomography. Nat Methods (2009) 1.32

Amyloids of shuffled prion domains that form prions have a parallel in-register beta-sheet structure. Biochemistry (2008) 1.32

The functional curli amyloid is not based on in-register parallel beta-sheet structure. J Biol Chem (2009) 1.30

Two prion variants of Sup35p have in-register parallel beta-sheet structures, independent of hydration. Biochemistry (2009) 1.30

Solid-state NMR yields structural constraints on the V3 loop from HIV-1 Gp120 bound to the 447-52D antibody Fv fragment. J Am Chem Soc (2004) 1.30

Measurement of amyloid fibril mass-per-length by tilted-beam transmission electron microscopy. Proc Natl Acad Sci U S A (2009) 1.28

Molecular-level examination of Cu2+ binding structure for amyloid fibrils of 40-residue Alzheimer's β by solid-state NMR spectroscopy. J Am Chem Soc (2011) 1.27

Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas. Proc Natl Acad Sci U S A (2006) 1.18

Sensitivity and resolution enhanced solid-state NMR for paramagnetic systems and biomolecules under very fast magic angle spinning. Acc Chem Res (2013) 1.17

Detection of a transient intermediate in a rapid protein folding process by solid-state nuclear magnetic resonance. J Am Chem Soc (2010) 1.15

Theory for cross effect dynamic nuclear polarization under magic-angle spinning in solid state nuclear magnetic resonance: the importance of level crossings. J Chem Phys (2012) 1.13

Sensitivity enhancement in (13)C solid-state NMR of protein microcrystals by use of paramagnetic metal ions for optimizing (1)H T(1) relaxation. J Magn Reson (2006) 1.12

Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors. J Transl Med (2009) 1.11

Structural evolution of Iowa mutant β-amyloid fibrils from polymorphic to homogeneous states under repeated seeded growth. J Am Chem Soc (2011) 1.10

Polymorph-specific kinetics and thermodynamics of β-amyloid fibril growth. J Am Chem Soc (2013) 1.09

Frequency-selective homonuclear dipolar recoupling in solid state NMR. J Chem Phys (2006) 1.09

Molecular alignment within beta-sheets in Abeta(14-23) fibrils: solid-state NMR experiments and theoretical predictions. Biophys J (2006) 1.09

Structure and dynamics of the HIV-1 Vpu transmembrane domain revealed by solid-state NMR with magic-angle spinning. Biochemistry (2006) 1.08

Efficient low-power heteronuclear decoupling in 13C high-resolution solid-state NMR under fast magic angle spinning. Magn Reson Chem (2007) 1.08

NMR-based structural modeling of graphite oxide using multidimensional 13C solid-state NMR and ab initio chemical shift calculations. J Am Chem Soc (2010) 1.07

Solution structure of (gamma)S-crystallin by molecular fragment replacement NMR. Protein Sci (2005) 1.06

Quantitative determination of site-specific conformational distributions in an unfolded protein by solid-state nuclear magnetic resonance. J Mol Biol (2009) 1.06

The Japanese mutant Aβ (ΔE22-Aβ(1-39)) forms fibrils instantaneously, with low-thioflavin T fluorescence: seeding of wild-type Aβ(1-40) into atypical fibrils by ΔE22-Aβ(1-39). Biochemistry (2011) 1.05

Chemical structures of hydrazine-treated graphene oxide and generation of aromatic nitrogen doping. Nat Commun (2012) 1.04

Site-specific identification of non-beta-strand conformations in Alzheimer's beta-amyloid fibrils by solid-state NMR. Biophys J (2003) 1.04

Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice. Nanomedicine (Lond) (2010) 1.04

The core of Ure2p prion fibrils is formed by the N-terminal segment in a parallel cross-β structure: evidence from solid-state NMR. J Mol Biol (2011) 1.03

Promoting trimerization of soluble human immunodeficiency virus type 1 (HIV-1) Env through the use of HIV-1/simian immunodeficiency virus chimeras. J Virol (2004) 1.03

Evidence from solid-state NMR for nonhelical conformations in the transmembrane domain of the amyloid precursor protein. Biophys J (2011) 1.02

Structural and dynamical characterization of tubular HIV-1 capsid protein assemblies by solid state nuclear magnetic resonance and electron microscopy. Protein Sci (2010) 1.01

Enhanced sensitivity and resolution in (1)H solid-state NMR spectroscopy of paramagnetic complexes under very fast magic angle spinning. J Am Chem Soc (2005) 1.01

Segmental polymorphism in a functional amyloid. Biophys J (2011) 1.01

A hexameric peptide barrel as building block of amyloid-β protofibrils. Angew Chem Int Ed Engl (2014) 1.00

Progress in 13C and 1H solid-state nuclear magnetic resonance for paramagnetic systems under very fast magic angle spinning. J Chem Phys (2008) 0.99

Simulated self-assembly of the HIV-1 capsid: protein shape and native contacts are sufficient for two-dimensional lattice formation. Biophys J (2011) 0.98

Dynamic nuclear polarization-enhanced ¹H-¹³C double resonance NMR in static samples below 20 K. J Magn Reson (2012) 0.98

Expression and purification of a recombinant peptide from the Alzheimer's beta-amyloid protein for solid-state NMR. Protein Expr Purif (2005) 0.98

Oligomerization state and supramolecular structure of the HIV-1 Vpu protein transmembrane segment in phospholipid bilayers. Protein Sci (2010) 0.97

A general Monte Carlo/simulated annealing algorithm for resonance assignment in NMR of uniformly labeled biopolymers. J Biomol NMR (2011) 0.97

Quantitative STEM mass measurement of biological macromolecules in a 300 kV TEM. J Microsc (2007) 0.96

Fiber diffraction data indicate a hollow core for the Alzheimer's aβ 3-fold symmetric fibril. J Mol Biol (2012) 0.96

Restraints on backbone conformations in solid state NMR studies of uniformly labeled proteins from quantitative amide 15N-15N and carbonyl 13C-13C dipolar recoupling data. J Magn Reson (2012) 0.96

Local and global structure of the monomeric subunit of the potassium channel KcsA probed by NMR. Biochim Biophys Acta (2007) 0.96

Repeat domains of melanosome matrix protein Pmel17 orthologs form amyloid fibrils at the acidic melanosomal pH. J Biol Chem (2010) 0.95

Solid state nuclear magnetic resonance with magic-angle spinning and dynamic nuclear polarization below 25 K. J Magn Reson (2012) 0.94

Constraints on protein structure in HIV-1 Rev and Rev-RNA supramolecular assemblies from two-dimensional solid state nuclear magnetic resonance. Biochemistry (2007) 0.94

Direct observation of dipolar couplings between distant protons in weakly aligned nucleic acids. Proc Natl Acad Sci U S A (2003) 0.93

Biodesulfurization of naphthothiophene and benzothiophene through selective cleavage of carbon-sulfur bonds by Rhodococcus sp. strain WU-K2R. Appl Environ Microbiol (2002) 0.93

Dual-axis electron tomography of biological specimens: Extending the limits of specimen thickness with bright-field STEM imaging. J Struct Biol (2010) 0.92