Pharmacotherapy and airway remodelling in asthma?

PubWeight™: 1.11‹?› | Rank: Top 10%

🔗 View Article (PMC 1746582)

Published in Thorax on February 01, 2003

Authors

P A Beckett1, P H Howarth

Author Affiliations

1: Respiratory Cell Molecular Biology Division, Southampton General Hospital, Southampton SO16 6YD, UK. Pab@soton.ac.uk

Articles citing this

A randomized clinical trial of peak flow versus symptom monitoring in older adults with asthma. Am J Respir Crit Care Med (2006) 2.88

Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling. Am J Pathol (2006) 1.25

Role of hyaluronan and hyaluronan-binding proteins in human asthma. J Allergy Clin Immunol (2011) 1.19

Inhaled corticosteroids and decline of lung function in community residents with asthma. Thorax (2006) 1.10

TGF-beta1 induces human bronchial epithelial cell-to-mesenchymal transition in vitro. Lung (2009) 1.00

Airway Remodeling in Chronic Obstructive Pulmonary Disease and Asthma: the Role of Matrix Metalloproteinase-9. Arch Immunol Ther Exp (Warsz) (2015) 0.86

Inhaled corticosteroids moderate lung function decline in adults with asthma. Thorax (2006) 0.85

Prolonged ozone exposure in an allergic airway disease model: adaptation of airway responsiveness and airway remodeling. Respir Res (2006) 0.83

Lost to follow-up in asthmatics does not mean treatment failure: causes and clinical outcomes of non-adherence to outpatient treatment in adult asthma. Allergy Asthma Immunol Res (2013) 0.83

Central role of cellular senescence in TSLP-induced airway remodeling in asthma. PLoS One (2013) 0.82

Steroids reduce local inflammatory mediator secretion and mucosal permeability in collagenous colitis patients. World J Gastroenterol (2006) 0.80

Corticosteroid administration reduces the concentration of hyaluronan in bronchoalveolar lavage in a murine model of eosinophilic airway inflammation. Inflamm Res (2012) 0.75

Airway remodeling in asthma: what really matters. Cell Tissue Res (2017) 0.75

Pharmacologic modulation of experimentally induced allergic asthma. Interdiscip Toxicol (2011) 0.75

Asthma exacerbations: prevention is better than cure. Ther Clin Risk Manag (2005) 0.75

Statins in Asthma: Potential Beneficial Effects and Limitations. Pulm Med (2015) 0.75

Bronchoconstriction Induces Structural and Functional Airway Alterations in Non-sensitized Rats. Lung (2016) 0.75

Articles cited by this

(truncated to the top 100)

The transforming growth factor-beta family. Annu Rev Cell Biol (1990) 10.62

Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group. N Engl J Med (1997) 8.48

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest (1999) 8.38

Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature (2002) 8.28

Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med (2000) 5.82

Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet (1990) 5.65

The pathology of asthma, with special reference to changes in the bronchial mucosa. J Clin Pathol (1960) 5.41

Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature (1997) 5.31

Effects of reducing or discontinuing inhaled budesonide in patients with mild asthma. N Engl J Med (1994) 4.76

Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis (1985) 4.59

A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med (1998) 4.52

Comparison of a beta 2-agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma. N Engl J Med (1991) 4.09

Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis (1989) 3.86

Subepithelial fibrosis in the bronchi of asthmatics. Lancet (1989) 3.70

Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta. J Biol Chem (1987) 3.25

Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group. Am J Respir Crit Care Med (1999) 3.22

A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema. Thorax (1969) 3.18

Meta-analysis of increased dose of inhaled steroid or addition of salmeterol in symptomatic asthma (MIASMA). BMJ (2000) 3.08

Efficacy and safety of inhaled corticosteroids. New developments. Am J Respir Crit Care Med (1998) 2.96

Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma. Am J Respir Cell Mol Biol (1997) 2.84

A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc Natl Acad Sci U S A (1992) 2.79

Transcription. A growing coactivator network. Nature (1996) 2.71

Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study. Am Rev Respir Dis (1993) 2.69

A model of airway narrowing in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis (1992) 2.67

Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness. J Exp Med (1998) 2.55

Protection against allergen-induced asthma by salmeterol. Lancet (1990) 2.51

Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med (1997) 2.47

Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J (2000) 2.42

Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis. Am J Respir Crit Care Med (1998) 2.36

Asthma and irreversible airflow obstruction. Thorax (1984) 2.30

Rate of decline of lung function in subjects with asthma. Eur J Respir Dis (1987) 2.27

Increased vascularity of the bronchial mucosa in mild asthma. Am J Respir Crit Care Med (1997) 2.25

Effect of long-term treatment with inhaled corticosteroids and beta-agonists on the bronchial responsiveness in children with asthma. J Allergy Clin Immunol (1987) 2.24

The matrix metalloproteinases and their inhibitors. Am J Respir Cell Mol Biol (1992) 2.19

Mechanics of airway narrowing. Am Rev Respir Dis (1986) 2.18

A comparative study of the effects of an inhaled corticosteroid, budesonide, and a beta 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial. J Allergy Clin Immunol (1992) 2.16

Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol (1990) 2.14

Epithelial-mesenchymal interactions in the pathogenesis of asthma. J Allergy Clin Immunol (2000) 2.12

Effect of early vs late intervention with inhaled corticosteroids in asthma. Chest (1995) 2.06

Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in asthma. J Allergy Clin Immunol (1999) 2.04

Effects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children. Respir Med (1994) 2.02

Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. A quantitative light and electron microscopic study. Am Rev Respir Dis (1992) 2.02

Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity. J Clin Invest (1994) 1.96

Effects of 22 months of treatment with inhaled corticosteroids and/or beta-2-agonists on lung function, airway responsiveness, and symptoms in children with asthma. The Dutch Chronic Non-specific Lung Disease Study Group. Am Rev Respir Dis (1992) 1.89

Reversal of human lymphocyte beta-adrenoceptor desensitization by glucocorticoids. Clin Pharmacol Ther (1982) 1.85

Inhaled corticosteroid reduced lamina reticularis of the basement membrane by modulation of insulin-like growth factor (IGF)-I expression in bronchial asthma. Clin Exp Allergy (1998) 1.80

Absence of immunoreactive vasoactive intestinal polypeptide in tissue from the lungs of patients with asthma. N Engl J Med (1989) 1.79

Comparative effects of inhaled salbutamol, sodium cromoglycate, and beclomethasone dipropionate on allergen-induced early asthmatic responses, late asthmatic responses, and increased bronchial responsiveness to histamine. J Allergy Clin Immunol (1987) 1.78

Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am Rev Respir Dis (1992) 1.75

Airways remodeling is a distinctive feature of asthma and is related to severity of disease. Chest (1997) 1.71

Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma. J Allergy Clin Immunol (2001) 1.67

Transforming growth factor beta 1 (TGF beta 1) gene expression by eosinophils in asthmatic airway inflammation. Am J Respir Cell Mol Biol (1996) 1.66

Mast cell tryptase is a mitogen for cultured fibroblasts. J Clin Invest (1991) 1.64

Transforming growth factor-beta 1 in asthma. Measurement in bronchoalveolar lavage fluid. Am J Respir Crit Care Med (1997) 1.64

Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation. J Allergy Clin Immunol (1998) 1.62

Anti-inflammatory effects of low-dose oral theophylline in atopic asthma. Lancet (1994) 1.61

Ligand-independent activation of the glucocorticoid receptor by beta2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells. J Biol Chem (1999) 1.59

Endothelin immunoreactivity of airway epithelium in asthmatic patients. Lancet (1991) 1.59

Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction. J Clin Invest (1996) 1.58

The long-acting beta2-agonist salmeterol xinafoate: effects on airway inflammation in asthma. Eur Respir J (1999) 1.58

Effects of formoterol and budesonide on GM-CSF and IL-8 secretion by triggered human bronchial epithelial cells. Eur Respir J (2001) 1.57

Risk factors for growth and decline of lung function in asthmatic individuals up to age 42 years. A 30-year follow-up study. Am J Respir Crit Care Med (1999) 1.52

Effect of long-term salmeterol therapy compared with as-needed albuterol use on airway hyperresponsiveness. Chest (1999) 1.51

Morphological studies of bronchial mucosal biopsies from asthmatics before and after ten years of treatment with inhaled steroids. Eur Respir J (1988) 1.51

An antiinflammatory effect of salmeterol, a long-acting beta(2) agonist, assessed in airway biopsies and bronchoalveolar lavage in asthma. Am J Respir Crit Care Med (1999) 1.51

Fibrogenic cytokines and connective tissue production. FASEB J (1994) 1.51

Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease. Eur Respir J (1998) 1.50

Airway hyperresponsiveness, inflammation, and subepithelial collagen deposition in recently diagnosed versus long-standing mild asthma. Influence of inhaled corticosteroids. Am J Respir Crit Care Med (2000) 1.49

Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway. Am J Respir Crit Care Med (1998) 1.48

Expression of growth factors and remodelling of the airway wall in bronchial asthma. Thorax (1998) 1.47

Inhaled beclomethasone improves the course of asthma and COPD. Eur Respir J (1992) 1.46

Effect of a single dose of salmeterol on the increase in airway eosinophils induced by allergen challenge in asthmatic subjects. Thorax (1999) 1.45

Enhanced proteoglycan deposition in the airway wall of atopic asthmatics. Am J Respir Crit Care Med (1999) 1.43

Airway subepithelial fibrosis in a murine model of atopic asthma: suppression by dexamethasone or anti-interleukin-5 antibody. Am J Respir Cell Mol Biol (2000) 1.41

Pulmonary function during clinical remission of asthma. How reversible is asthma? Aust N Z J Med (1973) 1.41

Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid. Am J Respir Crit Care Med (1997) 1.39

On the mechanism of mucosal folding in normal and asthmatic airways. J Appl Physiol (1985) (1997) 1.38

Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma. Am J Respir Crit Care Med (1994) 1.36

Bronchial subepithelial fibrosis correlates with airway responsiveness to methacholine. Chest (1997) 1.35

Time course of change in bronchial reactivity with an inhaled corticosteroid in asthma. Am Rev Respir Dis (1991) 1.30

Thrombin in the airways of asthmatic patients. Lung (1999) 1.28

Effect of therapy on bronchial hyperresponsiveness in the long-term management of asthma. Clin Allergy (1988) 1.27

Immunomodulation by theophylline in asthma. Demonstration by withdrawal of therapy. Am J Respir Crit Care Med (1995) 1.27

Decline of lung function in adults with bronchial asthma. Am J Respir Crit Care Med (1994) 1.27

Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists. Am J Respir Cell Mol Biol (1998) 1.25

Theophylline in the management of asthma: time for reappraisal? Eur Respir J (1994) 1.25

Regulation of TNF-alpha-induced eotaxin release from cultured human airway smooth muscle cells by beta2-agonists and corticosteroids. FASEB J (2001) 1.24

Triggering the induction of myofibroblast and fibrogenesis by airway epithelial shedding. Am J Respir Cell Mol Biol (2001) 1.21

Bronchoalveolar lavage in asthma: the effect of disodium cromoglycate (cromolyn) on leukocyte counts, immunoglobulins, and complement. J Allergy Clin Immunol (1984) 1.20

Ragweed sensitization-induced increase of myosin light chain kinase content in canine airway smooth muscle. Am J Respir Cell Mol Biol (1992) 1.19

The mechanism of cAMP-induced glucocorticoid receptor expression. Correlation to cellular glucocorticoid response. J Biol Chem (1989) 1.18

A theoretical analysis of the effect of airway smooth muscle load on airway narrowing. Am J Respir Crit Care Med (1996) 1.18

A prospective study of asthma in a rural community. Chest (1984) 1.17

Effect of prednisone and beclomethasone dipropionate on airway responsiveness in asthma: a comparative study. Thorax (1988) 1.17

Synergistic inhibition by beta(2)-agonists and corticosteroids on tumor necrosis factor-alpha-induced interleukin-8 release from cultured human airway smooth-muscle cells. Am J Respir Cell Mol Biol (2000) 1.16

Glucocorticoids inhibit proliferation, cyclin D1 expression, and retinoblastoma protein phosphorylation, but not activity of the extracellular-regulated kinases in human cultured airway smooth muscle. Am J Respir Cell Mol Biol (1999) 1.14

Modification of bronchial hyperreactivity after treatment with sodium cromoglycate during pollen season. J Allergy Clin Immunol (1985) 1.14

Matrix metalloproteases and lung disease. Thorax (1994) 1.13

Synthetic functions of airway smooth muscle in asthma. Trends Pharmacol Sci (1997) 1.12

Bronchial blood vessel dimensions in asthma. Am J Respir Crit Care Med (1997) 1.11

Articles by these authors

(truncated to the top 100)

T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am J Respir Cell Mol Biol (1996) 2.92

Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol (1994) 2.73

Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry. Am Rev Respir Dis (1990) 2.45

Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J (2000) 2.42

Paradoxical bronchoconstriction in asthmatic patients after salmeterol by metered dose inhaler. BMJ (1992) 2.25

Comparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever. Thorax (1984) 2.20

Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol (1990) 2.14

Interleukin 4 is localized to and released by human mast cells. J Exp Med (1992) 2.00

Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment. Thorax (2001) 1.95

Immunohistochemistry on resin sections: a comparison of resin embedding techniques for small mucosal biopsies. Biotech Histochem (1993) 1.79

Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation. J Immunol (1993) 1.78

What's new about hay fever? Br Med J (Clin Res Ed) (1985) 1.76

Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am Rev Respir Dis (1992) 1.75

Bronchoconstriction induced by ipratropium bromide in asthma: relation to hypotonicity. Br Med J (Clin Res Ed) (1984) 1.73

Airway wall remodelling in asthma. Thorax (1997) 1.65

Transforming growth factor-beta 1 in asthma. Measurement in bronchoalveolar lavage fluid. Am J Respir Crit Care Med (1997) 1.64

Endothelin immunoreactivity of airway epithelium in asthmatic patients. Lancet (1991) 1.59

The long-acting beta2-agonist salmeterol xinafoate: effects on airway inflammation in asthma. Eur Respir J (1999) 1.58

Altered protein tyrosine phosphorylation in asthmatic bronchial epithelium. Eur Respir J (2005) 1.56

Consensus statement on the treatment of allergic rhinitis. European Academy of Allergology and Clinical Immunology. Allergy (2000) 1.50

The safety aspects of fiberoptic bronchoscopy, bronchoalveolar lavage, and endobronchial biopsy in asthma. Am Rev Respir Dis (1991) 1.49

Astemizole, a potent histamine H1-receptor antagonist: effect in allergic rhinoconjunctivitis, on antigen and histamine induced skin weal responses and relationship to serum levels. Br J Clin Pharmacol (1984) 1.44

BSACI guidelines for the management of allergic and non-allergic rhinitis. Clin Exp Allergy (2008) 1.29

Genome-wide association study to identify genetic determinants of severe asthma. Thorax (2012) 1.27

Influence of albuterol, cromolyn sodium and ipratropium bromide on the airway and circulating mediator responses to allergen bronchial provocation in asthma. Am Rev Respir Dis (1985) 1.25

Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways. J Clin Invest (1994) 1.22

Bronchial mucosal manifestations of atopy: a comparison of markers of inflammation between atopic asthmatics, atopic nonasthmatics and healthy controls. Eur Respir J (1992) 1.20

Variant LTC(4) synthase allele modifies cysteinyl leukotriene synthesis in eosinophils and predicts clinical response to zafirlukast. Thorax (2000) 1.20

Heterogeneity of human mast cells based on cytokine content. J Immunol (1995) 1.15

Basic fibroblast growth factor in asthma: measurement in bronchoalveolar lavage fluid basally and following allergen challenge. J Allergy Clin Immunol (2001) 1.13

Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium. J Allergy Clin Immunol (2001) 1.11

Lymphocyte activation in bronchoalveolar lavage and peripheral blood in atopic asthma. Am Rev Respir Dis (1992) 1.11

Endothelin in bronchoalveolar lavage fluid and its relation to airflow obstruction in asthma. Am J Respir Crit Care Med (1995) 1.10

The control of allergens of dust mites and domestic pets: a position paper. Clin Exp Allergy (1992) 1.09

Bronchoconstriction in response to ipratropium bromide. Br Med J (Clin Res Ed) (1983) 1.09

Comparative nasal effects of bradykinin, kallidin and [Des-Arg9]-bradykinin in atopic rhinitic and normal volunteers. J Physiol (1991) 1.06

The expression of leukocyte-endothelial adhesion molecules is increased in perennial allergic rhinitis. Am J Respir Cell Mol Biol (1992) 1.05

New insights into airway inflammation by endobronchial biopsy. Am Rev Respir Dis (1992) 1.02

Remodelling of the upper airways in allergic rhinitis: is it a feature of the disease? Clin Exp Allergy (2003) 1.02

Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms. Eur Respir J (2007) 1.02

Intercellular adhesion molecule-1 (ICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in the bronchial mucosa of normal and asthmatic subjects. Eur Respir J (1992) 1.01

Leukocyte recruitment after local endobronchial allergen challenge in asthma. Relationship to procedure and to airway interleukin-8 release. Am J Respir Crit Care Med (1996) 1.01

Epithelial expression and release of FGF-2 from heparan sulphate binding sites in bronchial tissue in asthma. Thorax (2004) 0.98

Geographical variation in the prevalence of sensitization to common aeroallergens in adults: the GA(2) LEN survey. Allergy (2014) 0.97

TNF alpha is localized to nasal mucosal mast cells and is released in acute allergic rhinitis. Clin Exp Allergy (1995) 0.96

Effect of natural allergen exposure during the grass pollen season on airways inflammatory cells and asthma symptoms. Thorax (1996) 0.96

The mast cell as a primary effector cell in the pathogenesis of asthma. J Allergy Clin Immunol (1986) 0.93

Exhaled nitric oxide; relationship to clinicophysiological markers of asthma severity. Respir Med (1998) 0.93

Inhaled beclomethasone dipropionate downregulates airway lymphocyte activation in atopic asthma. Am J Respir Crit Care Med (1994) 0.92

Airway effects of local challenge with hypertonic saline in exercise-induced asthma. Am J Respir Crit Care Med (1994) 0.92

Osteopontin is expressed and functional in human eosinophils. Allergy (2009) 0.92

Transforming growth factor-beta in allergic inflammatory disease of the upper airways: friend or foe? Clin Exp Allergy (2009) 0.90

Allergic rhinitis: past, present and the future. Clin Otolaryngol Allied Sci (2003) 0.90

Relationship between mediator release from human lung mast cells in vitro and in vivo. Int Arch Allergy Appl Immunol (1985) 0.90

Cytokine immunoreactivity in seasonal rhinitis: regulation by a topical corticosteroid. Am J Respir Crit Care Med (1995) 0.89

Nasal effects of bradykinin and capsaicin: influence on plasma protein leakage and role of sensory neurons. J Appl Physiol (1985) (1992) 0.88

The antihistamines of the nineties. Clin Rev Allergy (1993) 0.88

Mechanisms and mediators of nasal symptoms in non-allergic rhinitis. Clin Exp Allergy (2008) 0.88

Early changes in T lymphocytes recovered by bronchoalveolar lavage after local allergen challenge of asthmatic airways. Am Rev Respir Dis (1992) 0.87

The relationship between atopic status and IL-10 nasal lavage levels in the acute and persistent inflammatory response to upper respiratory tract infection. Am J Respir Crit Care Med (2001) 0.87

Inflammatory and T-cell profile of asthmatic airways 6 hours after local allergen provocation. Am J Respir Crit Care Med (1996) 0.87

Astemizole and other H1-antihistaminic drug treatment of asthma. J Allergy Clin Immunol (1985) 0.86

Co-localization of immunoreactive transforming growth factor-beta 1 and decorin in bronchial biopsies from asthmatic and normal subjects. J Pathol (1998) 0.86

Genetic and environmental influences on airway inflammation in asthma. Int Arch Allergy Immunol (1995) 0.86

Comparative nasal effects of bradykinin and histamine: influence on nasal airways resistance and plasma protein exudation. Thorax (1993) 0.85

Exercise and isocapnic hyperventilation-induced bronchoconstriction in asthma: relevance of circulating basophils to measurements of plasma histamine. J Allergy Clin Immunol (1984) 0.85

Airway endothelin levels in asthma: influence of endobronchial allergen challenge and maintenance corticosteroid therapy. Eur Respir J (1997) 0.84

The novel use of the human nasal epithelial cell line RPMI 2650 as an in vitro model to study the influence of allergens and cytokines on transforming growth factor-beta gene expression and protein release. Clin Exp Allergy (2005) 0.84

Prostaglandin D2-induced bronchoconstriction is mediated only in part by the thromboxane prostanoid receptor. Eur Respir J (1995) 0.84

Effect of inhaled frusemide on responses of airways to bradykinin and adenosine 5'-monophosphate in asthma. Thorax (1994) 0.84

Nitric oxide and the respiratory system in health and disease. Respir Med (1998) 0.84

Stability of phenotypes defined by physiological variables and biomarkers in adults with asthma. Allergy (2014) 0.83

Leucocyte-endothelial adhesion molecules and their role in bronchial asthma and allergic rhinitis. Eur Respir J (1993) 0.83

Preliminary study of the cellular characteristics of primary bronchial fibroblasts in patients with asthma: expression of alpha-smooth muscle actin, fibronectin containing extra type III domain A, and smoothelin. J Investig Allergol Clin Immunol (2012) 0.83

Safety aspects of local endobronchial allergen challenge in asthmatic patients. Am J Respir Crit Care Med (1996) 0.83

Invited lecture: activation of the epithelial mesenchymal trophic unit in the pathogenesis of asthma. Int Arch Allergy Immunol (2001) 0.83

Exercise, asthma, and mast cells. Lancet (1983) 0.83

Immunoreactive endothelin in bronchial biopsy specimens: increased expression in asthma and modulation by corticosteroid therapy. J Allergy Clin Immunol (1997) 0.82

Effect of inhaled platelet-activating factor on bronchial inflammation in atopic non-asthmatic subjects. Int Arch Allergy Immunol (1992) 0.82

Bronchoconstriction induced by nebulised ipratropium bromide: relation to the bromide ion. Br Med J (Clin Res Ed) (1986) 0.81

Pathology of rhinitis and bronchial asthma. Clin Exp Allergy (1996) 0.81

Histamine and the nasal vasculature: the influence of H1 and H2-histamine receptor antagonism. Clin Otolaryngol Allied Sci (1996) 0.81

Cytokine production by cell cultures from bronchial subepithelial myofibroblasts. J Pathol (1996) 0.81

The T cell and the airway's fibrotic response in asthma. Chest (1993) 0.81

Effects of short-term exposure to 0.2 ppm ozone on biomarkers of inflammation in sputum, exhaled nitric oxide, and lung function in subjects with mild atopic asthma. J Occup Environ Med (2000) 0.80

Expression of c-erbB receptors and ligands in human nasal epithelium. J Allergy Clin Immunol (2000) 0.80

Kinins and rhinitis. Clin Exp Allergy (1992) 0.79

Circulating adhesion molecules in asthma. Am J Respir Crit Care Med (1994) 0.79

Allergic inflammation and its pharmacological modulation in asthma. Int Arch Allergy Appl Immunol (1991) 0.79

Endobronchial ultrasound to assess airway wall thickening: validation in vitro and in vivo. Eur Respir J (2004) 0.79

Cellular and mediator responses twenty-four hours after local endobronchial allergen challenge of asthmatic airways. J Allergy Clin Immunol (1996) 0.79

Inflammatory mediators in naturally occurring rhinitis. Clin Exp Allergy (1998) 0.79

Effect of systemic beta-agonist therapy on IgE production in allergic subjects in vivo. J Allergy Clin Immunol (1998) 0.79

Bronchial mucosal mast cells and their implications in the pathogenesis of asthma. Bull Eur Physiopathol Respir (1986) 0.78

Urinary glycosaminoglycan levels are increased in acute severe asthma--a role for eosinophil-derived gelatinase B? Int Arch Allergy Immunol (1997) 0.78

Inflammatory processes and bronchial hyperresponsiveness. Clin Exp Allergy (1991) 0.78

Localization of interleukin (IL) -4 but not IL-5 to human mast cell secretory granules by immunoelectron microscopy. Clin Exp Allergy (2000) 0.78

The influence of terfenadine and ipratropium bromide alone and in combination on bradykinin-induced nasal symptoms and plasma protein leakage. Clin Exp Allergy (1992) 0.78

Exhaled nitric oxide levels in exacerbations of asthma, chronic obstructive pulmonary disease and pneumonia. Saudi Med J (2001) 0.78

Paradoxical bronchoconstriction with nebulized albuterol but not with terbutaline. Am Rev Respir Dis (1993) 0.78