Published in J Biol Chem on January 14, 2003
Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells. Proc Natl Acad Sci U S A (2007) 1.87
Regulation of the protein C anticoagulant and antiinflammatory pathways. Curr Med Chem (2010) 1.48
Zymogenic and enzymatic properties of the 70-80 loop mutants of factor X/Xa. Protein Sci (2004) 1.12
Thrombomodulin allosterically modulates the activity of the anticoagulant thrombin. Proc Natl Acad Sci U S A (2003) 1.07
Activation of protein C by the thrombin-thrombomodulin complex: cooperative roles of Arg-35 of thrombin and Arg-67 of protein C. Proc Natl Acad Sci U S A (2006) 0.94
Mutagenesis studies toward understanding allostery in thrombin. Biochemistry (2009) 0.81
Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells. Proc Natl Acad Sci U S A (2007) 1.87
The influence of sodium ion binding on factor IXa activity. Thromb Haemost (2006) 1.47
Protease activated receptor 1 (PAR-1) activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial protein C receptor is occupied by its natural ligand. Thromb Haemost (2008) 1.35
Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein C eliminates its anticoagulant but not its protective signaling properties. J Biol Chem (2007) 1.34
Contribution of basic residues of the 70-80-loop to heparin binding and anticoagulant function of activated protein C. Biochemistry (2002) 1.22
Activated protein C inhibits high mobility group box 1 signaling in endothelial cells. Blood (2011) 1.22
Role of basic residues of the autolysis loop in the catalytic function of factor Xa. Biochemistry (2002) 1.22
Ixolaris: a factor Xa heparin-binding exosite inhibitor. Biochem J (2005) 1.14
Zymogenic and enzymatic properties of the 70-80 loop mutants of factor X/Xa. Protein Sci (2004) 1.12
Recombinant human activated protein C inhibits integrin-mediated neutrophil migration. Blood (2009) 1.11
Proexosite-1 on prothrombin is a factor Va-dependent recognition site for the prothrombinase complex. J Biol Chem (2003) 1.09
Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1. J Biol Chem (2010) 1.07
Mechanism by which exosites promote the inhibition of blood coagulation proteases by heparin-activated antithrombin. J Biol Chem (2007) 1.06
Exosite-dependent regulation of factor VIIIa by activated protein C. Blood (2003) 1.04
Identification of a specific exosite on activated protein C for interaction with protease-activated receptor 1. J Biol Chem (2007) 1.04
Localization of the heparin binding exosite of factor IXa. J Biol Chem (2002) 1.04
Thrombin inhibits nuclear factor kappaB and RhoA pathways in cytokine-stimulated vascular endothelial cells when EPCR is occupied by protein C. Thromb Haemost (2009) 1.02
Localization of phosphatidylserine binding sites to structural domains of factor Xa. J Biol Chem (2001) 1.02
Concentration dependent dual effect of thrombin in endothelial cells via Par-1 and Pi3 Kinase. J Cell Physiol (2009) 0.98
FRET studies with factor X mutants provide insight into the topography of the membrane-bound factor X/Xa. Biochem J (2007) 0.97
Contribution of basic residues of the autolysis loop to the substrate and inhibitor specificity of factor IXa. J Biol Chem (2003) 0.97
Characterization of a heparin-binding site on the catalytic domain of factor XIa: mechanism of heparin acceleration of factor XIa inhibition by the serpins antithrombin and C1-inhibitor. Biochemistry (2009) 0.96
Ixolaris binding to factor X reveals a precursor state of factor Xa heparin-binding exosite. Protein Sci (2007) 0.95
Activation of protein C by the thrombin-thrombomodulin complex: cooperative roles of Arg-35 of thrombin and Arg-67 of protein C. Proc Natl Acad Sci U S A (2006) 0.94
The conformation of the activation peptide of protein C is influenced by Ca2+ and Na+ binding. J Biol Chem (2004) 0.93
Calcium-binding sites of the thrombin-thrombomodulin-protein C complex: possible implications for the effect of platelet factor 4 on the activation of vitamin K-dependent coagulation factors. Thromb Haemost (2007) 0.93
Engineering functional antithrombin exosites in alpha1-proteinase inhibitor that specifically promote the inhibition of factor Xa and factor IXa. J Biol Chem (2008) 0.93
Heparin is a major activator of the anticoagulant serpin, protein Z-dependent protease inhibitor. J Biol Chem (2011) 0.92
Heparin-activated antithrombin interacts with the autolysis loop of target coagulation proteases. Blood (2004) 0.92
Identification of a basic region on tissue factor that interacts with the first epidermal growth factor-like domain of factor X. Biochemistry (2007) 0.90
Role of the N-terminal epidermal growth factor-like domain of factor X/Xa. J Biol Chem (2004) 0.90
Mutations of the anti-mullerian hormone gene in patients with persistent mullerian duct syndrome: biosynthesis, secretion, and processing of the abnormal proteins and analysis using a three-dimensional model. Mol Endocrinol (2003) 0.87
Characterization of the heparin-binding site of the protein z-dependent protease inhibitor. Biochemistry (2012) 0.87
Thrombomodulin enhances the reactivity of thrombin with protein C inhibitor by providing both a binding site for the serpin and allosterically modulating the activity of thrombin. J Biol Chem (2003) 0.86
Mechanisms of interactions of factor X and factor Xa with the acidic region in the factor VIII A1 domain. J Biol Chem (2004) 0.86
Determinants of the specificity of protease-activated receptors 1 and 2 signaling by factor Xa and thrombin. J Cell Biochem (2012) 0.86
Thrombin inhibits HMGB1-mediated proinflammatory signaling responses when endothelial protein C receptor is occupied by its natural ligand. BMB Rep (2013) 0.85
Contribution of the NH2-terminal EGF-domain of factor IXa to the specificity of intrinsic tenase. Thromb Haemost (2012) 0.85
Membrane-dependent interaction of factor Xa and prothrombin with factor Va in the prothrombinase complex. Biochemistry (2009) 0.85
The cofactor function of the N-terminal domain of tissue factor. J Biol Chem (2004) 0.85
Phosphatidylserine-induced factor Xa dimerization and binding to factor Va are competing processes in solution. Biochemistry (2012) 0.85
Expression, purification and characterization of factor IX derivatives using a novel vector system. Protein Expr Purif (2006) 0.84
Anticoagulant activity of a sulfated galactan: serpin-independent effect and specific interaction with factor Xa. Thromb Haemost (2009) 0.83
Adenosine regulates the proinflammatory signaling function of thrombin in endothelial cells. J Cell Physiol (2014) 0.82
Role of the residues of the 39-loop in determining the substrate and inhibitor specificity of factor IXa. J Biol Chem (2010) 0.81
Functional mapping of charged residues of the 82-116 sequence in factor Xa: evidence that lysine 96 is a factor Va independent recognition site for prothrombin in the prothrombinase complex. Biochemistry (2005) 0.81
Thrombin down-regulates the TGF-beta-mediated synthesis of collagen and fibronectin by human proximal tubule epithelial cells through the EPCR-dependent activation of PAR-1. J Cell Physiol (2010) 0.81
Identification of exosite residues of factor Xa involved in recognition of PAR-2 on endothelial cells. Biochemistry (2012) 0.81
The missense Thr211Pro mutation in the factor X activation peptide of a bleeding patient causes molecular defect in the clotting cascade. Thromb Haemost (2013) 0.81
Mutagenesis studies toward understanding allostery in thrombin. Biochemistry (2009) 0.81
Thrombin and activated protein C inhibit the expression of secretory group IIA phospholipase A(2) in the TNF-alpha-activated endothelial cells by EPCR and PAR-1 dependent mechanisms. Thromb Res (2009) 0.79
Residues of the 39-loop restrict the plasma inhibitor specificity of factor IXa. J Biol Chem (2013) 0.79
The functional significance of the autolysis loop in protein C and activated protein C. Thromb Haemost (2005) 0.79
Activated protein C protects against renal ischaemia/reperfusion injury, independent of its anticoagulant properties. Thromb Haemost (2016) 0.78
Autolysis loop restricts the specificity of activated protein C: analysis by FRET and functional assays. Biophys Chem (2008) 0.77
Factor Va alters the conformation of the Na+-binding loop of factor Xa in the prothrombinase complex. Biochemistry (2008) 0.77
Thrombomodulin-mediated catabolism of protein C by pleural mesothelial and vascular endothelial cells. Thromb Haemost (2007) 0.77
Functional properties and active-site topographies of factor X Gla- and prothrombin Gla-domain chimeras of activated protein C. Biochim Biophys Acta (2008) 0.77
Posttransplant soluble CD30 as a predictor of acute renal allograft rejection. Exp Clin Transplant (2009) 0.76
Proexosite-1-dependent recognition and activation of prothrombin by taipan venom. J Biol Chem (2004) 0.76
Role of P2 glycine in determining the specificity of antithrombin reaction with coagulation proteases. Biochem Biophys Res Commun (2009) 0.75
Inhibitory properties of the P1 Tyr variant of antithrombin. Biochemistry (2010) 0.75
Variable contributions of basic residues forming an APC exosite in the binding and inactivation of factor VIIIa. Biochemistry (2013) 0.75
Mutation of the H-helix in antithrombin decreases heparin stimulation of protease inhibition. Biochim Biophys Acta (2007) 0.75
Thrombomodulin modulates cell migration in human melanoma cell lines. Melanoma Res (2014) 0.75
Inhibition of a thrombin anion-binding exosite-2 mutant by the glycosaminoglycan-dependent serpins protein C inhibitor and heparin cofactor II. Thromb Res (2002) 0.75
Transmitting the allosteric signal in methylglyoxal synthase. Protein Eng Des Sel (2013) 0.75
Correction to Phosphatidylserine-Induced Factor Xa Dimerization and Binding to Factor Va Are Competing Processes in Solution. Biochemistry (2016) 0.75