Published in Nat Med on December 16, 2002
CD81 is required for hepatitis C virus glycoprotein-mediated viral infection. J Virol (2004) 3.53
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (2011) 3.07
Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells. Proc Natl Acad Sci U S A (2005) 2.49
Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. Cell Microbiol (2008) 2.49
CD81 is a central regulator of cellular events required for hepatitis C virus infection of human hepatocytes. J Virol (2008) 2.09
Living in the liver: hepatic infections. Nat Rev Immunol (2012) 2.03
Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures. Nat Med (2014) 1.97
A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax. Cell Host Microbe (2013) 1.95
Targeting of tetraspanin proteins--potential benefits and strategies. Nat Rev Drug Discov (2008) 1.91
CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency. J Clin Invest (2010) 1.79
Characterization of mice lacking the tetraspanin superfamily member CD151. Mol Cell Biol (2004) 1.57
Malaria parasite development in the mosquito and infection of the mammalian host. Annu Rev Microbiol (2009) 1.52
EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells. Biochem J (2003) 1.50
Mosquito immune responses and compatibility between Plasmodium parasites and anopheline mosquitoes. BMC Microbiol (2009) 1.36
Receptor complementation and mutagenesis reveal SR-BI as an essential HCV entry factor and functionally imply its intra- and extra-cellular domains. PLoS Pathog (2009) 1.36
Global phenotypic screening for antimalarials. Chem Biol (2012) 1.35
Malaria parasite pre-erythrocytic stage infection: gliding and hiding. Cell Host Microbe (2008) 1.30
Single-molecule analysis of CD9 dynamics and partitioning reveals multiple modes of interaction in the tetraspanin web. J Cell Biol (2008) 1.29
Development of the malaria parasite in the skin of the mammalian host. Proc Natl Acad Sci U S A (2010) 1.27
Looking under the skin: the first steps in malarial infection and immunity. Nat Rev Microbiol (2013) 1.20
A long and winding road: the Plasmodium sporozoite's journey in the mammalian host. Parasitol Int (2007) 1.18
Building of the tetraspanin web: distinct structural domains of CD81 function in different cellular compartments. Mol Cell Biol (2006) 1.17
Plasmodium yoelii yoelii 17XNL constitutively expressing GFP throughout the life cycle. Exp Parasitol (2006) 1.16
Tetraspanins in viral infections: a fundamental role in viral biology? J Virol (2005) 1.16
HIV-1 assembly differentially alters dynamics and partitioning of tetraspanins and raft components. Traffic (2010) 1.11
Plasmodium sporozoite-host interactions from the dermis to the hepatocyte. Curr Opin Microbiol (2009) 1.10
New approach for high-throughput screening of drug activity on Plasmodium liver stages. Antimicrob Agents Chemother (2006) 1.08
Suppression of host p53 is critical for Plasmodium liver-stage infection. Cell Rep (2013) 1.08
Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin. J Cell Sci (2009) 1.05
Hepatocyte permissiveness to Plasmodium infection is conveyed by a short and structurally conserved region of the CD81 large extracellular domain. PLoS Pathog (2008) 1.05
Liver immunology. Compr Physiol (2013) 0.99
Hepatitis C virus infection may lead to slower emergence of P. falciparum in blood. PLoS One (2011) 0.93
2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorg Med Chem (2010) 0.93
IgM, Fc mu Rs, and malarial immune evasion. J Immunol (2010) 0.92
Quantification of sporozoite invasion, migration, and development by microscopy and flow cytometry. Methods Mol Biol (2013) 0.92
The crucial role of hepatocyte growth factor receptor during liver-stage infection is not conserved among Plasmodium species. Nat Med (2011) 0.92
Interacting regions of CD81 and two of its partners, EWI-2 and EWI-2wint, and their effect on hepatitis C virus infection. J Biol Chem (2011) 0.92
Virology: Final entry key for hepatitis C. Nature (2009) 0.91
Drugs for malaria: something old, something new, something borrowed. F1000 Biol Rep (2011) 0.91
Tetraspanin CD81 is required for Listeria monocytogenes invasion. Infect Immun (2009) 0.91
Modeling cell-in-cell structure into its biological significance. Cell Death Dis (2013) 0.90
Malaria liver stage susceptibility locus identified on mouse chromosome 17 by congenic mapping. PLoS One (2008) 0.90
A virosomal malaria peptide vaccine elicits a long-lasting sporozoite-inhibitory antibody response in a phase 1a clinical trial. PLoS One (2007) 0.89
The tetraspanins CD9 and CD81 regulate CD9P1-induced effects on cell migration. PLoS One (2010) 0.88
The association of CD81 with tetraspanin-enriched microdomains is not essential for Hepatitis C virus entry. BMC Microbiol (2009) 0.87
Immune evasion strategies of pre-erythrocytic malaria parasites. Mediators Inflamm (2014) 0.86
Malaria. Transfus Med Hemother (2008) 0.86
Skin-draining lymph node priming is sufficient to induce sterile immunity against pre-erythrocytic malaria. EMBO Mol Med (2012) 0.85
Structural characterization of recombinant human CD81 produced in Pichia pastoris. Protein Expr Purif (2007) 0.85
Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes. Cell Microbiol (2014) 0.84
The extracellular δ-domain is essential for the formation of CD81 tetraspanin webs. Biophys J (2014) 0.84
Of men in mice: the success and promise of humanized mouse models for human malaria parasite infections. Cell Microbiol (2014) 0.84
CD81 and hepatitis C virus (HCV) infection. Viruses (2014) 0.84
A rapid and robust selection procedure for generating drug-selectable marker-free recombinant malaria parasites. Sci Rep (2014) 0.84
Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages. Eur J Med Chem (2014) 0.84
Acquired antibody responses against Plasmodium vivax infection vary with host genotype for duffy antigen receptor for chemokines (DARC). PLoS One (2010) 0.84
Novel function of CD81 in controlling hepatitis C virus replication. J Virol (2010) 0.84
Tetraspanins in mast cells. Front Immunol (2012) 0.84
Exosomes versus microexosomes: Shared components but distinct functions. J Plant Res (2017) 0.84
The Ig domain protein CD9P-1 down-regulates CD81 ability to support Plasmodium yoelii infection. J Biol Chem (2009) 0.83
CD81-receptor associations--impact for hepatitis C virus entry and antiviral therapies. Viruses (2014) 0.83
Early transcriptional responses of HepG2-A16 liver cells to infection by Plasmodium falciparum sporozoites. J Biol Chem (2011) 0.83
Susceptibility to Plasmodium liver stage infection is altered by hepatocyte polyploidy. Cell Microbiol (2014) 0.83
Host-based Prophylaxis Successfully Targets Liver Stage Malaria Parasites. Mol Ther (2015) 0.82
Malaria parasites target the hepatocyte receptor EphA2 for successful host infection. Science (2015) 0.80
French Haemovigilance Data on Platelet Transfusion. Transfus Med Hemother (2008) 0.79
Immunization of mice with live-attenuated late liver stage-arresting Plasmodium yoelii parasites generates protective antibody responses to preerythrocytic stages of malaria. Infect Immun (2014) 0.78
Susceptibility to Plasmodium yoelii preerythrocytic infection in BALB/c substrains is determined at the point of hepatocyte invasion. Infect Immun (2014) 0.78
TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection. Proc Natl Acad Sci U S A (2013) 0.78
Flow Cytometry Based Detection and Isolation of Plasmodium falciparum Liver Stages In Vitro. PLoS One (2015) 0.77
Recent insights into fatty acid acquisition and metabolism in malarial parasites. F1000 Biol Rep (2010) 0.77
Hepatitis B virus infection does not significantly influence Plasmodium parasite density in asymptomatic infections in Ghanaian transfusion recipients. PLoS One (2012) 0.76
Selection and refinement: the malaria parasite's infection and exploitation of host hepatocytes. Curr Opin Microbiol (2015) 0.76
Functions of Antibodies. Microbiol Spectr (2014) 0.75
Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers. Sci Rep (2017) 0.75
Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes. ACS Infect Dis (2016) 0.75
Mice expressing minimally humanized CD81 and occludin genes support hepatitis C virus uptake in vivo. J Virol (2016) 0.75
Current therapies and future possibilities for drug development against liver-stage malaria. J Clin Invest (2016) 0.75
A truncated form of CD9-partner 1 (CD9P-1), GS-168AT2, potently inhibits in vivo tumour-induced angiogenesis and tumour growth. Br J Cancer (2011) 0.75
Malaria. Transfus Med Hemother (2009) 0.75
In Vitro Analysis of the Interaction between Atovaquone and Proguanil against Liver Stage Malaria Parasites. Antimicrob Agents Chemother (2016) 0.75
Viruses and tetraspanins: lessons from single molecule approaches. Viruses (2014) 0.75
Channel catfish, Ictalurus punctatus (Rafinesque), tetraspanin membrane protein family: identification, characterization and phylogenetic analysis of tetraspanin 3 and tetraspanin 7 (CD231) transcripts. Fish Physiol Biochem (2012) 0.75
Protection against a malaria challenge by sporozoite inoculation. N Engl J Med (2009) 4.03
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (2011) 3.07
On the cytoadhesion of Plasmodium vivax-infected erythrocytes. J Infect Dis (2010) 2.91
A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites. J Biol Chem (2003) 2.84
Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor. J Infect Dis (2011) 2.69
On the diversity of malaria parasites in African apes and the origin of Plasmodium falciparum from Bonobos. PLoS Pathog (2010) 2.60
On the pathogenic role of brain-sequestered alphabeta CD8+ T cells in experimental cerebral malaria. J Immunol (2002) 2.40
TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice. J Clin Invest (2010) 2.32
Lateral organization of membrane proteins: tetraspanins spin their web. Biochem J (2009) 2.30
Novel point mutations in the dihydrofolate reductase gene of Plasmodium vivax: evidence for sequential selection by drug pressure. Antimicrob Agents Chemother (2003) 2.26
Perforin-dependent brain-infiltrating cytotoxic CD8+ T lymphocytes mediate experimental cerebral malaria pathogenesis. J Immunol (2003) 2.22
A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax. Blood (2011) 2.17
Quantification of Plasmodium falciparum gametocytes in differential stages of development by quantitative nucleic acid sequence-based amplification. Mol Biochem Parasitol (2004) 2.16
Practical PCR genotyping protocols for Plasmodium vivax using Pvcs and Pvmsp1. Malar J (2005) 2.15
Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells. Blood (2008) 2.12
Protective T cell immunity against malaria liver stage after vaccination with live sporozoites under chloroquine treatment. J Immunol (2004) 2.12
Outcome of treatment in adults with acute lymphoblastic leukemia: analysis of the LALA-94 trial. J Clin Oncol (2004) 2.11
Expression of the human germinal center-associated lymphoma (HGAL) protein, a new marker of germinal center B-cell derivation. Blood (2005) 1.99
A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44. Biochem J (2006) 1.92
The CD81 partner EWI-2wint inhibits hepatitis C virus entry. PLoS One (2008) 1.86
A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development. Sci Rep (2011) 1.85
TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts. Blood (2007) 1.85
The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis. Dev Cell (2011) 1.82
Invasion of host cells by malaria parasites: a tale of two protein families. Mol Microbiol (2007) 1.79
CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency. J Clin Invest (2010) 1.79
A pre-emptive strike against malaria's stealthy hepatic forms. Nat Rev Drug Discov (2009) 1.77
Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis. Clin Gastroenterol Hepatol (2012) 1.65
Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery. PLoS One (2011) 1.60
Active infection of human blood monocytes by Chikungunya virus triggers an innate immune response. J Immunol (2010) 1.60
A physical and functional link between cholesterol and tetraspanins. Eur J Immunol (2003) 1.54
Profiling of the tetraspanin web of human colon cancer cells. Mol Cell Proteomics (2006) 1.53
Vaccination with live Plasmodium yoelii blood stage parasites under chloroquine cover induces cross-stage immunity against malaria liver stage. J Immunol (2008) 1.53
The sensing of poorly deformable red blood cells by the human spleen can be mimicked in vitro. Blood (2010) 1.52
Genes contributing to prion pathogenesis. J Gen Virol (2008) 1.51
Gemcitabine plus oxaliplatin (GEMOX) in patients with advanced hepatocellular carcinoma (HCC): results of a phase II study. Cancer (2007) 1.51
EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells. Biochem J (2003) 1.50
Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection. Cell Host Microbe (2008) 1.50
EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. J Biol Chem (2006) 1.50
A plant-derived morphinan as a novel lead compound active against malaria liver stages. PLoS Med (2006) 1.49
Dual role of CCR2 in the constitution and the resolution of liver fibrosis in mice. Am J Pathol (2009) 1.49
Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation. FEBS Lett (2002) 1.48
CD8+ T cells and IFN-γ mediate the time-dependent accumulation of infected red blood cells in deep organs during experimental cerebral malaria. PLoS One (2011) 1.47
Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nat Med (2011) 1.46
Plasmodium falciparum--infected erythrocyte adhesion induces caspase activation and apoptosis in human endothelial cells. J Infect Dis (2003) 1.44
Rapid species diagnosis for invasive candidiasis using mass spectrometry. PLoS One (2010) 1.44
Outcome of treatment in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia--results of the prospective multicenter LALA-94 trial. Blood (2002) 1.44
Sterile protection against malaria is independent of immune responses to the circumsporozoite protein. PLoS One (2007) 1.41
Reduced fertility of female mice lacking CD81. Dev Biol (2005) 1.41
CD81-dependent binding of hepatitis C virus E1E2 heterodimers. J Virol (2003) 1.38
Patients with acute liver failure listed for superurgent liver transplantation in France: reevaluation of the Clichy-Villejuif criteria. Liver Transpl (2015) 1.38
Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection. J Infect Dis (2012) 1.36
Multiple levels of interactions within the tetraspanin web. Biochem Biophys Res Commun (2003) 1.34
Malaria transmission-blocking antigen, Pfs230, mediates human red blood cell binding to exflagellating male parasites and oocyst production. Mol Microbiol (2006) 1.33
An essential role of antibodies in the control of Chikungunya virus infection. J Immunol (2013) 1.31
Helminth infections are associated with protection from cerebral malaria and increased nitrogen derivatives concentrations in Thailand. Am J Trop Med Hyg (2002) 1.31
The molecular players of sperm-egg fusion in mammals. Semin Cell Dev Biol (2006) 1.31
Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein. EMBO Mol Med (2012) 1.29
Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand. Malar J (2011) 1.29
Single-molecule analysis of CD9 dynamics and partitioning reveals multiple modes of interaction in the tetraspanin web. J Cell Biol (2008) 1.29
Brain microvessel cross-presentation is a hallmark of experimental cerebral malaria. EMBO Mol Med (2013) 1.28
A pathogenic role for CD4+ T cells during Chikungunya virus infection in mice. J Immunol (2012) 1.27
MALDI-TOF MS-based drug susceptibility testing of pathogens: the example of Candida albicans and fluconazole. Proteomics (2009) 1.26
Gene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes. PLoS One (2008) 1.25
Expression of human CD81 differently affects host cell susceptibility to malaria sporozoites depending on the Plasmodium species. Cell Microbiol (2006) 1.25
Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains. Nat Cell Biol (2009) 1.25
Genetically attenuated P36p-deficient Plasmodium berghei sporozoites confer long-lasting and partial cross-species protection. Int J Parasitol (2007) 1.24
The tetraspanin CD81 is necessary for partitioning of coligated CD19/CD21-B cell antigen receptor complexes into signaling-active lipid rafts. J Immunol (2004) 1.23
CCR5 deficiency decreases susceptibility to experimental cerebral malaria. Blood (2003) 1.23
Cholesterol contributes to the organization of tetraspanin-enriched microdomains and to CD81-dependent infection by malaria sporozoites. J Cell Sci (2006) 1.23
Are extensive T cell epitope polymorphisms in the Plasmodium falciparum circumsporozoite antigen, a leading sporozoite vaccine candidate, selected by immune pressure? J Immunol (2005) 1.22