Published in Cell on December 27, 2002
scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J (2003) 3.60
Modeling tissue-specific signaling and organ function in three dimensions. J Cell Sci (2003) 3.52
Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents. Nat Rev Cancer (2010) 3.33
Tissue architecture: the ultimate regulator of breast epithelial function. Curr Opin Cell Biol (2003) 2.92
Engineered microenvironments for controlled stem cell differentiation. Tissue Eng Part A (2009) 2.48
Endocytic mechanisms for targeted drug delivery. Adv Drug Deliv Rev (2007) 2.38
Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Genes Dev (2004) 2.35
DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth. Mol Cell Biol (2006) 1.80
Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors. J Cell Biol (2003) 1.67
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". PLoS Genet (2010) 1.47
Biomaterials offer cancer research the third dimension. Nat Mater (2010) 1.45
NCI's provocative questions on cancer: some answers to ignite discussion. Oncotarget (2011) 1.42
MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional culture. J Exp Med (2005) 1.34
A versatile valve-enabled microfluidic cell co-culture platform and demonstration of its applications to neurobiology and cancer biology. Biomed Microdevices (2011) 1.27
Modeling Ewing sarcoma tumors in vitro with 3D scaffolds. Proc Natl Acad Sci U S A (2013) 1.23
Inhibiting myosin light chain kinase induces apoptosis in vitro and in vivo. Mol Cell Biol (2005) 1.18
The molecular portrait of in vitro growth by meta-analysis of gene-expression profiles. Genome Biol (2005) 1.17
Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression. Pharmacol Ther (2012) 1.13
Newly characterised ex vivo colospheres as a three-dimensional colon cancer cell model of tumour aggressiveness. Br J Cancer (2009) 1.13
Automated local bright feature image analysis of nuclear protein distribution identifies changes in tissue phenotype. Proc Natl Acad Sci U S A (2006) 1.13
PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha. J Clin Invest (2010) 1.09
Invading cancer cells are predominantly in G0/G1 resulting in chemoresistance demonstrated by real-time FUCCI imaging. Cell Cycle (2014) 1.09
In situ protein expression in tumour spheres: development of an immunostaining protocol for confocal microscopy. BMC Cancer (2010) 1.07
Integrin alphav-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen. J Cell Biol (2004) 1.07
Engineering strategies to recapitulate epithelial morphogenesis within synthetic three-dimensional extracellular matrix with tunable mechanical properties. Phys Biol (2011) 1.07
Periostin-binding DNA aptamer inhibits breast cancer growth and metastasis. Mol Ther (2013) 1.06
Oncogenic ras-induced down-regulation of autophagy mediator Beclin-1 is required for malignant transformation of intestinal epithelial cells. J Biol Chem (2009) 1.05
Modelling molecular mechanisms of breast cancer and invasion: lessons from the normal gland. Biochem Soc Trans (2007) 1.04
Determination of strongly overlapping signaling activity from microarray data. BMC Bioinformatics (2006) 0.99
Comparison of bone marrow cell growth on 2D and 3D alginate hydrogels. J Mater Sci Mater Med (2005) 0.99
Polarity determination in breast tissue: desmosomal adhesion, myoepithelial cells, and laminin 1. Breast Cancer Res (2003) 0.98
Maspin mediates increased tumor cell apoptosis upon induction of the mitochondrial permeability transition. Mol Cell Biol (2005) 0.95
Expression of periostin and its clinicopathological relevance in gastric cancer. World J Gastroenterol (2007) 0.94
Three-dimensional polymeric systems for cancer cell studies. Cytotechnology (2007) 0.93
Comparative Membranome expression analysis in primary tumors and derived cell lines. PLoS One (2010) 0.91
The contribution of growth hormone to mammary neoplasia. J Mammary Gland Biol Neoplasia (2008) 0.90
Jaceosidin induces apoptosis in human ovary cancer cells through mitochondrial pathway. J Biomed Biotechnol (2008) 0.87
Prediction of individual response to anticancer therapy: historical and future perspectives. Cell Mol Life Sci (2014) 0.86
On evolutionary origin of cancer. Cancer Cell Int (2005) 0.86
A short-term colorectal cancer sphere culture as a relevant tool for human cancer biology investigation. Br J Cancer (2013) 0.84
Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts. Carcinogenesis (2005) 0.84
Hsp-27 induction requires POU4F2/Brn-3b TF in doxorubicin-treated breast cancer cells, whereas phosphorylation alters its cellular localisation following drug treatment. Cell Stress Chaperones (2011) 0.84
Malignant stroma increases luminal breast cancer cell proliferation and angiogenesis through platelet-derived growth factor signaling. BMC Cancer (2014) 0.82
Role of periostin and its antagonist PNDA-3 in gastric cancer metastasis. World J Gastroenterol (2015) 0.82
An immunohistochemical method to study breast cancer cell subpopulations and their growth regulation by hormones in three-dimensional cultures. Front Endocrinol (Lausanne) (2011) 0.82
The Cancer BioChip System: a functional genomic assay for anchorage-independent three-dimensional breast cancer cell growth. Horm Cancer (2012) 0.81
Oncogenic ras-induced down-regulation of pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells. J Biol Chem (2011) 0.81
Micro-RNA-632 downregulates DNAJB6 in breast cancer. Lab Invest (2012) 0.81
Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture. Proteome Sci (2014) 0.81
Stem cell marker CD271 is expressed by vasculogenic mimicry-forming uveal melanoma cells in three-dimensional cultures. Mol Vis (2012) 0.80
Flow perfusion effects on three-dimensional culture and drug sensitivity of Ewing sarcoma. Proc Natl Acad Sci U S A (2015) 0.80
Ginsenoside Rg3 Induces Apoptosis of Human Breast Cancer (MDA-MB-231) Cells. J Cancer Prev (2013) 0.79
ErbB2-dependent downregulation of a pro-apoptotic protein Perp is required for oncogenic transformation of breast epithelial cells. Oncogene (2016) 0.78
Architecture Is the Message: The role of extracellular matrix and 3-D structure in tissue-specific gene expression and breast cancer. Pezcoller Found J (2007) 0.77
Anoikis of colon carcinoma cells triggered by β-catenin loss can be enhanced by tumor necrosis factor receptor 1 antagonists. Oncogene (2014) 0.77
Impact of multicellular tumor spheroids as an in vivo‑like tumor model on anticancer drug response. Int J Oncol (2016) 0.76
Increased Resistance of Breast, Prostate, and Embryonic Carcinoma Cells against Herpes Simplex Virus in Three-Dimensional Cultures. ISRN Oncol (2013) 0.76
Carcinogenesis and metastasis now in the third dimension--what's in it for pathologists? Am J Pathol (2006) 0.76
Matrine inhibits diethylnitrosamine-induced HCC proliferation in rats through inducing apoptosis via p53, Bax-dependent caspase-3 activation pathway and down-regulating MLCK overexpression. Iran J Pharm Res (2016) 0.75
Nutrigenomics and cancer. Avicenna J Med Biotechnol (2009) 0.75
Genetic variations in apoptosis pathway and the risk of ovarian cancer. Oncotarget (2016) 0.75
Unlocking Pandora's box: personalising cancer cell death in non-small cell lung cancer. EPMA J (2012) 0.75
PEG-peptide hydrogels reveal differential effects of matrix microenvironmental cues on melanoma drug sensitivity. Integr Biol (Camb) (2017) 0.75
Biomechanical regulation of drug sensitivity in an engineered model of human tumor. Biomaterials (2017) 0.75
Hallmarks of cancer: the next generation. Cell (2011) 140.01
The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08
The basics of epithelial-mesenchymal transition. J Clin Invest (2009) 32.82
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell (2004) 31.38
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature (2007) 21.53
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer (2009) 18.53
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell (2005) 18.20
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet (2008) 17.67
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature (2007) 15.20
Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell (2008) 14.80
A perspective on cancer cell metastasis. Science (2011) 13.31
Retracted A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell (2009) 10.51
Tumor metastasis: molecular insights and evolving paradigms. Cell (2011) 10.34
A progression puzzle. Nature (2002) 9.56
Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA (2003) 8.07
Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci U S A (2004) 7.96
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res (2008) 7.91
Ras oncogenes: split personalities. Nat Rev Mol Cell Biol (2008) 7.91
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol (2010) 6.67
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A (2010) 6.15
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci U S A (2011) 5.53
Modelling the molecular circuitry of cancer. Nat Rev Cancer (2002) 5.43
Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A (2007) 5.24
Cancer stem cells: mirage or reality? Nat Med (2009) 5.20
The signals and pathways activating cellular senescence. Int J Biochem Cell Biol (2004) 5.00
Rules for making human tumor cells. N Engl J Med (2002) 4.84
Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol (2010) 4.80
Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell (2011) 4.79
Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol (2002) 4.77
Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77
The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Nat Genet (2005) 4.70
Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle (2006) 4.67
Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell (2007) 4.30
Species- and cell type-specific requirements for cellular transformation. Cancer Cell (2004) 4.25
Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin Cancer Biol (2012) 3.98
Exploring a new twist on tumor metastasis. Cancer Res (2006) 3.96
The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med (2013) 3.96
Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell (2008) 3.95
Immortalization and transformation of primary human airway epithelial cells by gene transfer. Oncogene (2002) 3.80
Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Cell (2008) 3.75
The Spemann organizer gene, Goosecoid, promotes tumor metastasis. Proc Natl Acad Sci U S A (2006) 3.64
Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell (2013) 3.61
Retracted Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. Cancer Cell (2003) 3.56
Telomerase maintains telomere structure in normal human cells. Cell (2003) 3.29
Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice. Nat Rev Cancer (2003) 3.23
Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity. Cancer Res (2007) 3.04
Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci U S A (2010) 3.03
Telomeres: cancer to human aging. Annu Rev Cell Dev Biol (2006) 2.88
Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci U S A (2002) 2.82
Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc Natl Acad Sci U S A (2009) 2.75
Tumor-host interactions: a far-reaching relationship. J Clin Oncol (2010) 2.48
Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer. J Mammary Gland Biol Neoplasia (2010) 2.38
When cells get stressed: an integrative view of cellular senescence. J Clin Invest (2004) 2.37
A mouse model of human breast cancer metastasis to human bone. Cancer Res (2005) 2.24
Adaptation versus selection: the origins of metastatic behavior. Cancer Res (2007) 2.08
Micromanagers of malignancy: role of microRNAs in regulating metastasis. Trends Genet (2008) 2.03
Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. J Clin Invest (2011) 1.96
Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell (2013) 1.86
IGF-2 is a mediator of prolactin-induced morphogenesis in the breast. Dev Cell (2002) 1.79
Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? Int J Cancer (2011) 1.79
Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet (2003) 1.78
Retracted Concomitant suppression of three target genes can explain the impact of a microRNA on metastasis. Genes Dev (2009) 1.74
Cell plasticity and heterogeneity in cancer. Clin Chem (2012) 1.74
MicroRNAs in malignant progression. Cell Cycle (2007) 1.74
Retracted Concurrent suppression of integrin alpha5, radixin, and RhoA phenocopies the effects of miR-31 on metastasis. Cancer Res (2010) 1.73
Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling. Cancer Discov (2012) 1.71
Systemic stromal effects of estrogen promote the growth of estrogen receptor-negative cancers. Cancer Res (2007) 1.66
MicroRNAs: Crucial multi-tasking components in the complex circuitry of tumor metastasis. Cell Cycle (2009) 1.63
Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos. Mol Cell Biol (2003) 1.59
miR-31: a crucial overseer of tumor metastasis and other emerging roles. Cell Cycle (2010) 1.51
The outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions. Cancer Discov (2012) 1.45
Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proc Natl Acad Sci U S A (2008) 1.41
Retracted Activation of miR-31 function in already-established metastases elicits metastatic regression. Genes Dev (2011) 1.40
An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization. Cancer Cell (2013) 1.36
Metastatic colonization: settlement, adaptation and propagation of tumor cells in a foreign tissue environment. Semin Cancer Biol (2010) 1.36
Roles for microRNAs in the regulation of cell adhesion molecules. J Cell Sci (2011) 1.25
Heterogeneity of stromal fibroblasts in tumors. Cancer Biol Ther (2007) 1.21
Chemokine networks and breast cancer metastasis. Breast Dis (2007) 1.17
AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment. Cancer Res (2010) 1.17
Coevolution in the tumor microenvironment. Nat Genet (2008) 1.16
Senescence: does it all happen at the ends? Oncogene (2002) 0.98
High efficiency creation of human monoclonal antibody-producing hybridomas. J Immunol Methods (2004) 0.94
Assaying microRNA loss-of-function phenotypes in mammalian cells: emerging tools and their potential therapeutic utility. RNA Biol (2009) 0.90
Of mice and (wo)men: mouse models of breast cancer metastasis to bone. J Bone Miner Res (2010) 0.89
Functional genomics and the breast cancer problem. Cancer Cell (2002) 0.86
Cancer cell of origin: spotlight on luminal progenitors. Cell Stem Cell (2010) 0.83
Filling the mosaic of p53 actions: p53 represses RHAMM expression. Cell Cycle (2008) 0.82
Is metastasis predetermined? Mol Oncol (2007) 0.81
Poised with purpose: cell plasticity enhances tumorigenicity. Cell Cycle (2013) 0.81
Cancer Biology and Therapy: the road ahead. Cancer Biol Ther (2002) 0.81
Metastasis suppression: a role of the Dice(r). Genome Biol (2010) 0.78
Retrospective: Judah Folkman (1933-2008). Science (2008) 0.77
Addendum: A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat Cell Biol (2015) 0.76
Health for life. Your lifestyle, your genes, and cancer. Newsweek (2008) 0.75
All You Need Is Mentorship. Cell (2016) 0.75