Published in Mol Cell Biol on January 01, 2003
The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc Natl Acad Sci U S A (2007) 4.52
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci U S A (2007) 4.27
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci U S A (2004) 4.06
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev (2004) 3.95
Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat Cell Biol (2010) 3.61
Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood (2005) 2.91
The many facets of Notch ligands. Oncogene (2008) 2.57
Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest (2005) 2.38
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Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res (2008) 2.19
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Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res (2006) 1.91
Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest (2012) 1.87
Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7. Blood (2010) 1.84
A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis. Cancer Res (2008) 1.80
Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J (2004) 1.78
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VEGF and endothelial guidance in angiogenic sprouting. Organogenesis (2008) 1.63
Canonical and non-canonical Notch ligands. Curr Top Dev Biol (2010) 1.62
Notch signaling in the vasculature. Curr Top Dev Biol (2010) 1.62
Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest (2007) 1.60
Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells. Cancer Res (2011) 1.58
Notch inhibitors for cancer treatment. Pharmacol Ther (2013) 1.55
Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos. Blood (2008) 1.47
ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish. J Clin Invest (2010) 1.45
Tipping the balance: robustness of tip cell selection, migration and fusion in angiogenesis. PLoS Comput Biol (2009) 1.40
The functional role of Notch signaling in human gliomas. Neuro Oncol (2009) 1.39
VEGF and Notch in tip and stalk cell selection. Cold Spring Harb Perspect Med (2013) 1.38
Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration. Hepatology (2004) 1.37
Notch: from neural development to neurological disorders. J Neurochem (2008) 1.31
Molecular determinants of NOTCH4 transcription in vascular endothelium. Mol Cell Biol (2005) 1.27
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Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility. PLoS One (2012) 1.23
Notch inhibition as a promising new approach to cancer therapy. Adv Exp Med Biol (2012) 1.20
VEGF and Notch signaling: the yin and yang of angiogenic sprouting. Cell Adh Migr (2007) 1.19
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Notch activation induces endothelial cell senescence and pro-inflammatory response: implication of Notch signaling in atherosclerosis. Atherosclerosis (2012) 1.16
ETS factors regulate Vegf-dependent arterial specification. Dev Cell (2013) 1.16
Novel insights into the differential functions of Notch ligands in vascular formation. J Angiogenes Res (2009) 1.16
Angiopoietin-1/Tie2 signal augments basal Notch signal controlling vascular quiescence by inducing delta-like 4 expression through AKT-mediated activation of beta-catenin. J Biol Chem (2011) 1.14
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Sox17 is indispensable for acquisition and maintenance of arterial identity. Nat Commun (2013) 1.12
Kaposi's Sarcoma-associated herpesvirus lytic switch protein stimulates DNA binding of RBP-Jk/CSL to activate the Notch pathway. J Virol (2006) 1.11
The Notch signaling pathway is related to neurovascular progression of pancreatic cancer. Ann Surg (2005) 1.11
Negative feedback regulation of Met-dependent invasive growth by Notch. Mol Cell Biol (2005) 1.10
Opposing actions of Notch1 and VEGF in post-natal cardiac valve endothelial cells. Biochem Biophys Res Commun (2008) 1.07
Functional erythropoietin autocrine loop in melanoma. Am J Pathol (2005) 1.06
Notch modulates VEGF action in endothelial cells by inducing Matrix Metalloprotease activity. Vasc Cell (2011) 1.04
Transcriptional regulation of endothelial cell and vascular development. Circ Res (2013) 1.03
Advances in the pathophysiology of pre-eclampsia and related podocyte injury. Kidney Int (2014) 1.03
KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endothelia. PLoS Pathog (2009) 1.02
Notch signaling regulates endothelial progenitor cell activity during recovery from arterial injury in hypercholesterolemic mice. Circulation (2010) 1.02
Promoting angiogenesis via manipulation of VEGF responsiveness with notch signaling. Biomaterials (2009) 1.00
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Simvastatin increases notch signaling activity and promotes arteriogenesis after stroke. Stroke (2008) 1.00
Control of endothelial sprouting by a Tel-CtBP complex. Nat Cell Biol (2010) 0.99
gamma-Secretase: a multifaceted regulator of angiogenesis. J Cell Mol Med (2008) 0.99
Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli. BMC Dev Biol (2008) 0.99
Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specification. Circ Res (2008) 0.99
Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A. Arterioscler Thromb Vasc Biol (2009) 0.99
NOTCH decoys that selectively block DLL/NOTCH or JAG/NOTCH disrupt angiogenesis by unique mechanisms to inhibit tumor growth. Cancer Discov (2014) 0.99
Dll4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth. Blood (2008) 0.98
Endothelial differentiation: molecular mechanisms of specification and heterogeneity. Arterioscler Thromb Vasc Biol (2011) 0.98
Influence of Dll4 via HIF-1α-VEGF signaling on the angiogenesis of choroidal neovascularization under hypoxic conditions. PLoS One (2011) 0.97
Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis. J Exp Med (2013) 0.97
Ethanol stimulates endothelial cell angiogenic activity via a Notch- and angiopoietin-1-dependent pathway. Cardiovasc Res (2008) 0.97
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Instruction of circulating endothelial progenitors in vitro towards specialized blood-brain barrier and arterial phenotypes. PLoS One (2014) 0.94
Feed-forward signaling by membrane-bound ligand receptor circuit: the case of NOTCH DELTA-like 4 ligand in endothelial cells. J Biol Chem (2010) 0.94
Targeting microvasculature for neuroprotection after SCI. Neurotherapeutics (2011) 0.93
Oridonin inhibits tumor growth and metastasis through anti-angiogenesis by blocking the Notch signaling. PLoS One (2014) 0.93
Notch signaling in developmental and tumor angiogenesis. Genes Cancer (2011) 0.93
Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2. Ann Rheum Dis (2012) 0.92
Endothelial RAF1/ERK activation regulates arterial morphogenesis. Blood (2013) 0.92
New molecular pathways in angiogenesis. Br J Cancer (2003) 0.91
MOSAIC: a multiscale model of osteogenesis and sprouting angiogenesis with lateral inhibition of endothelial cells. PLoS Comput Biol (2012) 0.91
Notch and VEGF pathways play distinct but complementary roles in tumor angiogenesis. Vasc Cell (2013) 0.90
Differential expression of angioregulatory factors in normal and CNV-derived human retinal pigment epithelium. Graefes Arch Clin Exp Ophthalmol (2004) 0.90
Down-Regulated miR-30a in Clear Cell Renal Cell Carcinoma Correlated with Tumor Hematogenous Metastasis by Targeting Angiogenesis-Specific DLL4. PLoS One (2013) 0.88
Notch signaling change in pulmonary vascular remodeling in rats with pulmonary hypertension and its implication for therapeutic intervention. PLoS One (2012) 0.88
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Notch signals in the endothelium and cancer "stem-like" cells: opportunities for cancer therapy. Vasc Cell (2012) 0.86
Cell-cycle regulation of NOTCH signaling during C. elegans vulval development. Mol Syst Biol (2012) 0.86
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