Published in Immunology on January 01, 2003
Cell death: the significance of apoptosis. Int Rev Cytol (1980) 24.88
Autocrine T-cell suicide mediated by APO-1/(Fas/CD95) Nature (1995) 8.23
Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature (1995) 7.52
Type beta transforming growth factor: a bifunctional regulator of cellular growth. Proc Natl Acad Sci U S A (1985) 5.93
Apoptosis of T cells mediated by galectin-1. Nature (1995) 3.54
The liver as a site of T-cell apoptosis: graveyard, or killing field? Immunol Rev (2000) 2.13
The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo. Immunity (1994) 2.11
Suppression of the immune response by alpha-fetoprotein on the primary and secondary antibody response. J Exp Med (1975) 2.03
Mechanisms of hepatic toxicity. I. TNF-induced liver injury. Am J Physiol (1998) 1.89
Apoptosis within spontaneously accepted mouse liver allografts: evidence for deletion of cytotoxic T cells and implications for tolerance induction. J Immunol (1997) 1.81
Dynamics of intra-hepatic lymphocytes in chronic hepatitis C: enrichment for Valpha24+ T cells and rapid elimination of effector cells by apoptosis. Eur J Immunol (1998) 1.54
Characteristics of virus-specific CD8(+) T cells in the liver during the control and resolution phases of influenza pneumonia. Proc Natl Acad Sci U S A (1998) 1.34
IL-18 augments perforin-dependent cytotoxicity of liver NK-T cells. J Immunol (1998) 1.33
Inducible nonlymphoid expression of Fas ligand is responsible for superantigen-induced peripheral deletion of T cells. Immunity (1998) 1.26
TCR ligation on CD8+ T cells creates double-negative cells in vivo. J Immunol (1998) 1.12
ICAM-1 and B7-1 provide similar but distinct costimulation for CD8+ T cells, while CD4+ T cells are poorly costimulated by ICAM-1. Eur J Immunol (1999) 1.06
Liver damage preferentially results from CD8(+) T cells triggered by high affinity peptide antigens. J Exp Med (1998) 1.01
Multiple sites of post-activation CD8+ T cell disposal. Eur J Immunol (1997) 0.97
Involvement of mitochondrial permeability transition and caspase-9 activation in dimethyl sulfoxide-induced apoptosis of EL-4 lymphoma cells. Int Immunopharmacol (2001) 0.90
High frequency apoptosis of recent thymic emigrants in the liver of lymphopenic diabetes-prone BioBreeding rats. J Immunol (1998) 0.89
Hepatocyte-induced apoptosis of activated T cells, a mechanism of liver transplant tolerance, is related to the expression of ICAM-1 and hepatic lectin. Transplant Proc (2001) 0.88
Purification and biochemical characterization of human liver-derived inhibitory protein (LIP). J Immunol (1983) 0.81
Expression of cytokines and factors modulating apoptosis by human sinusoidal leucocytes. J Hepatol (2000) 0.80
Immunosuppressive factor from liver induces apoptosis in thymoma EL-4 cells but not normal MHC class II-specific T lymphocytes. Immunol Lett (1995) 0.77
Isolation and preliminary characterization of immunoinhibitory factors from dog erythrocytes and liver. Immunol Invest (1989) 0.77
Mouse parenchymal liver cells in culture secrete a growth inhibitor for myeloma cells. J Hepatol (1996) 0.77
T cell unresponsiveness in vitro can be due to activation in vivo. Int Immunol (1998) 0.77
Prevalence of diabetes among men and women in China. N Engl J Med (2010) 19.98
Reach and grasp by people with tetraplegia using a neurally controlled robotic arm. Nature (2012) 7.87
The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol (2010) 7.08
Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. Science (2013) 6.98
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A (2008) 6.53
Augmented Wnt signaling in a mammalian model of accelerated aging. Science (2007) 5.62
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A (2008) 5.48
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J Clin Invest (2005) 4.55
Regulation of homologous recombination in eukaryotes. Annu Rev Genet (2010) 4.33
miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells. Int J Cancer (2008) 4.09
Superoxide flashes in single mitochondria. Cell (2008) 4.08
The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter. Nat Cell Biol (2013) 3.39
CT-guided needle biopsy of lung lesions: a survey of severe complication based on 9783 biopsies in Japan. Eur J Radiol (2006) 3.39
Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. J Clin Invest (2008) 3.13
MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. PLoS Genet (2010) 3.12
Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. Cell Metab (2008) 2.91
Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance. Cell Metab (2012) 2.76
Prevalence of cardiovascular disease risk factor in the Chinese population: the 2007-2008 China National Diabetes and Metabolic Disorders Study. Eur Heart J (2011) 2.57
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. J Clin Invest (2013) 2.50
Minireview: GNAS: normal and abnormal functions. Endocrinology (2004) 2.50
STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells. Blood (2010) 2.48
Etiology of diarrhea in Bangladeshi infants in the first year of life analyzed using molecular methods. J Infect Dis (2013) 2.43
A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell (2009) 2.41
Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J Clin Invest (2010) 2.32
Light-sensitive neurons and channels mediate phototaxis in C. elegans. Nat Neurosci (2008) 2.32
Genome-wide association study dissects the genetic architecture of oil biosynthesis in maize kernels. Nat Genet (2012) 2.25
Genetic mechanisms of hepatocarcinogenesis. Oncogene (2002) 2.21
Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice. Proc Natl Acad Sci U S A (2003) 2.21
Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. Nat Med (2013) 2.19
Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in mice. Toxicol Appl Pharmacol (2003) 2.16
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. Circulation (2004) 2.15
Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Nat Methods (2013) 2.14
Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart. J Physiol (2004) 2.09
Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury. J Neurosci (2004) 2.08
Comparison of one-level minimally invasive and open transforaminal lumbar interbody fusion in degenerative and isthmic spondylolisthesis grades 1 and 2. Eur Spine J (2010) 2.02
Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. Blood (2008) 2.01
Evidence for novel cannabinoid receptors. Pharmacol Ther (2005) 2.00
Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Mol Pharmacol (2003) 1.95
Chronic inorganic arsenic exposure induces hepatic global and individual gene hypomethylation: implications for arsenic hepatocarcinogenesis. Carcinogenesis (2004) 1.91
Androgen receptor-negative human prostate cancer cells induce osteogenesis in mice through FGF9-mediated mechanisms. J Clin Invest (2008) 1.87
Transplacental arsenic carcinogenesis in mice. Toxicol Appl Pharmacol (2007) 1.86
Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma. Proc Natl Acad Sci U S A (2012) 1.86
The actinobacterial mce4 locus encodes a steroid transporter. J Biol Chem (2008) 1.86
R-loop-mediated genomic instability is caused by impairment of replication fork progression. Genes Dev (2011) 1.82
High HIV prevalence detected in 2006 and 2007 among men who have sex with men in China's largest municipality: an alarming epidemic in Chongqing, China. J Acquir Immune Defic Syndr (2009) 1.80
St John's wort induces both cytochrome P450 3A4-catalyzed sulfoxidation and 2C19-dependent hydroxylation of omeprazole. Clin Pharmacol Ther (2004) 1.79
The neural circuits and synaptic mechanisms underlying motor initiation in C. elegans. Cell (2011) 1.78
Controlled fabrication of a biological vascular substitute. Biomaterials (2005) 1.76
Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase. Am J Physiol Heart Circ Physiol (2005) 1.76
Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero. J Natl Cancer Inst (2004) 1.73
Minimally invasive or open transforaminal lumbar interbody fusion as revision surgery for patients previously treated by open discectomy and decompression of the lumbar spine. Eur Spine J (2010) 1.73
Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells. Cell (2012) 1.72
Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification. Arterioscler Thromb Vasc Biol (2010) 1.69
Activation of β-catenin signaling in androgen receptor-negative prostate cancer cells. Clin Cancer Res (2012) 1.68
Hypersensitivity of BKCa to Ca2+ sparks underlies hyporeactivity of arterial smooth muscle in shock. Circ Res (2007) 1.67
The noncoding RNA expression profile and the effect of lncRNA AK126698 on cisplatin resistance in non-small-cell lung cancer cell. PLoS One (2013) 1.65
Detection, characterization, and abundance of engineered nanoparticles in complex waters by hyperspectral imagery with enhanced Darkfield microscopy. Environ Sci Technol (2012) 1.65
WNK1 kinase isoform switch regulates renal potassium excretion. Proc Natl Acad Sci U S A (2006) 1.65
S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites. Cancer Cell (2012) 1.64
Blockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT. J Exp Med (2003) 1.64
Skin-derived precursors generate myelinating Schwann cells that promote remyelination and functional recovery after contusion spinal cord injury. J Neurosci (2007) 1.63
Quantitative assessment of air trapping in chronic obstructive pulmonary disease using inspiratory and expiratory volumetric MDCT. AJR Am J Roentgenol (2008) 1.62
Mechanism of silver nanoparticle toxicity is dependent on dissolved silver and surface coating in Caenorhabditis elegans. Environ Sci Technol (2011) 1.60
Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemaking. J Physiol (2004) 1.59
Alternative Gnas gene products have opposite effects on glucose and lipid metabolism. Proc Natl Acad Sci U S A (2005) 1.59
Towards a pharmacophore for amyloid. PLoS Biol (2011) 1.58
Epidemiological and clinical study of sporadic acute hepatitis E caused by indigenous strains of hepatitis E virus in Japan compared with acute hepatitis A. J Gastroenterol (2004) 1.58
Oncogene-induced senescence results in marked metabolic and bioenergetic alterations. Cell Cycle (2012) 1.57
TRF2 promotes multidrug resistance in gastric cancer cells. Cancer Biol Ther (2006) 1.57
Underexpressed microRNA-199b-5p targets hypoxia-inducible factor-1α in hepatocellular carcinoma and predicts prognosis of hepatocellular carcinoma patients. J Gastroenterol Hepatol (2011) 1.56
SLOW WALKER1, essential for gametogenesis in Arabidopsis, encodes a WD40 protein involved in 18S ribosomal RNA biogenesis. Plant Cell (2005) 1.56
Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. Cell Rep (2013) 1.56
The central cell plays a critical role in pollen tube guidance in Arabidopsis. Plant Cell (2007) 1.56
Urogenital carcinogenesis in female CD1 mice induced by in utero arsenic exposure is exacerbated by postnatal diethylstilbestrol treatment. Cancer Res (2006) 1.55
24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology (2006) 1.54
Coil sensitivity encoding in MR imaging: advantages and disadvantages in clinical practice. AJR Am J Roentgenol (2002) 1.53
MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression. J Exp Clin Cancer Res (2010) 1.51
Perinatal nicotine exposure induces asthma in second generation offspring. BMC Med (2012) 1.51
Metallothionein protection of cadmium toxicity. Toxicol Appl Pharmacol (2009) 1.49
Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease. Neurobiol Aging (2008) 1.49
Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha. Hepatology (2009) 1.48
Peripheral solitary pulmonary nodule: CT findings in patients with pulmonary emphysema. Radiology (2005) 1.48
Hypoxia-inducible factor-1 alpha contributes to hypoxia-induced chemoresistance in gastric cancer. Cancer Sci (2007) 1.48
Melanoma, a tumor based on a mutant stem cell? J Invest Dermatol (2006) 1.48
Polyphyletic strains of hepatitis E virus are responsible for sporadic cases of acute hepatitis in Japan. J Clin Microbiol (2002) 1.48
Construction of tissue engineered nerve grafts and their application in peripheral nerve regeneration. Prog Neurobiol (2010) 1.46
Direct repair of displaced anterior arch fracture of the atlas under microendoscopy: experience with seven patients. Eur Spine J (2011) 1.46
Observation and electric current control of a local spin in a single-molecule magnet. Nat Commun (2011) 1.46
The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth. Cancer Res (2012) 1.45
WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction. J Biol Chem (2009) 1.44
Multidirectional myocardial systolic function in hemodialysis patients with preserved left ventricular ejection fraction and different left ventricular geometry. Nephrol Dial Transplant (2012) 1.44
Retracted The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature (2012) 1.44
Band structure, phonon scattering, and the performance limit of single-walled carbon nanotube transistors. Phys Rev Lett (2005) 1.43
Aberrant DNA methylation and gene expression in livers of newborn mice transplacentally exposed to a hepatocarcinogenic dose of inorganic arsenic. Toxicology (2007) 1.42
Spoligotypes of Mycobacterium tuberculosis from different Provinces of China. J Clin Microbiol (2010) 1.42
Arabidopsis GLUTAMINE-RICH PROTEIN23 is essential for early embryogenesis and encodes a novel nuclear PPR motif protein that interacts with RNA polymerase II subunit III. Plant Cell (2006) 1.42
Activation of volume-sensitive Cl(-) channel is involved in carboplatin-induced apoptosis in human lung adenocarcinoma cells. Cancer Biol Ther (2010) 1.41
Detection of hepatitis B virus PreS1 antigen using a time-resolved fluoroimmunoassay. J Immunoassay Immunochem (2012) 1.41
DNA combing reveals intrinsic temporal disorder in the replication of yeast chromosome VI. J Mol Biol (2007) 1.41
Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics. Cancer Res (2008) 1.40