Published in Mol Cancer Ther on January 01, 2003
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev (2007) 6.71
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev (2004) 6.19
Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc Natl Acad Sci U S A (2005) 4.57
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell (2008) 4.44
ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes. PLoS One (2010) 3.15
Stem cell chromatin patterns: an instructive mechanism for DNA hypermethylation? Cell Cycle (2007) 2.55
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells. Mol Cell Biol (2004) 1.96
Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity. PLoS Biol (2008) 1.53
Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets. Nucleic Acids Res (2009) 1.52
Enhancer of zeste homolog 2 promotes the proliferation and invasion of epithelial ovarian cancer cells. Mol Cancer Res (2010) 1.46
Identification of driver and passenger DNA methylation in cancer by epigenomic analysis. Adv Genet (2010) 1.44
Methylation of homeobox genes is a frequent and early epigenetic event in breast cancer. Breast Cancer Res (2009) 1.43
Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network. Cell Stem Cell (2010) 1.34
Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3. Cell Mol Life Sci (2010) 1.25
Epigenetic silencing of CCAAT/enhancer-binding protein delta activity by YY1/polycomb group/DNA methyltransferase complex. J Biol Chem (2008) 1.21
Comprehensive analysis of β-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/β-catenin signaling. BMC Genomics (2014) 1.16
Inhibition of EZH2 suppresses self-renewal and induces radiation sensitivity in atypical rhabdoid teratoid tumor cells. Neuro Oncol (2012) 1.09
Differential control of Wnt target genes involves epigenetic mechanisms and selective promoter occupancy by T-cell factors. Mol Cell Biol (2007) 1.09
Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal. PLoS Genet (2012) 1.07
Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus. Sci Signal (2012) 1.06
Chromatin-modifying enzymes as therapeutic targets--Part 1. Expert Opin Ther Targets (2008) 1.04
Linking cell signaling and the epigenetic machinery. Nat Biotechnol (2010) 1.03
Identification of genes potentially involved in the increased risk of malignancy in NF1-microdeleted patients. Mol Med (2010) 1.03
Cancer as a manifestation of aberrant chromatin structure. Cancer J (2007) 1.01
Polycomb repressive complex 2 contributes to DNA double-strand break repair. Cell Cycle (2013) 0.98
The polycomb group protein SUZ12 regulates histone H3 lysine 9 methylation and HP1 alpha distribution. Chromosome Res (2007) 0.95
Clinical and biological relevance of enhancer of zeste homolog 2 in triple-negative breast cancer. Hum Pathol (2012) 0.95
Novel sequential ChIP and simplified basic ChIP protocols for promoter co-occupancy and target gene identification in human embryonic stem cells. BMC Biotechnol (2009) 0.93
Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis. Breast Cancer Res (2012) 0.91
Developmental regulation of Suz 12 localization. Chromosoma (2005) 0.89
Association of TGFβ signaling with the maintenance of a quiescent stem cell niche in human oral mucosa. Histochem Cell Biol (2016) 0.89
Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications. Med Res Rev (2015) 0.88
Deregulated expression of the polycomb-group protein SUZ12 target genes characterizes mantle cell lymphoma. Am J Pathol (2010) 0.87
The synovial sarcoma-associated SYT-SSX2 oncogene antagonizes the polycomb complex protein Bmi1. PLoS One (2009) 0.85
Mutations in the extra sex combs and Enhancer of Polycomb genes increase homologous recombination in somatic cells of Drosophila melanogaster. Genetics (2006) 0.84
Polycomb (PcG) proteins, BMI1 and SUZ12, regulate arsenic-induced cell transformation. J Biol Chem (2012) 0.83
In vivo analysis of Drosophila SU(Z)12 function. Mol Genet Genomics (2007) 0.83
EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis. Oncotarget (2016) 0.79
Polycomb and the emerging epigenetics of pancreatic cancer. J Gastrointest Cancer (2011) 0.79
Epigenetic factor EPC1 is a master regulator of DNA damage response by interacting with E2F1 to silence death and activate metastasis-related gene signatures. Nucleic Acids Res (2015) 0.78
Tissue-specific regulatory network extractor (TS-REX): a database and software resource for the tissue and cell type-specific investigation of transcription factor-gene networks. Nucleic Acids Res (2009) 0.78
The role of maintenance proteins in the preservation of epithelial cell identity during mammary gland remodeling and breast cancer initiation. Chin J Cancer (2013) 0.77
Gene silencing and Polycomb group proteins: an overview of their structure, mechanisms and phylogenetics. OMICS (2013) 0.77
Site-specific chromatin immunoprecipitation: a selective method to individually analyze neighboring transcription factor binding sites in vivo. BMC Res Notes (2012) 0.77
Integrative epigenome analysis identifies a Polycomb-targeted differentiation program as a tumor-suppressor event epigenetically inactivated in colorectal cancer. Cell Death Dis (2014) 0.76
ARE/SUZ12 dual specifically-regulated adenoviral TK/GCV system for CML blast crisis cells. J Exp Clin Cancer Res (2015) 0.75
Suppressor of Zeste 12 homolog RNA interference inhibits retinoblastoma cell invasion. Oncol Lett (2014) 0.75
Role of the long non-coding RNA HOTAIR in hepatocellular carcinoma. Oncol Lett (2017) 0.75
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell (2007) 30.22
The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99
ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res (2012) 9.13
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol (2010) 7.00
Suz12 binds to silenced regions of the genome in a cell-type-specific manner. Genome Res (2006) 6.75
Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes Dev (2002) 6.74
Unbiased location analysis of E2F1-binding sites suggests a widespread role for E2F1 in the human genome. Genome Res (2006) 6.54
T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity (2004) 6.43
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev (2004) 6.19
Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Genome Res (2008) 4.08
Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes. Proc Natl Acad Sci U S A (2007) 4.00
Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell (2009) 3.96
High-throughput screening of chromatin immunoprecipitates using CpG-island microarrays. Methods Enzymol (2004) 3.76
Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs. PLoS Genet (2007) 3.75
Identification of unknown target genes of human transcription factors using chromatin immunoprecipitation. Methods (2002) 3.37
Defining functional DNA elements in the human genome. Proc Natl Acad Sci U S A (2014) 3.35
ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes. PLoS One (2010) 3.15
Characterizing transcription factor binding sites using formaldehyde crosslinking and immunoprecipitation. Methods (2002) 2.99
A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members. Genome Res (2007) 2.97
Comparison of sample preparation methods for ChIP-chip assays. Biotechniques (2006) 2.89
Locating mammalian transcription factor binding sites: a survey of computational and experimental techniques. Genome Res (2006) 2.82
Sole-Search: an integrated analysis program for peak detection and functional annotation using ChIP-seq data. Nucleic Acids Res (2009) 2.74
Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter. J Biol Chem (2002) 2.68
Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression. Curr Biol (2003) 2.47
Genome-scale ChIP-chip analysis using 10,000 human cells. Biotechniques (2007) 2.28
Identification of novel pRb binding sites using CpG microarrays suggests that E2F recruits pRb to specific genomic sites during S phase. Oncogene (2003) 2.22
Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3. Genome Biol (2012) 2.19
KAP1 protein: an enigmatic master regulator of the genome. J Biol Chem (2011) 2.15
Probing chromatin immunoprecipitates with CpG-island microarrays to identify genomic sites occupied by DNA-binding proteins. Methods Enzymol (2003) 2.12
E2F in vivo binding specificity: comparison of consensus versus nonconsensus binding sites. Genome Res (2008) 2.07
E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9. J Biol Chem (2003) 2.02
CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome. Nucleic Acids Res (2005) 1.89
Identification of genes directly regulated by the oncogene ZNF217 using chromatin immunoprecipitation (ChIP)-chip assays. J Biol Chem (2007) 1.88
Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol (2013) 1.88
A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res (2006) 1.74
Genomic targets of the KRAB and SCAN domain-containing zinc finger protein 263. J Biol Chem (2009) 1.71
DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nat Genet (2013) 1.64
The identification of E2F1-specific target genes. Proc Natl Acad Sci U S A (2002) 1.63
N-Myc regulates a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor. Cancer Res (2008) 1.52
Identification of an OCT4 and SRY regulatory module using integrated computational and experimental genomics approaches. Genome Res (2007) 1.50
Using ChIP-chip technology to reveal common principles of transcriptional repression in normal and cancer cells. Genome Res (2008) 1.45
W-ChIPMotifs: a web application tool for de novo motif discovery from ChIP-based high-throughput data. Bioinformatics (2009) 1.42
Genomic approaches that aid in the identification of transcription factor target genes. Exp Biol Med (Maywood) (2004) 1.41
Functional analysis of KAP1 genomic recruitment. Mol Cell Biol (2011) 1.39
Using ChIP-seq technology to generate high-resolution profiles of histone modifications. Methods Mol Biol (2011) 1.37
Characterization of the contradictory chromatin signatures at the 3' exons of zinc finger genes. PLoS One (2011) 1.34
5-azacytidine treatment reorganizes genomic histone modification patterns. Epigenetics (2010) 1.34
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm. Genome Res (2013) 1.33
L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure. Mol Cell (2011) 1.32
Integration of Hi-C and ChIP-seq data reveals distinct types of chromatin linkages. Nucleic Acids Res (2012) 1.32
Genetic framework for GATA factor function in vascular biology. Proc Natl Acad Sci U S A (2011) 1.29
The transcription factor encyclopedia. Genome Biol (2012) 1.28
Cross-talk between site-specific transcription factors and DNA methylation states. J Biol Chem (2013) 1.24
Genome-wide analysis of transcription factor E2F1 mutant proteins reveals that N- and C-terminal protein interaction domains do not participate in targeting E2F1 to the human genome. J Biol Chem (2011) 1.18
Autophagy driven by a master regulator of hematopoiesis. Mol Cell Biol (2011) 1.13
Analysis of the mechanisms mediating tumor-specific changes in gene expression in human liver tumors. Cancer Res (2008) 1.13
Global loss of DNA methylation uncovers intronic enhancers in genes showing expression changes. Genome Biol (2014) 1.12
Epigenetic modulation of miR-122 facilitates human embryonic stem cell self-renewal and hepatocellular carcinoma proliferation. PLoS One (2011) 1.11
Spark: a navigational paradigm for genomic data exploration. Genome Res (2012) 1.10
Using ChIP-seq technology to identify targets of zinc finger transcription factors. Methods Mol Biol (2010) 1.06
Recombinant antibodies to histone post-translational modifications. Nat Methods (2013) 1.05
The use of transient chromatin immunoprecipitation assays to test models for E2F1-specific transcriptional activation. J Biol Chem (2004) 1.05
Genome-wide binding of the orphan nuclear receptor TR4 suggests its general role in fundamental biological processes. BMC Genomics (2010) 1.01
ZBTB33 binds unmethylated regions of the genome associated with actively expressed genes. Epigenetics Chromatin (2013) 0.93
LOcating non-unique matched tags (LONUT) to improve the detection of the enriched regions for ChIP-seq data. PLoS One (2013) 0.87
In vivo assays to examine transcription factor localization and target gene specificity. Methods (2002) 0.84
Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics (2014) 0.82
Identification and characterization of CRG-L2, a new marker for liver tumor development. Oncogene (2003) 0.81
Transcription factor effector domains. Subcell Biochem (2011) 0.81
Human ESC self-renewal promoting microRNAs induce epithelial-mesenchymal transition in hepatocytes by controlling the PTEN and TGFβ tumor suppressor signaling pathways. Mol Cancer Res (2012) 0.81
Can genome engineering be used to target cancer-associated enhancers? Epigenomics (2014) 0.81
Uncovering transcription factor modules using one- and three-dimensional analyses. J Biol Chem (2012) 0.78
Reply to Brunet and Doolittle: Both selected effect and causal role elements can influence human biology and disease. Proc Natl Acad Sci U S A (2014) 0.76
Using ChIPMotifs for de novo motif discovery of OCT4 and ZNF263 based on ChIP-based high-throughput experiments. Methods Mol Biol (2012) 0.75